The Experts below are selected from a list of 2673 Experts worldwide ranked by ideXlab platform
Adriano Piattelli - One of the best experts on this subject based on the ideXlab platform.
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peripheral dentinogenic ghost cell tumor of the gingiva
Journal of Periodontology, 2007Co-Authors: Giovanna Iezzi, Corrado Rubini, Massimiliano Fioroni, Adriano PiattelliAbstract:Background: A dentinogenic ghost cell tumor is a locally invasive neoplasm that is characterized by ameloblastoma-like islands of epithelial cells in a mature connective tissue stroma.Methods: A 43-year-old male patient presented a well-circumscribed sessile, exophytic mass of the gingiva with a diameter of 2 cm located in the canine area of the right maxilla. The lesion was enucleated.Results: The lesion showed Odontogenic Epithelium, ghost cells, dentinoid material, and giant cells. The final microscopic diagnosis was a dentinogenic ghost cell tumor.Conclusions: A dentinogenic ghost cell tumor is an extremely rare tumor, and only a few cases have been reported in the English literature. The peripheral, extraosseous lesion can be easily confused with other gingival lesions such as reactive or inflammatory lesions or other peripheral Odontogenic tumors. The clinical appearance of all of these lesions is similar; therefore, the definitive diagnosis depends on histology, and a biopsy with a microscopic exam...
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immunohistochemical analysis of a dentinogenic ghost cell tumour
Oral Oncology, 1998Co-Authors: Adriano Piattelli, Massimiliano Fioroni, L Di Alberti, Corrado RubiniAbstract:A dentinogenic ghost cell tumour in an 80-year-old male patient is presented. It is an extremely rare tumour and only 10 cases have been reported in the English literature. The lesion showed Odontogenic Epithelium, ghost cells, dentinoid, giant cells. The immunohistochemical analysis for Mib-1 and bel-2 showed a strong positivity of the cells of the Odontogenic Epithelium, while with p53 only a rare positivity was observed. Completely negative were the ghost cells, giant cells and dentinoid material. In this tumour the cells expressing Mib-1 and bcl-2 could be the cells that proliferate, and that could undergo malignant transformation.
Corrado Rubini - One of the best experts on this subject based on the ideXlab platform.
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peripheral dentinogenic ghost cell tumor of the gingiva
Journal of Periodontology, 2007Co-Authors: Giovanna Iezzi, Corrado Rubini, Massimiliano Fioroni, Adriano PiattelliAbstract:Background: A dentinogenic ghost cell tumor is a locally invasive neoplasm that is characterized by ameloblastoma-like islands of epithelial cells in a mature connective tissue stroma.Methods: A 43-year-old male patient presented a well-circumscribed sessile, exophytic mass of the gingiva with a diameter of 2 cm located in the canine area of the right maxilla. The lesion was enucleated.Results: The lesion showed Odontogenic Epithelium, ghost cells, dentinoid material, and giant cells. The final microscopic diagnosis was a dentinogenic ghost cell tumor.Conclusions: A dentinogenic ghost cell tumor is an extremely rare tumor, and only a few cases have been reported in the English literature. The peripheral, extraosseous lesion can be easily confused with other gingival lesions such as reactive or inflammatory lesions or other peripheral Odontogenic tumors. The clinical appearance of all of these lesions is similar; therefore, the definitive diagnosis depends on histology, and a biopsy with a microscopic exam...
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immunohistochemical analysis of a dentinogenic ghost cell tumour
Oral Oncology, 1998Co-Authors: Adriano Piattelli, Massimiliano Fioroni, L Di Alberti, Corrado RubiniAbstract:A dentinogenic ghost cell tumour in an 80-year-old male patient is presented. It is an extremely rare tumour and only 10 cases have been reported in the English literature. The lesion showed Odontogenic Epithelium, ghost cells, dentinoid, giant cells. The immunohistochemical analysis for Mib-1 and bel-2 showed a strong positivity of the cells of the Odontogenic Epithelium, while with p53 only a rare positivity was observed. Completely negative were the ghost cells, giant cells and dentinoid material. In this tumour the cells expressing Mib-1 and bcl-2 could be the cells that proliferate, and that could undergo malignant transformation.
Raghu Radhakrishnan - One of the best experts on this subject based on the ideXlab platform.
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dentinogenic ghost cell tumor of the peripheral variant mimicking epulis
International Journal of Dentistry, 2010Co-Authors: Uddipan Kumar, Hitesh Vij, Ruchieka Vij, Jitin Kharbanda, I N Aparna, Raghu RadhakrishnanAbstract:Dentinogenic ghost cell tumor (DGCT) is an uncommon locally invasive Odontogenic tumor regarded by many as a variant of calcifying Odontogenic cyst. The peripheral variant of this clinical rarity appears as a well-circumscribed mass mimicking a nonspecific gingival enlargement. Microscopic appearance of Odontogenic Epithelium admixed with focal areas of dentinoid formation and sheets of ghost cells giving the definitive diagnosis of dentinogenic ghost cell tumor imply that microscopic examination is compulsory for any gingival mass. Van Gieson histochemical stain further confirmed the nature of dentinoid-like material. A complete workup of a case of peripheral dentinogenic ghost cell tumor is presented in this paper and the current concept as well as the appraisal of literature is presented.
Pit Jakob Voss - One of the best experts on this subject based on the ideXlab platform.
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intraosseous dentinogenic ghost cell tumor a clinical report and literature update
Journal of Cranio-maxillofacial Surgery, 2014Co-Authors: Dimitrios Konstantakis, Panagiota Kosyfaki, Harald Ebhardt, Rainer Schmelzeisen, Pit Jakob VossAbstract:The dentinogenic ghost cell tumor (DGCT) is a relatively uncommon locally invasive neoplasm. This report describes the case of a 20-year-old Caucasian female patient who was diagnosed with an intraosseous DGCT in the left molar region of the mandible. Radiographic analysis revealed a well-circumscribed radiolucent lesion with focal radiopacity. Segmental resection of the mandible was performed by means of piezoelectric surgery. The histopathological examination yielded islands of Odontogenic Epithelium with clusters of ghost cells and dysplastic dentin, thus enabling the identification of the lesion as DGCT. Long-term surveillance of patients with intraosseous DGCTs is mandatory in order to detect in time any signs of recurrence. A literature update concerning intraosseous DGCTs is also provided.
Jung Hoon Yoon - One of the best experts on this subject based on the ideXlab platform.
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mucous cell differentiation in a unicystic ameloblastoma
International Journal of Oral and Maxillofacial Surgery, 2009Co-Authors: Jung Hoon YoonAbstract:Abstract The authors report a case of unicystic ameloblastoma with mucous cell differentiation in the right mandible of a 24-year-old Korean male who suffered from painful swelling for 2 months. A radiograph showed a well-circumscribed radiolucent lesion between the root of the right first premolar and the first molar tooth. Microscopic examination revealed the cystic lesion was lined with ameloblastic Epithelium and goblet cells in the Epithelium. The mucous cells reacted positively to mucicarmine stain. The possible pathogenic mechanism of this case reflects the pluripotential character of the Odontogenic Epithelium. The prognosis is probably that expected for conventional unicystic ameloblastoma.
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Odontogenic ghost cell tumour with clear cell components: clear cell Odontogenic ghost cell tumour?
Journal of Oral Pathology & Medicine, 2003Co-Authors: Jung Hoon YoonAbstract:A case of Odontogenic ghost cell tumour (OGCT) with clear cell components was encountered in the mandible of a 63-year-old man. The tumour revealed ameloblastomatous-type epithelial components accompanied by clusters of ghost cells and dentinoid juxtaposed to the Odontogenic Epithelium. In addition, some areas of the tumour tissue showed sheets and islands of clear, glycogen containing epithelial cells, which were separated by a thin fibrous connective tissue stroma. Both ameloblastic and clear cells exhibited positive immunoreactivities for cytokeratin 19 and AE1/3. It is not known whether this tumour represents a clear cell change of a pre-existing OGCT or a separate and distinct neoplasm derived de novo from the Odontogenic Epithelium. This tumour was given the term ‘clear cell OGCT’ because it captures the clear cell components, which is one of the most prominent distinguishing features of the tumour.
