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H Andersson - One of the best experts on this subject based on the ideXlab platform.

  • Oat Bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study
    European Journal of Clinical Nutrition, 2007
    Co-Authors: Lars Ellegard, H Andersson
    Abstract:

    Objective: To study whether Oat Bran with native β -glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7 α -hydroxy-4-cholesten-3-one (7 α -HC). Design: Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test. Setting: Outpatients at a metabolic-ward kitchen. Subjects: Nine volunteers with conventional ileostomies. Methods: Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded Oat Bran breakfast cereal daily, with either 11.6 g native or hydrolysed β -glucans. Results: Native Oat Bran increased median excretion of bile acids by 144% ( P =0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% ( P =0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% ( P =0.008) compared with hydrolysed Oat Bran. 7 α -HC reflecting bile acid synthesis increased by 57% ( P =0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% ( P =0.015). Conclusions: Oat Bran with native β -glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7 α -HC. Thus, 7 α -HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

  • Oat Bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study.
    European Journal of Clinical Nutrition, 2007
    Co-Authors: Lars Ellegard, H Andersson
    Abstract:

    OBJECTIVE: To study whether Oat Bran with native beta-glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7alpha-hydroxy-4-cholesten-3-one (7alpha-HC). DESIGN: Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test. SETTING: Outpatients at a metabolic-ward kitchen. SUBJECTS: Nine volunteers with conventional ileostomies. METHODS: Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded Oat Bran breakfast cereal daily, with either 11.6 g native or hydrolysed beta-glucans. RESULTS: Native Oat Bran increased median excretion of bile acids by 144% (P=0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% (P=0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% (P=0.008) compared with hydrolysed Oat Bran. 7alpha-HC reflecting bile acid synthesis increased by 57% (P=0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% (P=0.015). CONCLUSIONS: Oat Bran with native beta-glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7alpha-HC. Thus, 7alpha-HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

  • Oat Bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study.
    European journal of clinical nutrition, 2007
    Co-Authors: Lars Ellegard, H Andersson
    Abstract:

    To study whether Oat Bran with native β-glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7α-hydroxy-4-cholesten-3-one (7α-HC). Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test. Outpatients at a metabolic-ward kitchen. Nine volunteers with conventional ileostomies. Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded Oat Bran breakfast cereal daily, with either 11.6 g native or hydrolysed β-glucans. Native Oat Bran increased median excretion of bile acids by 144% (P=0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% (P=0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% (P=0.008) compared with hydrolysed Oat Bran. 7α-HC reflecting bile acid synthesis increased by 57% (P=0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% (P=0.015). Oat Bran with native β-glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7α-HC. Thus, 7α-HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

Lars Ellegard - One of the best experts on this subject based on the ideXlab platform.

  • Oat Bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study
    European Journal of Clinical Nutrition, 2007
    Co-Authors: Lars Ellegard, H Andersson
    Abstract:

    Objective: To study whether Oat Bran with native β -glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7 α -hydroxy-4-cholesten-3-one (7 α -HC). Design: Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test. Setting: Outpatients at a metabolic-ward kitchen. Subjects: Nine volunteers with conventional ileostomies. Methods: Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded Oat Bran breakfast cereal daily, with either 11.6 g native or hydrolysed β -glucans. Results: Native Oat Bran increased median excretion of bile acids by 144% ( P =0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% ( P =0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% ( P =0.008) compared with hydrolysed Oat Bran. 7 α -HC reflecting bile acid synthesis increased by 57% ( P =0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% ( P =0.015). Conclusions: Oat Bran with native β -glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7 α -HC. Thus, 7 α -HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

  • Oat Bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study.
    European Journal of Clinical Nutrition, 2007
    Co-Authors: Lars Ellegard, H Andersson
    Abstract:

    OBJECTIVE: To study whether Oat Bran with native beta-glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7alpha-hydroxy-4-cholesten-3-one (7alpha-HC). DESIGN: Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test. SETTING: Outpatients at a metabolic-ward kitchen. SUBJECTS: Nine volunteers with conventional ileostomies. METHODS: Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded Oat Bran breakfast cereal daily, with either 11.6 g native or hydrolysed beta-glucans. RESULTS: Native Oat Bran increased median excretion of bile acids by 144% (P=0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% (P=0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% (P=0.008) compared with hydrolysed Oat Bran. 7alpha-HC reflecting bile acid synthesis increased by 57% (P=0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% (P=0.015). CONCLUSIONS: Oat Bran with native beta-glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7alpha-HC. Thus, 7alpha-HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

  • Oat Bran rapidly increases bile acid excretion and bile acid synthesis: an ileostomy study.
    European journal of clinical nutrition, 2007
    Co-Authors: Lars Ellegard, H Andersson
    Abstract:

    To study whether Oat Bran with native β-glucans increases bile acid excretion and bile acid synthesis as measured by serum concentrations of 7α-hydroxy-4-cholesten-3-one (7α-HC). Short-term interventional crossover study evaluating cholesterol absorption, ileal excretion of cholesterol and bile acids, and serum levels of cholesterol and bile acid metabolites. Differences between diets evaluated with Wilcoxon's signed rank-sum test. Outpatients at a metabolic-ward kitchen. Nine volunteers with conventional ileostomies. Two 3-day-diet periods, with controlled, blinded basal diet including 75 g extruded Oat Bran breakfast cereal daily, with either 11.6 g native or hydrolysed β-glucans. Native Oat Bran increased median excretion of bile acids by 144% (P=0.008). Cholesterol excretion remained unchanged, cholesterol absorption decreased by 19% (P=0.013), whereas the sum of bile acid and cholesterol excretion increased by 40% (P=0.008) compared with hydrolysed Oat Bran. 7α-HC reflecting bile acid synthesis increased by 57% (P=0.008) within 24 h of consumption, whereas serum lathosterol concentration reflecting cholesterol synthesis increased by 12% (P=0.015). Oat Bran with native β-glucans increases bile acid excretion within 24 h of consumption and this increase can also be detected by rising serum concentrations of 7α-HC. Thus, 7α-HC could be used for rapid detection of dietary effects on bile acid metabolism. These effects could possibly be explained by entrapment of whole micelles in the gut owing to higher viscosity.

Claes Hallert - One of the best experts on this subject based on the ideXlab platform.

  • Oat Bran Increased Fecal Butyrate and Prevented Gastrointestinal Symptoms in Patients With Quiescent Ulcerative Colitis—Randomized Controlled Trial
    Crohn's & Colitis 360, 2020
    Co-Authors: Margareta Nyman, Thao Duy Nguyen, Ola Wikman, Henrik Hjortswang, Claes Hallert
    Abstract:

    Background Oat Bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC). Methods Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat Oat Bran or low-fiber wheat products. Results Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The Oat Bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets. Conclusions Oat Bran was well tolerated when given to patients with quiescent UC. (Less)

  • Oat Bran increased fecal butyrate and prevented gastrointestinal symptoms in patients with quiescent ulcerative colitis randomized controlled trial
    Crohn's & Colitis 360, 2020
    Co-Authors: Margareta Nyman, Thao Duy Nguyen, Ola Wikman, Henrik Hjortswang, Claes Hallert
    Abstract:

    Background Oat Bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC). Methods Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat Oat Bran or low-fiber wheat products. Results Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The Oat Bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets. Conclusions Oat Bran was well tolerated when given to patients with quiescent UC. (Less)

Margareta Nyman - One of the best experts on this subject based on the ideXlab platform.

  • Oat Bran Increased Fecal Butyrate and Prevented Gastrointestinal Symptoms in Patients With Quiescent Ulcerative Colitis—Randomized Controlled Trial
    Crohn's & Colitis 360, 2020
    Co-Authors: Margareta Nyman, Thao Duy Nguyen, Ola Wikman, Henrik Hjortswang, Claes Hallert
    Abstract:

    Background Oat Bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC). Methods Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat Oat Bran or low-fiber wheat products. Results Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The Oat Bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets. Conclusions Oat Bran was well tolerated when given to patients with quiescent UC. (Less)

  • Oat Bran increased fecal butyrate and prevented gastrointestinal symptoms in patients with quiescent ulcerative colitis randomized controlled trial
    Crohn's & Colitis 360, 2020
    Co-Authors: Margareta Nyman, Thao Duy Nguyen, Ola Wikman, Henrik Hjortswang, Claes Hallert
    Abstract:

    Background Oat Bran specifically increases colon butyrate concentrations and could therefore affect the progress of the disease in patients with ulcerative colitis (UC). Methods Patients with UC in remission were enrolled in a controlled multicenter study and randomized to eat Oat Bran or low-fiber wheat products. Results Ninety-four of the enrolled patients (n = 47 for both groups) completed the 24-week study. The Oat Bran group had significantly (P < 0.05) higher fecal butyrate concentrations and lower serum LDL levels, while deterioration of gastrointestinal symptoms was prevented, and subjective health maintained. The control diet significantly (P < 0.05) increased obstipation, reflux, and the symptom burden and had no effects on butyrate or LDL-cholesterol. The relapse rate was the same for both diets. Conclusions Oat Bran was well tolerated when given to patients with quiescent UC. (Less)

Huiyua Yao - One of the best experts on this subject based on the ideXlab platform.

  • optimization of viscozyme l assisted extraction of Oat Bran protein using response surface methodology
    Food Chemistry, 2008
    Co-Authors: Xiao Gua, Huiyua Yao
    Abstract:

    Abstract The study investigated enzymatic pretreatment of Oat Bran, using Viscozyme L to enhance protein extraction. Response surface methodology (RSM) was used to study the effects of pretreatment variables of Viscozyme L concentration (6–30 FBG), pH (3.0–5.0), incubation time (0.5–2.5 h) and temperature (35–55 °C) on protein extraction from Oat Bran. The results indicated that the generated regression model represented the relationship between the independent variables and the responses. Protein extraction from Oat Bran was mainly affected by pH and incubation temperature. From the RSM-generated model, the optimum conditions of enzymatic pretreatment were identified as Viscozyme L concentration 30 FBG/10 g of Oat Bran, pH 4.6, incubation time 2.8 h and temperature 44 °C. Under the optimum conditions, the predicted protein extracted from Oat Bran was 55.7%, whereas, the experimental extracted protein was 56.2%. The RSM-predicted and experimental extracted proteins were not significantly different from each other. The enzymatic pretreatment method under the optimum conditions extracted significantly more protein (56.2%) than did the alkaline (pH 9.5) method (14.76%). Viscozyme L pretreatment of Oat Bran improved protein extraction.