The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
C Garry - One of the best experts on this subject based on the ideXlab platform.
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igg4 related Orbit Disease an unusual cause of an Orbital mass
The Medical journal of Malaysia, 2018Co-Authors: V A Chidambaram, Anita Csy, C Robert, C GarryAbstract:IgG4-related Disease is a newly described systemic autoimmune and allergic Disease, characterized histologically by a fibroinflammatory response with IgG4 plasma cells. It was initially described as affecting the pancreas, but commonly involves the head and neck region as well. While a biopsy is essential for definitive diagnosis, cross sectional imaging may be the initial modality which may suggest this entity. We describe a case of pathologically proven IgG4 related Disease which highlights some key radiologic features seen in this entity. Our case highlights some key radiological features of IgG4- related Disease in the head and neck, with involvement of the lacrimal glands, pituitary gland and cranial nerves on CT.
V A Chidambaram - One of the best experts on this subject based on the ideXlab platform.
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igg4 related Orbit Disease an unusual cause of an Orbital mass
The Medical journal of Malaysia, 2018Co-Authors: V A Chidambaram, Anita Csy, C Robert, C GarryAbstract:IgG4-related Disease is a newly described systemic autoimmune and allergic Disease, characterized histologically by a fibroinflammatory response with IgG4 plasma cells. It was initially described as affecting the pancreas, but commonly involves the head and neck region as well. While a biopsy is essential for definitive diagnosis, cross sectional imaging may be the initial modality which may suggest this entity. We describe a case of pathologically proven IgG4 related Disease which highlights some key radiologic features seen in this entity. Our case highlights some key radiological features of IgG4- related Disease in the head and neck, with involvement of the lacrimal glands, pituitary gland and cranial nerves on CT.
таскина елизавета сергеевна - One of the best experts on this subject based on the ideXlab platform.
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the role of interleukins 17 23 and antibodies to the thyroid stimulating hormone receptor in the pathogenesis of endocrine ophthalmopathy
Clinical and experimental thyroidology, 2018Co-Authors: Svetlana V Charinzeva, Elizaveta S Taskina, харинцева светлана владимировна, таскина елизавета сергеевнаAbstract:Background. Endocrine ophthalmopathy (EOP) is an autoimmune Orbit Disease characterized by soft retrobulbar tissues damage. The level of antibodies to the thyroid-stimulating hormone receptor (TSHRAbs) is considered as a laboratory marker of EOP activity. Interleukins 17 (IL-17) and 23 (IL-23) play an important role in the pathogenesis of some autoimmune Diseases and directly correlate with clinical activity. At present, there is an open question about the role of these cytokines in EOP and their relationship with TSHRAbs. Aims. To assess pathogenetic role of IL-17, IL-23 and TSHRAbs in patients with EOP. Materials and methods. The study included 50 people (100 eyes) at the age of 43 [35; 50] years. Three study groups were formed: 32 patients with moderate severity of EOP (clinical group), 18 patients with thyroid pathology without EOP (comparison group) and 15 healthy subjects (control group). All groups were comparable in age and sex. The diagnosis was verified clinically, laboratory and instrumentally. A comprehensive ophthalmologic examination and blood sampling were performed to determine the concentrations of IL-17, IL-23 and TSHRAbs. Statistical processing of the data was carried out in the program “Statistica 10.0”, StatSoft, Inc. Results. An increase in the level of TSHRAbs was observed in all phases of EOP activity in comparison with both comparison group and control ( p < 0.05). But in the active phase TSHRAbs level reached the maximum values in 100% of patients. An increase in the IL-17 concentration in 5,3 times was found in the active EOP in comparison with the control group ( p < 0.05). Concentration of TSHRAbs and IL-17 in blood serum directly correlates with EOP activity ( p < 0.001). After carrying out pulse therapy with glucocorticosteroids, the consentration of IL-17 decreased almost to zero. There were no significant differences in the level of IL-23 in the groups ( p = 0.56). Conclusions. Determination of TSHRAbs and IL-17 levels in serum can be used as a laboratory diagnostic marker of EOP activity.
Anita Csy - One of the best experts on this subject based on the ideXlab platform.
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igg4 related Orbit Disease an unusual cause of an Orbital mass
The Medical journal of Malaysia, 2018Co-Authors: V A Chidambaram, Anita Csy, C Robert, C GarryAbstract:IgG4-related Disease is a newly described systemic autoimmune and allergic Disease, characterized histologically by a fibroinflammatory response with IgG4 plasma cells. It was initially described as affecting the pancreas, but commonly involves the head and neck region as well. While a biopsy is essential for definitive diagnosis, cross sectional imaging may be the initial modality which may suggest this entity. We describe a case of pathologically proven IgG4 related Disease which highlights some key radiologic features seen in this entity. Our case highlights some key radiological features of IgG4- related Disease in the head and neck, with involvement of the lacrimal glands, pituitary gland and cranial nerves on CT.
C Robert - One of the best experts on this subject based on the ideXlab platform.
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igg4 related Orbit Disease an unusual cause of an Orbital mass
The Medical journal of Malaysia, 2018Co-Authors: V A Chidambaram, Anita Csy, C Robert, C GarryAbstract:IgG4-related Disease is a newly described systemic autoimmune and allergic Disease, characterized histologically by a fibroinflammatory response with IgG4 plasma cells. It was initially described as affecting the pancreas, but commonly involves the head and neck region as well. While a biopsy is essential for definitive diagnosis, cross sectional imaging may be the initial modality which may suggest this entity. We describe a case of pathologically proven IgG4 related Disease which highlights some key radiologic features seen in this entity. Our case highlights some key radiological features of IgG4- related Disease in the head and neck, with involvement of the lacrimal glands, pituitary gland and cranial nerves on CT.