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Manabu Mochizuki - One of the best experts on this subject based on the ideXlab platform.
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A Validation Study of the Revised Diagnostic Criteria from the International Workshop on Ocular Sarcoidosis at a Single Institute in Japan.
Ocular immunology and inflammation, 2020Co-Authors: Mari Handa-miyauchi, Hiroshi Takase, Miyuki Tanaka, Masako Akiyama, Kyoko Ohno-matsui, Manabu MochizukiAbstract:To validate the revised criteria of the International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of Ocular Sarcoidosis (OS). A retrospective chart review study was performed on 323 pat...
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Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of Ocular Sarcoidosis.
The British journal of ophthalmology, 2019Co-Authors: Manabu Mochizuki, Hiroshi Takase, Nisha R. Acharya, Justine R. Smith, Toshikatsu Kaburaki, Narsing A RaoAbstract:Aims International criteria for the diagnosis of Ocular Sarcoidosis (OS) was established by the first International Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations of the criteria. To overcome the limitations, revised IWOS criteria was established in an international meeting. This manuscript was aimed at reporting the revised IWOS criteria. Methods A consensus workshop was carried out to discuss and revise the IWOS criteria. The workshop was held on 27 April 2017, in Nusa Dua, Bali, Indonesia. Prior to the workshop, a questionnaire proposing revised criteria and consisting of one item for differential diagnosis, seven items for Ocular clinical signs, 10 items for systemic investigations and three categories of diagnostic criteria was circulated to 30 uveitis specialists. Questionnaire items with over 75% support were taken as consensus agreement; items with below 50% support were taken as consensus disagreement and items with 50%–75% support were discussed at the workshop. Of the latter items, those supported by two-thirds majority in the workshop were taken as consensus agreement. Results The survey and subsequent workshop reached consensus agreements of the revised criteria for the diagnosis of OS as follows: (1) other causes of granulomatous uveitis must be ruled out; (2) seven intraOcular clinical signs suggestive of OS; (3) eight results of systemic investigations in suspected OS and (4) three categories of diagnostic criteria depending on biopsy results and combination of intraOcular signs and results of systemic investigations. Conclusions Revised IWOS criteria were proposed by a consensus workshop.
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Distinguishing features of Ocular Sarcoidosis in an international cohort of uveitis patients
Ophthalmology, 2017Co-Authors: Nisha R. Acharya, Narsing A Rao, Erica N. Browne, Manabu MochizukiAbstract:Purpose To determine which clinical features distinguish Ocular Sarcoidosis from other forms of uveitis in an international population and to estimate the sensitivity and specificity of the International Workshop on Ocular Sarcoidosis (IWOS) clinical signs and laboratory tests. Design Multicenter, retrospective medical record review. Participants Eight hundred eighty-four patients with uveitis from 19 centers in 12 countries. Methods Data collected included suspected cause of uveitis, clinical findings, and laboratory investigations within 6 months of presentation. The IWOS criteria were used to classify patients as having definite (biopsy-proven), presumed (evidence of bilateral hilar lymphadenopathy [BHL] on chest radiograph or CT scan), probable, or possible Ocular Sarcoidosis. Patients with biopsy positive results or BHL on chest radiograph or CT scan were considered Sarcoidosis cases. Main Outcome Measures Sensitivity and specificity of clinical signs and laboratory investigations for diagnosing Ocular Sarcoidosis. Results Of the 884 uveitis patients, 264 (30%) were suspected to have Ocular Sarcoidosis. One hundred eighty patients (20%) met the IWOS criteria; 98 were definite (biopsy-proven) disease, 69 presumed disease (BHL), 10 probable disease, and 3 possible disease. Among Sarcoidosis cases, the most common clinical signs were bilaterality (86%); snowballs or string of pearls (50%); mutton-fat keratic precipitates, iris nodules, or both (46%); and multiple chorioretinal peripheral lesions (45%). Sixty-two percent of Sarcoidosis cases had elevated angiotensin converting enzyme or lysozyme and 5% demonstrated abnormal liver enzyme test results. Of the patients suspected of having Sarcoidosis, 97 (37%) did not meet the IWOS criteria. Conclusions With the exception of BHL, IWOS clinical findings and investigational tests had low sensitivities for diagnosing Ocular Sarcoidosis. In particular, liver function tests seem to have little usefulness in diagnosing Ocular Sarcoidosis. Many patients suspected of having Sarcoidosis did not fit into the classification system, indicating that the guidelines may need to be reconsidered. Adding novel laboratory tests and using more advanced statistical methods may lead to the development of a more generalizable classification system.
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Validation of international criteria for the diagnosis of Ocular Sarcoidosis proposed by the first international workshop on Ocular Sarcoidosis.
Japanese journal of ophthalmology, 2010Co-Authors: Hiroshi Takase, Kentarou Shimizu, Yukiko Yamada, Atsue Hanada, Hidemi Takahashi, Manabu MochizukiAbstract:Purpose To validate the international criteria for the diagnosis of Ocular Sarcoidosis as proposed by the First International Workshop on Ocular Sarcoidosis (FIWOS).
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Validation of international criteria for the diagnosis of Ocular Sarcoidosis proposed by the first international workshop on Ocular Sarcoidosis
Japanese Journal of Ophthalmology, 2010Co-Authors: Hiroshi Takase, Kentarou Shimizu, Yukiko Yamada, Atsue Hanada, Hidemi Takahashi, Manabu MochizukiAbstract:Purpose To validate the international criteria for the diagnosis of Ocular Sarcoidosis as proposed by the First International Workshop on Ocular Sarcoidosis (FIWOS). Methods A retrospective case-control study examined 370 consecutive uveitis patients at Tokyo Medical and Dental University Hospital. The study group consisted of 50 patients with biopsy-proven Sarcoidosis and 320 control patients with other uveitis entities. Predictive values [sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV)] were calculated for seven clinical signs, five laboratory tests, and the diagnostic criteria. Results With the exception of the liver enzyme tests, there was a significantly higher incidence of positive results for all clinical signs and laboratory tests in the biopsy-proven Sarcoidosis patients than in the control uveitis patients. Although variability was noted in the predictive values of the seven clinical signs and five laboratory tests, the sensitivity, specificity, PPV, and NPV of the FIWOS criteria, which were based on the combined results of the clinical signs and laboratory tests, were 1.000, 0.956, 0.781, and 1.000, respectively. Conclusions The FIWOS criteria have high predictive values for diagnosing Ocular Sarcoidosis. To further confirm these findings, an international prospective multicenter study should be undertaken in the future.
Masaru Takeuchi - One of the best experts on this subject based on the ideXlab platform.
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Development of Acute Retinal Necrosis in a Patient with Ocular Sarcoidosis: A Case Report.
Ocular immunology and inflammation, 2019Co-Authors: Kei Takayama, Toshikatsu Kaburaki, Masaru TakeuchiAbstract:ABSTRACTPurpose: To report a case of acute retinal necrosis (ARN) caused by varicella-zoster virus (VZV) in an elderly patient with Ocular Sarcoidosis after oral corticosteroid indication.Methods: ...
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Age-related differences in the clinical features of Ocular Sarcoidosis
PLOS ONE, 2018Co-Authors: Kei Takayama, Kozo Harimoto, Tomohito Sato, Yutaka Sakurai, Manzo Taguchi, Takayuki Kanda, Masaru TakeuchiAbstract:The distribution of age at diagnosis in Ocular Sarcoidosis has shifted towards the older age groups in developed countries. In systemic Sarcoidosis, age-related differences in the clinical presentation, which reflect the therapeutic strategies, was reported. We retrospectively compared 100 consecutive patients from April 2010 to March 2016 who were initially diagnosed with Ocular Sarcoidosis by International Workshop on Ocular Sarcoidosis criteria. They were classified into elder (>65 years: 50 patients) and younger (≤65 years: 50 patients) groups by the age at diagnosis of uveitis associated with Sarcoidosis. All patients received ophthalmic examination to assess the presence of seven intraOcular signs and 4 laboratory parameters. Significantly fewer Ocular signs (2.8 ± 1.5 and 3.6 ± 1.5; P = 0.0034) and abnormal laboratory results (1.5 ± 1.2 and 2.0 ± 1.2; P = 0.023) were detected in the elder group than in the younger group; statistical differences were found between the groups regarding the frequencies of mutton-fat keratic precipitates (40% and 64%; P = 0.012), vitreous opacities (60% and 78%; P = 0.0059), bilateral inflammation (64% and 80%; P = 0.012), and bilateral hilar lymphadenopathy between the groups (52% and 78%; P < 0.001). Multiple linear regression analysis showed negative correlations between age and number of detected Ocular signs (r = -0.36, P < 0.001) and laboratory results (r = -0.20, P = 0.023). The characteristic Ocular signs and abnormal laboratory results had a lower frequency in the elder patients compared with the younger patients. Probable or possible Ocular Sarcoidosis by the international criteria should increase with increased life expectancy in developed countries.
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The International Workshop on Ocular Sarcoidosis criteria.
2018Co-Authors: Kei Takayama, Kozo Harimoto, Tomohito Sato, Yutaka Sakurai, Manzo Taguchi, Takayuki Kanda, Masaru TakeuchiAbstract:The International Workshop on Ocular Sarcoidosis criteria.
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Association of High-Mobility Group Box-1 With Th Cell-Related Cytokines in the Vitreous of Ocular Sarcoidosis Patients.
Investigative ophthalmology & visual science, 2017Co-Authors: Masaru Takeuchi, Tomohito Sato, Yutaka Sakurai, Manzo Taguchi, Kyoko Karasawa, Kohzou Harimoto, Masataka ItoAbstract:Purpose High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in Ocular Sarcoidosis with those in noninflammatory vitreoretinal diseases and evaluated its association with Th cell-related and proinflammatory cytokines. Methods The study group consisted of 24 patients with Ocular Sarcoidosis. The control group consisted of 27 patients with proliferative diabetic retinopathy (PDR) and 24 with idiopathic epiretinal membrane (ERM). Vitreous fluid samples were obtained at the beginning of vitrectomy. Vitreous levels of HMGB1 and IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, soluble CD40 ligand (sCD40L), and TNFα were measured. Results High-mobility group box-1 was detected in the vitreous of 23 of 24 patients (95.8%) with Ocular Sarcoidosis. Mean vitreous level of HMGB1 was the highest in the Sarcoidosis group, followed by the PDR and ERM groups, with significant differences between the three groups. In the Sarcoidosis group, vitreous levels of IL-6, IL-10, IL-31, IFN-γ, sCD40L, and TNFα were significantly higher than those in the idiopathic ERM group, and IFN-γ and sCD40L were significantly higher than those in the PDR group. Vitreous HMGB-1 level correlated significantly with IL-10, IFN-γ, and sCD40L levels but not with IL-6, IL-17, IL-31, or TNFα levels. Conclusions The vitreous level of HMGB1 is elevated in Ocular Sarcoidosis and is associated with vitreous levels of Th1- and regulatory T-related cytokines, but not with proinflammatory or Th17-related cytokines.
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Evaluation of microincision vitrectomy surgery using wide-viewing system for complications with Ocular Sarcoidosis.
Medicine, 2015Co-Authors: Kei Takayama, Atsushi Tanaka, Masanori Shibata, Tadashi Muraoka, Sho Ishikawa, Kouzo Harimoto, Masaru TakeuchiAbstract:We evaluate the outcomes of microincision vitrectomy surgery (MIVS) using wide-viewing system for complications with Ocular Sarcoidosis resistance to medical treatment. Consecutive clinical records of 24 eyes (19 patients) with complications of Ocular Sarcoidosis underwent MIVS between April 2010 and December 2013 were retrospectively reviewed. MIVS and phacoemulsification were performed in 18 eyes and MIVS only in 6 eyes. Best-corrected visual acuity (BCVA), inflammation scores in the anterior segment and in the posterior segment, and central retinal thickness (CRT) of eyes with cystoid macular edema (CME) before surgery and after 1 week, 1, 3, 6, and 12 months were evaluated. LogMAR (log of the minimum angle of resolution) converted from BCVA was improved in 83.3% after 12 months and 66.7% showed improvement of more than 2 lines. The mean LogMAR was significantly improved from 1.14 ± 1.18 to 0.36 ± 0.79 in all eyes and 0.83 ± 0.86 to 0.23 ± 0.41 in eyes with MIVS and phacoemulsification, although no improvement was observed in eyes with MIVS only. Significant decrease of the mean anterior inflammation score was observed after 1 month in eyes with MIVS only and after 12 months in eyes with MIVS and phacoemulsification, and the mean posterior inflammation scores decreased after 1 week in all eyes. In eyes with preoperative CME, mean CRT was significantly decreased from 1 week after surgery. There was no case in which Ocular inflammation was exacerbated by surgical stress. Improvement of visual acuity and resolution of Ocular inflammation could be achieved by MIVS using wide-viewing system for complications of Ocular Sarcoidosis.
Kalpana Babu - One of the best experts on this subject based on the ideXlab platform.
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Recommendations for the management of Ocular Sarcoidosis from the International Workshop on Ocular Sarcoidosis.
The British journal of ophthalmology, 2020Co-Authors: Hiroshi Takase, Kalpana Babu, Nisha R. Acharya, Bahram Bodaghi, Moncef Khairallah, Peter Mccluskey, Nattaporn Tesavibul, Jennifer E. Thorne, Ilknur Tugal-tutkun, Joyce Hisae YamamotoAbstract:Aims To establish expert recommendations for the management of Ocular Sarcoidosis (OS). Methods A question-based survey on the management of OS was circulated to international uveitis experts (members of the International Uveitis Study Group and the International Ocular Inflammation Society) electronically. Subsequently, a consensus workshop was conducted at the 7th International Workshop on Ocular Sarcoidosis (IWOS) in June 2019 in Sapporo, Japan as part of the Global Ocular Inflammation Workshops. Statements on the management of OS that were supported by a two-thirds majority of 10 international panel members of the workshop, after discussion and voting, were taken as consensus agreement. Results A total of 98 participants from 29 countries responded to the questionnaire survey. The subsequent consensus workshop established recommendations for the management of OS in five sections. The first section concerned evaluation and monitoring of inflammation. The second, third and fourth sections described Ocular manifestations that were indications for treatment, and the management of anterior uveitis, intermediate uveitis and posterior uveitis. In the fifth section, the use of systemic corticosteroids and systemic immunosuppressive drugs were detailed. Conclusions Recommendations for management of OS were formulated through an IWOS consensus workshop.
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Diagnostic Markers in Ocular Sarcoidosis in A High TB Endemic Population - A Multicentre Study.
Ocular immunology and inflammation, 2020Co-Authors: Kalpana Babu, Padmamalini Mahendradas, Jyotirmay Biswas, Manisha Agarwal, Reema Bansal, Sivakumar R. Rathinam, Soumyava Basu, Sudha K Ganesh, Vinaya Kumar Konana, Rajesh VedhanayakiAbstract:To look at markers to differentiate Ocular Sarcoidosis from Ocular tuberculosis in a high TB endemic population. Retrospective multicenter study involving seven tertiary eyecare centers in India be...
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High Resolution Chest Computerized Tomography in the Diagnosis of Ocular Sarcoidosis in a High TB Endemic Population.
Ocular immunology and inflammation, 2016Co-Authors: Kalpana Babu, Sai Bhakti Shukla, Mariamma PhilipsAbstract:ABSTRACTPurpose: To review the role of high resolution chest computed tomography (HRCT) in Ocular Sarcoidosis in a high TB endemic population.Methods: This was a retrospective study.Results: Out of 140 cases, 54 had Ocular Sarcoidosis, while 86 cases had Ocular tuberculosis. Abnormal HRCT findings was noted in 52 cases (96.3%) of Ocular Sarcoidosis compared with 55 cases (64.7%) of Ocular tuberculosis (p = 0.001). Mediastinal lymphadenopathy was the most common finding in both groups (p = 0.544). Hilar lymphadenopathy and fissural nodules were significantly seen in Ocular Sarcoidosis (p = 0.001). Necrosis was seen in three cases of Ocular Sarcoidosis. In nearly half of the cases, it was not possible to differentiate between Sarcoidosis and tuberculosis on HRCT.Conclusions: HRCT is a useful diagnostic tool in Ocular Sarcoidosis. Bilateral hilar lymphadenopathy and fissural nodules are significant findings in Ocular Sarcoidosis. A confident diagnosis of Ocular Sarcoidosis is made by the amalgamation of resu...
Narsing A Rao - One of the best experts on this subject based on the ideXlab platform.
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Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of Ocular Sarcoidosis.
The British journal of ophthalmology, 2019Co-Authors: Manabu Mochizuki, Hiroshi Takase, Nisha R. Acharya, Justine R. Smith, Toshikatsu Kaburaki, Narsing A RaoAbstract:Aims International criteria for the diagnosis of Ocular Sarcoidosis (OS) was established by the first International Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations of the criteria. To overcome the limitations, revised IWOS criteria was established in an international meeting. This manuscript was aimed at reporting the revised IWOS criteria. Methods A consensus workshop was carried out to discuss and revise the IWOS criteria. The workshop was held on 27 April 2017, in Nusa Dua, Bali, Indonesia. Prior to the workshop, a questionnaire proposing revised criteria and consisting of one item for differential diagnosis, seven items for Ocular clinical signs, 10 items for systemic investigations and three categories of diagnostic criteria was circulated to 30 uveitis specialists. Questionnaire items with over 75% support were taken as consensus agreement; items with below 50% support were taken as consensus disagreement and items with 50%–75% support were discussed at the workshop. Of the latter items, those supported by two-thirds majority in the workshop were taken as consensus agreement. Results The survey and subsequent workshop reached consensus agreements of the revised criteria for the diagnosis of OS as follows: (1) other causes of granulomatous uveitis must be ruled out; (2) seven intraOcular clinical signs suggestive of OS; (3) eight results of systemic investigations in suspected OS and (4) three categories of diagnostic criteria depending on biopsy results and combination of intraOcular signs and results of systemic investigations. Conclusions Revised IWOS criteria were proposed by a consensus workshop.
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Distinguishing features of Ocular Sarcoidosis in an international cohort of uveitis patients
Ophthalmology, 2017Co-Authors: Nisha R. Acharya, Narsing A Rao, Erica N. Browne, Manabu MochizukiAbstract:Purpose To determine which clinical features distinguish Ocular Sarcoidosis from other forms of uveitis in an international population and to estimate the sensitivity and specificity of the International Workshop on Ocular Sarcoidosis (IWOS) clinical signs and laboratory tests. Design Multicenter, retrospective medical record review. Participants Eight hundred eighty-four patients with uveitis from 19 centers in 12 countries. Methods Data collected included suspected cause of uveitis, clinical findings, and laboratory investigations within 6 months of presentation. The IWOS criteria were used to classify patients as having definite (biopsy-proven), presumed (evidence of bilateral hilar lymphadenopathy [BHL] on chest radiograph or CT scan), probable, or possible Ocular Sarcoidosis. Patients with biopsy positive results or BHL on chest radiograph or CT scan were considered Sarcoidosis cases. Main Outcome Measures Sensitivity and specificity of clinical signs and laboratory investigations for diagnosing Ocular Sarcoidosis. Results Of the 884 uveitis patients, 264 (30%) were suspected to have Ocular Sarcoidosis. One hundred eighty patients (20%) met the IWOS criteria; 98 were definite (biopsy-proven) disease, 69 presumed disease (BHL), 10 probable disease, and 3 possible disease. Among Sarcoidosis cases, the most common clinical signs were bilaterality (86%); snowballs or string of pearls (50%); mutton-fat keratic precipitates, iris nodules, or both (46%); and multiple chorioretinal peripheral lesions (45%). Sixty-two percent of Sarcoidosis cases had elevated angiotensin converting enzyme or lysozyme and 5% demonstrated abnormal liver enzyme test results. Of the patients suspected of having Sarcoidosis, 97 (37%) did not meet the IWOS criteria. Conclusions With the exception of BHL, IWOS clinical findings and investigational tests had low sensitivities for diagnosing Ocular Sarcoidosis. In particular, liver function tests seem to have little usefulness in diagnosing Ocular Sarcoidosis. Many patients suspected of having Sarcoidosis did not fit into the classification system, indicating that the guidelines may need to be reconsidered. Adding novel laboratory tests and using more advanced statistical methods may lead to the development of a more generalizable classification system.
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Review for Disease of the Year: Immunopathogenesis of Ocular Sarcoidosis
Ocular immunology and inflammation, 2010Co-Authors: Anita S. Y. Chan, Om P. Sharma, Narsing A RaoAbstract:Ocular Sarcoidosis is a heterogeneous disease having varied presentations and severities with genetic susceptibility playing a role. Sarcoidosis is characterized by the presence of noncaseating (non-necrotizing) granulomas in the affected organs or tissue systems. What causes these granulomas is not known, but current knowledge of the immunology of this enigmatic disease centers on a CD4 T helper type 1 cell response. This review deals with immunologic sequences that lead to the formation of sarcoid granulomas and explores the immunopathogenesis of Ocular inflammation seen in patients with Sarcoidosis.
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international criteria for the diagnosis of Ocular Sarcoidosis results of the first international workshop on Ocular Sarcoidosis iwos
Ocular Immunology and Inflammation, 2009Co-Authors: Carl P Herbort, Narsing A Rao, Manabu MochizukiAbstract:Aim: To report criteria for the diagnosis of intraOcular Sarcoidosis, taking into account suggestive clinical signs and appropriate laboratory investigations and biopsy results. Design: Concensus workshop of an international committee on nomenclature. Methods: An international group of uveitis specialists from Asia, Africa, Europe, and America met in a concensus conference in Shinagawa, Tokyo on October 28–29, 2006. Based on questionnaires that had been sent out prior to the conference, the participants discussed potential intraOcular clinical signs eligible for a diagnosis of Ocular Sarcoidosis. A refined definition of clinical signs, which received two-thirds majority of votes, was included in the list of signs consistent with Ocular Sarcoidosis. Laboratory investigations were similarly discussed and those tests reaching a two-thirds majority were retained for the diagnosis of Ocular Sarcoidosis. Finally diagnostic criteria were proposed based on Ocular signs, laboratory investigations, and biopsy resul...
Hiroshi Takase - One of the best experts on this subject based on the ideXlab platform.
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Recommendations for the management of Ocular Sarcoidosis from the International Workshop on Ocular Sarcoidosis.
The British journal of ophthalmology, 2020Co-Authors: Hiroshi Takase, Kalpana Babu, Nisha R. Acharya, Bahram Bodaghi, Moncef Khairallah, Peter Mccluskey, Nattaporn Tesavibul, Jennifer E. Thorne, Ilknur Tugal-tutkun, Joyce Hisae YamamotoAbstract:Aims To establish expert recommendations for the management of Ocular Sarcoidosis (OS). Methods A question-based survey on the management of OS was circulated to international uveitis experts (members of the International Uveitis Study Group and the International Ocular Inflammation Society) electronically. Subsequently, a consensus workshop was conducted at the 7th International Workshop on Ocular Sarcoidosis (IWOS) in June 2019 in Sapporo, Japan as part of the Global Ocular Inflammation Workshops. Statements on the management of OS that were supported by a two-thirds majority of 10 international panel members of the workshop, after discussion and voting, were taken as consensus agreement. Results A total of 98 participants from 29 countries responded to the questionnaire survey. The subsequent consensus workshop established recommendations for the management of OS in five sections. The first section concerned evaluation and monitoring of inflammation. The second, third and fourth sections described Ocular manifestations that were indications for treatment, and the management of anterior uveitis, intermediate uveitis and posterior uveitis. In the fifth section, the use of systemic corticosteroids and systemic immunosuppressive drugs were detailed. Conclusions Recommendations for management of OS were formulated through an IWOS consensus workshop.
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A Validation Study of the Revised Diagnostic Criteria from the International Workshop on Ocular Sarcoidosis at a Single Institute in Japan.
Ocular immunology and inflammation, 2020Co-Authors: Mari Handa-miyauchi, Hiroshi Takase, Miyuki Tanaka, Masako Akiyama, Kyoko Ohno-matsui, Manabu MochizukiAbstract:To validate the revised criteria of the International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of Ocular Sarcoidosis (OS). A retrospective chart review study was performed on 323 pat...
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Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of Ocular Sarcoidosis.
The British journal of ophthalmology, 2019Co-Authors: Manabu Mochizuki, Hiroshi Takase, Nisha R. Acharya, Justine R. Smith, Toshikatsu Kaburaki, Narsing A RaoAbstract:Aims International criteria for the diagnosis of Ocular Sarcoidosis (OS) was established by the first International Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations of the criteria. To overcome the limitations, revised IWOS criteria was established in an international meeting. This manuscript was aimed at reporting the revised IWOS criteria. Methods A consensus workshop was carried out to discuss and revise the IWOS criteria. The workshop was held on 27 April 2017, in Nusa Dua, Bali, Indonesia. Prior to the workshop, a questionnaire proposing revised criteria and consisting of one item for differential diagnosis, seven items for Ocular clinical signs, 10 items for systemic investigations and three categories of diagnostic criteria was circulated to 30 uveitis specialists. Questionnaire items with over 75% support were taken as consensus agreement; items with below 50% support were taken as consensus disagreement and items with 50%–75% support were discussed at the workshop. Of the latter items, those supported by two-thirds majority in the workshop were taken as consensus agreement. Results The survey and subsequent workshop reached consensus agreements of the revised criteria for the diagnosis of OS as follows: (1) other causes of granulomatous uveitis must be ruled out; (2) seven intraOcular clinical signs suggestive of OS; (3) eight results of systemic investigations in suspected OS and (4) three categories of diagnostic criteria depending on biopsy results and combination of intraOcular signs and results of systemic investigations. Conclusions Revised IWOS criteria were proposed by a consensus workshop.
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Validation of international criteria for the diagnosis of Ocular Sarcoidosis proposed by the first international workshop on Ocular Sarcoidosis.
Japanese journal of ophthalmology, 2010Co-Authors: Hiroshi Takase, Kentarou Shimizu, Yukiko Yamada, Atsue Hanada, Hidemi Takahashi, Manabu MochizukiAbstract:Purpose To validate the international criteria for the diagnosis of Ocular Sarcoidosis as proposed by the First International Workshop on Ocular Sarcoidosis (FIWOS).
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Validation of international criteria for the diagnosis of Ocular Sarcoidosis proposed by the first international workshop on Ocular Sarcoidosis
Japanese Journal of Ophthalmology, 2010Co-Authors: Hiroshi Takase, Kentarou Shimizu, Yukiko Yamada, Atsue Hanada, Hidemi Takahashi, Manabu MochizukiAbstract:Purpose To validate the international criteria for the diagnosis of Ocular Sarcoidosis as proposed by the First International Workshop on Ocular Sarcoidosis (FIWOS). Methods A retrospective case-control study examined 370 consecutive uveitis patients at Tokyo Medical and Dental University Hospital. The study group consisted of 50 patients with biopsy-proven Sarcoidosis and 320 control patients with other uveitis entities. Predictive values [sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV)] were calculated for seven clinical signs, five laboratory tests, and the diagnostic criteria. Results With the exception of the liver enzyme tests, there was a significantly higher incidence of positive results for all clinical signs and laboratory tests in the biopsy-proven Sarcoidosis patients than in the control uveitis patients. Although variability was noted in the predictive values of the seven clinical signs and five laboratory tests, the sensitivity, specificity, PPV, and NPV of the FIWOS criteria, which were based on the combined results of the clinical signs and laboratory tests, were 1.000, 0.956, 0.781, and 1.000, respectively. Conclusions The FIWOS criteria have high predictive values for diagnosing Ocular Sarcoidosis. To further confirm these findings, an international prospective multicenter study should be undertaken in the future.
