The Experts below are selected from a list of 725988 Experts worldwide ranked by ideXlab platform
Berit Olofsson - One of the best experts on this subject based on the ideXlab platform.
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hypervalent iodine reagents in the total synthesis of natural products
Natural Product Reports, 2011Co-Authors: Luiz F Silva, Berit OlofssonAbstract:Covering: 2008–2010 This report describes the recent applications of hypervalent iodine reagents in the total synthesis of natural products. The large diversity of high-yielding and chemoselective reactions that can be achieved, even for highly functionalized molecules, is summarized, demonstrating that hypervalent iodine reagents have become an essential tool in synthetic Organic Chemistry.
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hypervalent iodine reagents in the total synthesis of natural products
Natural Product Reports, 2011Co-Authors: Luiz F Silva, Berit OlofssonAbstract:This report describes the recent applications of hypervalent iodine reagents in the total synthesis of natural products. The large diversity of high-yielding and chemoselective reactions that can be achieved, even for highly functionalized molecules, is summarized, demonstrating that hypervalent iodine reagents have become an essential tool in synthetic Organic Chemistry.
Manfred T Reetz - One of the best experts on this subject based on the ideXlab platform.
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statistical analysis of the benefits of focused saturation mutagenesis in directed evolution based on reduced amino acid alphabets
ACS Catalysis, 2019Co-Authors: Aitao Li, Manfred T Reetz, Ge QuAbstract:Directed evolution of stereo-, regio-, and chemoselective enzymes has enriched the toolbox of synthetic Organic Chemistry. Among the different gene mutagenesis techniques, saturation mutagenesis (S...
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directed evolution of artificial metalloenzymes a universal means to tune the selectivity of transition metal catalysts
Accounts of Chemical Research, 2019Co-Authors: Manfred T ReetzAbstract:ConspectusTransition metal catalysts mediate a wide variety of chemo-, stereo-, and regioselective transformations, and therefore play a pivotal role in modern synthetic Organic Chemistry. Steric and electronic effects of ligands provide Organic chemists with an exceedingly useful tool. More than four decades ago, chemists began to think about a different approach, namely, embedding achiral ligand/metal moieties covalently or noncovalently in protein hosts with formation of artificial metalloenzymes. While structurally fascinating, this approach led in each case only to a single (bio)catalyst, with its selectivity and activity being a matter of chance. In order to solve this fundamental problem, my group proposed in 2000–2002 the idea of directed evolution of artificial metalloenzymes. In earlier studies, we had already demonstrated that directed evolution of enzymes constitutes a viable method for enhancing and inverting the stereoselectivity of enzymes as catalysts in Organic Chemistry. We speculated th...
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biocatalysis in Organic Chemistry and biotechnology past present and future
Journal of the American Chemical Society, 2013Co-Authors: Manfred T ReetzAbstract:Enzymes as catalysts in synthetic Organic Chemistry gained importance in the latter half of the 20th century, but nevertheless suffered from two major limitations. First, many enzymes were not accessible in large enough quantities for practical applications. The advent of recombinant DNA technology changed this dramatically in the late 1970s. Second, many enzymes showed a narrow substrate scope, often poor stereo- and/or regioselectivity and/or insufficient stability under operating conditions. With the development of directed evolution beginning in the 1990s and continuing to the present day, all of these problems can be addressed and generally solved. The present Perspective focuses on these and other developments which have popularized enzymes as part of the toolkit of synthetic Organic chemists and biotechnologists. Included is a discussion of the scope and limitation of cascade reactions using enzyme mixtures in vitro and of metabolic engineering of pathways in cells as factories for the production o...
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laboratory evolution of stereoselective enzymes a prolific source of catalysts for asymmetric reactions
Angewandte Chemie, 2011Co-Authors: Manfred T ReetzAbstract:: Asymmetric catalysis plays a key role in modern synthetic Organic Chemistry, with synthetic catalysts and enzymes being the two available options. During the latter part of the last century the use of enzymes in Organic Chemistry and biotechnology experienced a period of rapid growth. However, these biocatalysts have traditionally suffered from several limitations, including in many cases limited substrate scope, poor enantioselectivity, insufficient stability, and sometimes product inhibition. During the last 15 years, the genetic technique of directed evolution has been developed to such an extent that all of these long-standing problems can be addressed and solved. It is based on repeated cycles of gene mutagenesis, expression, and screening (or selection). This Review focuses on the directed evolution of enantioselective enzymes, which constitutes a fundamentally new approach to asymmetric catalysis. Emphasis is placed on the development of methods to make laboratory evolution faster and more efficient, thus providing chemists and biotechnologists with a rich and non-ending source of robust and selective catalysts for a variety of useful applications.
Stefan Matile - One of the best experts on this subject based on the ideXlab platform.
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cellular uptake lessons from supramolecular Organic Chemistry
Chemical Communications, 2015Co-Authors: Giulio Gasparini, Eunkyoung Bang, Javier Montenegro, Stefan MatileAbstract:The objective of this Feature Article is to reflect on the importance of established and emerging principles of supramolecular Organic Chemistry to address one of the most persistent problems in life sciences. The main topic is dynamic covalent Chemistry on cell surfaces, particularly disulfide exchange for thiol-mediated uptake. Examples of boronate and hydrazone exchange are added for contrast, comparison and completion. Of equal importance are the discussions of proximity effects in polyions and counterion hopping, and more recent highlights on ring tension and ion pair–π interactions. These lessons from supramolecular Organic Chemistry apply to cell-penetrating peptides, particularly the origin of “arginine magic” and the “pyrenebutyrate trick,” and the currently emerging complementary “disulfide magic” with cell-penetrating poly(disulfide)s. They further extend to the voltage gating of neuronal potassium channels, gene transfection, and the delivery of siRNA. The collected examples illustrate that the input from conceptually innovative Chemistry is essential to address the true challenges in biology beyond incremental progress and random screening.
Luiz F Silva - One of the best experts on this subject based on the ideXlab platform.
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hypervalent iodine reagents in the total synthesis of natural products
Natural Product Reports, 2011Co-Authors: Luiz F Silva, Berit OlofssonAbstract:Covering: 2008–2010 This report describes the recent applications of hypervalent iodine reagents in the total synthesis of natural products. The large diversity of high-yielding and chemoselective reactions that can be achieved, even for highly functionalized molecules, is summarized, demonstrating that hypervalent iodine reagents have become an essential tool in synthetic Organic Chemistry.
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hypervalent iodine reagents in the total synthesis of natural products
Natural Product Reports, 2011Co-Authors: Luiz F Silva, Berit OlofssonAbstract:This report describes the recent applications of hypervalent iodine reagents in the total synthesis of natural products. The large diversity of high-yielding and chemoselective reactions that can be achieved, even for highly functionalized molecules, is summarized, demonstrating that hypervalent iodine reagents have become an essential tool in synthetic Organic Chemistry.
Dean J Tantillo - One of the best experts on this subject based on the ideXlab platform.
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walking in the woods with quantum Chemistry applications of quantum chemical calculations in natural products research
Natural Product Reports, 2013Co-Authors: Dean J TantilloAbstract:Covering: up to March, 2013. This article was invited following the 2012 NPR Lectureship presented to Professor Dean Tantillo at the 21st IUPAC International Conference on Physical Organic Chemistry (ICPOC 21)This Highlight describes applications of quantum chemical calculations to problems in natural products Chemistry, including the elucidation of natural product structures (distinguishing between constitutional isomers, distinguishing between diastereomers, and assigning absolute configuration) and determination of reasonable mechanisms for their formation.
