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Birgit Lorenz - One of the best experts on this subject based on the ideXlab platform.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's Archive for Clinical and Experimental Ophthalmology, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I. Case report A 61-year-old woman presented with rapidly progressing right vision loss, lower altitudinal visual field defect and papilloedema. MRI showed intraorbital and intracranial swelling of the right Optic Nerve. Resection of the intracranial part of the right Optic Nerve up to the chiasm revealed anaplastic astrocytoma grade III. Within 1 year, the patient died of leptomeningeal metastasis despite radiotherapy. Clinical and MRI evaluation of the left eye and Optic Nerve were normal at all times. Discussion Unilateral adult malignant Glioma of the Optic Nerve is exceptional. The final diagnosis was only confirmed by Optic Nerve biopsy. In the literature, only one patient has been reported with a unilateral tumour manifestation; he was lost to follow-up 3 months later. All other cases were bilateral. To date, 44 case reports of adult malignant Optic Nerve Glioma have been published, either malignant astrocytoma or glioblastoma. These tumours can mimic Optic neuritis in their initial presentation. The diagnosis is seldom made before craniotomy. On MRI images, malignant Glioma cannot be distinguished from Optic Nerve enlargement due to other causes. Although radiotherapy appears to prolong life expectancy, all presently available treatment options (radiation, surgery, radio-chemotherapy) are of limited value. Most patients go blind and die within 1 or 2 years.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I.
Bettina Wabbels - One of the best experts on this subject based on the ideXlab platform.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's Archive for Clinical and Experimental Ophthalmology, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I. Case report A 61-year-old woman presented with rapidly progressing right vision loss, lower altitudinal visual field defect and papilloedema. MRI showed intraorbital and intracranial swelling of the right Optic Nerve. Resection of the intracranial part of the right Optic Nerve up to the chiasm revealed anaplastic astrocytoma grade III. Within 1 year, the patient died of leptomeningeal metastasis despite radiotherapy. Clinical and MRI evaluation of the left eye and Optic Nerve were normal at all times. Discussion Unilateral adult malignant Glioma of the Optic Nerve is exceptional. The final diagnosis was only confirmed by Optic Nerve biopsy. In the literature, only one patient has been reported with a unilateral tumour manifestation; he was lost to follow-up 3 months later. All other cases were bilateral. To date, 44 case reports of adult malignant Optic Nerve Glioma have been published, either malignant astrocytoma or glioblastoma. These tumours can mimic Optic neuritis in their initial presentation. The diagnosis is seldom made before craniotomy. On MRI images, malignant Glioma cannot be distinguished from Optic Nerve enlargement due to other causes. Although radiotherapy appears to prolong life expectancy, all presently available treatment options (radiation, surgery, radio-chemotherapy) are of limited value. Most patients go blind and die within 1 or 2 years.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I.
T.m. Kolawole - One of the best experts on this subject based on the ideXlab platform.
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Cerebro-vasculopathy and malignancy: catastrophic complications of radiotherapy for Optic Nerve Glioma in a von Recklinghausen neurofibromatosis patient
Neurosurgical review, 1996Co-Authors: Abdulhakim B. Jamjoom, Tajuddin Malabarey, Zain Alabedeen B. Jamjoom, Mohammed Al-sohaibani, Ahmed Hulailah, T.m. KolawoleAbstract:The authors report a unique case of a patient with intraorbital Optic Nerve Glioma and von Recklinghausen neurofibromatosis who developed cerebro-vasculopathy and malignant transformation in the orbit 18 months after radiotherapy treatment. The case is an important reminder of the possibly increased susceptibility of von Recklinghausen neurofibromatosis patients to the complications of radiotherapy.
Anke Demmler - One of the best experts on this subject based on the ideXlab platform.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's Archive for Clinical and Experimental Ophthalmology, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I. Case report A 61-year-old woman presented with rapidly progressing right vision loss, lower altitudinal visual field defect and papilloedema. MRI showed intraorbital and intracranial swelling of the right Optic Nerve. Resection of the intracranial part of the right Optic Nerve up to the chiasm revealed anaplastic astrocytoma grade III. Within 1 year, the patient died of leptomeningeal metastasis despite radiotherapy. Clinical and MRI evaluation of the left eye and Optic Nerve were normal at all times. Discussion Unilateral adult malignant Glioma of the Optic Nerve is exceptional. The final diagnosis was only confirmed by Optic Nerve biopsy. In the literature, only one patient has been reported with a unilateral tumour manifestation; he was lost to follow-up 3 months later. All other cases were bilateral. To date, 44 case reports of adult malignant Optic Nerve Glioma have been published, either malignant astrocytoma or glioblastoma. These tumours can mimic Optic neuritis in their initial presentation. The diagnosis is seldom made before craniotomy. On MRI images, malignant Glioma cannot be distinguished from Optic Nerve enlargement due to other causes. Although radiotherapy appears to prolong life expectancy, all presently available treatment options (radiation, surgery, radio-chemotherapy) are of limited value. Most patients go blind and die within 1 or 2 years.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I.
Johannes Seitz - One of the best experts on this subject based on the ideXlab platform.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's Archive for Clinical and Experimental Ophthalmology, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I. Case report A 61-year-old woman presented with rapidly progressing right vision loss, lower altitudinal visual field defect and papilloedema. MRI showed intraorbital and intracranial swelling of the right Optic Nerve. Resection of the intracranial part of the right Optic Nerve up to the chiasm revealed anaplastic astrocytoma grade III. Within 1 year, the patient died of leptomeningeal metastasis despite radiotherapy. Clinical and MRI evaluation of the left eye and Optic Nerve were normal at all times. Discussion Unilateral adult malignant Glioma of the Optic Nerve is exceptional. The final diagnosis was only confirmed by Optic Nerve biopsy. In the literature, only one patient has been reported with a unilateral tumour manifestation; he was lost to follow-up 3 months later. All other cases were bilateral. To date, 44 case reports of adult malignant Optic Nerve Glioma have been published, either malignant astrocytoma or glioblastoma. These tumours can mimic Optic neuritis in their initial presentation. The diagnosis is seldom made before craniotomy. On MRI images, malignant Glioma cannot be distinguished from Optic Nerve enlargement due to other causes. Although radiotherapy appears to prolong life expectancy, all presently available treatment options (radiation, surgery, radio-chemotherapy) are of limited value. Most patients go blind and die within 1 or 2 years.
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Unilateral adult malignant Optic Nerve Glioma
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2004Co-Authors: Bettina Wabbels, Anke Demmler, Johannes Seitz, Matthias Woenckhaus, Heinz-georg Bloß, Birgit LorenzAbstract:Introduction Adult malignant Optic Nerve Gliomas are rare and rapidly fatal visual pathway tumours. They represent a clinical entity different from the more common childhood benign Optic Nerve Gliomas, which are frequently associated with neurofibromatosis I.