The Experts below are selected from a list of 9126 Experts worldwide ranked by ideXlab platform
Michael J Campbell - One of the best experts on this subject based on the ideXlab platform.
-
both ultrasound features and Nuclear Atypia are associated with malignancy in thyroid nodules with Atypia of undetermined significance
Annals of Surgical Oncology, 2018Co-Authors: Naseem Eisa, Ahsan Khan, Mutaal M Akhter, Molly R Fensterwald, Saba Saleem, Ghaneh Fananapazir, Michael J CampbellAbstract:The optimal management of thyroid nodules that undergo fine-needle aspiration (FNA) with findings of Atypia of undetermined significance (AUS) is unclear. Categorizing nodules by AUS subtype and ultrasound characteristics may improve risk stratification. Therefore, the purpose of this study is to evaluate the association between AUS subtype and ultrasound features on risk of malignancy (ROM). We performed a review of all patients with a thyroid nodule who underwent an FNA at our institution between January 2010 and November 2015. Patients with AUS were divided into groups with (1) Nuclear Atypia, (2) architectural Atypia, or (3) Hurthle cell Atypia. Their ultrasound features were assessed using the American Thyroid Association (ATA) thyroid nodule sonographic patterns. We conducted a univariate and multivariable analysis to determine the association between AUS subtype and other variables of interest with ROM. Of the 3428 thyroid nodules that underwent FNA, 237 (6.9%) had AUS. Of the 97 surgically resected nodules, 67 (69%) were benign and 30 (31%) were malignant. On univariate analysis Nuclear Atypia (p < 0.01) was associated with a thyroid malignancy. On multivariable analysis, both ATA high-risk ultrasound features (p = 0.04, odds ratio [OR] 3.68) and Nuclear Atypia (p < 0.01, OR 11.8) were independently associated with a final diagnosis of thyroid carcinoma. Nuclear Atypia and ATA high-risk ultrasound features are useful in identifying patients with AUS that are at a higher risk of thyroid malignancy. Surgeons should take these factors into consideration when evaluating patients with AUS.
-
Both Ultrasound Features and Nuclear Atypia are Associated with Malignancy in Thyroid Nodules with Atypia of Undetermined Significance.
Annals of Surgical Oncology, 2018Co-Authors: Naseem Eisa, Mutaal M Akhter, Molly R Fensterwald, Saba Saleem, Ghaneh Fananapazir, Ahsan A. Khan, Michael J CampbellAbstract:The optimal management of thyroid nodules that undergo fine-needle aspiration (FNA) with findings of Atypia of undetermined significance (AUS) is unclear. Categorizing nodules by AUS subtype and ultrasound characteristics may improve risk stratification. Therefore, the purpose of this study is to evaluate the association between AUS subtype and ultrasound features on risk of malignancy (ROM). We performed a review of all patients with a thyroid nodule who underwent an FNA at our institution between January 2010 and November 2015. Patients with AUS were divided into groups with (1) Nuclear Atypia, (2) architectural Atypia, or (3) Hurthle cell Atypia. Their ultrasound features were assessed using the American Thyroid Association (ATA) thyroid nodule sonographic patterns. We conducted a univariate and multivariable analysis to determine the association between AUS subtype and other variables of interest with ROM. Of the 3428 thyroid nodules that underwent FNA, 237 (6.9%) had AUS. Of the 97 surgically resected nodules, 67 (69%) were benign and 30 (31%) were malignant. On univariate analysis Nuclear Atypia (p
Richard S Haber - One of the best experts on this subject based on the ideXlab platform.
-
thyroid cytology and the risk of malignancy in thyroid nodules importance of Nuclear Atypia in indeterminate specimens
Thyroid, 2001Co-Authors: Adam S Kelman, Allison Rathan, Jonas Leibowitz, David E Burstein, Richard S HaberAbstract:Fine needle aspiration (FNA) cytology is the best test for malignancy in thyroid nodules. However, cytologic interpretation of FNA specimens is often difficult, especially in the presence of indeterminate microfollicular cytologic patterns, which are thought to suggest follicular neoplasm (adenoma or carcinoma). To assess the risk of malignancy associated with specific cytologic patterns, we correlated preoperative FNA cytologic patterns (n = 484 reports including repeat aspirations) with final histological diagnoses for 368 surgical thyroid specimens obtained during the period 1994-1998. The overall prevalence of malignancy in the surgical specimens was 31% (113 cancers, including 96 papillary and 9 follicular carcinomas). For nodules with benign FNA cytologic diagnoses of nodular goiter and chronic thyroiditis there was a low risk of malignancy (6/99, or 6.1%). Nodules with indeterminate cytologic patterns in the absence of Nuclear Atypia (i.e., microfollicles without Nuclear Atypia) had a similarly low...
Naseem Eisa - One of the best experts on this subject based on the ideXlab platform.
-
both ultrasound features and Nuclear Atypia are associated with malignancy in thyroid nodules with Atypia of undetermined significance
Annals of Surgical Oncology, 2018Co-Authors: Naseem Eisa, Ahsan Khan, Mutaal M Akhter, Molly R Fensterwald, Saba Saleem, Ghaneh Fananapazir, Michael J CampbellAbstract:The optimal management of thyroid nodules that undergo fine-needle aspiration (FNA) with findings of Atypia of undetermined significance (AUS) is unclear. Categorizing nodules by AUS subtype and ultrasound characteristics may improve risk stratification. Therefore, the purpose of this study is to evaluate the association between AUS subtype and ultrasound features on risk of malignancy (ROM). We performed a review of all patients with a thyroid nodule who underwent an FNA at our institution between January 2010 and November 2015. Patients with AUS were divided into groups with (1) Nuclear Atypia, (2) architectural Atypia, or (3) Hurthle cell Atypia. Their ultrasound features were assessed using the American Thyroid Association (ATA) thyroid nodule sonographic patterns. We conducted a univariate and multivariable analysis to determine the association between AUS subtype and other variables of interest with ROM. Of the 3428 thyroid nodules that underwent FNA, 237 (6.9%) had AUS. Of the 97 surgically resected nodules, 67 (69%) were benign and 30 (31%) were malignant. On univariate analysis Nuclear Atypia (p < 0.01) was associated with a thyroid malignancy. On multivariable analysis, both ATA high-risk ultrasound features (p = 0.04, odds ratio [OR] 3.68) and Nuclear Atypia (p < 0.01, OR 11.8) were independently associated with a final diagnosis of thyroid carcinoma. Nuclear Atypia and ATA high-risk ultrasound features are useful in identifying patients with AUS that are at a higher risk of thyroid malignancy. Surgeons should take these factors into consideration when evaluating patients with AUS.
-
Both Ultrasound Features and Nuclear Atypia are Associated with Malignancy in Thyroid Nodules with Atypia of Undetermined Significance.
Annals of Surgical Oncology, 2018Co-Authors: Naseem Eisa, Mutaal M Akhter, Molly R Fensterwald, Saba Saleem, Ghaneh Fananapazir, Ahsan A. Khan, Michael J CampbellAbstract:The optimal management of thyroid nodules that undergo fine-needle aspiration (FNA) with findings of Atypia of undetermined significance (AUS) is unclear. Categorizing nodules by AUS subtype and ultrasound characteristics may improve risk stratification. Therefore, the purpose of this study is to evaluate the association between AUS subtype and ultrasound features on risk of malignancy (ROM). We performed a review of all patients with a thyroid nodule who underwent an FNA at our institution between January 2010 and November 2015. Patients with AUS were divided into groups with (1) Nuclear Atypia, (2) architectural Atypia, or (3) Hurthle cell Atypia. Their ultrasound features were assessed using the American Thyroid Association (ATA) thyroid nodule sonographic patterns. We conducted a univariate and multivariable analysis to determine the association between AUS subtype and other variables of interest with ROM. Of the 3428 thyroid nodules that underwent FNA, 237 (6.9%) had AUS. Of the 97 surgically resected nodules, 67 (69%) were benign and 30 (31%) were malignant. On univariate analysis Nuclear Atypia (p
Adam S Kelman - One of the best experts on this subject based on the ideXlab platform.
-
thyroid cytology and the risk of malignancy in thyroid nodules importance of Nuclear Atypia in indeterminate specimens
Thyroid, 2001Co-Authors: Adam S Kelman, Allison Rathan, Jonas Leibowitz, David E Burstein, Richard S HaberAbstract:Fine needle aspiration (FNA) cytology is the best test for malignancy in thyroid nodules. However, cytologic interpretation of FNA specimens is often difficult, especially in the presence of indeterminate microfollicular cytologic patterns, which are thought to suggest follicular neoplasm (adenoma or carcinoma). To assess the risk of malignancy associated with specific cytologic patterns, we correlated preoperative FNA cytologic patterns (n = 484 reports including repeat aspirations) with final histological diagnoses for 368 surgical thyroid specimens obtained during the period 1994-1998. The overall prevalence of malignancy in the surgical specimens was 31% (113 cancers, including 96 papillary and 9 follicular carcinomas). For nodules with benign FNA cytologic diagnoses of nodular goiter and chronic thyroiditis there was a low risk of malignancy (6/99, or 6.1%). Nodules with indeterminate cytologic patterns in the absence of Nuclear Atypia (i.e., microfollicles without Nuclear Atypia) had a similarly low...
Christine H Chung - One of the best experts on this subject based on the ideXlab platform.
-
cancer risk associated with Nuclear Atypia in cytologically indeterminate thyroid nodules a systematic review and meta analysis
Thyroid, 2017Co-Authors: Pablo Valderrabano, Laila Khazai, Zachary J Thompson, Susan C Sharpe, Valentina D Tarasova, Kristen J Otto, Julie E Hallangerjohnson, Trad J Wadsworth, Bruce M Wenig, Christine H ChungAbstract:Background: Indeterminate categories of thyroid cytopathology (categories B-III and B-IV of the Bethesda system) are integrated by a heterogeneous spectrum of cytological scenarios that are generally clustered for analysis and management recommendations. It has been suggested that aspirates exhibiting Nuclear Atypia have a higher risk of malignancy. This study aimed to assess whether cytologically indeterminate thyroid nodules with Nuclear Atypia have a significantly higher cancer risk than those without Nuclear Atypia. Methods: On June 30, 2016, PubMed and EMBASE were searched for articles in English or Spanish using a search strategy developed by an endocrinologist and a librarian. Case reports were excluded, and no date limits were used. The references of all included studies were also screened for relevant missing studies. Studies were included if the prevalences of malignancy of cytologically indeterminate thyroid nodules with histological confirmation with and without Nuclear Atypia were reported. S...
