The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Itamar Willner - One of the best experts on this subject based on the ideXlab platform.
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graphene oxide Nucleic Acid stabilized silver nanoclusters functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic dnas
Journal of the American Chemical Society, 2013Co-Authors: Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer–substrate complexes leads to the generation of fluorescence as a readout signal f...
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Graphene oxide/Nucleic-Acid-stabilized silver nanoclusters: Functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic DNAs
Journal of the American Chemical Society, 2013Co-Authors: X Q Liu, Ruth Aizen, Fuan Wang, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer-substrate complexes leads to the generation of fluorescence as a readout signal for the sensing events. The hybrid nanostructures are implemented for the analysis of hepatitis B virus gene (HBV), the immunodeficiency virus gene (HIV), and the syphilis (Treponema pallidum) gene. Multiplexed analysis of the genes is demonstrated. The Nucleic-Acid-AgNCs-modified GO is also applied to detect ATP or thrombin through the release of the respective AgNCs-labeled aptamer-substrate complexes from GO.
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Nucleic Acid functionalized pt nanoparticles catalytic labels for the amplified electrochemical detection of biomolecules
Analytical Chemistry, 2006Co-Authors: Ronen Polsky, Ron Gill, Lubov Kaganovsky, Itamar WillnerAbstract:Nucleic Acid-functionalized Pt nanoparticles (Pt-NPs) act as catalytic labels for the amplified electrochemical detection of DNA hybridization and aptamer/protein recognition. Hybridization of the Nucleic Acid-modified Pt-NPs with a sensing Nucleic Acid/analyte DNA complex associated with an electrode enables the amperometric, amplified, detection of the DNA by the Pt NP electrocatalyzed reduction of H2O2 (sensitivity limit, 1 × 10-11 M). Similarly, the association of aptamer-functionalized Pt- NPs to a thrombin aptamer/thrombin complex associated with an electrode allowed the amplified, electrocatalytic detection of thrombin with a sensitivity limit corresponding to 1 × 10-9 M.
Fuan Wang - One of the best experts on this subject based on the ideXlab platform.
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graphene oxide Nucleic Acid stabilized silver nanoclusters functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic dnas
Journal of the American Chemical Society, 2013Co-Authors: Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer–substrate complexes leads to the generation of fluorescence as a readout signal f...
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Graphene oxide/Nucleic-Acid-stabilized silver nanoclusters: Functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic DNAs
Journal of the American Chemical Society, 2013Co-Authors: X Q Liu, Ruth Aizen, Fuan Wang, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer-substrate complexes leads to the generation of fluorescence as a readout signal for the sensing events. The hybrid nanostructures are implemented for the analysis of hepatitis B virus gene (HBV), the immunodeficiency virus gene (HIV), and the syphilis (Treponema pallidum) gene. Multiplexed analysis of the genes is demonstrated. The Nucleic-Acid-AgNCs-modified GO is also applied to detect ATP or thrombin through the release of the respective AgNCs-labeled aptamer-substrate complexes from GO.
Ruth Aizen - One of the best experts on this subject based on the ideXlab platform.
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graphene oxide Nucleic Acid stabilized silver nanoclusters functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic dnas
Journal of the American Chemical Society, 2013Co-Authors: Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer–substrate complexes leads to the generation of fluorescence as a readout signal f...
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Graphene oxide/Nucleic-Acid-stabilized silver nanoclusters: Functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic DNAs
Journal of the American Chemical Society, 2013Co-Authors: X Q Liu, Ruth Aizen, Fuan Wang, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer-substrate complexes leads to the generation of fluorescence as a readout signal for the sensing events. The hybrid nanostructures are implemented for the analysis of hepatitis B virus gene (HBV), the immunodeficiency virus gene (HIV), and the syphilis (Treponema pallidum) gene. Multiplexed analysis of the genes is demonstrated. The Nucleic-Acid-AgNCs-modified GO is also applied to detect ATP or thrombin through the release of the respective AgNCs-labeled aptamer-substrate complexes from GO.
Omer Yehezkeli - One of the best experts on this subject based on the ideXlab platform.
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graphene oxide Nucleic Acid stabilized silver nanoclusters functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic dnas
Journal of the American Chemical Society, 2013Co-Authors: Fuan Wang, Ruth Aizen, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer–substrate complexes leads to the generation of fluorescence as a readout signal f...
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Graphene oxide/Nucleic-Acid-stabilized silver nanoclusters: Functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic DNAs
Journal of the American Chemical Society, 2013Co-Authors: X Q Liu, Ruth Aizen, Fuan Wang, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer-substrate complexes leads to the generation of fluorescence as a readout signal for the sensing events. The hybrid nanostructures are implemented for the analysis of hepatitis B virus gene (HBV), the immunodeficiency virus gene (HIV), and the syphilis (Treponema pallidum) gene. Multiplexed analysis of the genes is demonstrated. The Nucleic-Acid-AgNCs-modified GO is also applied to detect ATP or thrombin through the release of the respective AgNCs-labeled aptamer-substrate complexes from GO.
X Q Liu - One of the best experts on this subject based on the ideXlab platform.
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Graphene oxide/Nucleic-Acid-stabilized silver nanoclusters: Functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic DNAs
Journal of the American Chemical Society, 2013Co-Authors: X Q Liu, Ruth Aizen, Fuan Wang, Omer Yehezkeli, Itamar WillnerAbstract:Hybrid systems consisting of Nucleic-Acid-functionalized silver nanoclusters (AgNCs) and graphene oxide (GO) are used for the development of fluorescent DNA sensors and aptasensors, and for the multiplexed analysis of a series of genes of infectious pathogens. Two types of Nucleic-Acid-stabilized AgNCs are used: one type includes the red-emitting AgNCs (616 nm) and the second type is near-infrared-emitting AgNCs (775 nm). Whereas the Nucleic-Acid-stabilized AgNCs do not bind to GO, the conjugation of single-stranded Nucleic Acid to the DNA-stabilized AgNCs leads to the adsorption of the hybrid nanostructures to GO and to the fluorescence quenching of the AgNCs. By the conjugation of oligonucleotide sequences acting as probes for target genes, or as aptamer sequences, to the Nucleic-Acid-protected AgNCs, the desorption of the probe/Nucleic-Acid-stabilized AgNCs from GO through the formation of duplex DNA structures or aptamer-substrate complexes leads to the generation of fluorescence as a readout signal for the sensing events. The hybrid nanostructures are implemented for the analysis of hepatitis B virus gene (HBV), the immunodeficiency virus gene (HIV), and the syphilis (Treponema pallidum) gene. Multiplexed analysis of the genes is demonstrated. The Nucleic-Acid-AgNCs-modified GO is also applied to detect ATP or thrombin through the release of the respective AgNCs-labeled aptamer-substrate complexes from GO.
