The Experts below are selected from a list of 67590 Experts worldwide ranked by ideXlab platform
Sanjay A Desai - One of the best experts on this subject based on the ideXlab platform.
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Ajay D Pillai, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Sanjay A DesaiAbstract:Summary Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum . Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes. PaperFlick
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Ajay Pillai, Sanjay A DesaiAbstract:Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum. Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes.
Wang Nguitragool - One of the best experts on this subject based on the ideXlab platform.
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Ajay D Pillai, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Sanjay A DesaiAbstract:Summary Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum . Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes. PaperFlick
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Ajay Pillai, Sanjay A DesaiAbstract:Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum. Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes.
Abdullah A B Bokhari - One of the best experts on this subject based on the ideXlab platform.
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Ajay D Pillai, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Sanjay A DesaiAbstract:Summary Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum . Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes. PaperFlick
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Ajay Pillai, Sanjay A DesaiAbstract:Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum. Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes.
L Aravind - One of the best experts on this subject based on the ideXlab platform.
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Ajay D Pillai, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Sanjay A DesaiAbstract:Summary Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum . Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes. PaperFlick
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Ajay Pillai, Sanjay A DesaiAbstract:Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum. Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes.
Brad Turpin - One of the best experts on this subject based on the ideXlab platform.
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Ajay D Pillai, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Sanjay A DesaiAbstract:Summary Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum . Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes. PaperFlick
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malaria parasite clag3 genes determine channel mediated Nutrient Uptake by infected red blood cells
Cell, 2011Co-Authors: Wang Nguitragool, Abdullah A B Bokhari, Kempaiah Rayavara, Paresh Sharma, Brad Turpin, L Aravind, Ajay Pillai, Sanjay A DesaiAbstract:Development of malaria parasites within vertebrate erythrocytes requires Nutrient Uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for Nutrient Uptake inhibitors to identify a compound highly specific for channels from the Dd2 line of the human pathogen P. falciparum. Inheritance of this compound's affinity in a Dd2 × HB3 genetic cross maps to a single parasite locus on chromosome 3. DNA transfection and in vitro selections indicate that PSAC-inhibitor interactions are encoded by two clag3 genes previously assumed to function in cytoadherence. These genes are conserved in plasmodia, exhibit expression switching, and encode an integral protein on the host membrane, as predicted by functional studies. This protein increases host cell permeability to diverse solutes.
