The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform
Patrizio Caturegli - One of the best experts on this subject based on the ideXlab platform.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
PLoS ONE, 2009Co-Authors: Hiroaki Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Melissa A. Landek-salgado, Koichi Suzuki, Miho Kimura, Noel R. Rose, Patrizio CaturegliAbstract:Background Oncocytes of the thyroid gland (Hurthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings Using transgenic mice chronically expressing IFNγ in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hurthle cell tumors. Conclusions/Significance In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment of oncocytic lesions and autoimmune hypothyroidism.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
2009Co-Authors: Hiroaki J. Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Koichi Suzuki, Miho Kimura, Noel R. Rose, Melissa A. L, Patrizio CaturegliAbstract:Background: Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings: Using transgenic mice chronically expressing IFNc in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hürthle cell tumors. Conclusions/Significance: In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment o
Hiroaki Kimura - One of the best experts on this subject based on the ideXlab platform.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
PLoS ONE, 2009Co-Authors: Hiroaki Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Melissa A. Landek-salgado, Koichi Suzuki, Miho Kimura, Noel R. Rose, Patrizio CaturegliAbstract:Background Oncocytes of the thyroid gland (Hurthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings Using transgenic mice chronically expressing IFNγ in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hurthle cell tumors. Conclusions/Significance In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment of oncocytic lesions and autoimmune hypothyroidism.
Roberto Rocchi - One of the best experts on this subject based on the ideXlab platform.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
PLoS ONE, 2009Co-Authors: Hiroaki Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Melissa A. Landek-salgado, Koichi Suzuki, Miho Kimura, Noel R. Rose, Patrizio CaturegliAbstract:Background Oncocytes of the thyroid gland (Hurthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings Using transgenic mice chronically expressing IFNγ in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hurthle cell tumors. Conclusions/Significance In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment of oncocytic lesions and autoimmune hypothyroidism.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
2009Co-Authors: Hiroaki J. Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Koichi Suzuki, Miho Kimura, Noel R. Rose, Melissa A. L, Patrizio CaturegliAbstract:Background: Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings: Using transgenic mice chronically expressing IFNc in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hürthle cell tumors. Conclusions/Significance: In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment o
Shey Cherng Tzou - One of the best experts on this subject based on the ideXlab platform.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
PLoS ONE, 2009Co-Authors: Hiroaki Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Melissa A. Landek-salgado, Koichi Suzuki, Miho Kimura, Noel R. Rose, Patrizio CaturegliAbstract:Background Oncocytes of the thyroid gland (Hurthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings Using transgenic mice chronically expressing IFNγ in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hurthle cell tumors. Conclusions/Significance In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment of oncocytic lesions and autoimmune hypothyroidism.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
2009Co-Authors: Hiroaki J. Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Koichi Suzuki, Miho Kimura, Noel R. Rose, Melissa A. L, Patrizio CaturegliAbstract:Background: Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings: Using transgenic mice chronically expressing IFNc in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hürthle cell tumors. Conclusions/Significance: In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment o
Cindy Y. Chen - One of the best experts on this subject based on the ideXlab platform.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
PLoS ONE, 2009Co-Authors: Hiroaki Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Melissa A. Landek-salgado, Koichi Suzuki, Miho Kimura, Noel R. Rose, Patrizio CaturegliAbstract:Background Oncocytes of the thyroid gland (Hurthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings Using transgenic mice chronically expressing IFNγ in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hurthle cell tumors. Conclusions/Significance In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment of oncocytic lesions and autoimmune hypothyroidism.
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Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice
2009Co-Authors: Hiroaki J. Kimura, Cindy Y. Chen, Shey Cherng Tzou, Roberto Rocchi, Koichi Suzuki, Miho Kimura, Noel R. Rose, Melissa A. L, Patrizio CaturegliAbstract:Background: Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. Methodology/Principal Findings: Using transgenic mice chronically expressing IFNc in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human Oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in Oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in Oncocytes from patients with Hashimoto thyroiditis and Hürthle cell tumors. Conclusions/Significance: In summary, we report that Oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment o
