The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Eberhard W. Neuse - One of the best experts on this subject based on the ideXlab platform.
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Macromolecular Conjugates of Methotrexate, Ferrocene and Platinum in Cancer Chemotherapy
Journal of Inorganic and Organometallic Polymers and Materials, 2012Co-Authors: Alain I. Mufula, Eberhard W. NeuseAbstract:Most of the polyaspartamide carrier polymers synthesized in this program, were conjugated with methotrexate (MTX) and with Organoiron Compound (ferrocene), whereas other polyamides were conjugated with 1,2-diaminocyclohexanediaquaplatinum(II)dinitrate (DACH-Pt aq). The ferrocenylation agent throughout this project was 4-ferrocenylbutanoic acid. MTX and 4-ferrocenylbutanoic acid as well as folic acid were conjugated to pendant amino groups of various polyaspartamide carriers, through amidation reactions, via the HBTU-method. A very satisfactory degree of MTX and Fe were achieved. MTX content found was in range of 10–19% by mass, and Fe content found was in range of 6–13% by mass. The anchoring of platination agent (DACH-Pt aq) proceeded via well established methods involving dihydroxylato ligands. Pt content found was in the range of 6–8% by mass. Platinum incorporation was satisfactory.
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Polymeric Conjugates of Selected Aminoquinoline Derivatives as Potential Drug Adjuvants in Cancer Chemotherapy
Journal of Inorganic and Organometallic Polymers and Materials, 2011Co-Authors: Blessing A. Aderibigbe, Kayembe D. Jacques, Eberhard W. NeuseAbstract:In the chemotherapy of cancerous diseases, the clinical co-administration of an active anti-tumor drug with other Compounds acting as potentiating agents or adjuvants has demonstrated considerable merits in comparison with single-drug administration. Selected members of the 4- and 8-aminoquinoline-based class of antimalarials, such as chloroquine and hydroxychloroquine , have been identified as providers of such adjuvant effects in combination with certain standard antitumor drugs, although no significant clinical experiences have as yet been reported. The here described project aims at the synthesis of water-soluble macromolecular carriers to which selected aminoquinolines are bioreversibly conjugated together with cytotoxic drug species exemplified by a diaminoplatinum(II) complex and by the Organoiron Compound, ferrocene , the latter being a relative newcomer to the family of organometallic antineoplastic agents. As most medicinal agents differ from each other by their pharmacokinetic path and, therefore, experience different rates and degree of body distribution and organ accumulation, the simultaneous availability of two or more mutually potentiating drug species can best be achieved if a common transport vehicle, such as a multifunctional carrier polymer of the type synthesized in this study, is utilized for this purpose. The conjugates and co-conjugates, isolated by conventional methods as water-soluble solids, are compositionally characterized by NMR-spectroscopic and microanalytical techniques.
K Dey - One of the best experts on this subject based on the ideXlab platform.
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Reactions of Π-Allyltricarbonylhalogenoiron Complexes and Synthesis of New Organoiron Compounds
Indian National Science Academy, 2015Co-Authors: K DeyAbstract:Reactions of Π-Allyltricarbonylhalogenoiron Complexes and Synthesis of New Organoiron Compound
J. Pietrzak - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Mössbauer effect studies of low dimensional Organoiron Compound Fe(py)3Cl3·py
Inorganica Chimica Acta, 1991Co-Authors: M. Januszczyk, J. Janicki, H. Wojakowska, R. Krzyminiewski, J. PietrzakAbstract:Abstract The Fe(py)3Cl3·py complexes (where py is the pyridine molecule) of iron(III) have been prepared by the reaction of anhydrous ferric chloride with pyridine. Crystals of Fe(py)3Cl3·py may occur in two crystallographic systems: orthorhombic and monoclinic with the structural phase transition at a temperature close to 200 K. The obtained Mossbauer parameters of these complexes provide the possibility to determine the pyridine stoichiometry, electron spin and oxidation states of iron in single crystals.
M. Januszczyk - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Mössbauer effect studies of low dimensional Organoiron Compound Fe(py)3Cl3·py
Inorganica Chimica Acta, 1991Co-Authors: M. Januszczyk, J. Janicki, H. Wojakowska, R. Krzyminiewski, J. PietrzakAbstract:Abstract The Fe(py)3Cl3·py complexes (where py is the pyridine molecule) of iron(III) have been prepared by the reaction of anhydrous ferric chloride with pyridine. Crystals of Fe(py)3Cl3·py may occur in two crystallographic systems: orthorhombic and monoclinic with the structural phase transition at a temperature close to 200 K. The obtained Mossbauer parameters of these complexes provide the possibility to determine the pyridine stoichiometry, electron spin and oxidation states of iron in single crystals.
J. Janicki - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and Mössbauer effect studies of low dimensional Organoiron Compound Fe(py)3Cl3·py
Inorganica Chimica Acta, 1991Co-Authors: M. Januszczyk, J. Janicki, H. Wojakowska, R. Krzyminiewski, J. PietrzakAbstract:Abstract The Fe(py)3Cl3·py complexes (where py is the pyridine molecule) of iron(III) have been prepared by the reaction of anhydrous ferric chloride with pyridine. Crystals of Fe(py)3Cl3·py may occur in two crystallographic systems: orthorhombic and monoclinic with the structural phase transition at a temperature close to 200 K. The obtained Mossbauer parameters of these complexes provide the possibility to determine the pyridine stoichiometry, electron spin and oxidation states of iron in single crystals.