The Experts below are selected from a list of 660 Experts worldwide ranked by ideXlab platform
Tom F. Lue - One of the best experts on this subject based on the ideXlab platform.
-
Ultrasonography for Evaluation of Impotence
Lower Genitourinary Radiology, 1998Co-Authors: Sansern Borirakchanyavat, Tom F. LueAbstract:Erectile dysfunction is defined as the inability to achieve or maintain adequate penile erection (or both) for satisfactory intercourse.1 In the United States it is estimated that approximately 10 million to 18 million men suffer from erectile dysfunction.2 Penile erection is a complex phenomenon involving precisely timed neurologic and vascular responses. Although in the past erectile dysfunction has been attributed to psychogenic causes or explained as a normal part of the aging process, we now know that an Organic etiology can be found to explain most cases of Impotence. Organic Impotence can be due to ȧ variety of causative factors including vascular, neurogenic, endocrinologic, and anatomic abnormalities. Vasculogenic Impotence is likely the most common cause of Organic Impotence.3–6
-
Congenital defect in sinusoidal smooth muscles: a cause of Organic Impotence.
The Journal of urology, 1992Co-Authors: Sherif R. Aboself, Laurence S. Baskin, T.s. Benedict Yen, Tom F. LueAbstract:We report 2 cases of primary Impotence due to a congenital defect in the compliance of the sinusoidal spaces secondary to fibrosis and atrophy of the smooth muscles. Both patients were young adults at presentation. Diagnosis of this rare entity was achieved by penile Doppler ultrasound and cavernosometry/cavernosography of the cavernous bodies. Both patients underwent placement of a penile prosthesis, during which biopsy samples of the cavernous tissue were obtained, and diagnosis was confirmed by light and electron microscopy.
A J Cooper - One of the best experts on this subject based on the ideXlab platform.
-
evaluation of i c papaverine in patients with psychogenic and Organic Impotence
The Canadian Journal of Psychiatry, 1991Co-Authors: A J CooperAbstract:: Forty men with Organic or psychogenic Impotence, who were highly motivated for treatment, were offered instruction in the intracavernosal (I-C) self-injection of papaverine and regular ongoing supervision by the investigator. Twenty declined immediately, citing a number of reasons, notably qualms about pain of the injection, side-effects and the unnaturalness of the method. Eleven patients discontinued the drug within 11 months; nine used it for at least one year, and all were continuing with it albeit less frequently at the time of assessment. Those who discontinued treatment differed significantly from those who did not; the latter initially used the drug less frequently (less than once per month), did not have a regular sexual partner or had a poor relationship with their sexual partner, and reported a decline in libido during use of the drug. The findings suggest that I-C papaverine, although effective in treating Impotence, is not a panacea, and a large percentage of users (55% in our study) are likely to discontinue the drug within a relatively short period of time.
G. Pozza - One of the best experts on this subject based on the ideXlab platform.
-
Clinical reliability of multi-drug intracavernous vasoactive pharmacotherapy for diabetic Impotence
Acta Diabetologica, 1994Co-Authors: Francesco Montorsi, Giorgio Guazzoni, Patrizio Rigatti, F. Bergamaschi, M. Zucconi, G. Pizzini, A. Miani, G. PozzaAbstract:The aim of this study was to assess the effectiveness and safety of intracavernous injections of a fourdrug vasoactive mixture in diabetic patients with Organic Impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic Impotence were treated with intracavernous injections of a combination of 12.1 mg/ml papaverine hydrochloride, 1.01 mg/ml phentolamine mesylate, 10.1 μg/ml prostaglandin E1 and 0.15 mg/ml atropine sulphate (‘full-dose’ mixture). A mixture of the same drugs but at one-third concentrations (‘reduced-dose” mixture) was also used. The mean (±SEM) volumes of the full-dose and reduced-dose mixtures used were 0.21±0.03 ml and 0.31±0.02 ml, respectively. All the patients were able to sustain a rigid erection at the end of the titration phase of the study. At a mean follow-up of 18 months, 48 patients (80%) were successfully using the mixture, 6 patients (10%) were using the mixture at a dose lower than the initial dose and 6 patients (10%) had dropped out from the injection therapy. No major complications were seen. The association of multiple vasoactive drugs which use different mechanisms of action, thus exerting a pharmacological synergism, is an effective and safe procedure in intracavernous pharmacotherapy for diabetic patients with Organic Impotence.
Cameron D Harris - One of the best experts on this subject based on the ideXlab platform.
-
comparison of rigiscan and sleep laboratory nocturnal penile tumescence in the diagnosis of Organic Impotence
The Journal of Urology, 1995Co-Authors: Mark R Licht, Peter C. Wollan, Ronald W. Lewis, Cameron D HarrisAbstract:AbstractPurpose: We evaluated the relative use of RigiScan* *Dacomed, Minneapolis, Minnesota. measurement of radial rigidity compared to sleep laboratory measurement of axial rigidity and trained observer determination of erectile function in the diagnosis of Organic Impotence.Materials and Methods: A total of 28 patients underwent simultaneous 2-night formal sleep laboratory nocturnal penile tumescence and RigiScan monitoring. Standard normal values for radial rigidity and axial rigidity were tested for accuracy in predicting normal nocturnal penile tumescence compared to trained observer determination of the adequacy of an erection for penetration.Results: RigiScan tip measurements correlated poorly with buckling pressure, while base measurements strongly correlated (p = 0.0005). Observer determination of a functional erection was strongly associated with tip (p = 0.002), base (p = 0.0005) and buckling pressure measurements (p = 0.0005). Using observer determination as the gold standard receiver operati...
Francesco Montorsi - One of the best experts on this subject based on the ideXlab platform.
-
The predictive usefulness of age and kind of onset in discriminating psychogenic from Organic Impotence
Sexuality and Disability, 1994Co-Authors: Stefano Clerici, Giorgio Guazzoni, Alvise Orlandini, Patrizio Rigatti, Andrea Fossati, Francesco Montorsi, Cesare MaffeiAbstract:It is well known in clinical practice that psychogenic Impotence affects younger patients than Organic Impotence and with a more acute onset. In the present study the authors evaluated the predictive usefulness and discriminating power of the following sociodemographic and clinical variables: age, kind of onset (acute or gradual), civil status, number of partners, duration of illness. The sample was made of 133 patients suffering from erectile dysfunction for at least three months, consecutively admitted to the Multidisciplinary Centre for the Diagnosis and Treatment of Impotence of the Scientific Institute San Raffaele of Milan from May 1992 to April 1993. All patients underwent a thorough clinical and laboratory evaluation: 72 (54.5%) were psychogenic (mean age 42.6±11.2); 60 (45.5%) Organic (mean age 56.3±9.8). Stepwise logistic regression model identified age and kind of onset as significant predictors of kind of Impotence. According to the logistic regression classification table, sensitivity for psychogenic Impotence was 778, specificity was. 750, positive predictive power was .789, and negative predictive power was .738. These results indicate that age and kind of onset proved to be significant predictors of psychogenic Impotence and to have a good clinical functioning as both inclusion and exclusion criteria. These results suggest that a patient in his forties and with an acute onset of Impotence should be firstly assessed from a psychological point of view; and on the opposite, a 50 year old patient with a gradual onset presents a rationale for a thorough clinical evaluation.
-
Clinical reliability of multi-drug intracavernous vasoactive pharmacotherapy for diabetic Impotence
Acta Diabetologica, 1994Co-Authors: Francesco Montorsi, Giorgio Guazzoni, Patrizio Rigatti, F. Bergamaschi, M. Zucconi, G. Pizzini, A. Miani, G. PozzaAbstract:The aim of this study was to assess the effectiveness and safety of intracavernous injections of a fourdrug vasoactive mixture in diabetic patients with Organic Impotence. A group of 60 diabetic patients with either pure neurogenic, pure vasculogenic or mixed neurovasculogenic Impotence were treated with intracavernous injections of a combination of 12.1 mg/ml papaverine hydrochloride, 1.01 mg/ml phentolamine mesylate, 10.1 μg/ml prostaglandin E1 and 0.15 mg/ml atropine sulphate (‘full-dose’ mixture). A mixture of the same drugs but at one-third concentrations (‘reduced-dose” mixture) was also used. The mean (±SEM) volumes of the full-dose and reduced-dose mixtures used were 0.21±0.03 ml and 0.31±0.02 ml, respectively. All the patients were able to sustain a rigid erection at the end of the titration phase of the study. At a mean follow-up of 18 months, 48 patients (80%) were successfully using the mixture, 6 patients (10%) were using the mixture at a dose lower than the initial dose and 6 patients (10%) had dropped out from the injection therapy. No major complications were seen. The association of multiple vasoactive drugs which use different mechanisms of action, thus exerting a pharmacological synergism, is an effective and safe procedure in intracavernous pharmacotherapy for diabetic patients with Organic Impotence.