The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform
S. K. - One of the best experts on this subject based on the ideXlab platform.
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Solid tumour with initial presentation in the bone marrow—a clinicopathologic study of 25 adult cases
Hematological oncology, 1993Co-Authors: Kin Fai Ellick Wong, J. K. C. Chan, S. K.Abstract:This study reviews the clinicopathologic features of 25 adult patients without a known history of malignancy presenting with metastatic carcinoma in the bone marrow. The disease mainly affected middle-aged to elderly males (mean age, 61.6 years). Bone pain, generalized or confined to the back, was a common presenting complaint. Organomegaly was often absent. Laboratory abnormalities included anaemia, leukocytosis, thrombocytopenia and a leukoerythroblastic blood picture. Serum alkaline phosphatase level was raised in the majority of cases. In about one-third of the cases, malignancy was not suspected clinically, and bone marrow aspiration was carried out because of incidental finding of abnormal blood counts. The marrow aspirate findings were characterized by numerous to sparse cohesive tumour clusters with Nuclear Moulding. Over two-thirds of the patients had metastatic adenocarcinoma, and the lung was found to be the commonest site of primary disease. We conclude that since the marrow infiltration can be subtle, marrow smears should be carefully scrutinized for tumour cells in patients with leukoerythroblastic blood picture, in particular those with an elevated serum alkaline phosphatase level.
Kin Fai Ellick Wong - One of the best experts on this subject based on the ideXlab platform.
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Solid tumour with initial presentation in the bone marrow—a clinicopathologic study of 25 adult cases
Hematological oncology, 1993Co-Authors: Kin Fai Ellick Wong, J. K. C. Chan, S. K.Abstract:This study reviews the clinicopathologic features of 25 adult patients without a known history of malignancy presenting with metastatic carcinoma in the bone marrow. The disease mainly affected middle-aged to elderly males (mean age, 61.6 years). Bone pain, generalized or confined to the back, was a common presenting complaint. Organomegaly was often absent. Laboratory abnormalities included anaemia, leukocytosis, thrombocytopenia and a leukoerythroblastic blood picture. Serum alkaline phosphatase level was raised in the majority of cases. In about one-third of the cases, malignancy was not suspected clinically, and bone marrow aspiration was carried out because of incidental finding of abnormal blood counts. The marrow aspirate findings were characterized by numerous to sparse cohesive tumour clusters with Nuclear Moulding. Over two-thirds of the patients had metastatic adenocarcinoma, and the lung was found to be the commonest site of primary disease. We conclude that since the marrow infiltration can be subtle, marrow smears should be carefully scrutinized for tumour cells in patients with leukoerythroblastic blood picture, in particular those with an elevated serum alkaline phosphatase level.
Shameem Sheriff - One of the best experts on this subject based on the ideXlab platform.
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Cytological features of lobular carcinoma of breast: how important are the intracytoplasmic lumina?
Indian journal of pathology & microbiology, 2005Co-Authors: Julian Crasta, Purnima Makhija, Karuna Ramesh Kumar, Shameem SheriffAbstract:Lobular carcinoma is the most common pitfall in the cytodiagnosis of breast lesions. Of the cytological features described intracytoplasmic lumina are stressed by many authors as an important diagnostic feature. The present study aims at evaluating the importance of intracytoplasmic lumina in the cytodiagnosis of lobular carcinoma along with other cytological features. Fine needle aspirates from 11 cases of histologically proven classical lobular carcinomas of breast were reviewed. It was observed that the low cellularity, dispersed dyscohesive small cells, mild pleomorphism, Nuclear Moulding and Indian filing were the most important cytologic features which aid in the diagnosis of lobular carcinoma where as intracytoplasmic lumina were of little significance.
J. K. C. Chan - One of the best experts on this subject based on the ideXlab platform.
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Solid tumour with initial presentation in the bone marrow—a clinicopathologic study of 25 adult cases
Hematological oncology, 1993Co-Authors: Kin Fai Ellick Wong, J. K. C. Chan, S. K.Abstract:This study reviews the clinicopathologic features of 25 adult patients without a known history of malignancy presenting with metastatic carcinoma in the bone marrow. The disease mainly affected middle-aged to elderly males (mean age, 61.6 years). Bone pain, generalized or confined to the back, was a common presenting complaint. Organomegaly was often absent. Laboratory abnormalities included anaemia, leukocytosis, thrombocytopenia and a leukoerythroblastic blood picture. Serum alkaline phosphatase level was raised in the majority of cases. In about one-third of the cases, malignancy was not suspected clinically, and bone marrow aspiration was carried out because of incidental finding of abnormal blood counts. The marrow aspirate findings were characterized by numerous to sparse cohesive tumour clusters with Nuclear Moulding. Over two-thirds of the patients had metastatic adenocarcinoma, and the lung was found to be the commonest site of primary disease. We conclude that since the marrow infiltration can be subtle, marrow smears should be carefully scrutinized for tumour cells in patients with leukoerythroblastic blood picture, in particular those with an elevated serum alkaline phosphatase level.
Allen R. Gibbs - One of the best experts on this subject based on the ideXlab platform.
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The histology and immunohistochemistry of small cell mesothelioma.
Histopathology, 1992Co-Authors: F.g. Mayall, Allen R. GibbsAbstract:The object of this study was to describe the histology and immunohistochemistry of 13 small cell mesotheliomas, concentrating on reliable distinctions between them and small cell carcinoma. All 13 tumours showed regions of more typical mesothelioma if multiple blocks were examined. No tumours showed the streams, ribbons, rosettes, or haematoxyphilic blood vessels that are typical of small cell carcinoma. Mitotic figures were relatively scarce and the nuclei had a particularly characteristic open appearance with prominent nucleoli and delicate chromatin. Nuclear Moulding was not seen. No tumour produced neutral mucin. Immunohistochemical positivity for neuron-specific enolase (NSE) was found in 11/13, cytokeratin in 9/13 and Leu-7 in 4/13 but none was positive for chromogranin A, carcino-embryonic antigen (CEA) or leucocyte common antigen (LCA). We conclude that the accurate diagnosis of small cell mesothelioma is possible, provided that the clinical presentation is known, the tumour is adequately sampled and the microscopy carefully assessed. In small biopsy specimens, where the diagnosis is less straightforward, immunohistochemistry for CEA, and perhaps LCA and chromogranin A may be helpful. NSE and Leu-7 positivity is common in these tumours and might be misleading if interpreted as reliable evidence of neuroendocrine differentiation.
