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Steven L Richardson - One of the best experts on this subject based on the ideXlab platform.
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searching for the vibrational signatures of the zn zn stretching mode in decamethyldizincocene zn2 η5 cp 2 the first Organometallic Compound with a metallic homonuclear zn zn bond
Chemical Physics Letters, 2005Co-Authors: Steven L Richardson, Tunna Baruah, Mark R PedersonAbstract:Decamethyldizincocene (Zn2(η5-Cp*)2) is the first example of a stable Organometallic Compound with a homonuclear metal Zn–Zn bond. Although its structural properties have been characterized by X-ray diffraction and high-resolution mass spectroscopy, it has been suggested that its experimental infrared and Raman spectra might not be particularly useful in identifying the Zn–Zn stretch mode in Zn2(η5-Cp*)2. We have used density-functional theory (DFT) to calculate both an infrared (IR) and Raman spectra for Zn2(η5-Cp*)2. In particular, our results clearly identify a number of low frequency Raman active modes wherein Zn–Zn twist and stretch modes are clearly identifiable.
Mark R Pederson - One of the best experts on this subject based on the ideXlab platform.
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searching for the vibrational signatures of the zn zn stretching mode in decamethyldizincocene zn2 η5 cp 2 the first Organometallic Compound with a metallic homonuclear zn zn bond
Chemical Physics Letters, 2005Co-Authors: Steven L Richardson, Tunna Baruah, Mark R PedersonAbstract:Decamethyldizincocene (Zn2(η5-Cp*)2) is the first example of a stable Organometallic Compound with a homonuclear metal Zn–Zn bond. Although its structural properties have been characterized by X-ray diffraction and high-resolution mass spectroscopy, it has been suggested that its experimental infrared and Raman spectra might not be particularly useful in identifying the Zn–Zn stretch mode in Zn2(η5-Cp*)2. We have used density-functional theory (DFT) to calculate both an infrared (IR) and Raman spectra for Zn2(η5-Cp*)2. In particular, our results clearly identify a number of low frequency Raman active modes wherein Zn–Zn twist and stretch modes are clearly identifiable.
Tunna Baruah - One of the best experts on this subject based on the ideXlab platform.
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searching for the vibrational signatures of the zn zn stretching mode in decamethyldizincocene zn2 η5 cp 2 the first Organometallic Compound with a metallic homonuclear zn zn bond
Chemical Physics Letters, 2005Co-Authors: Steven L Richardson, Tunna Baruah, Mark R PedersonAbstract:Decamethyldizincocene (Zn2(η5-Cp*)2) is the first example of a stable Organometallic Compound with a homonuclear metal Zn–Zn bond. Although its structural properties have been characterized by X-ray diffraction and high-resolution mass spectroscopy, it has been suggested that its experimental infrared and Raman spectra might not be particularly useful in identifying the Zn–Zn stretch mode in Zn2(η5-Cp*)2. We have used density-functional theory (DFT) to calculate both an infrared (IR) and Raman spectra for Zn2(η5-Cp*)2. In particular, our results clearly identify a number of low frequency Raman active modes wherein Zn–Zn twist and stretch modes are clearly identifiable.
Pascal Hébraud - One of the best experts on this subject based on the ideXlab platform.
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Complexation of DNA with ruthenium Organometallic Compounds: the high complexation ratio limit.
Physical chemistry chemical physics : PCCP, 2014Co-Authors: Stéphane Despax, Fuchao Jia, Michel Pfeffer, Pascal HébraudAbstract:Interactions between DNA and ruthenium Organometallic Compounds are studied by using visible light absorption and circular dichroism measurements. A titration technique allowing for the absolute determination of the advancement degree of the complexation, without any assumption about the number of complexation modes is developed. When DNA is in excess, complexation involves intercalation of one of the Organometallic Compound ligands between DNA base pairs. But, in the high complexation ratio limit, where Organometallic Compounds are in excess relative to the DNA base pairs, a new mode of interaction is observed, in which the Organometallic Compound interacts weakly with DNA. The weak interaction mode, moreover, develops when all the DNA intercalation sites are occupied. A regime is reached in which one DNA base pair is linked to more than one Organometallic Compound.
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A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP
Cancer Research, 2009Co-Authors: Xiangjun Meng, Pascal Hébraud, Mili Leyva, Marjorie Jenny, Isabelle Gross, Samir Benosman, Bastien Fricker, Sebastien Harlepp, Anne Boos, Pauline WlosikAbstract:Cisplatin-derived anticancer therapy has been used for three decades despite its side effects. Other types of Organometallic complexes, namely, some ruthenium-derived Compounds (RDC), which would display cytotoxicity through different modes of action, might represent alternative therapeutic agents. We have studied both in vitro and in vivo the biological properties of RDC11, one of the most active Compounds of a new class of RDCs that contain a covalent bond between the ruthenium atom and a carbon. We showed that RDC11 inhibited the growth of various tumors implanted in mice more efficiently than cisplatin. Importantly, in striking contrast with cisplatin, RDC11 did not cause severe side effects on the liver, kidneys, or the neuronal sensory system. We analyzed the mode of action of RDC11 and showed that RDC11 interacted poorly with DNA and induced only limited DNA damages compared with cisplatin, suggesting alternative transduction pathways. Indeed, we found that target genes of the endoplasmic reticulum stress pathway, such as Bip, XBP1, PDI, and CHOP, were activated in RDC11-treated cells. Induction of the transcription factor CHOP, a crucial mediator of endoplasmic reticulum stress apoptosis, was also confirmed in tumors treated with RDC11. Activation of CHOP led to the expression of several of its target genes, including proapoptotic genes. In addition, the silencing of CHOP by RNA interference significantly reduced the cytotoxicity of RDC11. Altogether, our results led us to conclude that RDC11 acts by an atypical pathway involving CHOP and endoplasmic reticulum stress, and thus might provide an interesting alternative for anticancer therapy.
Xiao-jia Chen - One of the best experts on this subject based on the ideXlab platform.
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Superconductivity in an Organometallic Compound
Physical chemistry chemical physics : PCCP, 2019Co-Authors: Ren-shu Wang, Zhongbing Huang, Liu-cheng Chen, Hui Yang, Jia Cheng, Yun Gao, Xiao-jia ChenAbstract:Organometallic Compounds constitute a very large group of substances that contain at least one metal-to-carbon bond in which the carbon is part of an organic group. They have played a major role in the development of the science of chemistry. These Compounds are used to a large extent as catalysts (substances that increase the rate of reactions without themselves being consumed) and as intermediates in the laboratory and in industry. Recently, novel quantum phenomena such as topological insulators and superconductors were also suggested in these materials. However, there has been no report on the experimental exploration of the topological state. Evidence for superconductivity from the zero-resistivity state in any Organometallic Compound has not been achieved yet, though much effort has been made. Here we report the experimental realization of superconductivity with a critical temperature of 3.6 K in a potassium-doped Organometallic Compound, i.e. tri-o-tolylbismuthine, with evidence of both the Meissner effect and the zero-resistivity state through dc and ac magnetic susceptibility measurements. The obtained superconducting parameters classify this Compound as a type-II superconductor. The benzene ring is identified to be the essential superconducting unit in such a phenyl Organometallic Compound. The superconducting phase and its composition are determined by combined studies of X-ray diffraction and theoretical calculations as well as Raman spectroscopy measurements. These findings enrich the applications of Organometallic Compounds in superconductivity and add a new electron-acceptor family of organic superconductors. This work also points to a large pool for finding superconductors from Organometallic Compounds.