The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Robert H Poppenga - One of the best experts on this subject based on the ideXlab platform.
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an outbreak of sodium fluoroacetate 1080 intoxication in selenium and copper deficient sheep in california
Veterinary Pathology, 2013Co-Authors: Federico Giannitti, Mark L Anderson, S G Caspe, Asli Mete, Nancy East, M Mostrom, Robert H PoppengaAbstract:Sodium fluoroacetate is an Organofluorine Compound toxic to mammals, insects, and birds, currently registered for use only in livestock protection collars as a predacide in some North American states, with restricted use in California. A flock of 445 lambs and ewes in California were moved into a native pasture on a municipal refuse disposal site. Within 24 hours, 14 ewes were found dead, and the remaining sheep were moved off the site. Both ewes and lambs exhibited disoriented running, followed by apparent blindness, weakness, ataxia, coma, and death. Over the next 4 days, 63 ewes and 80 lambs died with a peak at 3 days after grazing the suspect pasture (157/445, 35% mortality). Two dead 4-month-old lambs and 2 ewes were submitted to the California Animal Health and Food Safety laboratory for necropsy. Grossly, there were bilateral diffuse pulmonary congestion and edema, hydrothorax and hydropericardium with fibrin clots, and multifocally extensive areas of epicardial petechiae, ecchymoses, and pallor. In 1 ewe, there was regional caudodorsal pulmonary hemorrhage and intraluminal tracheal clotted blood. Microscopically in all cases, there was multifocal acute myocardial degeneration and necrosis with nonsuppurative pleocellular myocarditis. Sodium fluoroacetate was detected in kidney from a lamb and a ewe at 27.5 and 12.5 parts per billion, respectively. All sheep were selenium deficient, and concurrent copper deficiency was diagnosed in 3. The pathological and toxicological findings were consistent with 1080 poisoning, possibly exacerbated by micronutrient deficiency. This outbreak raised an alert about the use of restricted products with potential lethal effect in animals in California.
Poppenga R. - One of the best experts on this subject based on the ideXlab platform.
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An Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in California
'SAGE Publications', 2013Co-Authors: Giannitti Federico, Anderson Mark, Caspe, Sergio Gaston, Mete A., East N.e., Mostrom M., Poppenga R.Abstract:Sodium fluoroacetate is an Organofluorine Compound toxic to mammals, insects, and birds, currently registered for use only in livestock protection collars as a predacide in some North American states, with restricted use in California. A flock of 445 lambs and ewes in California were moved into a native pasture on a municipal refuse disposal site. Within 24 hours, 14 ewes were found dead, and the remaining sheep were moved off the site. Both ewes and lambs exhibited disoriented running, followed by apparent blindness, weakness, ataxia, coma, and death. Over the next 4 days, 63 ewes and 80 lambs died with a peak at 3 days after grazing the suspect pasture (157/445, 35% mortality). Two dead 4-month-old lambs and 2 ewes were submitted to the California Animal Health and Food Safety laboratory for necropsy. Grossly, there were bilateral diffuse pulmonary congestion and edema, hydrothorax and hydropericardium with fibrin clots, and multifocally extensive areas of epicardial petechiae, ecchymoses, and pallor. In 1 ewe, there was regional caudodorsal pulmonary hemorrhage and intraluminal tracheal clotted blood. Microscopically in all cases, there was multifocal acute myocardial degeneration and necrosis with nonsuppurative pleocellular myocarditis. Sodium fluoroacetate was detected in kidney from a lamb and a ewe at 27.5 and 12.5 parts per billion, respectively. All sheep were selenium deficient, and concurrent copper deficiency was diagnosed in 3. The pathological and toxicological findings were consistent with 1080 poisoning, possibly exacerbated by micronutrient deficiency. This outbreak raised an alert about the use of restricted products with potential lethal effect in animals in California.EEA MercedesFil: Giannitti, Federico. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: Anderson, Mark. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Mete, A. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: East, N.E. University of California. School of Veterinary Medicine; Estados UnidosFil: Mostrom, M. North Dakota State University. Veterinary Diagnostic Laboratory; Estados UnidosFil: Poppenga, R. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados Unido
Federico Giannitti - One of the best experts on this subject based on the ideXlab platform.
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an outbreak of sodium fluoroacetate 1080 intoxication in selenium and copper deficient sheep in california
Veterinary Pathology, 2013Co-Authors: Federico Giannitti, Mark L Anderson, S G Caspe, Asli Mete, Nancy East, M Mostrom, Robert H PoppengaAbstract:Sodium fluoroacetate is an Organofluorine Compound toxic to mammals, insects, and birds, currently registered for use only in livestock protection collars as a predacide in some North American states, with restricted use in California. A flock of 445 lambs and ewes in California were moved into a native pasture on a municipal refuse disposal site. Within 24 hours, 14 ewes were found dead, and the remaining sheep were moved off the site. Both ewes and lambs exhibited disoriented running, followed by apparent blindness, weakness, ataxia, coma, and death. Over the next 4 days, 63 ewes and 80 lambs died with a peak at 3 days after grazing the suspect pasture (157/445, 35% mortality). Two dead 4-month-old lambs and 2 ewes were submitted to the California Animal Health and Food Safety laboratory for necropsy. Grossly, there were bilateral diffuse pulmonary congestion and edema, hydrothorax and hydropericardium with fibrin clots, and multifocally extensive areas of epicardial petechiae, ecchymoses, and pallor. In 1 ewe, there was regional caudodorsal pulmonary hemorrhage and intraluminal tracheal clotted blood. Microscopically in all cases, there was multifocal acute myocardial degeneration and necrosis with nonsuppurative pleocellular myocarditis. Sodium fluoroacetate was detected in kidney from a lamb and a ewe at 27.5 and 12.5 parts per billion, respectively. All sheep were selenium deficient, and concurrent copper deficiency was diagnosed in 3. The pathological and toxicological findings were consistent with 1080 poisoning, possibly exacerbated by micronutrient deficiency. This outbreak raised an alert about the use of restricted products with potential lethal effect in animals in California.
Giannitti Federico - One of the best experts on this subject based on the ideXlab platform.
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An Outbreak of Sodium Fluoroacetate (1080) Intoxication in Selenium- and Copper-Deficient Sheep in California
'SAGE Publications', 2013Co-Authors: Giannitti Federico, Anderson Mark, Caspe, Sergio Gaston, Mete A., East N.e., Mostrom M., Poppenga R.Abstract:Sodium fluoroacetate is an Organofluorine Compound toxic to mammals, insects, and birds, currently registered for use only in livestock protection collars as a predacide in some North American states, with restricted use in California. A flock of 445 lambs and ewes in California were moved into a native pasture on a municipal refuse disposal site. Within 24 hours, 14 ewes were found dead, and the remaining sheep were moved off the site. Both ewes and lambs exhibited disoriented running, followed by apparent blindness, weakness, ataxia, coma, and death. Over the next 4 days, 63 ewes and 80 lambs died with a peak at 3 days after grazing the suspect pasture (157/445, 35% mortality). Two dead 4-month-old lambs and 2 ewes were submitted to the California Animal Health and Food Safety laboratory for necropsy. Grossly, there were bilateral diffuse pulmonary congestion and edema, hydrothorax and hydropericardium with fibrin clots, and multifocally extensive areas of epicardial petechiae, ecchymoses, and pallor. In 1 ewe, there was regional caudodorsal pulmonary hemorrhage and intraluminal tracheal clotted blood. Microscopically in all cases, there was multifocal acute myocardial degeneration and necrosis with nonsuppurative pleocellular myocarditis. Sodium fluoroacetate was detected in kidney from a lamb and a ewe at 27.5 and 12.5 parts per billion, respectively. All sheep were selenium deficient, and concurrent copper deficiency was diagnosed in 3. The pathological and toxicological findings were consistent with 1080 poisoning, possibly exacerbated by micronutrient deficiency. This outbreak raised an alert about the use of restricted products with potential lethal effect in animals in California.EEA MercedesFil: Giannitti, Federico. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: Anderson, Mark. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: Caspe, Sergio Gaston. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Mercedes; ArgentinaFil: Mete, A. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados UnidosFil: East, N.E. University of California. School of Veterinary Medicine; Estados UnidosFil: Mostrom, M. North Dakota State University. Veterinary Diagnostic Laboratory; Estados UnidosFil: Poppenga, R. University of California. School of Veterinary Medicine. California Animal Health and Food Safety Laboratory System; Estados Unido
Jean-françois Paquin - One of the best experts on this subject based on the ideXlab platform.
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Triol-promoted activation of C–F bonds: Amination of benzylic fluorides under highly concentrated conditions mediated by 1,1,1-tris(hydroxymethyl)propane
Beilstein-Institut, 2013Co-Authors: Pier Alexandre Champagne, Alexandre Saint-martin, Mélina Drouin, Jean-françois PaquinAbstract:Activation of the C–F bond of benzylic fluorides was achieved using 1,1,1-tris(hydroxymethyl)propane (2) as a hydrogen bond-donating agent. Investigations demonstrated that hydrogen bond-donating solvents are promoting the activation and hydrogen bond-accepting ones are hindering it. However, the reaction is best run under highly concentrated conditions, where solvents cannot interfere with the interaction between the Organofluorine Compound and the triol. Various benzylic fluorides react with secondary amines or anilines to form benzylic amines in good yields