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Bernard Schwartz - One of the best experts on this subject based on the ideXlab platform.

  • three dimensional evaluation of Optic Disc Pallor in open angle glaucoma
    Acta Ophthalmologica, 2009
    Co-Authors: Mary Jo Sagaties, Bernard Schwartz
    Abstract:

    : We evaluated the extent of Pallor on the walls of the Optic cup three-dimensionally using simultaneous stereophotographs of the Optic Discs of 29 normals, 29 ocular hypertensives and 28 primary open angle glaucomas. Pallor was located at the bottom of the Optic cup. Pallor ascends the walls of the cup as its extent increases. Statistically significant differences in the extent of Pallor in all four quadrants of the Optic cup were observed, with the glaucomas having greater extents of Pallor than ocular hypertensives, and the ocular hypertensives greater than the normals. The greatest percentage increase in mean Pallor from normals to open angle glaucomas occurred on the nasal and inferior walls. This differential extent of Pallor could be useful in characterizing ocular hypertension and chronic open angle glaucoma.

  • Association of ocular pressure and Optic Disc cup volume with red blood cell sodium-potassium ATPase inhibition.
    Current eye research, 2000
    Co-Authors: Bernard Schwartz, Takenori Takamoto, Richard Abrahamson, Alice Wysocki
    Abstract:

    Purpose. To determine if there were significant differences between the number of red blood cell ouabain binding sites in normals and untreated ocular hypertensives plus one open-angle glaucoma patient. Methods. We measured the binding of 3 H ouabain to erythrocyte membranes of 23 normals, 25 ocular hypertensives and one open-angle glaucoma. We also measured the levels of plasma cortisol and digoxin in these subjects. Characteristics of cupping of the Optic Disc and thickness of the retinal nerve fiber layer, as well as area of Optic Disc Pallor of these subjects were measured by stereophotogrammetry and by computerized image analysis from single and stereo photographs. Results. The number of 3 H ouabain binding sites was observed to be significantly less in the ocular hypertensives and one glaucoma compared to the normals (p = 0.0009). In multi-variate analyses, to determine what other factors affected this difference, there was a significant negative association with mean intraocular pressure (p = 0.003...

  • computerized measurement of the three dimensional distribution of Optic Disc Pallor
    Current Eye Research, 1997
    Co-Authors: Mary Jo Sagaties Farmer, Bernard Schwartz, Takenori Takamoto
    Abstract:

    PURPOSE. To describe a method which provides quantitative measurements of the surface area of Pallor in each quadrant of the three-dimensional Optic cup, using photogrammetric measurements from simultaneous stereophotographs and computerized image analysis. METHODS. Simultaneous stereophotographs of one normal subject and two subjects with primary open angle glaucoma were digitized and analyzed for depth measurements. The boundaries of the Optic Disc, Optic cup and region of Pallor were identified. Pallor/Disc and Pallor/cup ratios were subsequently calculated for the superior, temporal, inferior and nasal walls. RESULTS. A digitized photograph and a Laplacian-filtered image were obtained for each eye to be studied. After processing each stereo pair through a similarity sequential detection-based algorithm, depth measurements are represented as a grey scale image, a contour plot, and a wire mesh, with the boundaries of the Optic Disc, Optic cup and Pallor superimposed. Ratios are given of the surface area...

Cécile Delettre - One of the best experts on this subject based on the ideXlab platform.

  • Advances in gene therapy for Wolfram syndrome
    Acta Ophthalmologica, 2017
    Co-Authors: Christian P. Hamel, Jolanta Malgorzata Jagodzinska, D. Bonner-wersinger, Sulev Kõks, Marie Seveno, Cécile Delettre
    Abstract:

    Summary The Wolfram Syndrome (WS) is an early onset genetic disease (1/200 000) featuring diabetes mellitus and progressive Optic neuropathy ensuing mutations in the WFS1 gene. To date, there is no treatment to stop the progression of the disease. We have characterized the visual impairment of 2 mutants animal models for WFS1 (Wfs1exon8-/- and Wfs1E864K) and shown that these 2 models developed an Optic atrophy. We started for 1 year intravitreous micro injections of therapeutic vector AAV2-CMV-WFS1 on 1 month-old Wfs1exon8-/-. Our results showed that mice injected exhibited a stabilization of their visual acuity at 3 and 6 months post-injection, and a decrease of Optic Disc Pallor and Optic nerve damage. These promising results demonstrate the validity of the pre-clinical approach to treat Wolfram Syndrome by gene therapy and encourage further studies under a treatment for the Wolfram Syndrome patients.

Da You Zhao - One of the best experts on this subject based on the ideXlab platform.

  • Choroidal melanoma in a patient with retinitis pigmentosa and Usher’s syndrome
    British Journal of Ophthalmology, 1998
    Co-Authors: Kaan Gündüz, Jerry A. Shields, Carol L. Shields, Da You Zhao
    Abstract:

    Editor,—Usher’s syndrome is an autosomal recessive condition characterised by retinitis pigmentosa and hearing loss. It is the most common cause of combined blindness and deafness in the USA. Usher’s syndrome has two well defined subtypes including type I and type II.1 Type I has more severe and early onset findings. A 59 year old woman with retinitis pigmentosa and type I Usher’s syndrome developed blurred vision in the left eye over a 4 month period. The best corrected visual acuity was 20/50 in the right eye and 20/80 in the left eye. Anterior segment examination and intraocular pressures (16 mm Hg) were normal bilaterally. Ophthalmoscopic examination showed mild Optic Disc Pallor, marked vascular attenuation, and retinal pigmentary changes in both eyes. Inferotemporally in the left eye, …

Avril Kennan - One of the best experts on this subject based on the ideXlab platform.

  • On the role of IMPDH1 in retinal degeneration.
    Advances in experimental medicine and biology, 2003
    Co-Authors: Aileen Aherne, Sara J. Bowne, Stephen P. Daiger, G. Jane Farrar, Paul F. Kenna, Peter Humphries, Avril Kennan
    Abstract:

    To date twelve loci have been associated with the autosomal dominant form of Retinitis Pigmentosa (adRP). The genes at eleven of these have now been identified (http://www.sph.uth.tmc.edu/Retnet/). One such locus (RP10) is on chromosome 7q and was original identified as a result of a large linkage study undertaken at this laboratory (Jordan et al., 1993). Affected individuals of this family show the classic clinical symptoms of RP, including bone spicule pattern pigmentary deposits, Optic Disc Pallor and retinal vascular attenuation (for a detailed clinical description of this family see Jordan et al., 1993). An unrelated American adRP family, UTAD045, exhibiting a later onset and a slower progression of symptoms, was also subsequently revealed to have a disease gene on the same region of 7q (McGuire et al., 1995).

N. Markomichelakis - One of the best experts on this subject based on the ideXlab platform.

  • Extensive unilateral visual field loss due to peripapillary arteriovenous malformation
    International Ophthalmology, 2011
    Co-Authors: A. Rouvas, P. Petrou, I. Ladas, I. Vergados, E. S. Andipa, M. Papathanasiou, N. Markomichelakis
    Abstract:

    We report on a case of extensive unilateral visual field loss due to a peripapillary arteriovenous communication. Interventional case report. A 27-year-old Caucasian woman who was initially managed for retrobulbar Optic neuritis underwent fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) 6 months later that revealed an unusual course of the central retinal vein with focal dilatation and co-existent aneurysmal distention of the adjacent large choroidal vein. Subsequent colour Doppler flow imaging of the dilated area confirmed the existence of arterial flow suggesting a “vascular steal” phenomenon resulting in choroidal and Optic Disc ischaemia. Brain magnetic resonance imaging (MRI) revealed small focal capillary vessel abnormalities in the parietal cortex. The present case highlights the important role of ICGA and FFA in the assessment of patients with Optic Disc Pallor and visual field loss. In our case an unusual ocular vascular abnormality was attributed to a congenital malformation and therefore an unnecessary therapeutic intervention was avoided.