The Experts below are selected from a list of 43908 Experts worldwide ranked by ideXlab platform
Hongshan Liang - One of the best experts on this subject based on the ideXlab platform.
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plant exine capsules based encapsulation strategy a high loading and long term effective delivery system for nobiletin
Food Research International, 2020Co-Authors: Di Wu, Youyan Liang, Bin Li, Hongshan LiangAbstract:Abstract The properties of high loading capacity and long-term absorption are of great significance in the field of Nutraceuticals or drugs delivery. Herein, we developed an innovative method to achieve these expected effects using plant exine capsules, a kind of natural pollen grains, which could provide large internal cavities for loading and robust exine against harsh conditions. In our work, we firstly made a soluble mixture of glycerol monostearate (GM) and nobiletin (NOB) inside the cavities of plant exine capsules by ultrasound with high temperature to obtain a supersaturated state of NOB, which could be characterized by XRD, DSC and FTIR. After that, the loaded capsules were cooled to room temperature. Alginate hydrogels were then selected for encapsulating and further controlling NOB release in simulated gastric and intestinal conditions. As a result, it demonstrated that our approach was able to reach an extremely high NOB loading capacity of 770 ± 40 mg/g using sunflower pollen grains (SPGs). Meanwhile, the existence of GM, SPGs and alginate hydrogels all retarded the release of the NOB synergistically, thus taking a slow release effect in the stomach while a long-term effective absorption in the intestine. Taken together, our processing method of encapsulating hydrophobic Nutraceuticals provides an important insight for broadening the applications of Nutraceutical or drug encapsulation and delivery.
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leveraging plant exine capsules as ph responsive delivery vehicles for hydrophobic Nutraceutical encapsulation
Food & Function, 2018Co-Authors: Di Wu, Youyan Liang, Kai Huang, Xinyi Jing, Bin Li, Hongshan LiangAbstract:Plant exine capsules are natural microscale capsules that are highly physically robust and chemically resilient. They are extracted from pollen grains and plant spores, and can be used as renewable and safe microcapsules for encapsulation applications. Herein, we report the successful evacuation of natural sunflower pollen grains (SPGs) and Lycopodiastrum casuarinoides spore exine capsules (SECs) and investigated the effects of different loading methods on the encapsulation and release of nobiletin, a model hydrophobic Nutraceutical. The compositional and morphological characterizations of SPGs and SECs obtained by the developed extraction protocol confirmed that the inside contents had been removed and hollow pollen cavities were obtained successfully. In addition, coumarin-6, a hydrophobic fluorescent probe, was encapsulated into SPGs and SECs, which proved the possibility of using them to encapsulate hydrophobic Nutraceuticals. Furthermore, controlled release in simulated digestive fluids (SDF) was achieved by coating calcium alginate onto the outside of the SPGs and SECs. Looking forward, this may provide an effective and potential delivery model to protect loads from degradation in the stomach and achieve pH-responsive delivery of hydrophobic Nutraceuticals after oral administration.
Di Wu - One of the best experts on this subject based on the ideXlab platform.
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plant exine capsules based encapsulation strategy a high loading and long term effective delivery system for nobiletin
Food Research International, 2020Co-Authors: Di Wu, Youyan Liang, Bin Li, Hongshan LiangAbstract:Abstract The properties of high loading capacity and long-term absorption are of great significance in the field of Nutraceuticals or drugs delivery. Herein, we developed an innovative method to achieve these expected effects using plant exine capsules, a kind of natural pollen grains, which could provide large internal cavities for loading and robust exine against harsh conditions. In our work, we firstly made a soluble mixture of glycerol monostearate (GM) and nobiletin (NOB) inside the cavities of plant exine capsules by ultrasound with high temperature to obtain a supersaturated state of NOB, which could be characterized by XRD, DSC and FTIR. After that, the loaded capsules were cooled to room temperature. Alginate hydrogels were then selected for encapsulating and further controlling NOB release in simulated gastric and intestinal conditions. As a result, it demonstrated that our approach was able to reach an extremely high NOB loading capacity of 770 ± 40 mg/g using sunflower pollen grains (SPGs). Meanwhile, the existence of GM, SPGs and alginate hydrogels all retarded the release of the NOB synergistically, thus taking a slow release effect in the stomach while a long-term effective absorption in the intestine. Taken together, our processing method of encapsulating hydrophobic Nutraceuticals provides an important insight for broadening the applications of Nutraceutical or drug encapsulation and delivery.
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leveraging plant exine capsules as ph responsive delivery vehicles for hydrophobic Nutraceutical encapsulation
Food & Function, 2018Co-Authors: Di Wu, Youyan Liang, Kai Huang, Xinyi Jing, Bin Li, Hongshan LiangAbstract:Plant exine capsules are natural microscale capsules that are highly physically robust and chemically resilient. They are extracted from pollen grains and plant spores, and can be used as renewable and safe microcapsules for encapsulation applications. Herein, we report the successful evacuation of natural sunflower pollen grains (SPGs) and Lycopodiastrum casuarinoides spore exine capsules (SECs) and investigated the effects of different loading methods on the encapsulation and release of nobiletin, a model hydrophobic Nutraceutical. The compositional and morphological characterizations of SPGs and SECs obtained by the developed extraction protocol confirmed that the inside contents had been removed and hollow pollen cavities were obtained successfully. In addition, coumarin-6, a hydrophobic fluorescent probe, was encapsulated into SPGs and SECs, which proved the possibility of using them to encapsulate hydrophobic Nutraceuticals. Furthermore, controlled release in simulated digestive fluids (SDF) was achieved by coating calcium alginate onto the outside of the SPGs and SECs. Looking forward, this may provide an effective and potential delivery model to protect loads from degradation in the stomach and achieve pH-responsive delivery of hydrophobic Nutraceuticals after oral administration.
Bin Li - One of the best experts on this subject based on the ideXlab platform.
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plant exine capsules based encapsulation strategy a high loading and long term effective delivery system for nobiletin
Food Research International, 2020Co-Authors: Di Wu, Youyan Liang, Bin Li, Hongshan LiangAbstract:Abstract The properties of high loading capacity and long-term absorption are of great significance in the field of Nutraceuticals or drugs delivery. Herein, we developed an innovative method to achieve these expected effects using plant exine capsules, a kind of natural pollen grains, which could provide large internal cavities for loading and robust exine against harsh conditions. In our work, we firstly made a soluble mixture of glycerol monostearate (GM) and nobiletin (NOB) inside the cavities of plant exine capsules by ultrasound with high temperature to obtain a supersaturated state of NOB, which could be characterized by XRD, DSC and FTIR. After that, the loaded capsules were cooled to room temperature. Alginate hydrogels were then selected for encapsulating and further controlling NOB release in simulated gastric and intestinal conditions. As a result, it demonstrated that our approach was able to reach an extremely high NOB loading capacity of 770 ± 40 mg/g using sunflower pollen grains (SPGs). Meanwhile, the existence of GM, SPGs and alginate hydrogels all retarded the release of the NOB synergistically, thus taking a slow release effect in the stomach while a long-term effective absorption in the intestine. Taken together, our processing method of encapsulating hydrophobic Nutraceuticals provides an important insight for broadening the applications of Nutraceutical or drug encapsulation and delivery.
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leveraging plant exine capsules as ph responsive delivery vehicles for hydrophobic Nutraceutical encapsulation
Food & Function, 2018Co-Authors: Di Wu, Youyan Liang, Kai Huang, Xinyi Jing, Bin Li, Hongshan LiangAbstract:Plant exine capsules are natural microscale capsules that are highly physically robust and chemically resilient. They are extracted from pollen grains and plant spores, and can be used as renewable and safe microcapsules for encapsulation applications. Herein, we report the successful evacuation of natural sunflower pollen grains (SPGs) and Lycopodiastrum casuarinoides spore exine capsules (SECs) and investigated the effects of different loading methods on the encapsulation and release of nobiletin, a model hydrophobic Nutraceutical. The compositional and morphological characterizations of SPGs and SECs obtained by the developed extraction protocol confirmed that the inside contents had been removed and hollow pollen cavities were obtained successfully. In addition, coumarin-6, a hydrophobic fluorescent probe, was encapsulated into SPGs and SECs, which proved the possibility of using them to encapsulate hydrophobic Nutraceuticals. Furthermore, controlled release in simulated digestive fluids (SDF) was achieved by coating calcium alginate onto the outside of the SPGs and SECs. Looking forward, this may provide an effective and potential delivery model to protect loads from degradation in the stomach and achieve pH-responsive delivery of hydrophobic Nutraceuticals after oral administration.
Youyan Liang - One of the best experts on this subject based on the ideXlab platform.
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plant exine capsules based encapsulation strategy a high loading and long term effective delivery system for nobiletin
Food Research International, 2020Co-Authors: Di Wu, Youyan Liang, Bin Li, Hongshan LiangAbstract:Abstract The properties of high loading capacity and long-term absorption are of great significance in the field of Nutraceuticals or drugs delivery. Herein, we developed an innovative method to achieve these expected effects using plant exine capsules, a kind of natural pollen grains, which could provide large internal cavities for loading and robust exine against harsh conditions. In our work, we firstly made a soluble mixture of glycerol monostearate (GM) and nobiletin (NOB) inside the cavities of plant exine capsules by ultrasound with high temperature to obtain a supersaturated state of NOB, which could be characterized by XRD, DSC and FTIR. After that, the loaded capsules were cooled to room temperature. Alginate hydrogels were then selected for encapsulating and further controlling NOB release in simulated gastric and intestinal conditions. As a result, it demonstrated that our approach was able to reach an extremely high NOB loading capacity of 770 ± 40 mg/g using sunflower pollen grains (SPGs). Meanwhile, the existence of GM, SPGs and alginate hydrogels all retarded the release of the NOB synergistically, thus taking a slow release effect in the stomach while a long-term effective absorption in the intestine. Taken together, our processing method of encapsulating hydrophobic Nutraceuticals provides an important insight for broadening the applications of Nutraceutical or drug encapsulation and delivery.
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leveraging plant exine capsules as ph responsive delivery vehicles for hydrophobic Nutraceutical encapsulation
Food & Function, 2018Co-Authors: Di Wu, Youyan Liang, Kai Huang, Xinyi Jing, Bin Li, Hongshan LiangAbstract:Plant exine capsules are natural microscale capsules that are highly physically robust and chemically resilient. They are extracted from pollen grains and plant spores, and can be used as renewable and safe microcapsules for encapsulation applications. Herein, we report the successful evacuation of natural sunflower pollen grains (SPGs) and Lycopodiastrum casuarinoides spore exine capsules (SECs) and investigated the effects of different loading methods on the encapsulation and release of nobiletin, a model hydrophobic Nutraceutical. The compositional and morphological characterizations of SPGs and SECs obtained by the developed extraction protocol confirmed that the inside contents had been removed and hollow pollen cavities were obtained successfully. In addition, coumarin-6, a hydrophobic fluorescent probe, was encapsulated into SPGs and SECs, which proved the possibility of using them to encapsulate hydrophobic Nutraceuticals. Furthermore, controlled release in simulated digestive fluids (SDF) was achieved by coating calcium alginate onto the outside of the SPGs and SECs. Looking forward, this may provide an effective and potential delivery model to protect loads from degradation in the stomach and achieve pH-responsive delivery of hydrophobic Nutraceuticals after oral administration.
Claudio Borghi - One of the best experts on this subject based on the ideXlab platform.
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short term effects of a combined Nutraceutical on lipid level fatty liver biomarkers hemodynamic parameters and estimated cardiovascular disease risk a double blind placebo controlled randomized clinical trial
Advances in Therapy, 2017Co-Authors: Arrigo F G Cicero, Federica Fogacci, Marilisa Bove, Maddalena Veronesi, Manfredi Rizzo, Marina Giovannini, Claudio BorghiAbstract:There is a growing interest in Nutraceuticals improving cardiovascular risk factor levels and related organ damage. This double-blind, placebo-controlled randomized clinical trial aims to compare the effect of a combined Nutraceutical containing red yeast rice (10 mg), phytosterols (800 mg), and l-tyrosol (5 mg) on lipid profile, blood pressure, endothelial function, and arterial stiffness in a group of 60 patients with polygenic hypercholesterolemia resistant to Mediterranean diet. After 8 weeks of treatment, when compared to the placebo group, the active treated patients experienced a more favorable percentage change in total cholesterol (−16.3% vs 9.9%, P < 0.001 always), LDL-C (−23.4% vs −13.2%, P < 0.001 always), and hepatic steatosis index (−2.8%, P < 0.01 vs −1.8%, P < 0.05). Moreover, ALT (−27.7%, P < 0.001), AST (−13.8%, P = 0.004), and serum uric acid (−12.3%, P = 0.005) were reduced by the tested Nutraceutical compound both compared to randomization and to placebo, which did not affect these parameters (P < 0.01 for all). Regarding the hemodynamic parameters, there was a decrease of systolic blood pressure (−5.6%) with the active treatment not observed with placebo (P < 0.05 vs baseline and placebo) and endothelial reactivity improved, too (−13.2%, P < 0.001 vs baseline). Consequently, the estimated 10-year cardiovascular risk score improved by 1.19% (SE 0.4%) (P = 0.01) in the Nutraceutical-treated patients. The tested Nutraceutical association is able to improve the positive effects of a Mediterranean diet on a large number of CV risk factors and consequently of the estimated CV risk. ClinicalTrials.gov identifier NCT02492464. IBSA Farmaceutici.
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Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial
High Blood Pressure & Cardiovascular Prevention, 2017Co-Authors: Arrigo Francesco Giuseppe Cicero, Alessandro Colletti, Federica Fogacci, Marilisa Bove, Martina Rosticci, Claudio BorghiAbstract:Background There is an increasing interest for combined Nutraceuticals that can act on several points of lipid and glucose metabolism with preventive purposes. However, the simple assemblage of Nutraceuticals with potentially additive mechanism of action need to be clinically tested. Methods To assess the effects of a combination of Nutraceuticals based on artichoke, red yeast rice, banaba, and coenzyme Q10, we performed a double bind, cross-over designed trial versus placebo in 30 adults with LDL cholesterol suboptimal in primary prevention of cardiovascular disease. After a period of 3 weeks of dietary habits correction, patients began a period of 6 weeks of treatment with Nutraceutical or placebo, followed by 2 weeks of washout and finally 6 weeks in cross-over. Data related to lipid pattern, insulin resistance, renal function, liver and CPK have been obtained at each visit. Results In particular, the after the Nutraceutical treatment the enrolled patients experienced a significant improvement in total cholesterol (−13.6 %), LDL-C (−18.2 %), non-HDL-C (−15 %), glutamic oxaloacetic transaminase (−10 %), glutamate-pyruvate transaminase (−30.9 %), and hs-CRP (−18.2 %) versus placebo. No changes have been observed in the other investigated parameters in both groups. Conclusions The tested combination of Nutraceuticals has shown clinical efficacy in the reduction of total cholesterol, non-HDL, LDL and triglycerides, while improving the level of liver transaminases and high sensitivity C-reactive protein. Further confirmation are needed to verify these observations on the middle and long term with a larger number of subjects.
