The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform
Herman Vromans - One of the best experts on this subject based on the ideXlab platform.
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the influence of cetomacrogol Ointment processing on structure a definitive screening design
European Journal of Pharmaceutical Sciences, 2017Co-Authors: A. J.p. Van Heugten, C. L. Braal, Herman Vromans, Marjan VersluijshelderAbstract:Batch-to-batch variability is a challenge for the industrial scale production of Ointments. Therefore the current investigation focussed on identifying and understanding critical process parameters (CPPs) for cetomacrogol Ointment. This was evaluated using a definitive screening design (DSD) approach in which fourteen batches were produced under predefined and controlled conditions using the following variables: addition of SiO2 nanoparticles, mixing speed, cooling rate, heating temperature, container filling temperature and isothermal mixing at the filling temperature. Ointment structure was evaluated using a number of rheological parameters. One of these parameters, yield stress was found to be strongly influenced by filling temperature and mixing speed (p=0.0065 and p=0.0013 respectively). Both significantly affect Ointment structure and they also have a significant interaction (p<0.05). Understanding the Ointment production process can help in defining a processing window to produce Ointment of constant quality.
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The influence of cetomacrogol Ointment processing on structure: A definitive screening design
European Journal of Pharmaceutical Sciences, 2017Co-Authors: A. J.p. Van Heugten, C. L. Braal, Marjan Versluijs-helder, Herman VromansAbstract:Batch-to-batch variability is a challenge for the industrial scale production of Ointments. Therefore the current investigation focussed on identifying and understanding critical process parameters (CPPs) for cetomacrogol Ointment. This was evaluated using a definitive screening design (DSD) approach in which fourteen batches were produced under predefined and controlled conditions using the following variables: addition of SiO2 nanoparticles, mixing speed, cooling rate, heating temperature, container filling temperature and isothermal mixing at the filling temperature. Ointment structure was evaluated using a number of rheological parameters. One of these parameters, yield stress was found to be strongly influenced by filling temperature and mixing speed (p = 0.0065 and p = 0.0013 respectively). Both significantly affect Ointment structure and they also have a significant interaction (p
H. B. Jakobsen - One of the best experts on this subject based on the ideXlab platform.
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once daily treatment of psoriasis with tacalcitol compared with twice daily treatment with calcipotriol a double blind trial
British Journal of Dermatology, 1997Co-Authors: Niels K. Veien, J.r. Bjerke, I Rossmannringdahl, H. B. JakobsenAbstract:Once daily topical treatment of psoriasis with tacalcitol Ointment (4 micrograms/g) was compared with twice daily treatment with calcipotriol Ointment (50 micrograms/g) in a double-blind, randomized study over a treatment period of 8 weeks. The severity of pruritus, erythema, infiltration and scaling was scored on a scale from 0 to 4. These features were scored at the initiation of treatment, after 2, 4, 6 and 8 weeks of treatment, and at 4 weeks after discontinuation of treatment. The sum score was the total score for erythema, infiltration and scaling. Serum levels of calcium, phosphate, ionized calcium and intact parathyroid hormone were used as safety parameters. Two hundred and eighty-seven adults with stable plaque psoriasis participated and were treated at least once. Both tacalcitol and calcipotriol Ointments effectively reduced the severity of psoriasis. The mean reduction in the sum score in the intention-to-treat population of 287 patients was 4.03 in the group treated with tacalcitol compared with 5.05 in the group treated with calcipotriol. The mean baseline sum scores were 7.64 and 7.15, respectively. The acceptability of both Ointments was excellent, and none of the patients had adverse effects in terms of increased serum calcium or other alterations in calcium metabolism. Although less effective than calcipotriol Ointment used twice daily, tacalcitol Ointment is an effective and useful once daily treatment of chronic plaque psoriasis.
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Once daily treatment of psoriasis with tacalcitol compared with twice daily treatment with calcipotriol. A double‐blind trial
The British journal of dermatology, 1997Co-Authors: Niels K. Veien, J.r. Bjerke, I. Rossmann-ringdahl, H. B. JakobsenAbstract:Once daily topical treatment of psoriasis with tacalcitol Ointment (4 micrograms/g) was compared with twice daily treatment with calcipotriol Ointment (50 micrograms/g) in a double-blind, randomized study over a treatment period of 8 weeks. The severity of pruritus, erythema, infiltration and scaling was scored on a scale from 0 to 4. These features were scored at the initiation of treatment, after 2, 4, 6 and 8 weeks of treatment, and at 4 weeks after discontinuation of treatment. The sum score was the total score for erythema, infiltration and scaling. Serum levels of calcium, phosphate, ionized calcium and intact parathyroid hormone were used as safety parameters. Two hundred and eighty-seven adults with stable plaque psoriasis participated and were treated at least once. Both tacalcitol and calcipotriol Ointments effectively reduced the severity of psoriasis. The mean reduction in the sum score in the intention-to-treat population of 287 patients was 4.03 in the group treated with tacalcitol compared with 5.05 in the group treated with calcipotriol. The mean baseline sum scores were 7.64 and 7.15, respectively. The acceptability of both Ointments was excellent, and none of the patients had adverse effects in terms of increased serum calcium or other alterations in calcium metabolism. Although less effective than calcipotriol Ointment used twice daily, tacalcitol Ointment is an effective and useful once daily treatment of chronic plaque psoriasis.
Niels K. Veien - One of the best experts on this subject based on the ideXlab platform.
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once daily treatment of psoriasis with tacalcitol compared with twice daily treatment with calcipotriol a double blind trial
British Journal of Dermatology, 1997Co-Authors: Niels K. Veien, J.r. Bjerke, I Rossmannringdahl, H. B. JakobsenAbstract:Once daily topical treatment of psoriasis with tacalcitol Ointment (4 micrograms/g) was compared with twice daily treatment with calcipotriol Ointment (50 micrograms/g) in a double-blind, randomized study over a treatment period of 8 weeks. The severity of pruritus, erythema, infiltration and scaling was scored on a scale from 0 to 4. These features were scored at the initiation of treatment, after 2, 4, 6 and 8 weeks of treatment, and at 4 weeks after discontinuation of treatment. The sum score was the total score for erythema, infiltration and scaling. Serum levels of calcium, phosphate, ionized calcium and intact parathyroid hormone were used as safety parameters. Two hundred and eighty-seven adults with stable plaque psoriasis participated and were treated at least once. Both tacalcitol and calcipotriol Ointments effectively reduced the severity of psoriasis. The mean reduction in the sum score in the intention-to-treat population of 287 patients was 4.03 in the group treated with tacalcitol compared with 5.05 in the group treated with calcipotriol. The mean baseline sum scores were 7.64 and 7.15, respectively. The acceptability of both Ointments was excellent, and none of the patients had adverse effects in terms of increased serum calcium or other alterations in calcium metabolism. Although less effective than calcipotriol Ointment used twice daily, tacalcitol Ointment is an effective and useful once daily treatment of chronic plaque psoriasis.
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Once daily treatment of psoriasis with tacalcitol compared with twice daily treatment with calcipotriol. A double‐blind trial
The British journal of dermatology, 1997Co-Authors: Niels K. Veien, J.r. Bjerke, I. Rossmann-ringdahl, H. B. JakobsenAbstract:Once daily topical treatment of psoriasis with tacalcitol Ointment (4 micrograms/g) was compared with twice daily treatment with calcipotriol Ointment (50 micrograms/g) in a double-blind, randomized study over a treatment period of 8 weeks. The severity of pruritus, erythema, infiltration and scaling was scored on a scale from 0 to 4. These features were scored at the initiation of treatment, after 2, 4, 6 and 8 weeks of treatment, and at 4 weeks after discontinuation of treatment. The sum score was the total score for erythema, infiltration and scaling. Serum levels of calcium, phosphate, ionized calcium and intact parathyroid hormone were used as safety parameters. Two hundred and eighty-seven adults with stable plaque psoriasis participated and were treated at least once. Both tacalcitol and calcipotriol Ointments effectively reduced the severity of psoriasis. The mean reduction in the sum score in the intention-to-treat population of 287 patients was 4.03 in the group treated with tacalcitol compared with 5.05 in the group treated with calcipotriol. The mean baseline sum scores were 7.64 and 7.15, respectively. The acceptability of both Ointments was excellent, and none of the patients had adverse effects in terms of increased serum calcium or other alterations in calcium metabolism. Although less effective than calcipotriol Ointment used twice daily, tacalcitol Ointment is an effective and useful once daily treatment of chronic plaque psoriasis.
Issam I Raad - One of the best experts on this subject based on the ideXlab platform.
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enhanced biofilm eradication and reduced cytotoxicity of a novel polygalacturonic and caprylic acid wound Ointment compared with common antiseptic Ointments
BioMed Research International, 2021Co-Authors: Bahgat Z. Gerges, Ruth Reitzel, Joel Rosenblatt, Ray Y Hachem, Ylan Truong, Issam I RaadAbstract:Antiseptic wound Ointments are widely used to treat dermal wounds that are microbially contaminated. Polygalacturonic acid (PG)+caprylic acid (CAP) is a novel combination that has been shown to eradicate biofilms. We developed a novel PG+CAP Ointment and compared the biofilm eradication capability and cytotoxicity of PG+CAP with that of commercially available antiseptic wound Ointments. We used a well-established biofilm model to quantitatively assess the eradication of organisms following exposure to the wound Ointments for 2 hours. PG+CAP Ointment completely eradicated Candida albicans, multidrug-resistant Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus biofilms, whereas MediHoney, polyhexamethylene biguanide (PHMB), and benzalkonium chloride (BZK) Ointments failed to eradicate all biofilms within 2 hours. We assessed cytotoxicity by exposing L-929 fibroblasts to extracts of each Ointment; Trypan blue exclusion was used to assess cell viability, and Alamar blue conversion was used to assess metabolic function. After exposure to PG+CAP and MediHoney, fibroblast viability was 96.23% and 95.23%, respectively (Trypan blue), and was comparable to untreated cells (98.77%). PHMB and BZK showed reduced viability (83.25% and 77.83%, respectively, ). Metabolic activity results followed a similar pattern. Cytotoxicity of PG+CAP Ointment towards erythrocytes was comparable to saline. PG+CAP Ointment seems to be safe and can rapidly eradicate microbial biofilm; thus, PG+CAP Ointment merits further in vivo testing as a potential antimicrobial wound Ointment.
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683. Assessment of Biofilm Eradication and Cytotoxicity of a Novel Polygalacturonic Acid + Caprylic Acid Wound Ointment Compared with Antiseptic Wound Ointments
Open Forum Infectious Diseases, 2019Co-Authors: Bahgat Z. Gerges, Ruth Reitzel, Joel Rosenblatt, Ray Y Hachem, Issam I RaadAbstract:Abstract Background Antiseptic wound Ointments are increasing importance from safety, microbiological and public health points of view. Previously, Rosenblatt et al. (2017) has assessed polygalacturonic acid (PG) + caprylic acid (CAP) solution for biofilm eradication efficacy and cytotoxicity. In this study, we assessed biofilm eradication and cytotoxicity of PG+CAP wound Ointment compared with commercially available wound Ointment comparators. Methods Assessment of antimicrobial efficacy was conducted using a well-established biofilm model. Twenty-four-hour biofilm was formed on silicone discs and exposed wound Ointments for 2 hours. Discs were then sonicated and cultured to quantitate any remaining viable biofilm. To assess cytotoxic effects of wound Ointments, L-929 fibroblasts were exposed to 2% extracts of each Ointment. The trypan exclusion test was used to access cell viability and Alamar blue was used to assess metabolic function. Ointments tested include, PG+CAP formulated in an inert Ointment base, benzalkonium chloride quaternary ammonia antiseptic Ointment (BZK), polyhexamethylene biguanide (PHMB) antiseptic Ointment, and 2-hydroxyethylcellulose + glycerol inert Ointment base. Untreated fibroblast cells were used as controls. Results Within 2 hours of exposure, PG+CAP Ointment able to completely eradicate C. albicans (CA), MDR Pseudomonas aeruginosa (PS), and MRSA. Additionally, PG+CAP was significantly more efficacious than BZK for MRSA (P = 0.002) and PS (P = 0.015) and PHMB for MRSA (P = 0.02). In the trypan blue exclusion test PG+CAP yielded 96.29% viable cells compared with 77.83% and 83.25%, for the QUAT and PHMB Ointments, respectively. Fibroblasts treated with 2% PG+CAP, retained 86.6% of metabolic activity compared with untreated cells while the QUAT and PHMB Ointments retained 37.5% and 44.5% metabolic activity, respectively. Conclusion PG+CAP has enhanced effects on eradication of biofilm in vitro as well as less toxicity in vitro relative to the antiseptic wound Ointments. Further in vivo studies are warranted. Disclosures All authors: No reported disclosures.
A. J.p. Van Heugten - One of the best experts on this subject based on the ideXlab platform.
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the influence of cetomacrogol Ointment processing on structure a definitive screening design
European Journal of Pharmaceutical Sciences, 2017Co-Authors: A. J.p. Van Heugten, C. L. Braal, Herman Vromans, Marjan VersluijshelderAbstract:Batch-to-batch variability is a challenge for the industrial scale production of Ointments. Therefore the current investigation focussed on identifying and understanding critical process parameters (CPPs) for cetomacrogol Ointment. This was evaluated using a definitive screening design (DSD) approach in which fourteen batches were produced under predefined and controlled conditions using the following variables: addition of SiO2 nanoparticles, mixing speed, cooling rate, heating temperature, container filling temperature and isothermal mixing at the filling temperature. Ointment structure was evaluated using a number of rheological parameters. One of these parameters, yield stress was found to be strongly influenced by filling temperature and mixing speed (p=0.0065 and p=0.0013 respectively). Both significantly affect Ointment structure and they also have a significant interaction (p<0.05). Understanding the Ointment production process can help in defining a processing window to produce Ointment of constant quality.
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The influence of cetomacrogol Ointment processing on structure: A definitive screening design
European Journal of Pharmaceutical Sciences, 2017Co-Authors: A. J.p. Van Heugten, C. L. Braal, Marjan Versluijs-helder, Herman VromansAbstract:Batch-to-batch variability is a challenge for the industrial scale production of Ointments. Therefore the current investigation focussed on identifying and understanding critical process parameters (CPPs) for cetomacrogol Ointment. This was evaluated using a definitive screening design (DSD) approach in which fourteen batches were produced under predefined and controlled conditions using the following variables: addition of SiO2 nanoparticles, mixing speed, cooling rate, heating temperature, container filling temperature and isothermal mixing at the filling temperature. Ointment structure was evaluated using a number of rheological parameters. One of these parameters, yield stress was found to be strongly influenced by filling temperature and mixing speed (p = 0.0065 and p = 0.0013 respectively). Both significantly affect Ointment structure and they also have a significant interaction (p
