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Oliver Findl - One of the best experts on this subject based on the ideXlab platform.

  • effect of Optic Material and haptic design on anterior capsule opacification and capsulorrhexis contraction
    American Journal of Ophthalmology, 2006
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl
    Abstract:

    PURPOSE: To examine the influence of Optic Material (silicone and hydrophobic acrylic) and haptic design (one-piece and three-piece open loop) of sharp Optic edge intraocular lenses (IOL) on anterior capsule opacification (ACO) and capsulorrhexis contraction. DESIGN: Randomized, controlled, double-blind clinical trial with intraindividual comparison. METHODS: This study was performed at the Department of Ophthalmology, Medical University of Vienna, Austria, and comprised 210 eyes of 105 patients with bilateral age-related cataract. In group 1 (n = 53 patients), a three-piece acrylic IOL was compared with a three-piece silicone IOL. In group 2 (n = 52 patients), the three-piece acrylic IOL was compared with the one-piece acrylic IOL. One year after the operation, standardized digital slit-lamp images of ACO were taken; 1 week and 1 year after the operation, digital retroillumination images were taken to assess capsulorrhexis size. The intensity of ACO was graded objectively (score, 0% to 100%), and the capsulorrhexis area (square millimeters) was determined objectively. RESULTS: One year after surgery, the mean ACO score was 21% for the acrylic and 20% for the silicone IOL (P = .4) in group 1 and 18% for both the three-piece and one-piece acrylic IOLs (P = .87) in group 2. Concerning the amount of capsulorrhexis contraction, there was no significant difference between the IOL types that were evaluated in this study (after Bonferroni-Holm correction, P > .05). CONCLUSION: In the hydrophobic sharp Optic edge IOLs that were examined, neither the Optic Material nor the haptic design had an influence on the amount of ACO or capsulorrhexis contraction.

  • influence of Optic edge design Optic Material and haptic design on capsular bend configuration
    Journal of Cataract and Refractive Surgery, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Wolf Buehl
    Abstract:

    Purpose To assess and classify capsular bend configuration at the Optic rim and its association with posterior capsule (PCO) and anterior capsule opacification (ACO) and capsulorhexis contraction with various intraocular lenses (IOLs). Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods A total of 659 post-cataract surgery eyes of 370 patients from different prospective randomized studies were evaluated. All eyes had standardized phacoemulsification surgery with implantation of an IOL in the capsular bag. The IOLs had a sharp or round Optic edge design and were made of silicone, acrylic, or poly(methyl methacrylate) Optic Materials. One year postoperatively, the configuration of the capsular bend at the Optic rim was assessed at the slitlamp, and standardized slitlamp images of ACO and fibrotic PCO were taken. One week, 1 year, and 3 years postoperatively, digital retroillumination images were taken for objective quantification of regeneratory PCO and the capsulorhexis area. The outcome measures were the type of capsular bend configuration, ACO score (0% to 100%), regeneratory PCO score (0 to 10), fibrotic PCO score (0 to 3), and amount of capsulorhexis contraction (mm2). Results Four main types of capsular bend configuration were classified: parallel, “Y,” right angle, and wrapping. The right-angle type was observed in the most cases (52%). Eyes with a wrapping capsular bend configuration had significantly less PCO, more capsulorhexis contraction, and more ACO than eyes with the other configurations. Wrapping capsule configuration was seen most often (55%) in round-edged silicone IOLs that had a thin Optic rim. Conclusion The design and Material of IOLs influenced the long-term capsular bend configuration at the Optic rim. The right-angle type was the most common capsular bend configuration. Intraocular lenses with silicone Optic Material and a thin Optic rim caused a wrapping capsule configuration and resulted in more capsulorhexis contraction and ACO, but less PCO.

  • long term efficacy of adding a sharp posterior Optic edge to a three piece silicone intraocular lens on capsule opacification five year results of a randomized study
    American Journal of Ophthalmology, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Barbara Kiss, Wolf Buehl, Michael Georgopoulos
    Abstract:

    Purpose To compare the intensity of capsule opacification with the sharp and the round Optic edge variant of an open-loop hydrophobic silicone intraocular lens (IOL). Design Randomized, controlled, double-blind clinical trial with intraindividual comparison. Methods Fifty-one patients with bilateral age-related cataract were included (102 eyes). Each patient had had cataract surgery in both eyes and received a Microsil IOL with a sharp Optic edge design (model S) in one eye and a Microsil IOL with a round Optic edge design (model R) in the fellow eye. Both IOLs had an identical haptic design (nonangulated polymethylmethacrylate) and silicone Optic Material. The patients were examined at the slit lamp, best-corrected visual acuity was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken 5 years after surgery. The intensity of regeneratory posterior capsule opacification (rPCO), fibrotic PCO (fPCO), and anterior capsule opacification (ACO) was assessed subjectively at the slit lamp, and of rPCO, objectively using automated image analysis software (AQUA). The need for an Nd:YAG laser capsulotomy (Nd:YAG-LCT) was noted. Results The mean AQUA PCO score was 1.2 for the model S and 2.4 for the model R lens ( P = .001). The model S lens also led to less peripheral fPCO ( P = .003). Concerning ACO, there was no significant difference between both IOL groups ( P = .72). Whereas no capsulotomy was required with the model S, four cases (16%) had been performed in the model R group. Conclusion Five years postoperatively, the sharp-edged silicone IOL showed less rPCO and fPCO than the round-edged IOL. However, regarding ACO, there was no significant difference between both IOL styles.

  • effect of Optic Material on posterior capsule opacification in intraocular lenses with sharp edge Optics randomized clinical trial
    Ophthalmology, 2005
    Co-Authors: Oliver Findl, Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer
    Abstract:

    PURPOSE: Comparison of the intensity of posterior capsule opacification (PCO) between a silicone intraocular lens (IOL) and a hydrophobic acrylic IOL, both of them 3-piece and open-loop and having truncated Optics with sharp edges. DESIGN: Randomized, controlled, patient- and examiner-masked trial with intrapatient comparison. PARTICIPANTS AND CONTROLS: One hundred six eyes of 53 patients with age-related bilateral cataract. METHODS: Each patient had cataract surgery in both eyes and received a silicone IOL in one eye and a hydrophobic acrylic IOL in the fellow eye. Follow-up examinations were at 1 and 3 years after surgery. The patients were examined at the slit lamp, visual acuity (VA) was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken. The amount of PCO was assessed subjectively at the slit lamp and objectively using automated image analysis software. Data of 56 eyes of 28 patients, who were examined at each follow-up, were analyzed. MAIN OUTCOME MEASURE: Posterior capsule opacification intensity at 3 years as measured with automated image analysis. RESULTS: At 1 and 3 years after surgery, PCO did not differ between the silicone (1.6 and 1.9 [image analysis scores, 0-10 scale], respectively) and acrylic IOLs (1.7 and 2.2) (P > 0.24). Furthermore, there was no significant difference in best-corrected VA, rhexis/IOL overlap, capsular folds, and amount of anterior capsule opacification during the follow-up period. In each group, one neodymium:yttrium-aluminum-garnet (YAG) laser capsulotomy was performed during the entire study duration. CONCLUSION: Silicone and hydrophobic acrylic are similarly effective in inducing the PCO-inhibiting effect of a rectangular, sharp Optic edge. Three years after surgery, the PCO intensity and the YAG rate were low with both IOL models.

  • effect of intraocular lens Optic edge design and Material on fibrotic capsule opacification and capsulorhexis contraction
    Journal of Cataract and Refractive Surgery, 2004
    Co-Authors: Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer, Oliver Findl
    Abstract:

    Purpose To examine the influence of intraocular lens (IOL) Optic edge design and Optic Material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction. Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar® OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior Optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex® OptiEdge silicone IOL with a sharp posterior Optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm2) was determined objectively. Results One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P Conclusions Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs.

Stefan Sacu - One of the best experts on this subject based on the ideXlab platform.

  • effect of Optic Material and haptic design on anterior capsule opacification and capsulorrhexis contraction
    American Journal of Ophthalmology, 2006
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl
    Abstract:

    PURPOSE: To examine the influence of Optic Material (silicone and hydrophobic acrylic) and haptic design (one-piece and three-piece open loop) of sharp Optic edge intraocular lenses (IOL) on anterior capsule opacification (ACO) and capsulorrhexis contraction. DESIGN: Randomized, controlled, double-blind clinical trial with intraindividual comparison. METHODS: This study was performed at the Department of Ophthalmology, Medical University of Vienna, Austria, and comprised 210 eyes of 105 patients with bilateral age-related cataract. In group 1 (n = 53 patients), a three-piece acrylic IOL was compared with a three-piece silicone IOL. In group 2 (n = 52 patients), the three-piece acrylic IOL was compared with the one-piece acrylic IOL. One year after the operation, standardized digital slit-lamp images of ACO were taken; 1 week and 1 year after the operation, digital retroillumination images were taken to assess capsulorrhexis size. The intensity of ACO was graded objectively (score, 0% to 100%), and the capsulorrhexis area (square millimeters) was determined objectively. RESULTS: One year after surgery, the mean ACO score was 21% for the acrylic and 20% for the silicone IOL (P = .4) in group 1 and 18% for both the three-piece and one-piece acrylic IOLs (P = .87) in group 2. Concerning the amount of capsulorrhexis contraction, there was no significant difference between the IOL types that were evaluated in this study (after Bonferroni-Holm correction, P > .05). CONCLUSION: In the hydrophobic sharp Optic edge IOLs that were examined, neither the Optic Material nor the haptic design had an influence on the amount of ACO or capsulorrhexis contraction.

  • influence of Optic edge design Optic Material and haptic design on capsular bend configuration
    Journal of Cataract and Refractive Surgery, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Wolf Buehl
    Abstract:

    Purpose To assess and classify capsular bend configuration at the Optic rim and its association with posterior capsule (PCO) and anterior capsule opacification (ACO) and capsulorhexis contraction with various intraocular lenses (IOLs). Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods A total of 659 post-cataract surgery eyes of 370 patients from different prospective randomized studies were evaluated. All eyes had standardized phacoemulsification surgery with implantation of an IOL in the capsular bag. The IOLs had a sharp or round Optic edge design and were made of silicone, acrylic, or poly(methyl methacrylate) Optic Materials. One year postoperatively, the configuration of the capsular bend at the Optic rim was assessed at the slitlamp, and standardized slitlamp images of ACO and fibrotic PCO were taken. One week, 1 year, and 3 years postoperatively, digital retroillumination images were taken for objective quantification of regeneratory PCO and the capsulorhexis area. The outcome measures were the type of capsular bend configuration, ACO score (0% to 100%), regeneratory PCO score (0 to 10), fibrotic PCO score (0 to 3), and amount of capsulorhexis contraction (mm2). Results Four main types of capsular bend configuration were classified: parallel, “Y,” right angle, and wrapping. The right-angle type was observed in the most cases (52%). Eyes with a wrapping capsular bend configuration had significantly less PCO, more capsulorhexis contraction, and more ACO than eyes with the other configurations. Wrapping capsule configuration was seen most often (55%) in round-edged silicone IOLs that had a thin Optic rim. Conclusion The design and Material of IOLs influenced the long-term capsular bend configuration at the Optic rim. The right-angle type was the most common capsular bend configuration. Intraocular lenses with silicone Optic Material and a thin Optic rim caused a wrapping capsule configuration and resulted in more capsulorhexis contraction and ACO, but less PCO.

  • long term efficacy of adding a sharp posterior Optic edge to a three piece silicone intraocular lens on capsule opacification five year results of a randomized study
    American Journal of Ophthalmology, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Barbara Kiss, Wolf Buehl, Michael Georgopoulos
    Abstract:

    Purpose To compare the intensity of capsule opacification with the sharp and the round Optic edge variant of an open-loop hydrophobic silicone intraocular lens (IOL). Design Randomized, controlled, double-blind clinical trial with intraindividual comparison. Methods Fifty-one patients with bilateral age-related cataract were included (102 eyes). Each patient had had cataract surgery in both eyes and received a Microsil IOL with a sharp Optic edge design (model S) in one eye and a Microsil IOL with a round Optic edge design (model R) in the fellow eye. Both IOLs had an identical haptic design (nonangulated polymethylmethacrylate) and silicone Optic Material. The patients were examined at the slit lamp, best-corrected visual acuity was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken 5 years after surgery. The intensity of regeneratory posterior capsule opacification (rPCO), fibrotic PCO (fPCO), and anterior capsule opacification (ACO) was assessed subjectively at the slit lamp, and of rPCO, objectively using automated image analysis software (AQUA). The need for an Nd:YAG laser capsulotomy (Nd:YAG-LCT) was noted. Results The mean AQUA PCO score was 1.2 for the model S and 2.4 for the model R lens ( P = .001). The model S lens also led to less peripheral fPCO ( P = .003). Concerning ACO, there was no significant difference between both IOL groups ( P = .72). Whereas no capsulotomy was required with the model S, four cases (16%) had been performed in the model R group. Conclusion Five years postoperatively, the sharp-edged silicone IOL showed less rPCO and fPCO than the round-edged IOL. However, regarding ACO, there was no significant difference between both IOL styles.

  • effect of Optic Material on posterior capsule opacification in intraocular lenses with sharp edge Optics randomized clinical trial
    Ophthalmology, 2005
    Co-Authors: Oliver Findl, Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer
    Abstract:

    PURPOSE: Comparison of the intensity of posterior capsule opacification (PCO) between a silicone intraocular lens (IOL) and a hydrophobic acrylic IOL, both of them 3-piece and open-loop and having truncated Optics with sharp edges. DESIGN: Randomized, controlled, patient- and examiner-masked trial with intrapatient comparison. PARTICIPANTS AND CONTROLS: One hundred six eyes of 53 patients with age-related bilateral cataract. METHODS: Each patient had cataract surgery in both eyes and received a silicone IOL in one eye and a hydrophobic acrylic IOL in the fellow eye. Follow-up examinations were at 1 and 3 years after surgery. The patients were examined at the slit lamp, visual acuity (VA) was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken. The amount of PCO was assessed subjectively at the slit lamp and objectively using automated image analysis software. Data of 56 eyes of 28 patients, who were examined at each follow-up, were analyzed. MAIN OUTCOME MEASURE: Posterior capsule opacification intensity at 3 years as measured with automated image analysis. RESULTS: At 1 and 3 years after surgery, PCO did not differ between the silicone (1.6 and 1.9 [image analysis scores, 0-10 scale], respectively) and acrylic IOLs (1.7 and 2.2) (P > 0.24). Furthermore, there was no significant difference in best-corrected VA, rhexis/IOL overlap, capsular folds, and amount of anterior capsule opacification during the follow-up period. In each group, one neodymium:yttrium-aluminum-garnet (YAG) laser capsulotomy was performed during the entire study duration. CONCLUSION: Silicone and hydrophobic acrylic are similarly effective in inducing the PCO-inhibiting effect of a rectangular, sharp Optic edge. Three years after surgery, the PCO intensity and the YAG rate were low with both IOL models.

  • effect of intraocular lens Optic edge design and Material on fibrotic capsule opacification and capsulorhexis contraction
    Journal of Cataract and Refractive Surgery, 2004
    Co-Authors: Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer, Oliver Findl
    Abstract:

    Purpose To examine the influence of intraocular lens (IOL) Optic edge design and Optic Material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction. Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar® OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior Optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex® OptiEdge silicone IOL with a sharp posterior Optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm2) was determined objectively. Results One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P Conclusions Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs.

Rupert Menapace - One of the best experts on this subject based on the ideXlab platform.

  • effect of Optic Material and haptic design on anterior capsule opacification and capsulorrhexis contraction
    American Journal of Ophthalmology, 2006
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl
    Abstract:

    PURPOSE: To examine the influence of Optic Material (silicone and hydrophobic acrylic) and haptic design (one-piece and three-piece open loop) of sharp Optic edge intraocular lenses (IOL) on anterior capsule opacification (ACO) and capsulorrhexis contraction. DESIGN: Randomized, controlled, double-blind clinical trial with intraindividual comparison. METHODS: This study was performed at the Department of Ophthalmology, Medical University of Vienna, Austria, and comprised 210 eyes of 105 patients with bilateral age-related cataract. In group 1 (n = 53 patients), a three-piece acrylic IOL was compared with a three-piece silicone IOL. In group 2 (n = 52 patients), the three-piece acrylic IOL was compared with the one-piece acrylic IOL. One year after the operation, standardized digital slit-lamp images of ACO were taken; 1 week and 1 year after the operation, digital retroillumination images were taken to assess capsulorrhexis size. The intensity of ACO was graded objectively (score, 0% to 100%), and the capsulorrhexis area (square millimeters) was determined objectively. RESULTS: One year after surgery, the mean ACO score was 21% for the acrylic and 20% for the silicone IOL (P = .4) in group 1 and 18% for both the three-piece and one-piece acrylic IOLs (P = .87) in group 2. Concerning the amount of capsulorrhexis contraction, there was no significant difference between the IOL types that were evaluated in this study (after Bonferroni-Holm correction, P > .05). CONCLUSION: In the hydrophobic sharp Optic edge IOLs that were examined, neither the Optic Material nor the haptic design had an influence on the amount of ACO or capsulorrhexis contraction.

  • influence of Optic edge design Optic Material and haptic design on capsular bend configuration
    Journal of Cataract and Refractive Surgery, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Wolf Buehl
    Abstract:

    Purpose To assess and classify capsular bend configuration at the Optic rim and its association with posterior capsule (PCO) and anterior capsule opacification (ACO) and capsulorhexis contraction with various intraocular lenses (IOLs). Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods A total of 659 post-cataract surgery eyes of 370 patients from different prospective randomized studies were evaluated. All eyes had standardized phacoemulsification surgery with implantation of an IOL in the capsular bag. The IOLs had a sharp or round Optic edge design and were made of silicone, acrylic, or poly(methyl methacrylate) Optic Materials. One year postoperatively, the configuration of the capsular bend at the Optic rim was assessed at the slitlamp, and standardized slitlamp images of ACO and fibrotic PCO were taken. One week, 1 year, and 3 years postoperatively, digital retroillumination images were taken for objective quantification of regeneratory PCO and the capsulorhexis area. The outcome measures were the type of capsular bend configuration, ACO score (0% to 100%), regeneratory PCO score (0 to 10), fibrotic PCO score (0 to 3), and amount of capsulorhexis contraction (mm2). Results Four main types of capsular bend configuration were classified: parallel, “Y,” right angle, and wrapping. The right-angle type was observed in the most cases (52%). Eyes with a wrapping capsular bend configuration had significantly less PCO, more capsulorhexis contraction, and more ACO than eyes with the other configurations. Wrapping capsule configuration was seen most often (55%) in round-edged silicone IOLs that had a thin Optic rim. Conclusion The design and Material of IOLs influenced the long-term capsular bend configuration at the Optic rim. The right-angle type was the most common capsular bend configuration. Intraocular lenses with silicone Optic Material and a thin Optic rim caused a wrapping capsule configuration and resulted in more capsulorhexis contraction and ACO, but less PCO.

  • long term efficacy of adding a sharp posterior Optic edge to a three piece silicone intraocular lens on capsule opacification five year results of a randomized study
    American Journal of Ophthalmology, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Barbara Kiss, Wolf Buehl, Michael Georgopoulos
    Abstract:

    Purpose To compare the intensity of capsule opacification with the sharp and the round Optic edge variant of an open-loop hydrophobic silicone intraocular lens (IOL). Design Randomized, controlled, double-blind clinical trial with intraindividual comparison. Methods Fifty-one patients with bilateral age-related cataract were included (102 eyes). Each patient had had cataract surgery in both eyes and received a Microsil IOL with a sharp Optic edge design (model S) in one eye and a Microsil IOL with a round Optic edge design (model R) in the fellow eye. Both IOLs had an identical haptic design (nonangulated polymethylmethacrylate) and silicone Optic Material. The patients were examined at the slit lamp, best-corrected visual acuity was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken 5 years after surgery. The intensity of regeneratory posterior capsule opacification (rPCO), fibrotic PCO (fPCO), and anterior capsule opacification (ACO) was assessed subjectively at the slit lamp, and of rPCO, objectively using automated image analysis software (AQUA). The need for an Nd:YAG laser capsulotomy (Nd:YAG-LCT) was noted. Results The mean AQUA PCO score was 1.2 for the model S and 2.4 for the model R lens ( P = .001). The model S lens also led to less peripheral fPCO ( P = .003). Concerning ACO, there was no significant difference between both IOL groups ( P = .72). Whereas no capsulotomy was required with the model S, four cases (16%) had been performed in the model R group. Conclusion Five years postoperatively, the sharp-edged silicone IOL showed less rPCO and fPCO than the round-edged IOL. However, regarding ACO, there was no significant difference between both IOL styles.

  • effect of Optic Material on posterior capsule opacification in intraocular lenses with sharp edge Optics randomized clinical trial
    Ophthalmology, 2005
    Co-Authors: Oliver Findl, Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer
    Abstract:

    PURPOSE: Comparison of the intensity of posterior capsule opacification (PCO) between a silicone intraocular lens (IOL) and a hydrophobic acrylic IOL, both of them 3-piece and open-loop and having truncated Optics with sharp edges. DESIGN: Randomized, controlled, patient- and examiner-masked trial with intrapatient comparison. PARTICIPANTS AND CONTROLS: One hundred six eyes of 53 patients with age-related bilateral cataract. METHODS: Each patient had cataract surgery in both eyes and received a silicone IOL in one eye and a hydrophobic acrylic IOL in the fellow eye. Follow-up examinations were at 1 and 3 years after surgery. The patients were examined at the slit lamp, visual acuity (VA) was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken. The amount of PCO was assessed subjectively at the slit lamp and objectively using automated image analysis software. Data of 56 eyes of 28 patients, who were examined at each follow-up, were analyzed. MAIN OUTCOME MEASURE: Posterior capsule opacification intensity at 3 years as measured with automated image analysis. RESULTS: At 1 and 3 years after surgery, PCO did not differ between the silicone (1.6 and 1.9 [image analysis scores, 0-10 scale], respectively) and acrylic IOLs (1.7 and 2.2) (P > 0.24). Furthermore, there was no significant difference in best-corrected VA, rhexis/IOL overlap, capsular folds, and amount of anterior capsule opacification during the follow-up period. In each group, one neodymium:yttrium-aluminum-garnet (YAG) laser capsulotomy was performed during the entire study duration. CONCLUSION: Silicone and hydrophobic acrylic are similarly effective in inducing the PCO-inhibiting effect of a rectangular, sharp Optic edge. Three years after surgery, the PCO intensity and the YAG rate were low with both IOL models.

  • effect of intraocular lens Optic edge design and Material on fibrotic capsule opacification and capsulorhexis contraction
    Journal of Cataract and Refractive Surgery, 2004
    Co-Authors: Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer, Oliver Findl
    Abstract:

    Purpose To examine the influence of intraocular lens (IOL) Optic edge design and Optic Material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction. Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar® OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior Optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex® OptiEdge silicone IOL with a sharp posterior Optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm2) was determined objectively. Results One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P Conclusions Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs.

Wolf Buehl - One of the best experts on this subject based on the ideXlab platform.

  • influence of Optic edge design Optic Material and haptic design on capsular bend configuration
    Journal of Cataract and Refractive Surgery, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Wolf Buehl
    Abstract:

    Purpose To assess and classify capsular bend configuration at the Optic rim and its association with posterior capsule (PCO) and anterior capsule opacification (ACO) and capsulorhexis contraction with various intraocular lenses (IOLs). Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods A total of 659 post-cataract surgery eyes of 370 patients from different prospective randomized studies were evaluated. All eyes had standardized phacoemulsification surgery with implantation of an IOL in the capsular bag. The IOLs had a sharp or round Optic edge design and were made of silicone, acrylic, or poly(methyl methacrylate) Optic Materials. One year postoperatively, the configuration of the capsular bend at the Optic rim was assessed at the slitlamp, and standardized slitlamp images of ACO and fibrotic PCO were taken. One week, 1 year, and 3 years postoperatively, digital retroillumination images were taken for objective quantification of regeneratory PCO and the capsulorhexis area. The outcome measures were the type of capsular bend configuration, ACO score (0% to 100%), regeneratory PCO score (0 to 10), fibrotic PCO score (0 to 3), and amount of capsulorhexis contraction (mm2). Results Four main types of capsular bend configuration were classified: parallel, “Y,” right angle, and wrapping. The right-angle type was observed in the most cases (52%). Eyes with a wrapping capsular bend configuration had significantly less PCO, more capsulorhexis contraction, and more ACO than eyes with the other configurations. Wrapping capsule configuration was seen most often (55%) in round-edged silicone IOLs that had a thin Optic rim. Conclusion The design and Material of IOLs influenced the long-term capsular bend configuration at the Optic rim. The right-angle type was the most common capsular bend configuration. Intraocular lenses with silicone Optic Material and a thin Optic rim caused a wrapping capsule configuration and resulted in more capsulorhexis contraction and ACO, but less PCO.

  • long term efficacy of adding a sharp posterior Optic edge to a three piece silicone intraocular lens on capsule opacification five year results of a randomized study
    American Journal of Ophthalmology, 2005
    Co-Authors: Stefan Sacu, Rupert Menapace, Oliver Findl, Barbara Kiss, Wolf Buehl, Michael Georgopoulos
    Abstract:

    Purpose To compare the intensity of capsule opacification with the sharp and the round Optic edge variant of an open-loop hydrophobic silicone intraocular lens (IOL). Design Randomized, controlled, double-blind clinical trial with intraindividual comparison. Methods Fifty-one patients with bilateral age-related cataract were included (102 eyes). Each patient had had cataract surgery in both eyes and received a Microsil IOL with a sharp Optic edge design (model S) in one eye and a Microsil IOL with a round Optic edge design (model R) in the fellow eye. Both IOLs had an identical haptic design (nonangulated polymethylmethacrylate) and silicone Optic Material. The patients were examined at the slit lamp, best-corrected visual acuity was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken 5 years after surgery. The intensity of regeneratory posterior capsule opacification (rPCO), fibrotic PCO (fPCO), and anterior capsule opacification (ACO) was assessed subjectively at the slit lamp, and of rPCO, objectively using automated image analysis software (AQUA). The need for an Nd:YAG laser capsulotomy (Nd:YAG-LCT) was noted. Results The mean AQUA PCO score was 1.2 for the model S and 2.4 for the model R lens ( P = .001). The model S lens also led to less peripheral fPCO ( P = .003). Concerning ACO, there was no significant difference between both IOL groups ( P = .72). Whereas no capsulotomy was required with the model S, four cases (16%) had been performed in the model R group. Conclusion Five years postoperatively, the sharp-edged silicone IOL showed less rPCO and fPCO than the round-edged IOL. However, regarding ACO, there was no significant difference between both IOL styles.

  • effect of Optic Material on posterior capsule opacification in intraocular lenses with sharp edge Optics randomized clinical trial
    Ophthalmology, 2005
    Co-Authors: Oliver Findl, Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer
    Abstract:

    PURPOSE: Comparison of the intensity of posterior capsule opacification (PCO) between a silicone intraocular lens (IOL) and a hydrophobic acrylic IOL, both of them 3-piece and open-loop and having truncated Optics with sharp edges. DESIGN: Randomized, controlled, patient- and examiner-masked trial with intrapatient comparison. PARTICIPANTS AND CONTROLS: One hundred six eyes of 53 patients with age-related bilateral cataract. METHODS: Each patient had cataract surgery in both eyes and received a silicone IOL in one eye and a hydrophobic acrylic IOL in the fellow eye. Follow-up examinations were at 1 and 3 years after surgery. The patients were examined at the slit lamp, visual acuity (VA) was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken. The amount of PCO was assessed subjectively at the slit lamp and objectively using automated image analysis software. Data of 56 eyes of 28 patients, who were examined at each follow-up, were analyzed. MAIN OUTCOME MEASURE: Posterior capsule opacification intensity at 3 years as measured with automated image analysis. RESULTS: At 1 and 3 years after surgery, PCO did not differ between the silicone (1.6 and 1.9 [image analysis scores, 0-10 scale], respectively) and acrylic IOLs (1.7 and 2.2) (P > 0.24). Furthermore, there was no significant difference in best-corrected VA, rhexis/IOL overlap, capsular folds, and amount of anterior capsule opacification during the follow-up period. In each group, one neodymium:yttrium-aluminum-garnet (YAG) laser capsulotomy was performed during the entire study duration. CONCLUSION: Silicone and hydrophobic acrylic are similarly effective in inducing the PCO-inhibiting effect of a rectangular, sharp Optic edge. Three years after surgery, the PCO intensity and the YAG rate were low with both IOL models.

  • effect of intraocular lens Optic edge design and Material on fibrotic capsule opacification and capsulorhexis contraction
    Journal of Cataract and Refractive Surgery, 2004
    Co-Authors: Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer, Oliver Findl
    Abstract:

    Purpose To examine the influence of intraocular lens (IOL) Optic edge design and Optic Material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction. Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar® OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior Optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex® OptiEdge silicone IOL with a sharp posterior Optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm2) was determined objectively. Results One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P Conclusions Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs.

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  • effect of Optic Material on posterior capsule opacification in intraocular lenses with sharp edge Optics randomized clinical trial
    Ophthalmology, 2005
    Co-Authors: Oliver Findl, Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer
    Abstract:

    PURPOSE: Comparison of the intensity of posterior capsule opacification (PCO) between a silicone intraocular lens (IOL) and a hydrophobic acrylic IOL, both of them 3-piece and open-loop and having truncated Optics with sharp edges. DESIGN: Randomized, controlled, patient- and examiner-masked trial with intrapatient comparison. PARTICIPANTS AND CONTROLS: One hundred six eyes of 53 patients with age-related bilateral cataract. METHODS: Each patient had cataract surgery in both eyes and received a silicone IOL in one eye and a hydrophobic acrylic IOL in the fellow eye. Follow-up examinations were at 1 and 3 years after surgery. The patients were examined at the slit lamp, visual acuity (VA) was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken. The amount of PCO was assessed subjectively at the slit lamp and objectively using automated image analysis software. Data of 56 eyes of 28 patients, who were examined at each follow-up, were analyzed. MAIN OUTCOME MEASURE: Posterior capsule opacification intensity at 3 years as measured with automated image analysis. RESULTS: At 1 and 3 years after surgery, PCO did not differ between the silicone (1.6 and 1.9 [image analysis scores, 0-10 scale], respectively) and acrylic IOLs (1.7 and 2.2) (P > 0.24). Furthermore, there was no significant difference in best-corrected VA, rhexis/IOL overlap, capsular folds, and amount of anterior capsule opacification during the follow-up period. In each group, one neodymium:yttrium-aluminum-garnet (YAG) laser capsulotomy was performed during the entire study duration. CONCLUSION: Silicone and hydrophobic acrylic are similarly effective in inducing the PCO-inhibiting effect of a rectangular, sharp Optic edge. Three years after surgery, the PCO intensity and the YAG rate were low with both IOL models.

  • effect of intraocular lens Optic edge design and Material on fibrotic capsule opacification and capsulorhexis contraction
    Journal of Cataract and Refractive Surgery, 2004
    Co-Authors: Stefan Sacu, Rupert Menapace, Wolf Buehl, Georg Rainer, Oliver Findl
    Abstract:

    Purpose To examine the influence of intraocular lens (IOL) Optic edge design and Optic Material on fibrosis of the anterior and peripheral posterior capsules and on capsulorhexis contraction. Setting Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Methods This randomized controlled patient- and examiner-masked study comprised 210 eyes of 105 patients with bilateral age-related cataract. In Group 1 (n = 53), the Sensar® OptiEdge AR40e hydrophobic acrylic IOL with a sharp posterior Optic edge was compared with the AR40 acrylic IOL with a round edge. In Group 2 (n = 52), the ClariFlex® OptiEdge silicone IOL with a sharp posterior Optic edge was compared with the PhacoFlex SI-40 silicone IOL with a round edge All IOLs were manufactured by Advanced Medical Optics, Inc. Standardized digital slitlamp images of anterior capsule opacification (ACO) and fibrotic posterior capsule opacification (PCO) were taken 1 year postoperatively, and digital retroillumination images were taken at 1 week and 1 year. The intensity of fibrotic PCO was graded subjectively (score 0 to 4), ACO was graded objectively (score 0% to 100%), and the capsulorhexis area (mm2) was determined objectively. Results One year after surgery, the mean ACO score was 32% in eyes with the sharp-edged acrylic IOL and 29% in eyes with the round-edged acrylic IOL (P Conclusions Acrylic and silicone IOLs with the sharp OptiEdge design led to significantly less fibrotic PCO but more ACO than round-edged acrylic and silicone IOLs. The sharp-edged silicone IOL caused significantly more capsulorhexis contraction than the round-edged silicone IOL and both acrylic IOLs.