The Experts below are selected from a list of 276 Experts worldwide ranked by ideXlab platform
Kensei Katsuoka - One of the best experts on this subject based on the ideXlab platform.
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bifonazole mycospor cream in the treatment of moccasin type tinea pedis comparison between combination therapy of bifonazole cream 10 urea ointment urepearl and Occlusive Dressing therapy with the same agents
Mycoses, 2000Co-Authors: H Tanuma, M Doi, N Sato, Shigeo Nishiyama, Michiko Abe, Hikaru Kume, Kensei KatsuokaAbstract:Moccasin-type tinea pedis(MTTP) is a hardly curable superficial dermatomycosis primarily characterized by hyperkeratosis of the sole. In this study, we compared the usefulness of combination therapy of bifonazole (Mycospor cream) + 10% urea ointment (Urepearl) (overlapping application group = group I) with Occlusive Dressing therapy with the same agents (group II) in the treatment of MTTP, and obtained the following results. (1) The clinical improvement rate (percentage of "marked improvement" and "moderate improvement") was 60.4% in group I and 83.3% in group II. (2) The mycological eradication rate was 48.7% in group I and 82.1% in group II after 4 weeks of treatment and 90.9 and 96.9%, after 12 weeks of treatment, respectively. (3) The clinical utility rate (percentage of "very beneficial" and "beneficial") was 83.3% in group I and 93.8% in group II. These results indicate the superiority of both combination therapy of bifonazole + 10% urea ointment (overlapping application group) and Occlusive Dressing therapy with the same agents in terms of efficacy and safety for the treatment of MTTP, and suggest that they can be recommended for treatment of patients for whom it is difficult to use oral antimycotic agents or for patients who fail to respond to oral medications alone.
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Bifonazole (Mycospor® cream) in the treatment of moccasin‐type tinea pedis. Comparison between combination therapy of bifonazole cream +10% urea ointment (Urepearl®) and Occlusive Dressing therapy with the same agents
Mycoses, 2000Co-Authors: H Tanuma, M Doi, N Sato, Shigeo Nishiyama, Michiko Abe, Hikaru Kume, Kensei KatsuokaAbstract:Moccasin-type tinea pedis(MTTP) is a hardly curable superficial dermatomycosis primarily characterized by hyperkeratosis of the sole. In this study, we compared the usefulness of combination therapy of bifonazole (Mycospor cream) + 10% urea ointment (Urepearl) (overlapping application group = group I) with Occlusive Dressing therapy with the same agents (group II) in the treatment of MTTP, and obtained the following results. (1) The clinical improvement rate (percentage of "marked improvement" and "moderate improvement") was 60.4% in group I and 83.3% in group II. (2) The mycological eradication rate was 48.7% in group I and 82.1% in group II after 4 weeks of treatment and 90.9 and 96.9%, after 12 weeks of treatment, respectively. (3) The clinical utility rate (percentage of "very beneficial" and "beneficial") was 83.3% in group I and 93.8% in group II. These results indicate the superiority of both combination therapy of bifonazole + 10% urea ointment (overlapping application group) and Occlusive Dressing therapy with the same agents in terms of efficacy and safety for the treatment of MTTP, and suggest that they can be recommended for treatment of patients for whom it is difficult to use oral antimycotic agents or for patients who fail to respond to oral medications alone.
Pradip K. Mascharak - One of the best experts on this subject based on the ideXlab platform.
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Design and construction of a silver(I)-loaded cellulose-based wound Dressing: trackable and sustained release of silver for controlled therapeutic delivery to wound sites
Journal of Materials Science: Materials in Medicine, 2015Co-Authors: Tara R Deboer, Indranil Chakraborty, Pradip K. MascharakAbstract:Although application of silver nitrate and silver sulfadiazine have been shown to be effective in thwarting infections at burn sites, optimization of the delivery of bioactive silver (Ag+) remains as an obstacle due to rapid precipitation and/or insolubility of the silver sources. To circumvent these shortcomings, we have designed a silver(I) complex [Ag(ImD)2]ClO4 (ImD = dansyl imidazole) that effectively increases the bioavailability of Ag+ and exhibits MIC values of 2.3 and 4.7 μg/mL against E. coli and S. aureus, respectively. This fluorescent silver complex has been incorporated within a robust hydrogel derived from carboxymethyl cellulose that allows slow release of silver. A complete Occlusive Dressing has finally been constructed with the Ag(ImD)CMC (1 % Ag loaded) pad sealed between a sterile mesh gauze (as bottom layer) and a rayon-based surgical tape (as the top layer). Such construction has afforded a Dressing that displays sustained delivery of silver onto a skin and soft tissue infection model and causes effective eradication of bacterial loads within 24 h. The transfer of the bioactive silver complex is readily visualized by the observed fluorescence that overlays precisely with the kill zone. The latter feature introduces a unique feature of therapeutic trackability to this silver-donating Occlusive Dressing.
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Design and construction of a silver(I)-loaded cellulose-based wound Dressing: trackable and sustained release of silver for controlled therapeutic delivery to wound sites
Journal of Materials Science: Materials in Medicine, 2015Co-Authors: Tara R Deboer, Indranil Chakraborty, Pradip K. MascharakAbstract:Although application of silver nitrate and silver sulfadiazine have been shown to be effective in thwarting infections at burn sites, optimization of the delivery of bioactive silver (Ag+) remains as an obstacle due to rapid precipitation and/or insolubility of the silver sources. To circumvent these shortcomings, we have designed a silver(I) complex [Ag(ImD)2]ClO4 (ImD = dansyl imidazole) that effectively increases the bioavailability of Ag+ and exhibits MIC values of 2.3 and 4.7 μg/mL against E. coli and S. aureus, respectively. This fluorescent silver complex has been incorporated within a robust hydrogel derived from carboxymethyl cellulose that allows slow release of silver. A complete Occlusive Dressing has finally been constructed with the Ag(ImD)CMC (1 % Ag loaded) pad sealed between a sterile mesh gauze (as bottom layer) and a rayon-based surgical tape (as the top layer). Such construction has afforded a Dressing that displays sustained delivery of silver onto a skin and soft tissue infection model and causes effective eradication of bacterial loads within 24 h. The transfer of the bioactive silver complex is readily visualized by the observed fluorescence that overlays precisely with the kill zone. The latter feature introduces a unique feature of therapeutic trackability to this silver-donating Occlusive Dressing.
H Tanuma - One of the best experts on this subject based on the ideXlab platform.
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bifonazole mycospor cream in the treatment of moccasin type tinea pedis comparison between combination therapy of bifonazole cream 10 urea ointment urepearl and Occlusive Dressing therapy with the same agents
Mycoses, 2000Co-Authors: H Tanuma, M Doi, N Sato, Shigeo Nishiyama, Michiko Abe, Hikaru Kume, Kensei KatsuokaAbstract:Moccasin-type tinea pedis(MTTP) is a hardly curable superficial dermatomycosis primarily characterized by hyperkeratosis of the sole. In this study, we compared the usefulness of combination therapy of bifonazole (Mycospor cream) + 10% urea ointment (Urepearl) (overlapping application group = group I) with Occlusive Dressing therapy with the same agents (group II) in the treatment of MTTP, and obtained the following results. (1) The clinical improvement rate (percentage of "marked improvement" and "moderate improvement") was 60.4% in group I and 83.3% in group II. (2) The mycological eradication rate was 48.7% in group I and 82.1% in group II after 4 weeks of treatment and 90.9 and 96.9%, after 12 weeks of treatment, respectively. (3) The clinical utility rate (percentage of "very beneficial" and "beneficial") was 83.3% in group I and 93.8% in group II. These results indicate the superiority of both combination therapy of bifonazole + 10% urea ointment (overlapping application group) and Occlusive Dressing therapy with the same agents in terms of efficacy and safety for the treatment of MTTP, and suggest that they can be recommended for treatment of patients for whom it is difficult to use oral antimycotic agents or for patients who fail to respond to oral medications alone.
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Bifonazole (Mycospor® cream) in the treatment of moccasin‐type tinea pedis. Comparison between combination therapy of bifonazole cream +10% urea ointment (Urepearl®) and Occlusive Dressing therapy with the same agents
Mycoses, 2000Co-Authors: H Tanuma, M Doi, N Sato, Shigeo Nishiyama, Michiko Abe, Hikaru Kume, Kensei KatsuokaAbstract:Moccasin-type tinea pedis(MTTP) is a hardly curable superficial dermatomycosis primarily characterized by hyperkeratosis of the sole. In this study, we compared the usefulness of combination therapy of bifonazole (Mycospor cream) + 10% urea ointment (Urepearl) (overlapping application group = group I) with Occlusive Dressing therapy with the same agents (group II) in the treatment of MTTP, and obtained the following results. (1) The clinical improvement rate (percentage of "marked improvement" and "moderate improvement") was 60.4% in group I and 83.3% in group II. (2) The mycological eradication rate was 48.7% in group I and 82.1% in group II after 4 weeks of treatment and 90.9 and 96.9%, after 12 weeks of treatment, respectively. (3) The clinical utility rate (percentage of "very beneficial" and "beneficial") was 83.3% in group I and 93.8% in group II. These results indicate the superiority of both combination therapy of bifonazole + 10% urea ointment (overlapping application group) and Occlusive Dressing therapy with the same agents in terms of efficacy and safety for the treatment of MTTP, and suggest that they can be recommended for treatment of patients for whom it is difficult to use oral antimycotic agents or for patients who fail to respond to oral medications alone.
Tara R Deboer - One of the best experts on this subject based on the ideXlab platform.
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Design and construction of a silver(I)-loaded cellulose-based wound Dressing: trackable and sustained release of silver for controlled therapeutic delivery to wound sites
Journal of Materials Science: Materials in Medicine, 2015Co-Authors: Tara R Deboer, Indranil Chakraborty, Pradip K. MascharakAbstract:Although application of silver nitrate and silver sulfadiazine have been shown to be effective in thwarting infections at burn sites, optimization of the delivery of bioactive silver (Ag+) remains as an obstacle due to rapid precipitation and/or insolubility of the silver sources. To circumvent these shortcomings, we have designed a silver(I) complex [Ag(ImD)2]ClO4 (ImD = dansyl imidazole) that effectively increases the bioavailability of Ag+ and exhibits MIC values of 2.3 and 4.7 μg/mL against E. coli and S. aureus, respectively. This fluorescent silver complex has been incorporated within a robust hydrogel derived from carboxymethyl cellulose that allows slow release of silver. A complete Occlusive Dressing has finally been constructed with the Ag(ImD)CMC (1 % Ag loaded) pad sealed between a sterile mesh gauze (as bottom layer) and a rayon-based surgical tape (as the top layer). Such construction has afforded a Dressing that displays sustained delivery of silver onto a skin and soft tissue infection model and causes effective eradication of bacterial loads within 24 h. The transfer of the bioactive silver complex is readily visualized by the observed fluorescence that overlays precisely with the kill zone. The latter feature introduces a unique feature of therapeutic trackability to this silver-donating Occlusive Dressing.
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Design and construction of a silver(I)-loaded cellulose-based wound Dressing: trackable and sustained release of silver for controlled therapeutic delivery to wound sites
Journal of Materials Science: Materials in Medicine, 2015Co-Authors: Tara R Deboer, Indranil Chakraborty, Pradip K. MascharakAbstract:Although application of silver nitrate and silver sulfadiazine have been shown to be effective in thwarting infections at burn sites, optimization of the delivery of bioactive silver (Ag+) remains as an obstacle due to rapid precipitation and/or insolubility of the silver sources. To circumvent these shortcomings, we have designed a silver(I) complex [Ag(ImD)2]ClO4 (ImD = dansyl imidazole) that effectively increases the bioavailability of Ag+ and exhibits MIC values of 2.3 and 4.7 μg/mL against E. coli and S. aureus, respectively. This fluorescent silver complex has been incorporated within a robust hydrogel derived from carboxymethyl cellulose that allows slow release of silver. A complete Occlusive Dressing has finally been constructed with the Ag(ImD)CMC (1 % Ag loaded) pad sealed between a sterile mesh gauze (as bottom layer) and a rayon-based surgical tape (as the top layer). Such construction has afforded a Dressing that displays sustained delivery of silver onto a skin and soft tissue infection model and causes effective eradication of bacterial loads within 24 h. The transfer of the bioactive silver complex is readily visualized by the observed fluorescence that overlays precisely with the kill zone. The latter feature introduces a unique feature of therapeutic trackability to this silver-donating Occlusive Dressing.
Michiko Abe - One of the best experts on this subject based on the ideXlab platform.
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bifonazole mycospor cream in the treatment of moccasin type tinea pedis comparison between combination therapy of bifonazole cream 10 urea ointment urepearl and Occlusive Dressing therapy with the same agents
Mycoses, 2000Co-Authors: H Tanuma, M Doi, N Sato, Shigeo Nishiyama, Michiko Abe, Hikaru Kume, Kensei KatsuokaAbstract:Moccasin-type tinea pedis(MTTP) is a hardly curable superficial dermatomycosis primarily characterized by hyperkeratosis of the sole. In this study, we compared the usefulness of combination therapy of bifonazole (Mycospor cream) + 10% urea ointment (Urepearl) (overlapping application group = group I) with Occlusive Dressing therapy with the same agents (group II) in the treatment of MTTP, and obtained the following results. (1) The clinical improvement rate (percentage of "marked improvement" and "moderate improvement") was 60.4% in group I and 83.3% in group II. (2) The mycological eradication rate was 48.7% in group I and 82.1% in group II after 4 weeks of treatment and 90.9 and 96.9%, after 12 weeks of treatment, respectively. (3) The clinical utility rate (percentage of "very beneficial" and "beneficial") was 83.3% in group I and 93.8% in group II. These results indicate the superiority of both combination therapy of bifonazole + 10% urea ointment (overlapping application group) and Occlusive Dressing therapy with the same agents in terms of efficacy and safety for the treatment of MTTP, and suggest that they can be recommended for treatment of patients for whom it is difficult to use oral antimycotic agents or for patients who fail to respond to oral medications alone.
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Bifonazole (Mycospor® cream) in the treatment of moccasin‐type tinea pedis. Comparison between combination therapy of bifonazole cream +10% urea ointment (Urepearl®) and Occlusive Dressing therapy with the same agents
Mycoses, 2000Co-Authors: H Tanuma, M Doi, N Sato, Shigeo Nishiyama, Michiko Abe, Hikaru Kume, Kensei KatsuokaAbstract:Moccasin-type tinea pedis(MTTP) is a hardly curable superficial dermatomycosis primarily characterized by hyperkeratosis of the sole. In this study, we compared the usefulness of combination therapy of bifonazole (Mycospor cream) + 10% urea ointment (Urepearl) (overlapping application group = group I) with Occlusive Dressing therapy with the same agents (group II) in the treatment of MTTP, and obtained the following results. (1) The clinical improvement rate (percentage of "marked improvement" and "moderate improvement") was 60.4% in group I and 83.3% in group II. (2) The mycological eradication rate was 48.7% in group I and 82.1% in group II after 4 weeks of treatment and 90.9 and 96.9%, after 12 weeks of treatment, respectively. (3) The clinical utility rate (percentage of "very beneficial" and "beneficial") was 83.3% in group I and 93.8% in group II. These results indicate the superiority of both combination therapy of bifonazole + 10% urea ointment (overlapping application group) and Occlusive Dressing therapy with the same agents in terms of efficacy and safety for the treatment of MTTP, and suggest that they can be recommended for treatment of patients for whom it is difficult to use oral antimycotic agents or for patients who fail to respond to oral medications alone.
