The Experts below are selected from a list of 8919 Experts worldwide ranked by ideXlab platform
Peter Shah - One of the best experts on this subject based on the ideXlab platform.
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the uk paediatric Ocular Trauma study 2 pots2 demographics and mechanisms of injuries
Clinical Ophthalmology, 2018Co-Authors: Freda Sii, Richard J Blanch, Robert J Barry, Joseph Abbott, Caroline J Macewen, Peter ShahAbstract:Purpose Pediatric Ocular Trauma is an important cause of visual morbidity worldwide, accounting for up to one-third of all Ocular Trauma admissions. It has long-term implications for those affected and significant economic consequences for healthcare providers. It has been estimated that 90% of all Ocular Trauma is preventable. Targeted strategies are required to reduce the incidence and the severity of pediatric Ocular Trauma; this requires an understanding of the epidemiology and characteristics of these injuries and the children involved. Methods Prospective, observational study of pediatric Ocular Trauma cases presenting to UK-based ophthalmologists over a 1-year period; reporting cards were distributed by the British Ophthalmological Surveillance Unit, and clinicians were asked to report incidents of acute orbital and Ocular Trauma in children aged ≤16 years requiring inpatient or day-case admission. A validated, standardized questionnaire was sent to reporting ophthalmologists to collect data on the demographics and circumstances of injury. Results Median age at presentation was 7.7 years, with boys more than twice as likely to be affected than girls (M:F =2.1:1.0). Almost 50% of injuries occurred at home, with 25% occurring in school or nursery. A total of 67% of injuries occurred during play, and 31% involved a sharp implement. Conclusion Pediatric Ocular Trauma remains an important public health problem. At least three-quarters of all injuries are preventable through measures, including education of children and responsible adults, restricting access to sharp implements, improving adult supervision, and appropriate use of eye protection.
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The UK Paediatric Ocular Trauma Study 1 (POTS1): development of a global standardized protocol for prospective data collection in pediatric Ocular Trauma.
Clinical ophthalmology (Auckland N.Z.), 2017Co-Authors: Freda Sii, Richard J Blanch, Robert J Barry, Joseph Abbott, Caroline J Macewen, Peter ShahAbstract:BACKGROUND: Ocular Trauma is an important cause of visual morbidity in children worldwide. Pediatric Ocular Trauma accounts for up to one third of all Ocular Trauma admissions, with significant economic implications for health care providers. It is estimated that 90% of all Ocular Trauma is preventable. Development of strategies to reduce the incidence and severity of pediatric Ocular Trauma requires an understanding of the epidemiology of these injuries and their characteristics. This will enable appropriate targeting of resources toward prevention and allow effective service planning. At present, there is no standardized methodology for the collection of global cross-sectional data in pediatric Ocular Trauma, and the ability to undertake detailed epidemiological and health-economic analyses is limited. Furthermore, it is difficult to draw international comparisons in incidence, etiology, and outcomes of pediatric Ocular Trauma due to the range of published reporting criteria. This study describes two novel questionnaires for standardized data collection in pediatric Ocular Trauma, which can be adopted across a range of health care settings internationally. METHODS: Two standardized data collection questionnaires have been developed from previously reported templates. The first enables collection of demographic and incident data on serious pediatric Ocular Trauma requiring hospitalization, and the second enables follow-up outcome data collection. Both the questionnaires are designed to collect primarily categorical data in order to increase ease of completion and facilitate quantitative analysis. These questionnaires enable acquisition of standardized data on the incidence, etiology, and outcomes of pediatric Ocular Trauma. DISCUSSION: These questionnaires enable collection of standardized data and are designed for global use across all health care settings. Through prospective data collection, epidemiological trends can be determined, allowing health care providers to develop collaborative global preventive strategies. Furthermore, the same questionnaires may be used in future studies to draw comparisons with baseline data, allowing assessment of the efficacy of targeted preventative interventions. Language: en
Swati Haridas - One of the best experts on this subject based on the ideXlab platform.
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Imaging in posterior segment Ocular Trauma
Kerala Journal of Ophthalmology, 2019Co-Authors: G Mahesh, Aarti Jain, Paurnima Bodhankar, Abhishek Sethi, Sailesh Kumar, Swati HaridasAbstract:Management of posterior segment Ocular Trauma is a challenge. A proper knowledge of the imaging in this condition is greatly helpful in charting out a strategy in planning the treatment. Ultrasound B scan is very useful in the event of obscured posterior segment. Optical coherence tomography and fundus autofluorescence are helpful in macular problems after Trauma. Computed tomography and Magnetic resonance imaging are useful to detect problems in the retroOcular space and in orbit. These will help in proper documentation of the posterior segment and has a medicolegal value. This review article will deal with the different practical uses of imaging technique in posterior segment Ocular Trauma.
Richard J Blanch - One of the best experts on this subject based on the ideXlab platform.
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the uk paediatric Ocular Trauma study 2 pots2 demographics and mechanisms of injuries
Clinical Ophthalmology, 2018Co-Authors: Freda Sii, Richard J Blanch, Robert J Barry, Joseph Abbott, Caroline J Macewen, Peter ShahAbstract:Purpose Pediatric Ocular Trauma is an important cause of visual morbidity worldwide, accounting for up to one-third of all Ocular Trauma admissions. It has long-term implications for those affected and significant economic consequences for healthcare providers. It has been estimated that 90% of all Ocular Trauma is preventable. Targeted strategies are required to reduce the incidence and the severity of pediatric Ocular Trauma; this requires an understanding of the epidemiology and characteristics of these injuries and the children involved. Methods Prospective, observational study of pediatric Ocular Trauma cases presenting to UK-based ophthalmologists over a 1-year period; reporting cards were distributed by the British Ophthalmological Surveillance Unit, and clinicians were asked to report incidents of acute orbital and Ocular Trauma in children aged ≤16 years requiring inpatient or day-case admission. A validated, standardized questionnaire was sent to reporting ophthalmologists to collect data on the demographics and circumstances of injury. Results Median age at presentation was 7.7 years, with boys more than twice as likely to be affected than girls (M:F =2.1:1.0). Almost 50% of injuries occurred at home, with 25% occurring in school or nursery. A total of 67% of injuries occurred during play, and 31% involved a sharp implement. Conclusion Pediatric Ocular Trauma remains an important public health problem. At least three-quarters of all injuries are preventable through measures, including education of children and responsible adults, restricting access to sharp implements, improving adult supervision, and appropriate use of eye protection.
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The UK Paediatric Ocular Trauma Study 1 (POTS1): development of a global standardized protocol for prospective data collection in pediatric Ocular Trauma.
Clinical ophthalmology (Auckland N.Z.), 2017Co-Authors: Freda Sii, Richard J Blanch, Robert J Barry, Joseph Abbott, Caroline J Macewen, Peter ShahAbstract:BACKGROUND: Ocular Trauma is an important cause of visual morbidity in children worldwide. Pediatric Ocular Trauma accounts for up to one third of all Ocular Trauma admissions, with significant economic implications for health care providers. It is estimated that 90% of all Ocular Trauma is preventable. Development of strategies to reduce the incidence and severity of pediatric Ocular Trauma requires an understanding of the epidemiology of these injuries and their characteristics. This will enable appropriate targeting of resources toward prevention and allow effective service planning. At present, there is no standardized methodology for the collection of global cross-sectional data in pediatric Ocular Trauma, and the ability to undertake detailed epidemiological and health-economic analyses is limited. Furthermore, it is difficult to draw international comparisons in incidence, etiology, and outcomes of pediatric Ocular Trauma due to the range of published reporting criteria. This study describes two novel questionnaires for standardized data collection in pediatric Ocular Trauma, which can be adopted across a range of health care settings internationally. METHODS: Two standardized data collection questionnaires have been developed from previously reported templates. The first enables collection of demographic and incident data on serious pediatric Ocular Trauma requiring hospitalization, and the second enables follow-up outcome data collection. Both the questionnaires are designed to collect primarily categorical data in order to increase ease of completion and facilitate quantitative analysis. These questionnaires enable acquisition of standardized data on the incidence, etiology, and outcomes of pediatric Ocular Trauma. DISCUSSION: These questionnaires enable collection of standardized data and are designed for global use across all health care settings. Through prospective data collection, epidemiological trends can be determined, allowing health care providers to develop collaborative global preventive strategies. Furthermore, the same questionnaires may be used in future studies to draw comparisons with baseline data, allowing assessment of the efficacy of targeted preventative interventions. Language: en
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Caspase-9 mediates photoreceptor death after blunt Ocular Trauma.
Investigative ophthalmology & visual science, 2014Co-Authors: Richard J Blanch, Zubair Ahmed, Adam Thompson, Nsikan Akpan, David R. J. Snead, Martin Berry, Carol M. Troy, Robert A. H. Scott, Ann LoganAbstract:PURPOSE Ocular Trauma is common in civilian and military populations. Commotio retinae involves acute disruption of photoreceptor outer segments after blunt Ocular Trauma, with subsequent photoreceptor apoptosis causing permanent visual impairment. The mechanisms of photoreceptor death in commotio retinae have not previously been described, although caspase-dependent death is important in other nonTraumatic retinal degenerations. We assessed the role of caspase-9 as a mediator of photoreceptor death in a rat model of ballistic Ocular Trauma causing commotio retinae. METHODS Bilateral commotio retinae was induced in rats by ballistic Ocular Trauma. Caspase-9 activity was assessed by immunohistochemistry, Western blotting, and bVAD-fmk active caspase capture. Caspase-9 was inhibited by unilateral intravitreal injection of highly specific X-linked inhibitor of apoptosis (IAP) baculoviral IAP repeat 3 (XBIR3) domain linked to the cell transduction peptide penetratin 1 (Pen-1) after ballistic injury, and the affected eyes were compared with control eyes treated with Pen-1 injection alone, and retinal function was assessed by electroretinogram a-wave amplitude and photoreceptor survival by outer nuclear layer thickness. RESULTS Increased levels of cleaved caspase-9 were shown in photoreceptors 5 hours after injury, and catalytically active full-length caspase-9 was isolated from retinas. Photoreceptor death after commotio retinae was reduced by caspase-9 inhibition by using Pen-1-XBIR3, and electroretinographic measurements of photoreceptor function was preserved, providing structural and functional neuroprotection. CONCLUSIONS The time course of caspase-9 activation and the neuroprotective effects of inhibition suggest that caspase-9 initiates cell death in a proportion of photoreceptors after blunt Ocular Trauma and that an intravitreally delivered biologic inhibitor may be an effective translational treatment strategy.
Giora Treister - One of the best experts on this subject based on the ideXlab platform.
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A standardized classification of Ocular Trauma
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1996Co-Authors: Ferenc Kuhn, Robert Morris, C. D. Witherspoon, Klaus Heimann, John B Jeffers, Giora TreisterAbstract:No internationally standardized classification of Ocular Trauma terminology has existed heretofore. Despite a growing interest in eye injuries, the absence of a common language continues to impede both clinical care and research. A classification was initially developed based on the authors' extensive personal experience. It then under-went repeated reviews over a 3-year period by international ophthalmic specialists. Written and oral suggestions from respondents in 19 countries and from selected Ocular Trauma experts were considered and incorporated. By always using the entire globe as the tissue of reference, the new classification is unambiguous, consistent, simple, and comprehensive. It provides definitions for the terms commonly used in eye Trauma and creates a logical system of injury types. In addition to widespread international acceptance by professionals, the new classification has been endorsed by the International Society of Ocular Trauma, the United States Eye Injury Registry, the American Academy of Ophthalmology, the Hungarian Eye injury Registry, the Vetreous Society, and the Retina Society. It can be reasonably expected that the system will ultimately become the standardized international language of Ocular Trauma.
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A Standardized Classification of Ocular Trauma
Ophthalmology, 1996Co-Authors: Ferenc Kuhn, Robert Morris, C. D. Witherspoon, Klaus Heimann, John B Jeffers, Giora TreisterAbstract:• Background: No internationally standardized classification of Ocular Trauma terminology has existed heretofore. Despite a growing interest in eye injuries, the absence of a common language continues to impede both clinical care and research. • Methods: A classification was initially developed based on the authors' extensive personal experience. It then underwent repeated reviews over a 3-year period by international ophthalmic specialists. Written and oral suggestions from respondents in 19 countries and from selected Ocular Trauma experts were considered and incorporated. • Results: By always using the entire globe as the tissue of reference, the new classification is unambiguous, consistent, simple, and comprehensive. It provides definitions for the terms commonly used in eye Trauma and creates a logical system of injury types. • Conclusion: In addition to widespread international acceptance by professionals, the new classification has been endorsed by the International Society of Ocular Trauma, the United States Eye Injury Registry, the American Academy of Ophthalmology, the Hungarian Eye injury Registry, the Vetreous Society, and the Retina Society. It can be reasonably expected that the system will ultimately become the standardized international language of Ocular Trauma.
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a standardized classification of Ocular Trauma
Annual Meeting of the Association for Research in Vision and Ophthalmology, 1996Co-Authors: Ferenc Kuhn, Robert Morris, C. D. Witherspoon, Klaus Heimann, John B Jeffers, Giora TreisterAbstract:Background : No internationally standardized classification of Ocular Trauma terminology has existed previously. Despite a growing interest in eye injuries, the absence of a common language continues to impede both clinical care and research. Methods : A classification has been developed initially based on the authors' extensive personal experience. It then has undergone repeated reviews over a 3-year period by international ophthalmic audiences, incorporating suggestions from respondents in 13 countries and selected Ocular Trauma experts. Results : By always using the entire globe as the tissue of reference, the new classification is unambiguous, consistent, and simple. It provides definitions for the commonly used eye Trauma terms within the framework of a comprehensive system. Conclusion : The new classification has been endorsed by the Board of Directors of the International Society of Ocular Trauma, the United States Eye Injury Registry, the Hungarian Eye Injury Registry, the Vitreous Society, the Retina Society, and the American Academy of Ophthalmology. It can be reasonably expected that the system eventually will become the standardized international language of Ocular Trauma. The authors urge ophthalmologists to begin using this terminology in both clinical practice and research.
Robert Morris - One of the best experts on this subject based on the ideXlab platform.
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fishing related Ocular Trauma
American Journal of Ophthalmology, 2005Co-Authors: Virgil D Alfaro, Robert Morris, Eric P Jablon, Monica Rodriguez Fontal, Simon J Villalba, Michael Grossman, Enrique RoigmeloAbstract:Purpose To evaluate the characteristics of fishing-related Ocular injuries. Design Retrospective observational analysis of a computerized databank. Methods The United States Eye Injury Registry was used to analyze 143 patients with fishing-related Ocular injury. Epidemiolgic and clinical information was evaluated including the age and gender of the subjects, classification of Ocular Trauma, surgical management, and final visual acuity. Results Of the 732 cases of sport-related Ocular Trauma, 143 (19.54%) occurred while fishing; of these, 79% were male patients who ranged in age from 6 to 68 years (mean, 37 years). Corneal laceration, globe rupture, and hyphema were the most common diagnoses at presentation and were caused by fishing hooks, lures, and weights. Thirty-five bystanders are included in the study. Thirty-eight percent of patients had visual acuity less than 20/50, and 21% had a visual acuity of less than 20/200. Open globe injuries portended a poor visual outcome compared with closed globe injuries. Conclusions Fishing-related Ocular injuries represent a large percent of sports-related Trauma, often resulting in significant visual loss. Preventive measures such as the use of protective eyewear should be advised in this activity.
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A standardized classification of Ocular Trauma
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1996Co-Authors: Ferenc Kuhn, Robert Morris, C. D. Witherspoon, Klaus Heimann, John B Jeffers, Giora TreisterAbstract:No internationally standardized classification of Ocular Trauma terminology has existed heretofore. Despite a growing interest in eye injuries, the absence of a common language continues to impede both clinical care and research. A classification was initially developed based on the authors' extensive personal experience. It then under-went repeated reviews over a 3-year period by international ophthalmic specialists. Written and oral suggestions from respondents in 19 countries and from selected Ocular Trauma experts were considered and incorporated. By always using the entire globe as the tissue of reference, the new classification is unambiguous, consistent, simple, and comprehensive. It provides definitions for the terms commonly used in eye Trauma and creates a logical system of injury types. In addition to widespread international acceptance by professionals, the new classification has been endorsed by the International Society of Ocular Trauma, the United States Eye Injury Registry, the American Academy of Ophthalmology, the Hungarian Eye injury Registry, the Vetreous Society, and the Retina Society. It can be reasonably expected that the system will ultimately become the standardized international language of Ocular Trauma.
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A Standardized Classification of Ocular Trauma
Ophthalmology, 1996Co-Authors: Ferenc Kuhn, Robert Morris, C. D. Witherspoon, Klaus Heimann, John B Jeffers, Giora TreisterAbstract:• Background: No internationally standardized classification of Ocular Trauma terminology has existed heretofore. Despite a growing interest in eye injuries, the absence of a common language continues to impede both clinical care and research. • Methods: A classification was initially developed based on the authors' extensive personal experience. It then underwent repeated reviews over a 3-year period by international ophthalmic specialists. Written and oral suggestions from respondents in 19 countries and from selected Ocular Trauma experts were considered and incorporated. • Results: By always using the entire globe as the tissue of reference, the new classification is unambiguous, consistent, simple, and comprehensive. It provides definitions for the terms commonly used in eye Trauma and creates a logical system of injury types. • Conclusion: In addition to widespread international acceptance by professionals, the new classification has been endorsed by the International Society of Ocular Trauma, the United States Eye Injury Registry, the American Academy of Ophthalmology, the Hungarian Eye injury Registry, the Vetreous Society, and the Retina Society. It can be reasonably expected that the system will ultimately become the standardized international language of Ocular Trauma.
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a standardized classification of Ocular Trauma
Annual Meeting of the Association for Research in Vision and Ophthalmology, 1996Co-Authors: Ferenc Kuhn, Robert Morris, C. D. Witherspoon, Klaus Heimann, John B Jeffers, Giora TreisterAbstract:Background : No internationally standardized classification of Ocular Trauma terminology has existed previously. Despite a growing interest in eye injuries, the absence of a common language continues to impede both clinical care and research. Methods : A classification has been developed initially based on the authors' extensive personal experience. It then has undergone repeated reviews over a 3-year period by international ophthalmic audiences, incorporating suggestions from respondents in 13 countries and selected Ocular Trauma experts. Results : By always using the entire globe as the tissue of reference, the new classification is unambiguous, consistent, and simple. It provides definitions for the commonly used eye Trauma terms within the framework of a comprehensive system. Conclusion : The new classification has been endorsed by the Board of Directors of the International Society of Ocular Trauma, the United States Eye Injury Registry, the Hungarian Eye Injury Registry, the Vitreous Society, the Retina Society, and the American Academy of Ophthalmology. It can be reasonably expected that the system eventually will become the standardized international language of Ocular Trauma. The authors urge ophthalmologists to begin using this terminology in both clinical practice and research.
