The Experts below are selected from a list of 70944 Experts worldwide ranked by ideXlab platform
A Varisano - One of the best experts on this subject based on the ideXlab platform.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles' contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles’ contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
F Romano - One of the best experts on this subject based on the ideXlab platform.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles' contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles’ contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
hadrontherapy a geant4 based tool for proton ion therapy studies
Progress in nuclear science and technology, 2011Co-Authors: G.a. Pablo Cirrone, C Agodi, G Cuttone, F Romano, Daniele Sardina, Andrea Attili, A. Alessandra Blancato, Marzio De Napoli, Enrico S Mazzaglia, Francesco Di RosaAbstract:Hadrontherapy is a C++ , free and Open Source Application developed using the Geant4 Monte Carlo libraries. The basic version of Hadrontherapy is contained in the official Geant4 distribution (www.cern.ch/Geant4/download), in- side the category of the advanced examples. This version permits the simulation of a typical proton/ion transport beam line and the calculation of dose and fluence distributions inside a test phantom. A more complete version of the program is separately maintained and released by the authors and it offers a wider set of tools useful for Users interested in proton/ion-therapy studies. It gives the possibility to retrieve ion stopping powers in arbitrary geometrical configuration, to calculate 3D distributions of fluences, dose deposited and LET of primary and of the generated secondary beams, to simulate typical nuclear physics experiments, to interactively switch between different implemented geometries, etc. In this work the main characteristics of the actual full version of Hadrontherapy will be reported and results dis- cussed and compared with the available experimental data. For more information the reader can refer to the Hadrontherapy website.
-
hadrontherapy an Open Source geant4 based Application for proton ion therapy studies
IEEE Nuclear Science Symposium, 2009Co-Authors: G.a. Pablo Cirrone, G Cuttone, F Romano, Andrea Attili, Francesco Di Rosa, Santi E Mazzaglia, Faiza Bourhaleb, G Russo, Pekka Kataniemi, A HeikkinenAbstract:Hadrontherapy is an Open Source Application based on the Geant4 Monte Carlo libraries. It can be downloaded with the Geant4 official code and can be found in the category of the advanced examples ($G4Install/examples/advanced folder of the Geant4 distribution). Since its original version, released in 2004, Hadrontherapy permitted the simulation of a typical proton therapy beam line, together with all it elements (collimators, scattering systems, etc.) and the calculation of the corresponding dose distribution curves in water and other materials. In this paper we will report on the newest development and improvement of Hadrontherapy as it will be released in the Geant4 9.3 version. The new version of Application will furnish a set of tools useful for Users interested in studies related to proton/ion therapy. The new version of Hadrontherapy will permit, in fact, the transport of carbon beams, using the state-of-art of the Geant4 electromagnetic and hadronic models, the calculation of some basic parameters like stopping powers, or the possibility to easily change the geometrical configuration for the simulation of typical nuclear physics experiment of interest in the hadrontherapy field. Other capabilities are inserted in the new Hadrontherapy version even if not all are reported in this paper. For more information the reader can refer to the on-line manual of Hadrontherapy that can be found inside the Geant4 official website (www.cern.ch/geant4).
G Cuttone - One of the best experts on this subject based on the ideXlab platform.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles' contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles’ contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
hadrontherapy a geant4 based tool for proton ion therapy studies
Progress in nuclear science and technology, 2011Co-Authors: G.a. Pablo Cirrone, C Agodi, G Cuttone, F Romano, Daniele Sardina, Andrea Attili, A. Alessandra Blancato, Marzio De Napoli, Enrico S Mazzaglia, Francesco Di RosaAbstract:Hadrontherapy is a C++ , free and Open Source Application developed using the Geant4 Monte Carlo libraries. The basic version of Hadrontherapy is contained in the official Geant4 distribution (www.cern.ch/Geant4/download), in- side the category of the advanced examples. This version permits the simulation of a typical proton/ion transport beam line and the calculation of dose and fluence distributions inside a test phantom. A more complete version of the program is separately maintained and released by the authors and it offers a wider set of tools useful for Users interested in proton/ion-therapy studies. It gives the possibility to retrieve ion stopping powers in arbitrary geometrical configuration, to calculate 3D distributions of fluences, dose deposited and LET of primary and of the generated secondary beams, to simulate typical nuclear physics experiments, to interactively switch between different implemented geometries, etc. In this work the main characteristics of the actual full version of Hadrontherapy will be reported and results dis- cussed and compared with the available experimental data. For more information the reader can refer to the Hadrontherapy website.
-
hadrontherapy an Open Source geant4 based Application for proton ion therapy studies
IEEE Nuclear Science Symposium, 2009Co-Authors: G.a. Pablo Cirrone, G Cuttone, F Romano, Andrea Attili, Francesco Di Rosa, Santi E Mazzaglia, Faiza Bourhaleb, G Russo, Pekka Kataniemi, A HeikkinenAbstract:Hadrontherapy is an Open Source Application based on the Geant4 Monte Carlo libraries. It can be downloaded with the Geant4 official code and can be found in the category of the advanced examples ($G4Install/examples/advanced folder of the Geant4 distribution). Since its original version, released in 2004, Hadrontherapy permitted the simulation of a typical proton therapy beam line, together with all it elements (collimators, scattering systems, etc.) and the calculation of the corresponding dose distribution curves in water and other materials. In this paper we will report on the newest development and improvement of Hadrontherapy as it will be released in the Geant4 9.3 version. The new version of Application will furnish a set of tools useful for Users interested in studies related to proton/ion therapy. The new version of Hadrontherapy will permit, in fact, the transport of carbon beams, using the state-of-art of the Geant4 electromagnetic and hadronic models, the calculation of some basic parameters like stopping powers, or the possibility to easily change the geometrical configuration for the simulation of typical nuclear physics experiment of interest in the hadrontherapy field. Other capabilities are inserted in the new Hadrontherapy version even if not all are reported in this paper. For more information the reader can refer to the on-line manual of Hadrontherapy that can be found inside the Geant4 official website (www.cern.ch/geant4).
G.a. Pablo Cirrone - One of the best experts on this subject based on the ideXlab platform.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles' contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles’ contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
hadrontherapy a geant4 based tool for proton ion therapy studies
Progress in nuclear science and technology, 2011Co-Authors: G.a. Pablo Cirrone, C Agodi, G Cuttone, F Romano, Daniele Sardina, Andrea Attili, A. Alessandra Blancato, Marzio De Napoli, Enrico S Mazzaglia, Francesco Di RosaAbstract:Hadrontherapy is a C++ , free and Open Source Application developed using the Geant4 Monte Carlo libraries. The basic version of Hadrontherapy is contained in the official Geant4 distribution (www.cern.ch/Geant4/download), in- side the category of the advanced examples. This version permits the simulation of a typical proton/ion transport beam line and the calculation of dose and fluence distributions inside a test phantom. A more complete version of the program is separately maintained and released by the authors and it offers a wider set of tools useful for Users interested in proton/ion-therapy studies. It gives the possibility to retrieve ion stopping powers in arbitrary geometrical configuration, to calculate 3D distributions of fluences, dose deposited and LET of primary and of the generated secondary beams, to simulate typical nuclear physics experiments, to interactively switch between different implemented geometries, etc. In this work the main characteristics of the actual full version of Hadrontherapy will be reported and results dis- cussed and compared with the available experimental data. For more information the reader can refer to the Hadrontherapy website.
-
hadrontherapy an Open Source geant4 based Application for proton ion therapy studies
IEEE Nuclear Science Symposium, 2009Co-Authors: G.a. Pablo Cirrone, G Cuttone, F Romano, Andrea Attili, Francesco Di Rosa, Santi E Mazzaglia, Faiza Bourhaleb, G Russo, Pekka Kataniemi, A HeikkinenAbstract:Hadrontherapy is an Open Source Application based on the Geant4 Monte Carlo libraries. It can be downloaded with the Geant4 official code and can be found in the category of the advanced examples ($G4Install/examples/advanced folder of the Geant4 distribution). Since its original version, released in 2004, Hadrontherapy permitted the simulation of a typical proton therapy beam line, together with all it elements (collimators, scattering systems, etc.) and the calculation of the corresponding dose distribution curves in water and other materials. In this paper we will report on the newest development and improvement of Hadrontherapy as it will be released in the Geant4 9.3 version. The new version of Application will furnish a set of tools useful for Users interested in studies related to proton/ion therapy. The new version of Hadrontherapy will permit, in fact, the transport of carbon beams, using the state-of-art of the Geant4 electromagnetic and hadronic models, the calculation of some basic parameters like stopping powers, or the possibility to easily change the geometrical configuration for the simulation of typical nuclear physics experiment of interest in the hadrontherapy field. Other capabilities are inserted in the new Hadrontherapy version even if not all are reported in this paper. For more information the reader can refer to the on-line manual of Hadrontherapy that can be found inside the Geant4 official website (www.cern.ch/geant4).
Santi E Mazzaglia - One of the best experts on this subject based on the ideXlab platform.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles’ contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
a monte carlo study for the calculation of the average linear energy transfer let distributions for a clinical proton beam line and a radiobiological carbon ion beam line
Physics in Medicine and Biology, 2014Co-Authors: F Romano, G Cuttone, G.a. Pablo Cirrone, Santi E Mazzaglia, F Di Rosa, Ivan Petrovic, Ristic A Fira, A VarisanoAbstract:Fluence, depth absorbed dose and linear energy transfer (LET) distributions of proton and carbon ion beams have been investigated using the Monte Carlo code Geant4 (GEometry ANd Tracking). An Open Source Application was developed with the aim to simulate two typical transport beam lines, one used for ocular therapy and cell irradiations with protons and the other for cell irradiations with carbon ions. This tool allows evaluation of the primary and total dose averaged LET and predict their spatial distribution in voxelized or sliced geometries. In order to reproduce the LET distributions in a realistic way, and also the secondary particles' contributions due to nuclear interactions were considered in the computations. Pristine and spread-out Bragg peaks were taken into account both for proton and carbon ion beams, with the maximum energy of 62 MeV/n. Depth dose distributions were compared with experimental data, showing good agreement. Primary and total LET distributions were analysed in order to study the influence of contributions of secondary particles in regions at different depths. A non-negligible influence of high-LET components was found in the entrance channel for proton beams, determining the total dose averaged LET by the factor 3 higher than the primary one. A completely different situation was obtained for carbon ions. In this case, secondary particles mainly contributed in the tail that is after the peak. The results showed how the weight of light and heavy secondary ions can considerably influence the computation of LET depth distributions. This has an important role in the interpretation of results coming from radiobiological experiments and, therefore, in hadron treatment planning procedures.
-
hadrontherapy an Open Source geant4 based Application for proton ion therapy studies
IEEE Nuclear Science Symposium, 2009Co-Authors: G.a. Pablo Cirrone, G Cuttone, F Romano, Andrea Attili, Francesco Di Rosa, Santi E Mazzaglia, Faiza Bourhaleb, G Russo, Pekka Kataniemi, A HeikkinenAbstract:Hadrontherapy is an Open Source Application based on the Geant4 Monte Carlo libraries. It can be downloaded with the Geant4 official code and can be found in the category of the advanced examples ($G4Install/examples/advanced folder of the Geant4 distribution). Since its original version, released in 2004, Hadrontherapy permitted the simulation of a typical proton therapy beam line, together with all it elements (collimators, scattering systems, etc.) and the calculation of the corresponding dose distribution curves in water and other materials. In this paper we will report on the newest development and improvement of Hadrontherapy as it will be released in the Geant4 9.3 version. The new version of Application will furnish a set of tools useful for Users interested in studies related to proton/ion therapy. The new version of Hadrontherapy will permit, in fact, the transport of carbon beams, using the state-of-art of the Geant4 electromagnetic and hadronic models, the calculation of some basic parameters like stopping powers, or the possibility to easily change the geometrical configuration for the simulation of typical nuclear physics experiment of interest in the hadrontherapy field. Other capabilities are inserted in the new Hadrontherapy version even if not all are reported in this paper. For more information the reader can refer to the on-line manual of Hadrontherapy that can be found inside the Geant4 official website (www.cern.ch/geant4).
