The Experts below are selected from a list of 120 Experts worldwide ranked by ideXlab platform
David Goldberg - One of the best experts on this subject based on the ideXlab platform.
-
somatization in cross cultural perspective a world health Organization Study in primary care
American Journal of Psychiatry, 1997Co-Authors: Oye Gureje, Gregory E Simon, Tevfik B Ustun, David GoldbergAbstract:Objective: The purpose of this Study was to examine the phenomenon of somatization in different cultures by determining its frequency and correlates in primary care settings in 14 countries. Method: Consecutive primary care patients (N=25,916) were screened with the 12-item General Health Questionnaire, and a stratified sample (N=5,438) was interviewed with the Composite International Diagnostic Interview. Interviewed patients were also assessed for physical disease burden, self-rated overall health, physician-rated physical health status, number of disability days, and interviewer-rated occupational role functioning. The authors determined center-specific associations with the rise of logistic regression analyses in which confounding variables were controlled. Results: ICD-10-defined somatization disorder was relatively uncommon in most primary care settings. A less restrictively defined form was more common. Symptom rates were much higher in the South American sites. There was a modest association with low education. Otherwise, frequency of unexplained somatic symptoms did not clearly vary according to geography or level of economic development. Somatiz-ing patients were at elevated risk for self-reported disease burden, negative perception of their health, and comorbid depression and generalized anxiety disorder. Somatization was also commonly associated with disability. Cultures did not differ markedly in the pattern of these associated features. Conclusions: Somatization is a common problem in primary care across cultures and is associated with significant health problems and disability.
Kiyoshi Migita - One of the best experts on this subject based on the ideXlab platform.
-
anti gp210 and anti centromere antibodies are different risk factors for the progression of primary biliary cirrhosis
Hepatology, 2007Co-Authors: Minoru Nakamura, Hisayoshi Kondo, Tsuyoshi Mori, Atsumasa Komori, Mutsumi Matsuyama, Masahiro Ito, Yasushi Takii, Makiko Koyabu, Terufumi Yokoyama, Kiyoshi MigitaAbstract:The predictive role of antinuclear antibodies (ANAs) remains elusive in the long-term outcome of primary biliary cirrhosis (PBC). The progression of PBC was evaluated in association with ANAs using stepwise Cox proportional hazard regression and an unconditional stepwise logistic regression model based on the data of 276 biopsy-proven, definite PBC patients who have been registered to the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ). When death of hepatic failure/liver transplantation (LT) was defined as an end-point, positive anti-gp210 antibodies (Hazard ratio (HR) = 6.742, 95% confidence interval (CI): 2.408, 18.877), the late stage (Scheuer's stage 3, 4) (HR = 4.285, 95% CI:1.682,10.913) and male sex (HR = 3.266, 95% CI: 1.321,8.075) were significant risk factors at the time of initial liver biopsy. When clinical progression to death of hepatic failure/LT (i.e., hepatic failure type progression) or to the development of esophageal varices or hepatocellular carcinoma without developing jaundice (Total bilirubin < 1.5 mg/dL) (i.e., portal hypertension type progression) was defined as an end-point in the early stage (Scheuer's stage 1, 2) PBC patients, positive anti-gp210 antibodies was a significant risk factor for hepatic failure type progression [odds ratio (OR) = 33.777, 95% CI: 5.930, 636.745], whereas positive anti-centromere antibodies was a significant risk factor for portal hypertension type progression (OR = 4.202, 95% CI: 1.307, 14.763). Histologically, positive anti-gp210 antibodies was most significantly associated with more severe interface hepatitis and lobular inflammation, whereas positive anticentromere antibodies was most significantly associated with more severe ductular reaction. Conclusion: These results indicate 2 different progression types in PBC, hepatic failure type and portal hypertension type progression, which may be represented by positive-anti-gp210 and positive-anticentromere antibodies, respectively. (HEPATOLOGY 2007;45:118–127.)
-
Anti‐gp210 and anti‐centromere antibodies are different risk factors for the progression of primary biliary cirrhosis
Hepatology (Baltimore Md.), 2006Co-Authors: Minoru Nakamura, Hisayoshi Kondo, Tsuyoshi Mori, Atsumasa Komori, Mutsumi Matsuyama, Masahiro Ito, Yasushi Takii, Makiko Koyabu, Terufumi Yokoyama, Kiyoshi MigitaAbstract:The predictive role of antinuclear antibodies (ANAs) remains elusive in the long-term outcome of primary biliary cirrhosis (PBC). The progression of PBC was evaluated in association with ANAs using stepwise Cox proportional hazard regression and an unconditional stepwise logistic regression model based on the data of 276 biopsy-proven, definite PBC patients who have been registered to the National Hospital Organization Study Group for Liver Disease in Japan (NHOSLJ). When death of hepatic failure/liver transplantation (LT) was defined as an end-point, positive anti-gp210 antibodies (Hazard ratio (HR) = 6.742, 95% confidence interval (CI): 2.408, 18.877), the late stage (Scheuer's stage 3, 4) (HR = 4.285, 95% CI:1.682,10.913) and male sex (HR = 3.266, 95% CI: 1.321,8.075) were significant risk factors at the time of initial liver biopsy. When clinical progression to death of hepatic failure/LT (i.e., hepatic failure type progression) or to the development of esophageal varices or hepatocellular carcinoma without developing jaundice (Total bilirubin < 1.5 mg/dL) (i.e., portal hypertension type progression) was defined as an end-point in the early stage (Scheuer's stage 1, 2) PBC patients, positive anti-gp210 antibodies was a significant risk factor for hepatic failure type progression [odds ratio (OR) = 33.777, 95% CI: 5.930, 636.745], whereas positive anti-centromere antibodies was a significant risk factor for portal hypertension type progression (OR = 4.202, 95% CI: 1.307, 14.763). Histologically, positive anti-gp210 antibodies was most significantly associated with more severe interface hepatitis and lobular inflammation, whereas positive anticentromere antibodies was most significantly associated with more severe ductular reaction. Conclusion: These results indicate 2 different progression types in PBC, hepatic failure type and portal hypertension type progression, which may be represented by positive-anti-gp210 and positive-anticentromere antibodies, respectively. (HEPATOLOGY 2007;45:118–127.)
Muhammad Ismail - One of the best experts on this subject based on the ideXlab platform.
-
World Allergy Organization Study on Aerobiology for Creating First Pollen and Mold Calendar With Clinical Significance in Islamabad, Pakistan; A Project of World Allergy Organization and Pakistan Allergy, Asthma & Clinical Immunology Centre of Islama
World Allergy Organization Journal, 2012Co-Authors: Shahid Abbas, Connie H. Katelaris, Anand B. Singh, Syed M. Raza, Mir Ajab Khan, Muhammad Rashid, Maryam Abbas, Muhammad IsmailAbstract:Pollen and mold allergies are highly problematic in Islamabad. This Study was conducted to investigate the type and concentration of airborne pollens/molds causing allergic diseases in susceptible individuals. A volumetric spore trap (Burkard) was placed at the height of 11 m and ran continuously for 3 years. Once a week, the collecting drum was prepared by affixing Melinex tape with a double sided adhesive that was coated with a thin layer of silicone grease. Every Sunday at 9:00 AM the drum was replaced by another drum and the pollen/mold spores were removed and permanently mounted on slides. Using a microscope, the trapped particles were identified and recorded as counts per cubic meter of air per hour. From these data, the pollen and mold calendars were constructed and expressed as counts per cubic meter of air per day. Skin prick tests were performed on more than 1000 patients attending the Pakistan Allergy, Asthma & Clinical Immunology Centre of Islamabad. The results indicated that there were 2 main pollen plants that contributed to seasonal allergies. These were Broussonetia papyrifera and Cannabis sativa during the March/April season and the July/September season, respectively. Although mold spores were continuously detected throughout the year, the most prominent mold was undetected mold and unconfirmed mold species similar to Stachybotrys species, which was high from July to September/October. Two additional molds contributing to allergic reactions were Pithomyces species and Cladosporium species, which were active during January and April, with the latter also being detected between October and November. These results may prove beneficial to both patients and physicians in planning a therapeutic protocol for avoidance and amelioration.
H Mohammed - One of the best experts on this subject based on the ideXlab platform.
-
A cross-industry assessment of the flow rate-time profiles of test equipment typically used for dry-powder inhaler (DPI) testing:: Part 2 –analysis of transient air flow in the testing of DPIs with compendial cascade impactors
2020Co-Authors: Hendrik Versteeg, F Chambers, Dl Roberts, A Cooper, M Copley, Jp Mitchell, H MohammedAbstract:We describe a computational model that captures the physics of the unsteady airflow start-up that accompanies the testing of dry-powder inhalers (DPI) with cascade impactors (CIs) specifically when following methods described in the pharmacopeial compendia. This transient has been measured in a multi-Organization Study for a wide range of conditions and reported in a companion article. The DPI test system is simulated as a series of flow resistances, starting with the inhaler itself, including each stage of the CI, and finishing with the prescribed flow control valve, wherein the flow is held at sonic Accepted Manuscript m SA Kingdom ited Kingdom Kingdom ted Kingdom Kingdom c., London, Ontari , United Kingdom nited Kingd @gmail.com gmail.comMJolyo ondon, ON, Canad , C be a computationa omputatio up that accompan that accom ctors (CIs) specifi ors (CIs) spe ia. This a velocity. The resulting non-dimensional equations indicate the relative importance of the several flow resistances. The model agrees well with the available experimental data for the Next Generation Impactor (NGI™) and qualitatively with the available data from a variety of the configurations of the Andersen 8-stage cascade impactor (ACI), including the typical 4-kPa pressure drop across an entry fixed orifice mimicking surrogate low-, medium- and high-resistance DPIs. The model indicates that the start-up times for the NGI and for the ACI are very reasonably estimated by a simple “reference time,” given in equation (26) and, for an inlet flow rate of 60 L/min, having a value of 277 ms and 113 ms for the NGI and ACI (60-L/min configuration), respectively. The model also enables a baseline, universal design curve for the flow rise-time performance of testing DPIs with the NGI (Figures 9a,b), because this impactor requires no change of components for any inlet flow rate
-
A cross-industry assessment of the flow rate-elapsed time profiles of test equipment typically used for dry-powder inhaler (DPI) testing: Part 2– analysis of transient air flow in the testing of DPIs with compendial cascade impactors
2020Co-Authors: Hendrik Versteeg, F Chambers, Dl Roberts, A Cooper, M Copley, Jp Mitchell, H MohammedAbstract:We describe a computational model that captures the physics of the unsteady airflow start-up that accompanies the testing of dry-powder inhalers (DPI) with cascade impactors (CIs) specifically when following methods described in the pharmacopeial compendia. This transient has been measured in a multi-Organization Study for a wide range of conditions and reported in a companion article. The DPI test system is simulated as a series of flow resistances, starting with the inhaler itself, including each stage of the CI, and finishing with the prescribed flow control valve, wherein the flow is held at sonic Accepted Manuscript m SA Kingdom ited Kingdom Kingdom ted Kingdom Kingdom c., London, Ontari , United Kingdom nited Kingd @gmail.com gmail.comMJolyo ondon, ON, Canad , C be a computationa omputatio up that accompan that accom ctors (CIs) specifi ors (CIs) spe ia. This a velocity. The resulting non-dimensional equations indicate the relative importance of the several flow resistances. The model agrees well with the available experimental data for the Next Generation Impactor (NGI™) and qualitatively with the available data from a variety of the configurations of the Andersen 8-stage cascade impactor (ACI), including the typical 4-kPa pressure drop across an entry fixed orifice mimicking surrogate low-, medium- and high-resistance DPIs. The model indicates that the start-up times for the NGI and for the ACI are very reasonably estimated by a simple “reference time,” given in equation (26) and, for an inlet flow rate of 60 L/min, having a value of 277 ms and 113 ms for the NGI and ACI (60-L/min configuration), respectively. The model also enables a baseline, universal design curve for the flow rise-time performance of testing DPIs with the NGI (Figures 9a,b), because this impactor requires no change of components for any inlet flow rate
Susanne Täuber - One of the best experts on this subject based on the ideXlab platform.
-
The Challenge of Merging: Merger Patterns, Premerger Status, and Merger Support
Personality & social psychology bulletin, 2006Co-Authors: Steffen R. Giessner, G. Tendayi Viki, Sabine Otten, Deborah J. Terry, Susanne TäuberAbstract:Employees of merging Organizations often show resistance to the merger. The employees' support depends on the companies' premerger status and on the merger pattern. Based on an inter-group perspective, three studies were conducted to investigate the influence of premerger status (high, low) and merger pattern (assimilation, integration-equality, integration-proportionality, transformation) on participants' support for a pending Organizational merger Students (Study 1) and employees (Study 2) had to take the perspective of employees of a fictitious merging Organization. Study 3 investigated students' perceptions of a potentially pending university merger using a 2 (status) x 3 (merger pattern: assimilation, integration-equality, integration-proportionality) design. Across all studies, the low-status group favored integration-equality and transformation whereas the high-status group preferred integration-proportionality and assimilation. Perceived threat mediated the effects. Legitimacy was a stronger mediator for effects of the low-status group.