The Experts below are selected from a list of 168 Experts worldwide ranked by ideXlab platform
Noboru Mizuno - One of the best experts on this subject based on the ideXlab platform.
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demonstration of axon terminals of projection fibers from the periaqueductal gray onto neurons in the Nucleus Raphe Magnus which send their axons to the trigeminal sensory nuclei
Brain Research, 1993Co-Authors: Yasuhide Shinonaga, Masahiko Takada, Noboru MizunoAbstract:Axon terminals of projection fibers from the periaqueductal gray (PAG) onto neurons in the Nucleus Raphe Magnus (NRM) sending their axons to the principal sensory trigeminal Nucleus (Vp) or caudal spinal trigeminal Nucleus (Vc) were demonstrated light microscopically: In the rats which were injected with Phaseolus vulgaris leucoagglutinin (PHA-L) and wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) respectively into the PAG and trigeminal sensory complex (Vp or Vc), presumed axon terminals labeled anterogradely with PHA-L appeared to make synaptic contacts with NRM neurons labeled retrogradely with WGA-HRP.
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Collateral projections of single neurons in the Nucleus Raphe Magnus to both the sensory trigeminal nuclei and spinal cord in the rat
Brain research, 1993Co-Authors: Masahiko Takada, Yasuhide Shinonaga, Noboru MizunoAbstract:After injecting Diamidino yellow and Fast blue respectively into the sensory trigeminal nuclei and spinal cord, we observed doubly labeled cells in the Nucleus Raphe Magnus (NRM). Combining the fluorescent retrograde double labeling with serotonin (5-HT) immunofluorescence histochemistry, we further found that about 30% of the doubly labeled NRM neurons showed 5-HT-like immunoreactivity (5-HT-LI). Such 5-HT-LI NRM neurons may modulate nociceptive activities simultaneously in the sensory trigeminal nuclei and spinal cord by sending axon collaterals to these regions.
R Dallel - One of the best experts on this subject based on the ideXlab platform.
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Morphine microinjected into the Nucleus Raphe Magnus does not block the activity of spinal trigeminal Nucleus oralis convergent neurons in the rat.
Brain research, 1998Co-Authors: C Dualé, J L Molat, R DallelAbstract:This study investigated the effects of morphine microinjection into the Nucleus Raphe Magnus (RMg) on electrically evoked C-fiber activities of convergent neurons in the spinal trigeminal Nucleus oralis (Sp5O), in halothane-anesthetized rats. Although the neurons could be depressed by systemic morphine (6 mg/kg, i.v.) in a naloxone-reversible fashion, morphine microinjected into the RMg (2. 5 microgram or 5 microgram) neither depressed their C-fiber-evoked responses, nor the diffuse noxious inhibitory controls acting on them. It is concluded that the RMg is not involved in reinforcing descending inhibitory controls that are tonic or triggered by noxious stimuli acting on Sp5O convergent neurons.
Masahiko Takada - One of the best experts on this subject based on the ideXlab platform.
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demonstration of axon terminals of projection fibers from the periaqueductal gray onto neurons in the Nucleus Raphe Magnus which send their axons to the trigeminal sensory nuclei
Brain Research, 1993Co-Authors: Yasuhide Shinonaga, Masahiko Takada, Noboru MizunoAbstract:Axon terminals of projection fibers from the periaqueductal gray (PAG) onto neurons in the Nucleus Raphe Magnus (NRM) sending their axons to the principal sensory trigeminal Nucleus (Vp) or caudal spinal trigeminal Nucleus (Vc) were demonstrated light microscopically: In the rats which were injected with Phaseolus vulgaris leucoagglutinin (PHA-L) and wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) respectively into the PAG and trigeminal sensory complex (Vp or Vc), presumed axon terminals labeled anterogradely with PHA-L appeared to make synaptic contacts with NRM neurons labeled retrogradely with WGA-HRP.
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Collateral projections of single neurons in the Nucleus Raphe Magnus to both the sensory trigeminal nuclei and spinal cord in the rat
Brain research, 1993Co-Authors: Masahiko Takada, Yasuhide Shinonaga, Noboru MizunoAbstract:After injecting Diamidino yellow and Fast blue respectively into the sensory trigeminal nuclei and spinal cord, we observed doubly labeled cells in the Nucleus Raphe Magnus (NRM). Combining the fluorescent retrograde double labeling with serotonin (5-HT) immunofluorescence histochemistry, we further found that about 30% of the doubly labeled NRM neurons showed 5-HT-like immunoreactivity (5-HT-LI). Such 5-HT-LI NRM neurons may modulate nociceptive activities simultaneously in the sensory trigeminal nuclei and spinal cord by sending axon collaterals to these regions.
Yasuhide Shinonaga - One of the best experts on this subject based on the ideXlab platform.
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demonstration of axon terminals of projection fibers from the periaqueductal gray onto neurons in the Nucleus Raphe Magnus which send their axons to the trigeminal sensory nuclei
Brain Research, 1993Co-Authors: Yasuhide Shinonaga, Masahiko Takada, Noboru MizunoAbstract:Axon terminals of projection fibers from the periaqueductal gray (PAG) onto neurons in the Nucleus Raphe Magnus (NRM) sending their axons to the principal sensory trigeminal Nucleus (Vp) or caudal spinal trigeminal Nucleus (Vc) were demonstrated light microscopically: In the rats which were injected with Phaseolus vulgaris leucoagglutinin (PHA-L) and wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) respectively into the PAG and trigeminal sensory complex (Vp or Vc), presumed axon terminals labeled anterogradely with PHA-L appeared to make synaptic contacts with NRM neurons labeled retrogradely with WGA-HRP.
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Collateral projections of single neurons in the Nucleus Raphe Magnus to both the sensory trigeminal nuclei and spinal cord in the rat
Brain research, 1993Co-Authors: Masahiko Takada, Yasuhide Shinonaga, Noboru MizunoAbstract:After injecting Diamidino yellow and Fast blue respectively into the sensory trigeminal nuclei and spinal cord, we observed doubly labeled cells in the Nucleus Raphe Magnus (NRM). Combining the fluorescent retrograde double labeling with serotonin (5-HT) immunofluorescence histochemistry, we further found that about 30% of the doubly labeled NRM neurons showed 5-HT-like immunoreactivity (5-HT-LI). Such 5-HT-LI NRM neurons may modulate nociceptive activities simultaneously in the sensory trigeminal nuclei and spinal cord by sending axon collaterals to these regions.
Bao-cheng Lin - One of the best experts on this subject based on the ideXlab platform.
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Arginine vasopressin in hypothalamic paraventricular Nucleus is transferred to the Nucleus Raphe Magnus to participate in pain modulation.
Peptides, 2009Co-Authors: Jun Yang, Wen-yan Liu, Huifeng Yuan, Wang, Cai Song, Daiwei Yang, Bao-cheng LinAbstract:Hypothalamic paraventricular Nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our previous study has pointed that pain stimulation induced AVP increase in the Nucleus Raphe Magnus (NRM), which plays a role in pain modulation. The present study was designed to investigate the source of AVP in the rat NRM during pain process using the methods of Nucleus push-pull perfusion and radioimmunoassay. The results showed that pain stimulation increased the AVP concentration in the NRM perfusion liquid, PVN cauterization inhibited the role that pain stimulation induced the increase of AVP concentration in the NRM perfusion liquid, and PVN microinjection of L-glutamate sodium, which excited the PVN neurons, could increase the AVP concentration in the NRM perfusion liquid. The data suggested that AVP in the PVN might be transferred to the NRM to participate in pain modulation.
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Effect of arginine vasopressin in the Nucleus Raphe Magnus on antinociception in the rat.
Peptides, 2006Co-Authors: Jun Yang, Jian-min Chen, Wen-yan Liu, Cao-you Song, Cheng-hai Wang, Bao-cheng LinAbstract:Previous work has shown that arginine vasopressin (AVP) regulates antinociception through brain nuclei rather than the spinal cord and peripheral organs. The present study investigated the nociceptive effect of AVP in the Nucleus Raphe Magnus (NRM) of the rat. Microinjection of AVP into the NRM increased pain threshold in a dose-dependent manner, while local administration of AVP-receptor antagonist-d(CH2)5Tyr(Et)DAVP decreased the pain threshold. Pain stimulation elevated AVP concentration in the NRM perfuse liquid. NRM pretreatment with AVP-receptor antagonist completely reversed AVP's effect on pain threshold in the NRM. The data suggest that AVP in the NRM is involved in antinociception.
