The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform
A. Abiose - One of the best experts on this subject based on the ideXlab platform.
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria.
PLoS neglected tropical diseases, 2017Co-Authors: Michele E. Murdoch, I. Murdoch, Jennifer R Evans, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, A. AbioseAbstract:Background Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. Methods A clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were performed in 6,790 individuals aged 5+ years in endemic communities and 1,343 individuals in nonendemic communities. Results / Discussion There was increased risk for all forms of onchocercal skin disease in endemic communities with the most common finding being the presence of nodules (1,438 individuals, 21.2%), followed by atrophy (367, 6.1% of those < 50 years), acute papular Onchodermatitis, APOD (233, 3.4%), depigmentation (216, 3.2%) and chronic papular Onchodermatitis, CPOD (155, 2.3%). A further 645 individuals (9.5%) complained of pruritus but had completely normal skin. APOD was more common in males whereas atrophy, hanging groin and nodules were more common in females. After controlling for age and sex, microfilarial positivity was a risk factor for CPOD, depigmentation, hanging groin and nodules (OR 1.54, p = 0.046; OR 2.29, p = 0.002; OR 2.18, p = 0.002 and OR 3.80, p
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria - Fig 2
2017Co-Authors: Michele E. Murdoch, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, Ian E. Murdoch, Jennifer Evans, A. AbioseAbstract:Age and gender-specific prevalence of a) acute papular Onchodermatitis, b) chronic papular onchodermatiits and c) reactive skin lesions (i.e. acute papular Onchodermatitis +/- chronic papular Onchodermatitis +/- lichenified Onchodermatitis) in endemic savanna communities, Kaduna State, Northern Nigeria. Error bars represent mean and 95% CI.
Michele E. Murdoch - One of the best experts on this subject based on the ideXlab platform.
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Onchodermatitis: Where Are We Now?
'MDPI AG', 2018Co-Authors: Michele E. MurdochAbstract:Onchocerciasis causes debilitating pruritus and rashes as well as visual impairment and blindness. Prior to control measures, eye disease was particularly prominent in savanna areas of sub-Saharan Africa whilst skin disease was more common across rainforest regions of tropical Africa. Mass drug distribution with ivermectin is changing the global scene of onchocerciasis. There has been successful progressive elimination in Central and Southern American countries and the World Health Organization has set a target for elimination in Africa of 2025. This literature review was conducted to examine progress regarding onchocercal skin disease. PubMed searches were performed using keywords ‘onchocerciasis’, ‘Onchodermatitis’ and ‘onchocercal skin disease’ over the past eight years. Articles in English, or with an English abstract, were assessed for relevance, including any pertinent references within the articles. Recent progress in awareness of, understanding and treatment of onchocercal skin disease is reviewed with particular emphasis on publications within the past five years. The global burden of Onchodermatitis is progressively reducing and is no longer seen in children in many formerly endemic foci
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria.
PLoS neglected tropical diseases, 2017Co-Authors: Michele E. Murdoch, I. Murdoch, Jennifer R Evans, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, A. AbioseAbstract:Background Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. Methods A clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were performed in 6,790 individuals aged 5+ years in endemic communities and 1,343 individuals in nonendemic communities. Results / Discussion There was increased risk for all forms of onchocercal skin disease in endemic communities with the most common finding being the presence of nodules (1,438 individuals, 21.2%), followed by atrophy (367, 6.1% of those < 50 years), acute papular Onchodermatitis, APOD (233, 3.4%), depigmentation (216, 3.2%) and chronic papular Onchodermatitis, CPOD (155, 2.3%). A further 645 individuals (9.5%) complained of pruritus but had completely normal skin. APOD was more common in males whereas atrophy, hanging groin and nodules were more common in females. After controlling for age and sex, microfilarial positivity was a risk factor for CPOD, depigmentation, hanging groin and nodules (OR 1.54, p = 0.046; OR 2.29, p = 0.002; OR 2.18, p = 0.002 and OR 3.80, p
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria - Fig 2
2017Co-Authors: Michele E. Murdoch, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, Ian E. Murdoch, Jennifer Evans, A. AbioseAbstract:Age and gender-specific prevalence of a) acute papular Onchodermatitis, b) chronic papular onchodermatiits and c) reactive skin lesions (i.e. acute papular Onchodermatitis +/- chronic papular Onchodermatitis +/- lichenified Onchodermatitis) in endemic savanna communities, Kaduna State, Northern Nigeria. Error bars represent mean and 95% CI.
Mackenzie Charles - One of the best experts on this subject based on the ideXlab platform.
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Studies on the pathogenesis and control of parasitic infections
Faculty of Veterinary Science, 2017Co-Authors: Mackenzie CharlesAbstract:The work represented in this thesis covers three areas: the pathogenesis and immunobiology of nematode infections, the control and elimination of filarial nematode diseases, and lastly contributions to experimental and diagnostic pathology involving different diseases and medical conditions. A number of fundamental concepts are addressed: the role of eosinophil leucocytes in directly killing certain stages of helminths, acting in conjunction with antibodies and complement; the clinical significance of cell mediated immune responses in human onchocerciasis and its relationship to the clinical variation seen in this disease, including the classification of Onchodermatitis in humans. The studies in chemotherapy focus not only understanding the pathological effects of chemotherapy in filariasis, but also on understanding the mechanisms of action of these anthelminthic drugs and the role of the host in their action; the function and action of two major anti-filarial agents, diethylcarbamazine and ivermectin, are now understood from this work. The more recent studies describe work towards developing more effective and safer anti-filarial drugs, with flubendazole being a major focus. A central theme of the research is translating laboratory work into field relevance in the diseases that cause significant morbidity in animals and humans, namely onchocerciasis, lymphatic filariasis, and canine dirofilariasis. The fieldwork presented also includes effects of the mass distribution of drugs used to eliminate the infection. A major success has been achieved with the progress towards elimination of onchocerciasis and filariasis from Ecuador, Sudan and Tanzania. Lastly, this collection of studies covers a range of areas that have been investigated by the author as part of serving as a general pathologist in academic setting contributing to equine medicine, wound healing, toxic disasters and breast cancer
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Studies on the pathogenesis and control of parasitic infections
Faculty of Veterinary Science, 2017Co-Authors: Mackenzie CharlesAbstract:The work represented in this thesis covers three areas: the pathogenesis and immunobiology of nematode infections, the control and elimination of filarial nematode diseases, and lastly contributions to experimental and diagnostic pathology involving different diseases and medical conditions. A number of fundamental concepts are addressed: the role of eosinophil leucocytes in directly killing certain stages of helminths, acting in conjunction with antibodies and complement; the clinical significance of cell mediated immune responses in human onchocerciasis and its relationship to the clinical variation seen in this disease, including the classification of Onchodermatitis in humans. The studies in chemotherapy focus not only understanding the pathological effects of chemotherapy in filariasis, but also on understanding the mechanisms of action of these anthelminthic drugs and the role of the host in their action; the function and action of two major anti-filarial agents, diethylcarbamazine and ivermectin, are now understood from this work. The more recent studies describe work towards developing more effective and safer anti-filarial drugs, with flubendazole being a major focus. A central theme of the research is translating laboratory work into field relevance in the diseases that cause significant morbidity in animals and humans, namely onchocerciasis, lymphatic filariasis, and canine dirofilariasis. The fieldwork presented also includes effects of the mass distribution of drugs used to eliminate the infection. A major success has been achieved with the progress towards elimination of onchocerciasis and filariasis from Ecuador, Sudan and Tanzania. Lastly, this collection of studies covers a range of areas that have been investigated by the author as part of serving as a general pathologist in academic setting contributing to equine medicine, wound healing, toxic disasters and breast cancer.Access is restricted to staff and students of the University of Sydney . UniKey credentials are required. Non university access may be obtained by visiting the University of Sydney Library
Ngozi Njepuome - One of the best experts on this subject based on the ideXlab platform.
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria.
PLoS neglected tropical diseases, 2017Co-Authors: Michele E. Murdoch, I. Murdoch, Jennifer R Evans, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, A. AbioseAbstract:Background Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. Methods A clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were performed in 6,790 individuals aged 5+ years in endemic communities and 1,343 individuals in nonendemic communities. Results / Discussion There was increased risk for all forms of onchocercal skin disease in endemic communities with the most common finding being the presence of nodules (1,438 individuals, 21.2%), followed by atrophy (367, 6.1% of those < 50 years), acute papular Onchodermatitis, APOD (233, 3.4%), depigmentation (216, 3.2%) and chronic papular Onchodermatitis, CPOD (155, 2.3%). A further 645 individuals (9.5%) complained of pruritus but had completely normal skin. APOD was more common in males whereas atrophy, hanging groin and nodules were more common in females. After controlling for age and sex, microfilarial positivity was a risk factor for CPOD, depigmentation, hanging groin and nodules (OR 1.54, p = 0.046; OR 2.29, p = 0.002; OR 2.18, p = 0.002 and OR 3.80, p
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria - Fig 2
2017Co-Authors: Michele E. Murdoch, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, Ian E. Murdoch, Jennifer Evans, A. AbioseAbstract:Age and gender-specific prevalence of a) acute papular Onchodermatitis, b) chronic papular onchodermatiits and c) reactive skin lesions (i.e. acute papular Onchodermatitis +/- chronic papular Onchodermatitis +/- lichenified Onchodermatitis) in endemic savanna communities, Kaduna State, Northern Nigeria. Error bars represent mean and 95% CI.
Haliru Yahaya - One of the best experts on this subject based on the ideXlab platform.
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria.
PLoS neglected tropical diseases, 2017Co-Authors: Michele E. Murdoch, I. Murdoch, Jennifer R Evans, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, A. AbioseAbstract:Background Onchocerca volvulus infection can result in blindness, itching and skin lesions. Previous research concentrated on blindness. Methods A clinical classification system of the cutaneous changes in onchocerciasis was used for the first time in this study within the context of an early ivermectin drug trial in the savanna region of Kaduna State, northern Nigeria. Skin examinations were performed in 6,790 individuals aged 5+ years in endemic communities and 1,343 individuals in nonendemic communities. Results / Discussion There was increased risk for all forms of onchocercal skin disease in endemic communities with the most common finding being the presence of nodules (1,438 individuals, 21.2%), followed by atrophy (367, 6.1% of those < 50 years), acute papular Onchodermatitis, APOD (233, 3.4%), depigmentation (216, 3.2%) and chronic papular Onchodermatitis, CPOD (155, 2.3%). A further 645 individuals (9.5%) complained of pruritus but had completely normal skin. APOD was more common in males whereas atrophy, hanging groin and nodules were more common in females. After controlling for age and sex, microfilarial positivity was a risk factor for CPOD, depigmentation, hanging groin and nodules (OR 1.54, p = 0.046; OR 2.29, p = 0.002; OR 2.18, p = 0.002 and OR 3.80, p
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Pre-control relationship of onchocercal skin disease with onchocercal infection in Guinea Savanna, Northern Nigeria - Fig 2
2017Co-Authors: Michele E. Murdoch, Haliru Yahaya, Ngozi Njepuome, Simon Cousens, Barrie R. Jones, Ian E. Murdoch, Jennifer Evans, A. AbioseAbstract:Age and gender-specific prevalence of a) acute papular Onchodermatitis, b) chronic papular onchodermatiits and c) reactive skin lesions (i.e. acute papular Onchodermatitis +/- chronic papular Onchodermatitis +/- lichenified Onchodermatitis) in endemic savanna communities, Kaduna State, Northern Nigeria. Error bars represent mean and 95% CI.
