The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Dominick J. H. Mccabe - One of the best experts on this subject based on the ideXlab platform.
-
sequential fluctuating paraneoplastic Ocular Flutter opsoclonus myoclonus syndrome and lambert eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2011Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert-Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus-myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus, and ‘cerebellar' signs, all of which improved spontaneously within six weeks. Approximately eight weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High titre anti- P/Q-type voltage gated calcium channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus-myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Anti-voltage gated calcium channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus-myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter–opsoclonus–myoclonus syndrome and Lambert–Eaton myasthenic syndrome in small-cell lung cancer
Journal of neurology neurosurgery and psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
Robert J Simister - One of the best experts on this subject based on the ideXlab platform.
-
sequential fluctuating paraneoplastic Ocular Flutter opsoclonus myoclonus syndrome and lambert eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2011Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert-Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus-myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus, and ‘cerebellar' signs, all of which improved spontaneously within six weeks. Approximately eight weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High titre anti- P/Q-type voltage gated calcium channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus-myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Anti-voltage gated calcium channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus-myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter–opsoclonus–myoclonus syndrome and Lambert–Eaton myasthenic syndrome in small-cell lung cancer
Journal of neurology neurosurgery and psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
Alberto E. Paniz-mondolfi - One of the best experts on this subject based on the ideXlab platform.
-
Ocular Flutter following Zika virus infection
Journal of NeuroVirology, 2017Co-Authors: Emely Karam, Jose Giraldo, Flor Rodriguez, Carlos E. Hernandez-pereira, Alfonso J. Rodriguez-morales, Gabriela M. Blohm, Alberto E. Paniz-mondolfiAbstract:Zika virus (ZIKV) is an emerging flavivirus which has been linked to a number of neurologic manifestations such as Guillain-Barré syndrome (GBS), transverse myelitis, and meningo-encephalitis. Ophthalmologic manifestations are increasingly being reported; however, Ocular dyskinesias have not been described in this context to date. Herein, we report a case of a 22-year-old female who presented with Ocular Flutter and associated Guillain-Barré syndrome following acute ZIKV infection. We speculate that although such symptoms may have originated from a direct viral insult, a post-infectious autoimmune mechanism may not be excluded. Physicians should include ZIKV as well as other flaviviruses in their diagnostic workup for all patients with Ocular Flutter/opsoclonus, after excluding other non-infectious causes of central nervous system pathology. To the best of our knowledge, this is the first report on the association of Ocular Flutter, GBS, and ZIKV infection.
-
Ocular Flutter following Zika virus infection.
Journal of neurovirology, 2017Co-Authors: Emely Karam, Jose Giraldo, Flor Rodriguez, Carlos E. Hernandez-pereira, Alfonso J. Rodriguez-morales, Gabriela M. Blohm, Alberto E. Paniz-mondolfiAbstract:Zika virus (ZIKV) is an emerging flavivirus which has been linked to a number of neurologic manifestations such as Guillain-Barre syndrome (GBS), transverse myelitis, and meningo-encephalitis. Ophthalmologic manifestations are increasingly being reported; however, Ocular dyskinesias have not been described in this context to date. Herein, we report a case of a 22-year-old female who presented with Ocular Flutter and associated Guillain-Barre syndrome following acute ZIKV infection. We speculate that although such symptoms may have originated from a direct viral insult, a post-infectious autoimmune mechanism may not be excluded. Physicians should include ZIKV as well as other flaviviruses in their diagnostic workup for all patients with Ocular Flutter/opsoclonus, after excluding other non-infectious causes of central nervous system pathology. To the best of our knowledge, this is the first report on the association of Ocular Flutter, GBS, and ZIKV infection.
Bethan Lang - One of the best experts on this subject based on the ideXlab platform.
-
glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus perm but not in saccadic oscillations
Journal of Neurology, 2012Co-Authors: Takahiro Iizuka, Bethan Lang, Maria Isabel Leite, Patrick Waters, Yoshiaki Urano, Saori Miyakawa, Junichi Hamada, Fumihiko Sakai, Hideki Mochizuki, Angela VincentAbstract:Glycine receptor (GlyR) antibodies were recently identified in a few patients with progressive encephalomyelitis with rigidity and myoclonus (PERM); none of these patients had antibodies against glutamic acid decarboxylase (GAD). An inhibitory glycinergic transmission defect has also been implicated in the mechanism underlying saccadic oscillations, including Ocular Flutter or opsoclonus; GlyR antibodies have not been reported in these patients. The purpose was to determine whether GlyR antibodies are found in patients with PERM, Ocular Flutter syndrome (OFS), and opsoclonus-myoclonus syndrome (OMS). GlyR antibodies were first measured in archived sera and CSF from five patients, including one patient with GAD antibody-positive PERM, two patients with OFS, and two patients with OMS. GlyR antibodies were also measured in archived sera from nine other adult patients with OMS. GlyR antibodies and GAD antibodies were both found at high titers in the serum and CSF of the patient with PERM, and their levels paralleled disease activity over time. GlyR antibodies were not found at significant levels in 13 patients with saccadic oscillations. GlyR and GAD antibodies can co-exist in PERM and follow the clinical course. Although saccadic oscillations are a feature of this condition, GlyR antibodies are not commonly found in patients with isolated saccadic oscillations.
-
sequential fluctuating paraneoplastic Ocular Flutter opsoclonus myoclonus syndrome and lambert eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2011Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert-Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus-myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus, and ‘cerebellar' signs, all of which improved spontaneously within six weeks. Approximately eight weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High titre anti- P/Q-type voltage gated calcium channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus-myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Anti-voltage gated calcium channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus-myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter–opsoclonus–myoclonus syndrome and Lambert–Eaton myasthenic syndrome in small-cell lung cancer
Journal of neurology neurosurgery and psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
David Chao - One of the best experts on this subject based on the ideXlab platform.
-
sequential fluctuating paraneoplastic Ocular Flutter opsoclonus myoclonus syndrome and lambert eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2011Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter-opsoclonus-myoclonus syndrome and Lambert-Eaton myasthenic syndrome in small cell lung cancer
Journal of Neurology Neurosurgery and Psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert-Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus-myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus, and ‘cerebellar' signs, all of which improved spontaneously within six weeks. Approximately eight weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High titre anti- P/Q-type voltage gated calcium channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus-myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Anti-voltage gated calcium channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus-myoclonus syndrome.
-
Sequential fluctuating paraneoplastic Ocular Flutter–opsoclonus–myoclonus syndrome and Lambert–Eaton myasthenic syndrome in small-cell lung cancer
Journal of neurology neurosurgery and psychiatry, 2010Co-Authors: Robert J Simister, Bethan Lang, Michael Beckles, David Chao, Dominick J. H. MccabeAbstract:Paraneoplastic cerebellar degeneration may occur in association with Lambert–Eaton myasthenic syndrome (LEMS), but to our knowledge, the co-occurrence of paraneoplastic opsoclonus–myoclonus syndrome and LEMS has not been previously reported. A 67-year-old woman presented with a complex partial seizure and evolving Ocular Flutter, opsoclonus, myoclonus and ‘cerebellar’ signs, all of which improved spontaneously within 6 weeks. Approximately 8 weeks after symptom onset, the patient became encephalopathic, she had a further complex partial seizure, and she became areflexic with potentiation of deep tendon reflexes. Radiological, bronchoscopic and histological investigations revealed small-cell lung cancer, and neurophysiological investigations confirmed a diagnosis of LEMS. High-titre anti-P/Q-type voltage-gated calcium-channel antibodies were identified in the serum, which increased as the signs of opsoclonus and myoclonus resolved. The encephalopathy and clinical features of LEMS responded dramatically to chemotherapy and radiotherapy. Spontaneous improvement of paraneoplastic opsoclonus–myoclonus syndrome may occur, and this syndrome may occur in association with LEMS. Antivoltage-gated calcium-channel antibodies are not implicated in the pathogenesis of paraneoplastic opsoclonus–myoclonus syndrome.
