The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform
Elisha Berman - One of the best experts on this subject based on the ideXlab platform.
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enhancement of 5 fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models walker 256 carcinosarcoma and Novikoff Hepatoma as evaluated by 19f magnetic resonance spectroscopy
Cancer Investigation, 2000Co-Authors: Itzhak Katzir, Jashovam Shani, Walter Wolf, Shruty Chatterjeeparti, Elisha BermanAbstract:AbstractAlthough 5-fluorouracil (5-FU) is one of the most effective single agents in treating solid tumors, its low effectiveness as a single agent has led to development of a number of modulators intended to enhance its therapeutic effectiveness. Of these, methotrexate (MTX) and trimetrexate (TMTX) have been shown to have synergistic anticancer activity with 5-FU. The effect of these two drugs on the uptake and the intratumoral metabolism of 5-FU was studied in two rat tumor models using 19F-nuclear magnetic resonance spectroscopy: on excised samples of Walker 256 carcinosarcoma and noninvasively (in vivo) in Novikoff Hepatoma. In the rats bearing the Walker 256 tumor, a 4-hr pretreatment with MTX showed the maximal increase in the rate of conversion from 5-FU to its fluorinated nucleotides/nucleosides. In the rats bearing the Novikoff Hepatoma, both modulators increased the amounts of cyctotoxic anabolites of 5-FU, but at the doses administered, the cumulative amounts of 5-FU anabolites formed after MTX...
Itzhak Katzir - One of the best experts on this subject based on the ideXlab platform.
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enhancement of 5 fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models walker 256 carcinosarcoma and Novikoff Hepatoma as evaluated by 19f magnetic resonance spectroscopy
Cancer Investigation, 2000Co-Authors: Itzhak Katzir, Jashovam Shani, Walter Wolf, Shruty Chatterjeeparti, Elisha BermanAbstract:AbstractAlthough 5-fluorouracil (5-FU) is one of the most effective single agents in treating solid tumors, its low effectiveness as a single agent has led to development of a number of modulators intended to enhance its therapeutic effectiveness. Of these, methotrexate (MTX) and trimetrexate (TMTX) have been shown to have synergistic anticancer activity with 5-FU. The effect of these two drugs on the uptake and the intratumoral metabolism of 5-FU was studied in two rat tumor models using 19F-nuclear magnetic resonance spectroscopy: on excised samples of Walker 256 carcinosarcoma and noninvasively (in vivo) in Novikoff Hepatoma. In the rats bearing the Walker 256 tumor, a 4-hr pretreatment with MTX showed the maximal increase in the rate of conversion from 5-FU to its fluorinated nucleotides/nucleosides. In the rats bearing the Novikoff Hepatoma, both modulators increased the amounts of cyctotoxic anabolites of 5-FU, but at the doses administered, the cumulative amounts of 5-FU anabolites formed after MTX...
Shruty Chatterjeeparti - One of the best experts on this subject based on the ideXlab platform.
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enhancement of 5 fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models walker 256 carcinosarcoma and Novikoff Hepatoma as evaluated by 19f magnetic resonance spectroscopy
Cancer Investigation, 2000Co-Authors: Itzhak Katzir, Jashovam Shani, Walter Wolf, Shruty Chatterjeeparti, Elisha BermanAbstract:AbstractAlthough 5-fluorouracil (5-FU) is one of the most effective single agents in treating solid tumors, its low effectiveness as a single agent has led to development of a number of modulators intended to enhance its therapeutic effectiveness. Of these, methotrexate (MTX) and trimetrexate (TMTX) have been shown to have synergistic anticancer activity with 5-FU. The effect of these two drugs on the uptake and the intratumoral metabolism of 5-FU was studied in two rat tumor models using 19F-nuclear magnetic resonance spectroscopy: on excised samples of Walker 256 carcinosarcoma and noninvasively (in vivo) in Novikoff Hepatoma. In the rats bearing the Walker 256 tumor, a 4-hr pretreatment with MTX showed the maximal increase in the rate of conversion from 5-FU to its fluorinated nucleotides/nucleosides. In the rats bearing the Novikoff Hepatoma, both modulators increased the amounts of cyctotoxic anabolites of 5-FU, but at the doses administered, the cumulative amounts of 5-FU anabolites formed after MTX...
Walter Wolf - One of the best experts on this subject based on the ideXlab platform.
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enhancement of 5 fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models walker 256 carcinosarcoma and Novikoff Hepatoma as evaluated by 19f magnetic resonance spectroscopy
Cancer Investigation, 2000Co-Authors: Itzhak Katzir, Jashovam Shani, Walter Wolf, Shruty Chatterjeeparti, Elisha BermanAbstract:AbstractAlthough 5-fluorouracil (5-FU) is one of the most effective single agents in treating solid tumors, its low effectiveness as a single agent has led to development of a number of modulators intended to enhance its therapeutic effectiveness. Of these, methotrexate (MTX) and trimetrexate (TMTX) have been shown to have synergistic anticancer activity with 5-FU. The effect of these two drugs on the uptake and the intratumoral metabolism of 5-FU was studied in two rat tumor models using 19F-nuclear magnetic resonance spectroscopy: on excised samples of Walker 256 carcinosarcoma and noninvasively (in vivo) in Novikoff Hepatoma. In the rats bearing the Walker 256 tumor, a 4-hr pretreatment with MTX showed the maximal increase in the rate of conversion from 5-FU to its fluorinated nucleotides/nucleosides. In the rats bearing the Novikoff Hepatoma, both modulators increased the amounts of cyctotoxic anabolites of 5-FU, but at the doses administered, the cumulative amounts of 5-FU anabolites formed after MTX...
Jashovam Shani - One of the best experts on this subject based on the ideXlab platform.
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enhancement of 5 fluorouracil anabolism by methotrexate and trimetrexate in two rat solid tumor models walker 256 carcinosarcoma and Novikoff Hepatoma as evaluated by 19f magnetic resonance spectroscopy
Cancer Investigation, 2000Co-Authors: Itzhak Katzir, Jashovam Shani, Walter Wolf, Shruty Chatterjeeparti, Elisha BermanAbstract:AbstractAlthough 5-fluorouracil (5-FU) is one of the most effective single agents in treating solid tumors, its low effectiveness as a single agent has led to development of a number of modulators intended to enhance its therapeutic effectiveness. Of these, methotrexate (MTX) and trimetrexate (TMTX) have been shown to have synergistic anticancer activity with 5-FU. The effect of these two drugs on the uptake and the intratumoral metabolism of 5-FU was studied in two rat tumor models using 19F-nuclear magnetic resonance spectroscopy: on excised samples of Walker 256 carcinosarcoma and noninvasively (in vivo) in Novikoff Hepatoma. In the rats bearing the Walker 256 tumor, a 4-hr pretreatment with MTX showed the maximal increase in the rate of conversion from 5-FU to its fluorinated nucleotides/nucleosides. In the rats bearing the Novikoff Hepatoma, both modulators increased the amounts of cyctotoxic anabolites of 5-FU, but at the doses administered, the cumulative amounts of 5-FU anabolites formed after MTX...
