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Onkar Nath Nagi - One of the best experts on this subject based on the ideXlab platform.
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efficacy of intra articular tranexamic acid in Blood Loss reduction following primary unilateral total knee arthroplasty
Knee Surgery Sports Traumatology Arthroscopy, 2012Co-Authors: Shuvendu Prosad Roy, Umair Firdos Tanki, Amitabh Dutta, Sumit Kumar Jain, Onkar Nath NagiAbstract:Purpose The surgical stress of total knee arthroplasty (TKA) procedure and the application of intra-Operative pneumatic thigh tourniquet increases local fibrinolytic activity, which contributes significantly to post-Operative Blood Loss. Tranexamic acid, an antifibrinolytic drug, is commonly used to control post-Operative Blood Loss. The recommended mode of administration of tranexamic acid is either oral or intravenous. However, the mechanism of action of the tranexamic acid points towards the possible effectiveness it may have following local/intra-articular application. This prospective, double-blinded, randomized preliminary study evaluated the efficacy of intra-articular tranexamic acid in reducing TKA-associated post-Operative Blood Loss.
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efficacy of intra articular tranexamic acid in Blood Loss reduction following primary unilateral total knee arthroplasty
Knee Surgery Sports Traumatology Arthroscopy, 2012Co-Authors: Shuvendu Prosad Roy, Umair Firdos Tanki, Amitabh Dutta, Sumit Kumar Jain, Onkar Nath NagiAbstract:The surgical stress of total knee arthroplasty (TKA) procedure and the application of intra-Operative pneumatic thigh tourniquet increases local fibrinolytic activity, which contributes significantly to post-Operative Blood Loss. Tranexamic acid, an antifibrinolytic drug, is commonly used to control post-Operative Blood Loss. The recommended mode of administration of tranexamic acid is either oral or intravenous. However, the mechanism of action of the tranexamic acid points towards the possible effectiveness it may have following local/intra-articular application. This prospective, double-blinded, randomized preliminary study evaluated the efficacy of intra-articular tranexamic acid in reducing TKA-associated post-Operative Blood Loss. Fifty consenting patients with osteoarthritis of the knee scheduled for primary unilateral cemented-TKA were randomly allocated to one of the two groups: Tranexamic Acid (TA) group (n = 25, 500 mg/5 ml tranexamic acid) and the control group (n = 25, 5 ml 0.9% saline). The drug and control solution were administered intra-articularly through the drain tube immediately after the wound closure. Parameters related to Blood Loss (drop in haemoglobin, haematocrit differential) and the drain output [volume (ml)] were compared between the two groups. On a comparative basis, TA-group obtained significant reduction in the drain output [95% CI: 360.41–539.59, p < 0.001] at 48 h post-Operatively. Even though the control group received sixfold more Blood transfusion than TA-group, it showed a greater drop in haemoglobin and haematocrit (p < 0.05). Local application of tranexamic acid seems to be effective in reducing post-TKA Blood Loss as well as Blood transfusion requirements. Therapeutic study, Level II.
Shuvendu Prosad Roy - One of the best experts on this subject based on the ideXlab platform.
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efficacy of intra articular tranexamic acid in Blood Loss reduction following primary unilateral total knee arthroplasty
Knee Surgery Sports Traumatology Arthroscopy, 2012Co-Authors: Shuvendu Prosad Roy, Umair Firdos Tanki, Amitabh Dutta, Sumit Kumar Jain, Onkar Nath NagiAbstract:Purpose The surgical stress of total knee arthroplasty (TKA) procedure and the application of intra-Operative pneumatic thigh tourniquet increases local fibrinolytic activity, which contributes significantly to post-Operative Blood Loss. Tranexamic acid, an antifibrinolytic drug, is commonly used to control post-Operative Blood Loss. The recommended mode of administration of tranexamic acid is either oral or intravenous. However, the mechanism of action of the tranexamic acid points towards the possible effectiveness it may have following local/intra-articular application. This prospective, double-blinded, randomized preliminary study evaluated the efficacy of intra-articular tranexamic acid in reducing TKA-associated post-Operative Blood Loss.
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efficacy of intra articular tranexamic acid in Blood Loss reduction following primary unilateral total knee arthroplasty
Knee Surgery Sports Traumatology Arthroscopy, 2012Co-Authors: Shuvendu Prosad Roy, Umair Firdos Tanki, Amitabh Dutta, Sumit Kumar Jain, Onkar Nath NagiAbstract:The surgical stress of total knee arthroplasty (TKA) procedure and the application of intra-Operative pneumatic thigh tourniquet increases local fibrinolytic activity, which contributes significantly to post-Operative Blood Loss. Tranexamic acid, an antifibrinolytic drug, is commonly used to control post-Operative Blood Loss. The recommended mode of administration of tranexamic acid is either oral or intravenous. However, the mechanism of action of the tranexamic acid points towards the possible effectiveness it may have following local/intra-articular application. This prospective, double-blinded, randomized preliminary study evaluated the efficacy of intra-articular tranexamic acid in reducing TKA-associated post-Operative Blood Loss. Fifty consenting patients with osteoarthritis of the knee scheduled for primary unilateral cemented-TKA were randomly allocated to one of the two groups: Tranexamic Acid (TA) group (n = 25, 500 mg/5 ml tranexamic acid) and the control group (n = 25, 5 ml 0.9% saline). The drug and control solution were administered intra-articularly through the drain tube immediately after the wound closure. Parameters related to Blood Loss (drop in haemoglobin, haematocrit differential) and the drain output [volume (ml)] were compared between the two groups. On a comparative basis, TA-group obtained significant reduction in the drain output [95% CI: 360.41–539.59, p < 0.001] at 48 h post-Operatively. Even though the control group received sixfold more Blood transfusion than TA-group, it showed a greater drop in haemoglobin and haematocrit (p < 0.05). Local application of tranexamic acid seems to be effective in reducing post-TKA Blood Loss as well as Blood transfusion requirements. Therapeutic study, Level II.
Sen Chen - One of the best experts on this subject based on the ideXlab platform.
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the influence of a half course tourniquet strategy on peri Operative Blood Loss and early functional recovery in primary total knee arthroplasty
International Orthopaedics, 2014Co-Authors: Sen Chen, Jianping Li, Hao Peng, Jianlin Zhou, Hongsong Fang, Huifeng ZhengAbstract:Purpose The aim of this study was to explore the influence of a half-course tourniquet strategy on the peri-Operative Blood Loss and early functional recovery in primary total knee arthroplasty.
Ernst L F B Raaymakers - One of the best experts on this subject based on the ideXlab platform.
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a comparison of hemiarthroplasty with total hip replacement for displaced intracapsular fracture of the femoral neck a randomised controlled multicentre trial in patients aged 70 years and over
Journal of Bone and Joint Surgery-british Volume, 2010Co-Authors: Michel P. J. Van Den Bekerom, J M Schnater, H Bonke, Ellen Bp M Reuling, Elsa F Hilverdink, C. N. Van Dijk, J. Carel Goslings, Inger N Sierevelt, Ernst L F B RaaymakersAbstract:The aim of this study was to analyse the functional outcome after a displaced intracapsular fracture of the femoral neck in active patients aged over 70 years without osteoarthritis or rheumatoid arthritis of the hip, randomised to receive either a hemiarthroplasty or a total hip replacement (THR). We studied 252 patients of whom 47 (19%) were men, with a mean age of 81.1 years (70.2 to 95.6). They were randomly allocated to be treated with either a cemented hemiarthroplasty (137 patients) or cemented THR (115 patients). At one- and five-year follow-up no differences were observed in the modified Harris hip score, revision rate of the prosthesis, local and general complications, or mortality. The intra-Operative Blood Loss was lower in the hemiarthroplasty group (7% > 500 ml) than in the THR group (26% > 500 ml) and the duration of surgery was longer in the THR group (28% > 1.5 hours versus 12% > 1.5 hours). There were no dislocations of any bipolar hemiarthroplasty and eight dislocations of a THR during follow-up. Because of a higher intra-Operative Blood Loss (p
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a comparison of hemiarthroplasty with total hip replacement for displaced intracapsular fracture of the femoral neck a randomised controlled multicentre trial in patients aged 70 years and over
Journal of Bone and Joint Surgery-british Volume, 2010Co-Authors: M P J Van Den Bekerom, J M Schnater, H Bonke, Ellen Bp M Reuling, Elsa F Hilverdink, J. Carel Goslings, Inger N Sierevelt, C N Van Dijk, Ernst L F B RaaymakersAbstract:The aim of this study was to analyse the functional outcome after a displaced intracapsular fracture of the femoral neck in active patients aged over 70 years without osteoarthritis or rheumatoid arthritis of the hip, randomised to receive either a hemiarthroplasty or a total hip replacement (THR). We studied 252 patients of whom 47 (19%) were men, with a mean age of 81.1 years (70.2 to 95.6). They were randomly allocated to be treated with either a cemented hemiarthroplasty (137 patients) or cemented THR (115 patients). At one- and five-year follow-up no differences were observed in the modified Harris hip score, revision rate of the prosthesis, local and general complications, or mortality. The intra-Operative Blood Loss was lower in the hemiarthroplasty group (7% > 500 ml), THR group (26% > 500 ml) and the duration of surgery was longer in the THR group (28% > 1.5 hours versus 12% > 1.5 hours). There were no dislocations of any bipolar hemiarthroplasty than in the eight dislocations of a THR during follow-up. Because of a higher intra-Operative Blood Loss (p < 0.001), an increased duration of the operation (p < 0.001) and a higher number of early and late dislocations (p = 0.002), we do not recommend THR as the treatment of choice in patients aged ≥ 70 years with a fracture of the femoral neck in the absence of advanced radiological osteoarthritis or rheumatoid arthritis of the hip.
Umair Firdos Tanki - One of the best experts on this subject based on the ideXlab platform.
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efficacy of intra articular tranexamic acid in Blood Loss reduction following primary unilateral total knee arthroplasty
Knee Surgery Sports Traumatology Arthroscopy, 2012Co-Authors: Shuvendu Prosad Roy, Umair Firdos Tanki, Amitabh Dutta, Sumit Kumar Jain, Onkar Nath NagiAbstract:Purpose The surgical stress of total knee arthroplasty (TKA) procedure and the application of intra-Operative pneumatic thigh tourniquet increases local fibrinolytic activity, which contributes significantly to post-Operative Blood Loss. Tranexamic acid, an antifibrinolytic drug, is commonly used to control post-Operative Blood Loss. The recommended mode of administration of tranexamic acid is either oral or intravenous. However, the mechanism of action of the tranexamic acid points towards the possible effectiveness it may have following local/intra-articular application. This prospective, double-blinded, randomized preliminary study evaluated the efficacy of intra-articular tranexamic acid in reducing TKA-associated post-Operative Blood Loss.
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efficacy of intra articular tranexamic acid in Blood Loss reduction following primary unilateral total knee arthroplasty
Knee Surgery Sports Traumatology Arthroscopy, 2012Co-Authors: Shuvendu Prosad Roy, Umair Firdos Tanki, Amitabh Dutta, Sumit Kumar Jain, Onkar Nath NagiAbstract:The surgical stress of total knee arthroplasty (TKA) procedure and the application of intra-Operative pneumatic thigh tourniquet increases local fibrinolytic activity, which contributes significantly to post-Operative Blood Loss. Tranexamic acid, an antifibrinolytic drug, is commonly used to control post-Operative Blood Loss. The recommended mode of administration of tranexamic acid is either oral or intravenous. However, the mechanism of action of the tranexamic acid points towards the possible effectiveness it may have following local/intra-articular application. This prospective, double-blinded, randomized preliminary study evaluated the efficacy of intra-articular tranexamic acid in reducing TKA-associated post-Operative Blood Loss. Fifty consenting patients with osteoarthritis of the knee scheduled for primary unilateral cemented-TKA were randomly allocated to one of the two groups: Tranexamic Acid (TA) group (n = 25, 500 mg/5 ml tranexamic acid) and the control group (n = 25, 5 ml 0.9% saline). The drug and control solution were administered intra-articularly through the drain tube immediately after the wound closure. Parameters related to Blood Loss (drop in haemoglobin, haematocrit differential) and the drain output [volume (ml)] were compared between the two groups. On a comparative basis, TA-group obtained significant reduction in the drain output [95% CI: 360.41–539.59, p < 0.001] at 48 h post-Operatively. Even though the control group received sixfold more Blood transfusion than TA-group, it showed a greater drop in haemoglobin and haematocrit (p < 0.05). Local application of tranexamic acid seems to be effective in reducing post-TKA Blood Loss as well as Blood transfusion requirements. Therapeutic study, Level II.