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Xunming Ji - One of the best experts on this subject based on the ideXlab platform.
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fast diffusion kurtosis imaging dki with inherent correlation based normalization icon enhances automatic segmentation of heterogeneous diffusion mri lesion in acute stroke
NMR in Biomedicine, 2016Co-Authors: Iris Yuwen Zhou, Takahiro Igarashi, Emiri T. Mandeville, Eng H Lo, Mark Vangel, Suktak Chan, Yu Wang, Xunming JiAbstract:Diffusion kurtosis imaging (DKI) has been shown to augment diffusion-weighted imaging (DWI) for the definition of irreversible ischemic injury. However, the complexity of cerebral structure/composition makes the kurtosis map heterogeneous, limiting the specificity of kurtosis hyperintensity to acute ischemia. We propose an Inherent COrrelation-based Normalization (ICON) analysis to suppress the intrinsic kurtosis heterogeneity for improved characterization of heterogeneous ischemic tissue injury. Fast DKI and relaxation measurements were performed on normal (n = 10) and stroke rats following middle cerebral artery occlusion (MCAO) (n = 20). We evaluated the correlations between mean kurtosis (MK), mean diffusivity (MD) and fractional anisotropy (FA) derived from the fast DKI sequence and relaxation rates R1 and R2, and found a highly significant correlation between MK and R1 (p < 0.001). We showed that ICON analysis suppressed the intrinsic kurtosis heterogeneity in normal cerebral tissue, enabling automated tissue segmentation in an animal stroke model. We found significantly different kurtosis and diffusivity lesion volumes: 147 ± 59 and 180 ± 66 mm3, respectively (p = 0.003, paired t-Test). The ratio of kurtosis to diffusivity lesion volume was 84% ± 19% (p < 0.001, One-Sample t-Test). We found that relaxation-normalized MK (RNMK), but not MD, values were significantly different between kurtosis and diffusivity lesions (p < 0.001, analysis of variance). Our study showed that fast DKI with ICON analysis provides a promising means of demarcation of heterogeneous DWI stroke lesions.
Eddy Prayitno - One of the best experts on this subject based on the ideXlab platform.
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optimasi formula sediaan fast dissolving tablet lidah buaya aloe vera l webb dengan bahan penghancur sodium croscarmellose dan bahan pengisi sorbitol
2011Co-Authors: Eddy PrayitnoAbstract:Daging Lidah Buaya (Aloe vera (L.) Webb) mempunyai khasiat sebagai nutrisi. Penggunaan lidah buaya dimasyarakat masih secara tradisional, sehingga perlu dikembangkan menjadi bentuk sediaan yang praktis dan kemudahan dalam penggunaan yaitu fast dissolving tablet. Penelitian ini bertujuan untuk melihat pengaruh bahan penghancur sodium croscarmellose dengan bahan pengisi sorbitol dan mendapatkan formula fast dissolving tablet yang optimum. Fast dissolving tablet lidah buaya dibuat menjadi 4 formula dengan variasi konsentrasi bahan penghancur dan bahan pengisi berbanding sebagai berikut: (10% : 25%), (25% : 25%), (10% : 35%), (25% : 35%). Fast dissolving tablet dibuat dengan metode kempa langsung. Fast dissolving tablet diuji sifat alir campuran serbuk meliputi kecepatan alir dan pengetapan setelah itu campuran serbuk dibuat tablet dan diuji sifat fisik tablet meliputi: uji keseragaman bobot, kekerasan, kerapuhan, waktu hancur dan tanggapan rasa. Data dianalisis menggunakan metode factorial design dan didapatkan titik optimum pada contour plot superimposed. Berdasarkan titik optimum didapatkan formula optimum untuk diverifikasi. Validitas hasil verifikasi dengan hasil prediksi berdasarkan metode factorial design diuji statistik dengan menggunakan SPSS versi 17 dengan uji One Sample t-Test dengan taraf kepercayaan 95%. Hasil penelitian menunjukkan adanya pengaruh antara bahan penghancur dan bahan pengisi, yakni kenaikan konsentrasi sodium croscarmellose dapat mempercepat waktu hancur, menurunkan kekerasan tablet, kecepatan alir dan respon rasa, sedangkan penurunan konsentrasi sorbitol dapat menurunkan kecepatan alir dan respon rasa. Pada daerah contour plot superimposed didapatkan daerah optimum dengan perbandingan sodium croscarmellose 72,87 mg dan sorbitol 175,00 mg.
Martuty Rahayu - One of the best experts on this subject based on the ideXlab platform.
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optimasi formula sediaan fast dissolving tablet lidah buaya aloe vera l webb dengan bahan penghancur crospovidOne dan bahan pengisi sorbitol
2011Co-Authors: Martuty RahayuAbstract:Tanaman lidah buaya (Aloe vera (L.) Webb.) merupakan salah satu tanaman yang dapat digunakan sebagai nutrisi dalam tubuh, karena mengandung asam amino, mineral, vitamin, enzim, protein. Tanaman ini akan dibuat dalam sediaan fast dissolving tablet, maka diperlukan suatu superdisintegrant dan bahan pengisi-pemanis. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi crospovidOne dengan sorbitol dan mendapatkan formula fast dissolving tablet yang optimum. Fast dissolving tablet lidah buaya dibuat menjadi 4 formula dengan variasi konsentrasi bahan penghancur dan bahan pengisi berbanding sebagai berikut: 10%-25%, 25%-25%, 10%-35%, 25%-35%. Fast dissolving tablet dibuat dengan metode kempa langsung. Fast dissolving tablet diuji sifat alir campuran serbuk dan diuji sifat fisik tablet. Data dianalisis menggunakan metode factorial design dan didapatkan titik optimum pada contour plot superimposed. Berdasarkan titik optimum didapatkan formula optimum untuk dibuat tablet verifikasi. Validitas hasil verifikasi dengan hasil prediksi berdasarkan metode factorial design diuji statistik dengan menggunakan SPSS versi 17 dengan uji One Sample t-Test dengan taraf kepercayaan 95%. Hasil penelitian menunjukkan makin tinggi konsentrasi crospovidOne dapat meningkatkan kecepatan alir dan kerapuhan, serta menurunkan pengetapan, keseragaman bobot, kekerasan tablet, waktu hancur tablet dan respon rasa, sedangkan makin tinggi sorbitol dapat menurunkan kecepatan alir dan kerapuhan, serta meningkatkan pengetapan, keseragaman bobot, kekerasan tablet, waktu hancur tablet dan respon rasa. Campuran crospovidOne dengan konsentrasi 50- 102,5 mg dan sorbitol 125-164 mg dapat digunakan sebagai formula yang optimum.
Iris Yuwen Zhou - One of the best experts on this subject based on the ideXlab platform.
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fast diffusion kurtosis imaging dki with inherent correlation based normalization icon enhances automatic segmentation of heterogeneous diffusion mri lesion in acute stroke
NMR in Biomedicine, 2016Co-Authors: Iris Yuwen Zhou, Takahiro Igarashi, Emiri T. Mandeville, Eng H Lo, Mark Vangel, Suktak Chan, Yu Wang, Xunming JiAbstract:Diffusion kurtosis imaging (DKI) has been shown to augment diffusion-weighted imaging (DWI) for the definition of irreversible ischemic injury. However, the complexity of cerebral structure/composition makes the kurtosis map heterogeneous, limiting the specificity of kurtosis hyperintensity to acute ischemia. We propose an Inherent COrrelation-based Normalization (ICON) analysis to suppress the intrinsic kurtosis heterogeneity for improved characterization of heterogeneous ischemic tissue injury. Fast DKI and relaxation measurements were performed on normal (n = 10) and stroke rats following middle cerebral artery occlusion (MCAO) (n = 20). We evaluated the correlations between mean kurtosis (MK), mean diffusivity (MD) and fractional anisotropy (FA) derived from the fast DKI sequence and relaxation rates R1 and R2, and found a highly significant correlation between MK and R1 (p < 0.001). We showed that ICON analysis suppressed the intrinsic kurtosis heterogeneity in normal cerebral tissue, enabling automated tissue segmentation in an animal stroke model. We found significantly different kurtosis and diffusivity lesion volumes: 147 ± 59 and 180 ± 66 mm3, respectively (p = 0.003, paired t-Test). The ratio of kurtosis to diffusivity lesion volume was 84% ± 19% (p < 0.001, One-Sample t-Test). We found that relaxation-normalized MK (RNMK), but not MD, values were significantly different between kurtosis and diffusivity lesions (p < 0.001, analysis of variance). Our study showed that fast DKI with ICON analysis provides a promising means of demarcation of heterogeneous DWI stroke lesions.
Peter S. N. Rowe - One of the best experts on this subject based on the ideXlab platform.
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BOne (femur) gene expression (mRNA) as measured by quantitative RT/PCR (qRT-PCR) for wild type and HYP mice infused with vehicle or SPR4-peptide (see also Figure 4).
2014Co-Authors: Lesya V. Zelenchuk, Anne-marie Hedge, Peter S. N. RoweAbstract:Column headings represent; WT = wild type mice, HYP = X-linked hypophosphatemic rickets mice, SPR4 = infused SPR4-peptide and Vehicle = Saline infused. For gene analysis mice were sacrificed on day 28 and mRNA prepared from bOne marrow stromal cell depleted femurs as detailed in methods (N = 6). For qRT-PCR gene analysis fold differences in expression calculated by the Pfaffl method [163] were statistically analyzed for significance using the One Sample t-Test and the Wilcoxon Signed rank-test with theoretical means set to 1. Results for all tests were considered to be significantly different at p
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BOne (femur) gene expression (mRNA) comparisons as measured by quantitative RT/PCR (qRT-PCR) for wild type (WT) and HYP mice infused with vehicle or SPR4-peptide for 28 days.
2014Co-Authors: Lesya V. Zelenchuk, Anne-marie Hedge, Peter S. N. RoweAbstract:Mice were sacrificed on day 28 and femurs collected for RNA purification as described in methods. Column headings represent; WT = wild type mice, HYP = X-linked hypophosphatemic rickets mice, SPR4 = infused SPR4-peptide and Vehicle = Saline infused. For gene analysis mRNA was prepared from bOne marrow stromal cell “depleted” femurs as detailed in methods. For qRT-PCR gene analysis fold differences in expression calculated by the Pfaffl method [163] were statistically analyzed for significance using the One Sample t-Test and the Wilcoxon Signed rank-test with theoretical means set to 1. Results are significant (* = p
