Orthomyxoviridae

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George F Rohrmann - One of the best experts on this subject based on the ideXlab platform.

Margot N Pearson - One of the best experts on this subject based on the ideXlab platform.

Alongkorn Amonsin - One of the best experts on this subject based on the ideXlab platform.

  • Outbreaks of Tilapia Lake Virus Infection, Thailand, 2015-2016.
    Emerging Infectious Diseases, 2017
    Co-Authors: Win Surachetpong, Taveesak Janetanakit, Nutthawan Nonthabenjawan, Puntanat Tattiyapong, Kwanrawee Sirikanchana, Alongkorn Amonsin
    Abstract:

    During 2015-2016, several outbreaks of tilapia lake virus infection occurred among tilapia in Thailand. Phylogenetic analysis showed that the virus from Thailand grouped with a tilapia virus (family Orthomyxoviridae) from Israel. This emerging virus is a threat to tilapia aquaculture in Asia and worldwide.

  • Outbreaks of Tilapia Lake Virus Infection, Thailand, 2015–2016
    Centers for Disease Control and Prevention, 2017
    Co-Authors: Win Surachetpong, Taveesak Janetanakit, Nutthawan Nonthabenjawan, Puntanat Tattiyapong, Kwanrawee Sirikanchana, Alongkorn Amonsin
    Abstract:

    During 2015–2016, several outbreaks of tilapia lake virus infection occurred among tilapia in Thailand. Phylogenetic analysis showed that the virus from Thailand grouped with a tilapia virus (family Orthomyxoviridae) from Israel. This emerging virus is a threat to tilapia aquaculture in Asia and worldwide

Patricia A. Nuttall - One of the best experts on this subject based on the ideXlab platform.

  • Viruses transmitted by ticks
    Ticks, 2008
    Co-Authors: Milan Labuda, Patricia A. Nuttall
    Abstract:

    Ticks transmit a wide variety of arboviruses (arthropod-borne viruses). Tick-borne viruses are found in six different viral families (Asfarviridae, Reoviridae, Rhabdoviridae, Orthomyxoviridae, Bunyaviridae, Flaviviridae) and at least nine genera. Some as yet unassigned tick-borne viruses may belong to a seventh family, the Arenaviridae. With only one exception (African swine fever virus) all tick-borne viruses (as well as all other arboviruses) are RNA viruses. Some tick-borne viruses pose a significant threat to the health of humans (tick-borne encephalitis virus, Crimean–Congo haemorrhagic fever virus) or livestock (African swine fever virus, Nairobi sheep disease virus). This chapter first considers the characteristics of ticks important in virus transmission and then presents an overview of the tick-borne members of different virus families

  • Immune Protection Conferred by the Baculovirus-Related Glycoprotein of Thogoto Virus (Orthomyxoviridae)
    Virology, 1995
    Co-Authors: Linda D. Jones, Mary A. Morse, Anthony C. Marriott, Patricia A. Nuttall
    Abstract:

    The coding region of segment 4 of Thogoto (THO) virus, a tick-borne member of the Orthomyxoviridae, was expressed in a baculovirus system under the control of the polyhedrin promoter. This construct expressed authentic envelope glycoprotein as determined by size and antigenic reactivity with a panel of monoclonal antibodies (MAbs). Immunization of hamsters with Spodoptera frugiperda (Sf21) cells infected with the recombinant baculovirus induced neutralizing and protective antibodies against virus challenge; control hamsters developed clinical disease with high-titer viremia 3 days postchallenge. In contrast to hamsters, guinea pigs are comparatively resistant to THO virus infection but support nonviremic transmission between cofeeding infected and uninfected ticks. However, when uninfected ticks fed on guinea pigs immunized with the baculovirus recombinant, only 2% became infected following virus challenge of the animals compared to 26% of ticks on control nonimmune guinea pigs. Furthermore, neutralizing MAbs specific for THO viral glycoprotein protected mice against lethal challenge with THO virus; nonneutralizing MAbs specific for the glycoprotein, which inhibit THO viral agglutinating activity, did not induce a protective response. Thus at least in the murine model, protective immunity is conferred by antibodies directed against the neutralizing epitope(s) of the baculovirus-related glycoprotein of THO virus.

  • Identification of viral structural polypeptides of Thogoto virus (a tick-borne orthomyxo-like virus) and functions associated with the glycoprotein.
    Journal of General Virology, 1992
    Co-Authors: Agustín Portela, Linda D. Jones, Patricia A. Nuttall
    Abstract:

    Thogoto (THO) virus is a tick-borne virus which shares morphological and genetic features with members of the Orthomyxoviridae family although the viral glycoprotein appears to be related to gp64 of baculoviruses. Characterization of THO virus was undertaken to clarify its taxonomic position. Purified virus preparations contained at least six virus-encoded polypeptides with apparent M r values ranging from 29K to 92K. A 75K polypeptide was identified as an envelope-associated glycoprotein by Triton X-100 and salt dissociation studies, and by proteolytic degradation of the exposed proteins of the virion. By the same criteria, the nucleoprotein and the matrix protein were identified as the 52K and 29K polypeptides, respectively. Immunofluorescence studies using monoclonal antibodies (MAbs) located the glycoprotein on the external cell membrane and the nucleoprotein in the nucleus of infected cells indicating that virus replication involved a nuclear phase. In addition, the virus displayed haemagglutination and haemolytic activities with an optimum at pH 6. These activities are functions of the viral glycoprotein since they were inhibited by antiglycoprotein MAbs. The data reported here support the notion that THO virus is a member of the Orthomyxoviridae family but that it should be classified in a group distinct from the other influenza viruses.

Win Surachetpong - One of the best experts on this subject based on the ideXlab platform.

  • Outbreaks of Tilapia Lake Virus Infection, Thailand, 2015-2016.
    Emerging Infectious Diseases, 2017
    Co-Authors: Win Surachetpong, Taveesak Janetanakit, Nutthawan Nonthabenjawan, Puntanat Tattiyapong, Kwanrawee Sirikanchana, Alongkorn Amonsin
    Abstract:

    During 2015-2016, several outbreaks of tilapia lake virus infection occurred among tilapia in Thailand. Phylogenetic analysis showed that the virus from Thailand grouped with a tilapia virus (family Orthomyxoviridae) from Israel. This emerging virus is a threat to tilapia aquaculture in Asia and worldwide.

  • Outbreaks of Tilapia Lake Virus Infection, Thailand, 2015–2016
    Centers for Disease Control and Prevention, 2017
    Co-Authors: Win Surachetpong, Taveesak Janetanakit, Nutthawan Nonthabenjawan, Puntanat Tattiyapong, Kwanrawee Sirikanchana, Alongkorn Amonsin
    Abstract:

    During 2015–2016, several outbreaks of tilapia lake virus infection occurred among tilapia in Thailand. Phylogenetic analysis showed that the virus from Thailand grouped with a tilapia virus (family Orthomyxoviridae) from Israel. This emerging virus is a threat to tilapia aquaculture in Asia and worldwide