The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform
S. Rodrigo - One of the best experts on this subject based on the ideXlab platform.
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ORIGINAL RESEARCH Human Subinsular Asymmetry Studied by Diffusion Tensor Imaging and Fiber Tracking
2014Co-Authors: S. Rodrigo, O. Naggara, N. Golestani, C. Poupon, Y. Cointepas, J. F. Mangin, Le D. Bihan, J. F. MederAbstract:BACKGROUND AND PURPOSE: Our aim was to improve our understanding of the subinsular white matter microstructural asymmetries in healthy right-handed subjects. Structural brain asymmetries could be related to functional asymmetries such as hemisphere language dominance or handedness. Besides the known gray matter asymmetries, white matter asymmetries could also play a key role in the understanding of hemispheric specialization, notably that of language. MATERIALS AND METHODS: White matter asymmetries were studied by diffusion tensor imaging at 1.5T (41 diffusion-gradient directions; b-value set to 700 s/mm2; matrix, 1282; in-plane resolution, 1.875 1.875 mm; section thickness, 2.0 mm) and fiber tracking (BrainVISA software). The main white matter bundles passing through the subinsular area were segmented, and fractional anisotropy (FA) was measured along each of the segmented bundles. RESULTS: In line with published results, we found an asymmetry of the arcuate Fasciculus and the subinsular white matter, namely left-greater-than-right FA in right-handed controls. Furthermore, by segmenting major tracts coursing through this region, we showed that the subinsular portions of the uncinate Fasciculus (UF) and the inferior Occipitofrontal Fasciculus (IOF) contribute to this FA asymme-try. Those tracts have been reported to be likely implicated in the language network
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Language lateralization in temporal lobe epilepsy using functional MRI and probabilistic tractography.
Epilepsia, 2008Co-Authors: S. Rodrigo, Catherine Oppenheim, Francine Chassoux, Jérôme Hodel, Aimée De Vanssay, Sonia Baudoin-chial, Bertrand Devaux, Jean-françois MederAbstract:Summary Purpose: Language functional magnetic resonance imaging (fMRI) is used to noninvasively assess hemispheric language specialization as part of the presurgical work-up in temporal lobe epilepsy (TLE). White matter asymmetries on diffusion tensor imaging (DTI) may be related to language specialization as shown in controls and TLE. To refine our understanding of the effect of epilepsy on the structure–function relationships, we focused on the arcuate Fasciculus (ArcF) and the inferior Occipitofrontal Fasciculus (IOF) and tested the relationship between DTI- and fMRI-based lateralization indices in TLE. Methods: fMRI with three language tasks and DTI were obtained in 20 patients (12 right and 8 left TLE). The ArcF, a major language-related tract, and the IOF were segmented bilaterally using probabilistic tractography to obtain fractional anisotropy (FA) lateralization indices. These were correlated with fMRI-based lateralization indices computed in the inferior frontal gyrus (Pearson's correlation coefficient). Results: fMRI indices were left-lateralized in 16 patients and bilateral or right-lateralized in four. In the ArcF, FA was higher on the left than on the right side, reaching significance in right but not in left TLE. We found a positive correlation between ArcF anisotropy and fMRI-based lateralization indices in right TLE (p < 0.009), but not in left TLE patients. No correlation was observed for the IOF. Conclusions: Right TLE patients with more left-lateralized functional activations also showed a leftward-lateralized arcuate Fasciculus. The decoupling between the functional and structural indices of the ArcF underlines the complexity of the language network in left TLE patients.
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FULL-LENGTH ORIGINAL RESEARCH Language lateralization in temporal lobe epilepsy using functional MRI and probabilistic tractography
2008Co-Authors: S. Rodrigo, Catherine Oppenheim, Francine Chassoux, Sonia Baudoin-chial, Bertrand DevauxAbstract:SUMMARY Purpose: Language functional magnetic resonance imaging (fMRI) is used to noninvasively assess hemispheric language specialization as part of the presurgical work-up in temporal lobe epilepsy (TLE). White matter asymmetries on diffusion tensor imaging (DTI) may be related to language specialization as shown in controls and TLE. To refine our understanding of the effect of epilepsy on the structure–function relationships, we focused on the arcuate Fasciculus (ArcF) and the inferior Occipitofrontal Fasciculus (IOF) and tested the relationship between DTI- and fMRI-based lateralization indices in TLE. Methods: fMRI with three language tasks and DTI were obtained in 20 patients (12 right and 8 left TLE). The ArcF, a major language-related tract, and the IOF were segmented bilaterally using probabilistic tractography to obtain fractional anisotropy (FA) lateralization indices. These were correlated with fMRI-based lateralization indices computed in the inferior frontal gyrus (Pearson’s correlation coefficient). Results: fMRI indices were left-lateralized in 16 patients and bilateral or right-lateralized in four. In the ArcF, FA was higher on the left than on the right side, reaching significance in right but not in left TLE. We found a positive correlation between ArcF anisotropy and fMRI-based lateralization indices in right TLE (p < 0.009), but not in left TLE patients. No correlation was observed for the IOF. Conclusions: Right TLE patients with more leftlateralized functional activations also showed a leftward-lateralized arcuate Fasciculus. The decoupling between the functional and structural indices of the ArcF underlines the complexity of the lan
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Human subinsular asymmetry studied by diffusion tensor imaging and fiber tracking.
AJNR. American journal of neuroradiology, 2007Co-Authors: S. Rodrigo, O. Naggara, N. Golestani, C. Poupon, Y. Cointepas, J. F. Mangin, Catherine Oppenheim, D. Le Bihan, J. F. MederAbstract:BACKGROUND AND PURPOSE: Our aim was to improve our understanding of the subinsular white matter microstructural asymmetries in healthy right-handed subjects. Structural brain asymmetries could be related to functional asymmetries such as hemisphere language dominance or handedness. Besides the known gray matter asymmetries, white matter asymmetries could also play a key role in the understanding of hemispheric specialization, notably that of language. MATERIALS AND METHODS: White matter asymmetries were studied by diffusion tensor imaging at 1.5T (41 diffusion-gradient directions; b-value set to 700 s/mm(2); matrix, 128(2); in-plane resolution, 1.875 x 1.875 mm; section thickness, 2.0 mm) and fiber tracking (BrainVISA software). The main white matter bundles passing through the subinsular area were segmented, and fractional anisotropy (FA) was measured along each of the segmented bundles. RESULTS: In line with published results, we found an asymmetry of the arcuate Fasciculus and the subinsular white matter, namely left-greater-than-right FA in right-handed controls. Furthermore, by segmenting major tracts coursing through this region, we showed that the subinsular portions of the uncinate Fasciculus (UF) and the inferior Occipitofrontal Fasciculus (IOF) contribute to this FA asymmetry. Those tracts have been reported to be likely implicated in the language network. CONCLUSION: Because the left hemisphere hosts language functions in most right-handers, the significant leftward asymmetry observed within the arcuate Fasciculus, the subinsular part of the UF and IOF may be related to the hemispheric specialization for language.
Chris Rorden - One of the best experts on this subject based on the ideXlab platform.
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The anatomy underlying acute versus chronic spatial neglect: a longitudinal study
Brain, 2010Co-Authors: Hans-otto Karnath, Johannes Rennig, Leif Johannsen, Chris RordenAbstract:Our aim was to examine how brain imaging in the initial phase of a stroke could predict both acute/subacute as well as chronic spatial neglect. We present the first voxel-wise longitudinal lesion-behaviour mapping study, examining acute/subacute as well as chronic performance in the same individuals. Acute brain imaging (acquired on average 6.2 days post-injury) was used to evaluate neglect symptoms at the initial (mean 12.4 days post-stroke) and the chronic (mean 491 days) phase of the stroke. Chronic neglect was found in about one-third of the patients with acute neglect. Analysis suggests that lesion of the superior and middle temporal gyri predict both acute/subacute as well as chronic neglect. At the subcortical level, the basal ganglia as well as the inferior Occipitofrontal Fasciculus/extreme capsule appear to play a significant role for both acute/subacute as well as chronic neglect. Beyond, the uncinate Fasciculus was critically related to the emergence of chronic spatial neglect. We infer that individuals who experience spatial neglect in the initial phase of the stroke yet do not have injury to these cortical and subcortical structures are likely to recover, and thus have a favourable prognosis.
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Damage to White Matter Fiber Tracts in Acute Spatial Neglect
Cerebral cortex (New York N.Y. : 1991), 2009Co-Authors: Hans-otto Karnath, Chris Rorden, Luca Francesco TiciniAbstract:Previous statistical voxelwise lesion-behavior mapping (VLBM) studies have demonstrated that spatial neglect is associated with cortical and subcortical gray matter damage. However, it has also been suggested that the disorder may result from white matter injury. Our aim was to investigate the white matter connectivity in a large sample of 140 stroke patients. We combined a VLBM approach with the histological maps of the human white matter fiber tracts provided by the Julich probabilistic cytoarchitectonic atlas. We found that damage of right perisylvian white matter connections—the superior longitudinal Fasciculus, the inferior Occipitofrontal Fasciculus, and the superior Occipitofrontal Fasciculus—is a typical finding in patients with spatial neglect. However, the analysis also revealed that the largest portion of the lesion area, namely between 89.1% and 96.6%, affected brain structures other than the perisylvian white matter fiber tracts. Predominantly, these included gray matter structures such as the superior temporal, inferior parietal, inferior frontal, and insular cortices, as well as subcortically the putamen and the caudate nucleus. Damage of gray matter structures thus appears to be a strong predictor of spatial neglect.
Seyede Ghazal Mohades - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH ARTICLE White-Matter Development is Different in Bilingual and Monolingual Children: A Longitudinal DTI Study
2016Co-Authors: Seyede Ghazal Mohades, Peter Van Schuerbeek, Yves Rosseel, Robert Luypaert, Piet Van, De Craen, Chris BaekenAbstract:Although numerous people grow up speaking more than one language, the impact of bilin-gualism on brain developing neuroanatomy is still poorly understood. This study aimed to determine whether the changes in the mean fractional-anisotropy (MFA) of language path-ways are different between bilingual and monolingual children. Simultaneous-bilinguals, se-quential-bilinguals and monolingual, male and female 10–13 years old children participated in this longitudinal study over a period of two years. We used diffusion tensor tractography to obtain mean fractional-anisotropy values of four language related pathways and one con-trol bundle: 1-left-inferior-Occipitofrontal Fasciculus/lIFOF, 2-left-arcuate Fasciculus/lAF/ lSLF, 3-bundle arising from the anterior part of corpus-callosum and projecting to orbital lobe/AC-OL, 4-fibres emerging from anterior-midbody of corpus-callosum (CC) to motor cor-tices/AMB-PMC, 5- right-inferior-Occipitofrontal Fasciculus rIFOF as the control pathway un-related to language. These values and their rate of change were compared between 3 groups. FA-values did not change significantly over two years for lAF/lSLF and AC-OL. Se-quential-bilinguals had the highest degree of change in the MFA value of lIFOF, and AMB-PMC did not present significant group differences. The comparison of MFA of lIFOF yielded a significantly higher FA-value in simultaneous bilinguals compared to monolinguals. These findings acknowledge the existing difference of the development of the semantic processing specific pathway between children with different semantic processing procedure. These also support the hypothesis that age of second language acquisition affects the maturation and myelination of some language specific white-matter pathways
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White-matter development is different in bilingual and monolingual children: a longitudinal DTI study.
PloS one, 2015Co-Authors: Seyede Ghazal Mohades, Peter Van Schuerbeek, Yves Rosseel, Piet Van De Craen, Robert Luypaert, Chris BaekenAbstract:Although numerous people grow up speaking more than one language, the impact of bilingualism on brain developing neuroanatomy is still poorly understood. This study aimed to determine whether the changes in the mean fractional-anisotropy (MFA) of language pathways are different between bilingual and monolingual children. Simultaneous-bilinguals, sequential-bilinguals and monolingual, male and female 10–13 years old children participated in this longitudinal study over a period of two years. We used diffusion tensor tractography to obtain mean fractional-anisotropy values of four language related pathways and one control bundle: 1-left-inferior-Occipitofrontal Fasciculus/lIFOF, 2-left-arcuate Fasciculus/lAF/lSLF, 3-bundle arising from the anterior part of corpus-callosum and projecting to orbital lobe/AC-OL, 4-fibres emerging from anterior-midbody of corpus-callosum (CC) to motor cortices/AMB-PMC, 5- right-inferior-Occipitofrontal Fasciculus rIFOF as the control pathway unrelated to language. These values and their rate of change were compared between 3 groups. FA-values did not change significantly over two years for lAF/lSLF and AC-OL. Sequential-bilinguals had the highest degree of change in the MFA value of lIFOF, and AMB-PMC did not present significant group differences. The comparison of MFA of lIFOF yielded a significantly higher FA-value in simultaneous bilinguals compared to monolinguals. These findings acknowledge the existing difference of the development of the semantic processing specific pathway between children with different semantic processing procedure. These also support the hypothesis that age of second language acquisition affects the maturation and myelination of some language specific white-matter pathways.
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DTI reveals structural differences in white matter tracts between bilingual and monolingual children
Brain research, 2011Co-Authors: Seyede Ghazal Mohades, Peter Van Schuerbeek, Piet Van De Craen, Esli Struys, Katrien Mondt, Robert LuypaertAbstract:The impact of bilingualism on the microstructure of the white matter pathways related to language processing is assessed in elementary school children by magnetic resonance diffusion tensor imaging (MR-DTI). Forty children, 8-11 years old, subdivided into 3 different groups (15 simultaneous bilinguals, 15 sequential bilinguals and 10 monolinguals), were scanned. The hypothesis was that the starting age and the manner of second language acquisition would affect the characteristics of language circuitry. In each subject the mean fractional anisotropy (FA) was obtained for four major white matter pathways: 1 - the left arcuate Fasciculus/superior longitudinal Fasciculus (lAF/lSLF) that connects Broca's area in the opercular and triangular regions of the left inferior frontal gyrus to the posterior language zone, 2 - the left inferior Occipitofrontal Fasciculus (lIFOF), connecting anterior regions in the frontal lobe with posterior regions in the temporal occipital lobes, 3 - the bundle arising from the anterior part of the corpus callosum projecting to the orbital lobe (AC-OL) and 4 - the fibers emerging from the anterior midbody (AMB) of the corpus callosum that associate with the premotor and supplementary motor cortices (AMB-PMC). The three groups did not show significant differences in mean FA over the lAF/lSLF or AMB-PMC tracts. In simultaneous bilingual subjects the lIFOF tracts had higher mean FA value compared to monolinguals and also sequential bilinguals, whereas the comparison for the AC-OL fibers yielded a significantly lower mean FA value in simultaneous bilingual subjects compared to monolinguals. In both cases the FA value for sequential bilinguals was intermediate to that of the other two groups. To our knowledge, this study provides the first evidence of bilingualism related adaptation of white matter microstructure in the human brain.
Robert Luypaert - One of the best experts on this subject based on the ideXlab platform.
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RESEARCH ARTICLE White-Matter Development is Different in Bilingual and Monolingual Children: A Longitudinal DTI Study
2016Co-Authors: Seyede Ghazal Mohades, Peter Van Schuerbeek, Yves Rosseel, Robert Luypaert, Piet Van, De Craen, Chris BaekenAbstract:Although numerous people grow up speaking more than one language, the impact of bilin-gualism on brain developing neuroanatomy is still poorly understood. This study aimed to determine whether the changes in the mean fractional-anisotropy (MFA) of language path-ways are different between bilingual and monolingual children. Simultaneous-bilinguals, se-quential-bilinguals and monolingual, male and female 10–13 years old children participated in this longitudinal study over a period of two years. We used diffusion tensor tractography to obtain mean fractional-anisotropy values of four language related pathways and one con-trol bundle: 1-left-inferior-Occipitofrontal Fasciculus/lIFOF, 2-left-arcuate Fasciculus/lAF/ lSLF, 3-bundle arising from the anterior part of corpus-callosum and projecting to orbital lobe/AC-OL, 4-fibres emerging from anterior-midbody of corpus-callosum (CC) to motor cor-tices/AMB-PMC, 5- right-inferior-Occipitofrontal Fasciculus rIFOF as the control pathway un-related to language. These values and their rate of change were compared between 3 groups. FA-values did not change significantly over two years for lAF/lSLF and AC-OL. Se-quential-bilinguals had the highest degree of change in the MFA value of lIFOF, and AMB-PMC did not present significant group differences. The comparison of MFA of lIFOF yielded a significantly higher FA-value in simultaneous bilinguals compared to monolinguals. These findings acknowledge the existing difference of the development of the semantic processing specific pathway between children with different semantic processing procedure. These also support the hypothesis that age of second language acquisition affects the maturation and myelination of some language specific white-matter pathways
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White-matter development is different in bilingual and monolingual children: a longitudinal DTI study.
PloS one, 2015Co-Authors: Seyede Ghazal Mohades, Peter Van Schuerbeek, Yves Rosseel, Piet Van De Craen, Robert Luypaert, Chris BaekenAbstract:Although numerous people grow up speaking more than one language, the impact of bilingualism on brain developing neuroanatomy is still poorly understood. This study aimed to determine whether the changes in the mean fractional-anisotropy (MFA) of language pathways are different between bilingual and monolingual children. Simultaneous-bilinguals, sequential-bilinguals and monolingual, male and female 10–13 years old children participated in this longitudinal study over a period of two years. We used diffusion tensor tractography to obtain mean fractional-anisotropy values of four language related pathways and one control bundle: 1-left-inferior-Occipitofrontal Fasciculus/lIFOF, 2-left-arcuate Fasciculus/lAF/lSLF, 3-bundle arising from the anterior part of corpus-callosum and projecting to orbital lobe/AC-OL, 4-fibres emerging from anterior-midbody of corpus-callosum (CC) to motor cortices/AMB-PMC, 5- right-inferior-Occipitofrontal Fasciculus rIFOF as the control pathway unrelated to language. These values and their rate of change were compared between 3 groups. FA-values did not change significantly over two years for lAF/lSLF and AC-OL. Sequential-bilinguals had the highest degree of change in the MFA value of lIFOF, and AMB-PMC did not present significant group differences. The comparison of MFA of lIFOF yielded a significantly higher FA-value in simultaneous bilinguals compared to monolinguals. These findings acknowledge the existing difference of the development of the semantic processing specific pathway between children with different semantic processing procedure. These also support the hypothesis that age of second language acquisition affects the maturation and myelination of some language specific white-matter pathways.
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DTI reveals structural differences in white matter tracts between bilingual and monolingual children
Brain research, 2011Co-Authors: Seyede Ghazal Mohades, Peter Van Schuerbeek, Piet Van De Craen, Esli Struys, Katrien Mondt, Robert LuypaertAbstract:The impact of bilingualism on the microstructure of the white matter pathways related to language processing is assessed in elementary school children by magnetic resonance diffusion tensor imaging (MR-DTI). Forty children, 8-11 years old, subdivided into 3 different groups (15 simultaneous bilinguals, 15 sequential bilinguals and 10 monolinguals), were scanned. The hypothesis was that the starting age and the manner of second language acquisition would affect the characteristics of language circuitry. In each subject the mean fractional anisotropy (FA) was obtained for four major white matter pathways: 1 - the left arcuate Fasciculus/superior longitudinal Fasciculus (lAF/lSLF) that connects Broca's area in the opercular and triangular regions of the left inferior frontal gyrus to the posterior language zone, 2 - the left inferior Occipitofrontal Fasciculus (lIFOF), connecting anterior regions in the frontal lobe with posterior regions in the temporal occipital lobes, 3 - the bundle arising from the anterior part of the corpus callosum projecting to the orbital lobe (AC-OL) and 4 - the fibers emerging from the anterior midbody (AMB) of the corpus callosum that associate with the premotor and supplementary motor cortices (AMB-PMC). The three groups did not show significant differences in mean FA over the lAF/lSLF or AMB-PMC tracts. In simultaneous bilingual subjects the lIFOF tracts had higher mean FA value compared to monolinguals and also sequential bilinguals, whereas the comparison for the AC-OL fibers yielded a significantly lower mean FA value in simultaneous bilingual subjects compared to monolinguals. In both cases the FA value for sequential bilinguals was intermediate to that of the other two groups. To our knowledge, this study provides the first evidence of bilingualism related adaptation of white matter microstructure in the human brain.
Catherine Oppenheim - One of the best experts on this subject based on the ideXlab platform.
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Language lateralization in temporal lobe epilepsy using functional MRI and probabilistic tractography.
Epilepsia, 2008Co-Authors: S. Rodrigo, Catherine Oppenheim, Francine Chassoux, Jérôme Hodel, Aimée De Vanssay, Sonia Baudoin-chial, Bertrand Devaux, Jean-françois MederAbstract:Summary Purpose: Language functional magnetic resonance imaging (fMRI) is used to noninvasively assess hemispheric language specialization as part of the presurgical work-up in temporal lobe epilepsy (TLE). White matter asymmetries on diffusion tensor imaging (DTI) may be related to language specialization as shown in controls and TLE. To refine our understanding of the effect of epilepsy on the structure–function relationships, we focused on the arcuate Fasciculus (ArcF) and the inferior Occipitofrontal Fasciculus (IOF) and tested the relationship between DTI- and fMRI-based lateralization indices in TLE. Methods: fMRI with three language tasks and DTI were obtained in 20 patients (12 right and 8 left TLE). The ArcF, a major language-related tract, and the IOF were segmented bilaterally using probabilistic tractography to obtain fractional anisotropy (FA) lateralization indices. These were correlated with fMRI-based lateralization indices computed in the inferior frontal gyrus (Pearson's correlation coefficient). Results: fMRI indices were left-lateralized in 16 patients and bilateral or right-lateralized in four. In the ArcF, FA was higher on the left than on the right side, reaching significance in right but not in left TLE. We found a positive correlation between ArcF anisotropy and fMRI-based lateralization indices in right TLE (p < 0.009), but not in left TLE patients. No correlation was observed for the IOF. Conclusions: Right TLE patients with more left-lateralized functional activations also showed a leftward-lateralized arcuate Fasciculus. The decoupling between the functional and structural indices of the ArcF underlines the complexity of the language network in left TLE patients.
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FULL-LENGTH ORIGINAL RESEARCH Language lateralization in temporal lobe epilepsy using functional MRI and probabilistic tractography
2008Co-Authors: S. Rodrigo, Catherine Oppenheim, Francine Chassoux, Sonia Baudoin-chial, Bertrand DevauxAbstract:SUMMARY Purpose: Language functional magnetic resonance imaging (fMRI) is used to noninvasively assess hemispheric language specialization as part of the presurgical work-up in temporal lobe epilepsy (TLE). White matter asymmetries on diffusion tensor imaging (DTI) may be related to language specialization as shown in controls and TLE. To refine our understanding of the effect of epilepsy on the structure–function relationships, we focused on the arcuate Fasciculus (ArcF) and the inferior Occipitofrontal Fasciculus (IOF) and tested the relationship between DTI- and fMRI-based lateralization indices in TLE. Methods: fMRI with three language tasks and DTI were obtained in 20 patients (12 right and 8 left TLE). The ArcF, a major language-related tract, and the IOF were segmented bilaterally using probabilistic tractography to obtain fractional anisotropy (FA) lateralization indices. These were correlated with fMRI-based lateralization indices computed in the inferior frontal gyrus (Pearson’s correlation coefficient). Results: fMRI indices were left-lateralized in 16 patients and bilateral or right-lateralized in four. In the ArcF, FA was higher on the left than on the right side, reaching significance in right but not in left TLE. We found a positive correlation between ArcF anisotropy and fMRI-based lateralization indices in right TLE (p < 0.009), but not in left TLE patients. No correlation was observed for the IOF. Conclusions: Right TLE patients with more leftlateralized functional activations also showed a leftward-lateralized arcuate Fasciculus. The decoupling between the functional and structural indices of the ArcF underlines the complexity of the lan
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Human subinsular asymmetry studied by diffusion tensor imaging and fiber tracking.
AJNR. American journal of neuroradiology, 2007Co-Authors: S. Rodrigo, O. Naggara, N. Golestani, C. Poupon, Y. Cointepas, J. F. Mangin, Catherine Oppenheim, D. Le Bihan, J. F. MederAbstract:BACKGROUND AND PURPOSE: Our aim was to improve our understanding of the subinsular white matter microstructural asymmetries in healthy right-handed subjects. Structural brain asymmetries could be related to functional asymmetries such as hemisphere language dominance or handedness. Besides the known gray matter asymmetries, white matter asymmetries could also play a key role in the understanding of hemispheric specialization, notably that of language. MATERIALS AND METHODS: White matter asymmetries were studied by diffusion tensor imaging at 1.5T (41 diffusion-gradient directions; b-value set to 700 s/mm(2); matrix, 128(2); in-plane resolution, 1.875 x 1.875 mm; section thickness, 2.0 mm) and fiber tracking (BrainVISA software). The main white matter bundles passing through the subinsular area were segmented, and fractional anisotropy (FA) was measured along each of the segmented bundles. RESULTS: In line with published results, we found an asymmetry of the arcuate Fasciculus and the subinsular white matter, namely left-greater-than-right FA in right-handed controls. Furthermore, by segmenting major tracts coursing through this region, we showed that the subinsular portions of the uncinate Fasciculus (UF) and the inferior Occipitofrontal Fasciculus (IOF) contribute to this FA asymmetry. Those tracts have been reported to be likely implicated in the language network. CONCLUSION: Because the left hemisphere hosts language functions in most right-handers, the significant leftward asymmetry observed within the arcuate Fasciculus, the subinsular part of the UF and IOF may be related to the hemispheric specialization for language.
