The Experts below are selected from a list of 9 Experts worldwide ranked by ideXlab platform
Alireza Khoshroo - One of the best experts on this subject based on the ideXlab platform.
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Self-assembled monolayers of Organosulfur Derivative on gold nanoparticles as electrochemical sensor for determination of isoprenaline
Journal of the Iranian Chemical Society, 2018Co-Authors: Mohammad Mazloum-ardakani, Zahra Dehghani, Alireza KhoshrooAbstract:In this paper, the use of molecular self-assembled monolayers of 5-(1,3-dithiolan-2-eyl)-3-methyl banzen-1,2-diol (DMD) on gold nanoparticles was described (DMD-AuNPs). The redox properties of modified electrode at various scan rates were investigated by cyclic voltammetry. A pair of well-defined quasi-reversible redox peaks of DMD were obtained at the modified electrode. Dramatically enhanced electrocatalytic activity was exemplified at the DMD-AuNPs, as an electrochemical sensor to investigate the electro-oxidation of isoprenaline (IP). With this modified electrode, the oxidation potential of the IP was shifted about 235 mV toward a less positive potential value than that of an unmodified electrode. The values of electron transfer coefficients ( α = 0.5), catalytic rate constant ( ks = 9.2 s^−1) and diffusion coefficient ( D = 8.9 × 10^−5 cm^2 s^−1) were calculated for IP. The response of catalytic current with IP concentration showed a linear relation in the range from 0.5 to 800 µM with a detection limit of 0.21 µM. Finally, this modified electrode was used for the determination of IP in IP injections.
Mohammad Mazloum-ardakani - One of the best experts on this subject based on the ideXlab platform.
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Self-assembled monolayers of Organosulfur Derivative on gold nanoparticles as electrochemical sensor for determination of isoprenaline
Journal of the Iranian Chemical Society, 2018Co-Authors: Mohammad Mazloum-ardakani, Zahra Dehghani, Alireza KhoshrooAbstract:In this paper, the use of molecular self-assembled monolayers of 5-(1,3-dithiolan-2-eyl)-3-methyl banzen-1,2-diol (DMD) on gold nanoparticles was described (DMD-AuNPs). The redox properties of modified electrode at various scan rates were investigated by cyclic voltammetry. A pair of well-defined quasi-reversible redox peaks of DMD were obtained at the modified electrode. Dramatically enhanced electrocatalytic activity was exemplified at the DMD-AuNPs, as an electrochemical sensor to investigate the electro-oxidation of isoprenaline (IP). With this modified electrode, the oxidation potential of the IP was shifted about 235 mV toward a less positive potential value than that of an unmodified electrode. The values of electron transfer coefficients ( α = 0.5), catalytic rate constant ( ks = 9.2 s^−1) and diffusion coefficient ( D = 8.9 × 10^−5 cm^2 s^−1) were calculated for IP. The response of catalytic current with IP concentration showed a linear relation in the range from 0.5 to 800 µM with a detection limit of 0.21 µM. Finally, this modified electrode was used for the determination of IP in IP injections.
Zahra Dehghani - One of the best experts on this subject based on the ideXlab platform.
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Self-assembled monolayers of Organosulfur Derivative on gold nanoparticles as electrochemical sensor for determination of isoprenaline
Journal of the Iranian Chemical Society, 2018Co-Authors: Mohammad Mazloum-ardakani, Zahra Dehghani, Alireza KhoshrooAbstract:In this paper, the use of molecular self-assembled monolayers of 5-(1,3-dithiolan-2-eyl)-3-methyl banzen-1,2-diol (DMD) on gold nanoparticles was described (DMD-AuNPs). The redox properties of modified electrode at various scan rates were investigated by cyclic voltammetry. A pair of well-defined quasi-reversible redox peaks of DMD were obtained at the modified electrode. Dramatically enhanced electrocatalytic activity was exemplified at the DMD-AuNPs, as an electrochemical sensor to investigate the electro-oxidation of isoprenaline (IP). With this modified electrode, the oxidation potential of the IP was shifted about 235 mV toward a less positive potential value than that of an unmodified electrode. The values of electron transfer coefficients ( α = 0.5), catalytic rate constant ( ks = 9.2 s^−1) and diffusion coefficient ( D = 8.9 × 10^−5 cm^2 s^−1) were calculated for IP. The response of catalytic current with IP concentration showed a linear relation in the range from 0.5 to 800 µM with a detection limit of 0.21 µM. Finally, this modified electrode was used for the determination of IP in IP injections.
Hae Young Chung - One of the best experts on this subject based on the ideXlab platform.
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Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-κB Signaling in C57/BL6 Mouse Kidney
Journal of Medicinal Food, 2009Co-Authors: Sang Woon Chung, Stephen D. Anton, Takako Yokozawa, Hae Young ChungAbstract:Abstract Allylmethylsulfide (AMS), a volatile Organosulfur Derivative from garlic, has been shown to have radioprotective effects in radiation-challenged cell and animal models, but the mechanism of radioprotection is not well understood. To determine the mechanism of radioprotection in an in vivo model, we first verified the antioxidant capacity of AMS using 2,2′-azobis(2-amidinopropane) dihydrochloride-induced human embryonic kidney 293T cells by measuring reactive oxygen species generation, reduced glutathione, protein tyrosine kinase/protein tyrosine phosphatase balance, and nuclear factor-κB (NF-κB) protein levels. We then investigated the protective effects of AMS (55 and 275 μmol/kg, intraperitoneal treatment) on 15 Gy X-ray-irradiated mouse kidney. The results showed that AMS decreased the free radical-induced lipid peroxidation in mice exposed to X-rays. Moreover, the antioxidative AMS suppressed the activation of NF-κB and its dependent genes such as vascular cell adhesion molecule-1, inducible ...
Sang Woon Chung - One of the best experts on this subject based on the ideXlab platform.
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Allylmethylsulfide Down-Regulates X-Ray Irradiation-Induced Nuclear Factor-κB Signaling in C57/BL6 Mouse Kidney
Journal of Medicinal Food, 2009Co-Authors: Sang Woon Chung, Stephen D. Anton, Takako Yokozawa, Hae Young ChungAbstract:Abstract Allylmethylsulfide (AMS), a volatile Organosulfur Derivative from garlic, has been shown to have radioprotective effects in radiation-challenged cell and animal models, but the mechanism of radioprotection is not well understood. To determine the mechanism of radioprotection in an in vivo model, we first verified the antioxidant capacity of AMS using 2,2′-azobis(2-amidinopropane) dihydrochloride-induced human embryonic kidney 293T cells by measuring reactive oxygen species generation, reduced glutathione, protein tyrosine kinase/protein tyrosine phosphatase balance, and nuclear factor-κB (NF-κB) protein levels. We then investigated the protective effects of AMS (55 and 275 μmol/kg, intraperitoneal treatment) on 15 Gy X-ray-irradiated mouse kidney. The results showed that AMS decreased the free radical-induced lipid peroxidation in mice exposed to X-rays. Moreover, the antioxidative AMS suppressed the activation of NF-κB and its dependent genes such as vascular cell adhesion molecule-1, inducible ...