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Gabor Gigler - One of the best experts on this subject based on the ideXlab platform.

  • antiinflammatory effect of a protein kinase c inhibitor k 252a on the development of the dextran induced paw Edema in the rat preliminary results
    Acta Physiologica Hungarica, 1992
    Co-Authors: M Papp, Hiroshi Kase, Gabor Gigler
    Abstract:

    : The effect of a metabolite of Nocardiopsis sp. as a protein kinase C inhibitor from microbial origin was investigated on the onset and development of dextran-induced paw Edema in the rat. It was published that this compound (K-252a) interferes with histamine release from mast cells, while dextran-induced paw and Nose Edema are induced by vasoactive agents, like histamine etc., released from the disrupted mast cells. The antiinflammatory effect of the K-252a is effectuated by the inhibition of protein kinase C. Groups of male Wistar rats with 180-200 g b.w. were used; each group consisted of 10-10 rats. The following groups were consisted: rats given orally DMSO (control), rats given 1 mg/kg, or 3 mg/kg b.w. of K-252a dissolved in DMSO and given p.o. one hour before dextran injection. Dextran (BDH Chem. LTD, molW: 200.000, England) was injected intraperitoneally in 10% solution, in a dose of one ml/100 g b.w. Volume of the hind leg was measured by a mercury plethysmometer. Time-sequence of the Edema was followed. Increase in volume of hind leg paw was related to its 0-min volume in %. Results were analyzed by the Kruskal-Wallis-test. Edema of the legs and Noses appeared in each of the control rats in one hour. The 1 mg/kg dose of K-252a retarded the appearance of the Edema by 1 hour, the 3 mg/kg dose, however, prevented its onset for 4 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

M Papp - One of the best experts on this subject based on the ideXlab platform.

  • antiinflammatory effect of a protein kinase c inhibitor k 252a on the development of the dextran induced paw Edema in the rat preliminary results
    Acta Physiologica Hungarica, 1992
    Co-Authors: M Papp, Hiroshi Kase, Gabor Gigler
    Abstract:

    : The effect of a metabolite of Nocardiopsis sp. as a protein kinase C inhibitor from microbial origin was investigated on the onset and development of dextran-induced paw Edema in the rat. It was published that this compound (K-252a) interferes with histamine release from mast cells, while dextran-induced paw and Nose Edema are induced by vasoactive agents, like histamine etc., released from the disrupted mast cells. The antiinflammatory effect of the K-252a is effectuated by the inhibition of protein kinase C. Groups of male Wistar rats with 180-200 g b.w. were used; each group consisted of 10-10 rats. The following groups were consisted: rats given orally DMSO (control), rats given 1 mg/kg, or 3 mg/kg b.w. of K-252a dissolved in DMSO and given p.o. one hour before dextran injection. Dextran (BDH Chem. LTD, molW: 200.000, England) was injected intraperitoneally in 10% solution, in a dose of one ml/100 g b.w. Volume of the hind leg was measured by a mercury plethysmometer. Time-sequence of the Edema was followed. Increase in volume of hind leg paw was related to its 0-min volume in %. Results were analyzed by the Kruskal-Wallis-test. Edema of the legs and Noses appeared in each of the control rats in one hour. The 1 mg/kg dose of K-252a retarded the appearance of the Edema by 1 hour, the 3 mg/kg dose, however, prevented its onset for 4 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

Hiroshi Kase - One of the best experts on this subject based on the ideXlab platform.

  • antiinflammatory effect of a protein kinase c inhibitor k 252a on the development of the dextran induced paw Edema in the rat preliminary results
    Acta Physiologica Hungarica, 1992
    Co-Authors: M Papp, Hiroshi Kase, Gabor Gigler
    Abstract:

    : The effect of a metabolite of Nocardiopsis sp. as a protein kinase C inhibitor from microbial origin was investigated on the onset and development of dextran-induced paw Edema in the rat. It was published that this compound (K-252a) interferes with histamine release from mast cells, while dextran-induced paw and Nose Edema are induced by vasoactive agents, like histamine etc., released from the disrupted mast cells. The antiinflammatory effect of the K-252a is effectuated by the inhibition of protein kinase C. Groups of male Wistar rats with 180-200 g b.w. were used; each group consisted of 10-10 rats. The following groups were consisted: rats given orally DMSO (control), rats given 1 mg/kg, or 3 mg/kg b.w. of K-252a dissolved in DMSO and given p.o. one hour before dextran injection. Dextran (BDH Chem. LTD, molW: 200.000, England) was injected intraperitoneally in 10% solution, in a dose of one ml/100 g b.w. Volume of the hind leg was measured by a mercury plethysmometer. Time-sequence of the Edema was followed. Increase in volume of hind leg paw was related to its 0-min volume in %. Results were analyzed by the Kruskal-Wallis-test. Edema of the legs and Noses appeared in each of the control rats in one hour. The 1 mg/kg dose of K-252a retarded the appearance of the Edema by 1 hour, the 3 mg/kg dose, however, prevented its onset for 4 hours.(ABSTRACT TRUNCATED AT 250 WORDS)

Petrović Nenad T. - One of the best experts on this subject based on the ideXlab platform.

  • Rhinoplasty without nasal packing and splinting
    Military Health Department Ministry of Defance Serbia, 2018
    Co-Authors: Vulović Dejan, Kozarski Jevta, Radivojčević Uroš, Stepić Nenad, Milićević Saša, Petrović Nenad T.
    Abstract:

    Background/Aim. Most surgeons, at the end of corrective rhinoplasty, use endonasal tamponade and external splinting, primarily because of hemostasis and immobilization. Possible complications of this surgery are various. Pain, Nose Edema, palpebral swelling and ecchymosis, are the most common and usual. The aim of our study was to evaluate the incidence of nonaesthetic complications and the efficiency of corrective rhinoplasty without the use of tamponade and external splint. Methods. One hundred and fiftyone patients, who underwent primary corrective rhinoplasty without endonasal tamponade and without an external splint, were analyzed at the Clinical Centre “Kragujevac” in Kragujevac, Serbia, in the period 1999–May 2016. The surgeries were done by the same surgeon. Instead of a splint, sterile skin adhesive tapes were used. Study was prospective, consecutive case-series type. We analyzed the possible complications and subjective estimates of the patients who underwent primary corrective rhinoplasty in described fashion. In assessing postoparative pain, the visual analogue scale (VAS) in a range of 1 to 5 was used. Palpebral swelling and ecchymosis, were estimated 24h after surgery, by the Surgeon Periorbital Rating of Edema and Ecchymosis (SPREE) scale ranging from 0 to 5. The degree of restriction of nasal respiration was evaluated by the scale 1–4. The overall comfort of patients in the postoperative period was evaluated according to a scale: good, no opinion, bad. The patient satisfaction with the aesthetic result was analyzed on 7th and 30th day after surgery, by a scale from 1 (very satisfied) to 5 (very dissatisfied). Results. There were 151 patients aged between 18–47 years. Females were more frequent (72.18%). Most of the patients (40.39%) had moderate pain. None of the patients had neither severe nor the worst pain and 59 patients had no pain at all. Eyelid Edema and periorbital ecchymosis were moderate in all patients (100%). The other complications did not occur, apart from one (0.66%) unilateral epistaxis, on postoperative day 10. Most of the patients (52.97%), immediately after surgery, could freely breathe through the Nose. The general impression of the patient comfort after surgery was mainly good (74.17%). The majority of patients (52.28%), were satisfied with aesthetic result after 7 days, and 52.32% after 1 month. There were very satisfied patients: on day 7 - 27.15% and on day 30 - 39.73%. Conclusion. We concluded that the rhinoplasty without using tamponade and immobilization was safe, comfortable and economical. The degree of pain, Edema and ecchymosis were low, as well as the incidence of other complications

Antônio Carlos Nicodemo - One of the best experts on this subject based on the ideXlab platform.

  • Copyright © 2014 by The American Society of Tropical Medicine and Hygiene Case Report: Reactivation of Mucosal and Cutaneous Leishmaniasis in a Renal Transplanted Patient
    2016
    Co-Authors: Felipe F. Tuon, Giovana Marina Bombonatto, Eveline Roesler Battaglin, Marcus Henrique Sakumoto, Valdir Sabbaga Amato, Raphael Abegão De Camargo, Antônio Carlos Nicodemo
    Abstract:

    Abstract. Mucosal leishmaniasis (ML) is a chronic form of tegumentary leishmaniasis, which causes destructive lesions of nasal, pharyngeal, and laryngeal mucosa. We describe a case of leishmaniasis reactivation with simultaneous cutaneous and mucosal forms in a renal transplanted patient with no history of prior leishmaniasis. Reactivation after renal transplantation was not reported in Brazil. A 67-year-old woman receiving prednisone 20 mg/day, tacrolimus 1 mg/day, and mycophenolic acid 360 mg/day presented with Nose Edema with erythema and cutaneous lesions. Amastigotes were identified on biopsies and the polymerase chain reaction confirmed Leishmania (Viannia) braziliensis. The patient was treated with liposomal amphotericin B but died 3 weeks after as a result of bacterial septic shock. In conclusion, tegumentary leishmaniasis can reactivate with simultaneous cutaneous and mucosal forms in a renal transplanted patient during the immunosuppressant therapy