The Experts below are selected from a list of 6927 Experts worldwide ranked by ideXlab platform
Thomas J. Webster - One of the best experts on this subject based on the ideXlab platform.
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titanium surfaces with adherent selenium nanoclusters as a novel anticancer Orthopedic Material
Journal of Biomedical Materials Research Part A, 2009Co-Authors: Phong A Tran, Love Sarin, Robert H Hurt, Thomas J. WebsterAbstract:Current Orthopedic implants have several problems that include poor osseointegration for extended periods of time, stress shielding and wear debris-associated bone cell death. In addition, numerous patients receive Orthopedic implants as a result of bone cancer resection, yet current Orthopedic Materials were not designed to prevent either the occurrence or reoccurrence of cancer. The objective of this in vitro study was to create a new bioMaterial which can both restore bone and prevent cancer growth at the implant-tissue interface. Elemental selenium was chosen as the biologically active agent in this study because of its known chemopreventive and chemotherapeutic properties. It was found that when selenite salts were reduced by glutathione in the presence of an immersed titanium substrate, elemental selenium nucleated and grew into adherent, hemispherical nanoclusters that formed a nanostructured composite surface. Three types of surfaces with different selenium surface densities on titanium were fabricated and confirmed by SEM images, AFM, and XPS profiles. Compared to conventional untreated titanium, a high-density selenium-doped surface inhibited cancerous bone cell proliferation while promoting healthy bone cell functions (including adhesion, proliferation, alkaline phosphatase activity and calcium deposition). These findings showed for the first time the potential of selenium nanoclusters as a chemopreventive titanium Orthopedic Material coating that can also promote healthy bone cell functions.
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Better osteoblast adhesion on nanoparticulate selenium- A promising Orthopedic implant Material.
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Venu Perla, Thomas J. WebsterAbstract:Apart from problems such as poor osseointegra- tion, stress shielding, and wear debris-associated bone cell death, a major concern of metallic Orthopedic implants is that they slowly corrode under in vivo environments. It is possible that continuous tissue exposure to metallic corro- sion products limits Orthopedic implant efficacy; this is es- pecially true for patients receiving implants due to bone cancer. To date, there is no metallic Orthopedic implant available in the market that specifically deals with the pre- vention and/or recurring cancer that may happen in these patients. The objective of this study was to deal with these problems in an integrated way by introducing a new bio- Material to the Orthopedic community with anticancer chemistry: selenium (Se). In this study, six types of Se com- pacts were tested for bone cell (osteoblast) adhesion under in vitro conditions. Two types of cylindrical compacts were made with conventional Se metal particles in the micron (6.539 1.364-m diameter) and submicron (0.963 0.139-m diameter) range. These two types of compacts were chemically etched with different concentrations of NaOH to create two additional types of Se particles in each category: conventional size particles with nanosurface roughness and nanometer particles (0.204- to 0.264-m di- ameter). Results showed for the first time, enhanced osteo- blast adhesion on particulate surfaces of the compacts made from conventional Se compared with reference nonparticu- late wrought titanium sheets. More importantly, this study provided the first evidence that osteoblast density was fur- ther increased on the surfaces of the Se compacts with nano- meter particles. These initial findings indicate that there may be a promising future for nanoparticulate Se as an anticancer biocompatible Orthopedic Material. © 2005 Wiley Periodi- cals, Inc. J Biomed Mater Res 75A: 356 -364, 2005
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better osteoblast adhesion on nanoparticulate selenium a promising Orthopedic implant Material
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Venu Perla, Thomas J. WebsterAbstract:Apart from problems such as poor osseointegration, stress shielding, and wear debris-associated bone cell death, a major concern of metallic Orthopedic implants is that they slowly corrode under in vivo environments. It is possible that continuous tissue exposure to metallic corrosion products limits Orthopedic implant efficacy; this is especially true for patients receiving implants due to bone cancer. To date, there is no metallic Orthopedic implant available in the market that specifically deals with the prevention and/or recurring cancer that may happen in these patients. The objective of this study was to deal with these problems in an integrated way by introducing a new bioMaterial to the Orthopedic community with anticancer chemistry: selenium (Se). In this study, six types of Se compacts were tested for bone cell (osteoblast) adhesion under in vitro conditions. Two types of cylindrical compacts were made with conventional Se metal particles in the micron (6.539 +/- 1.364-microm diameter) and submicron (0.963 +/- 0.139-microm diameter) range. These two types of compacts were chemically etched with different concentrations of NaOH to create two additional types of Se particles in each category: conventional size particles with nanosurface roughness and nanometer particles (0.204- to 0.264-microm diameter). Results showed for the first time, enhanced osteoblast adhesion on particulate surfaces of the compacts made from conventional Se compared with reference nonparticulate wrought titanium sheets. More importantly, this study provided the first evidence that osteoblast density was further increased on the surfaces of the Se compacts with nanometer particles. These initial findings indicate that there may be a promising future for nanoparticulate Se as an anticancer biocompatible Orthopedic Material.
Venu Perla - One of the best experts on this subject based on the ideXlab platform.
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Better osteoblast adhesion on nanoparticulate selenium- A promising Orthopedic implant Material.
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Venu Perla, Thomas J. WebsterAbstract:Apart from problems such as poor osseointegra- tion, stress shielding, and wear debris-associated bone cell death, a major concern of metallic Orthopedic implants is that they slowly corrode under in vivo environments. It is possible that continuous tissue exposure to metallic corro- sion products limits Orthopedic implant efficacy; this is es- pecially true for patients receiving implants due to bone cancer. To date, there is no metallic Orthopedic implant available in the market that specifically deals with the pre- vention and/or recurring cancer that may happen in these patients. The objective of this study was to deal with these problems in an integrated way by introducing a new bio- Material to the Orthopedic community with anticancer chemistry: selenium (Se). In this study, six types of Se com- pacts were tested for bone cell (osteoblast) adhesion under in vitro conditions. Two types of cylindrical compacts were made with conventional Se metal particles in the micron (6.539 1.364-m diameter) and submicron (0.963 0.139-m diameter) range. These two types of compacts were chemically etched with different concentrations of NaOH to create two additional types of Se particles in each category: conventional size particles with nanosurface roughness and nanometer particles (0.204- to 0.264-m di- ameter). Results showed for the first time, enhanced osteo- blast adhesion on particulate surfaces of the compacts made from conventional Se compared with reference nonparticu- late wrought titanium sheets. More importantly, this study provided the first evidence that osteoblast density was fur- ther increased on the surfaces of the Se compacts with nano- meter particles. These initial findings indicate that there may be a promising future for nanoparticulate Se as an anticancer biocompatible Orthopedic Material. © 2005 Wiley Periodi- cals, Inc. J Biomed Mater Res 75A: 356 -364, 2005
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better osteoblast adhesion on nanoparticulate selenium a promising Orthopedic implant Material
Journal of Biomedical Materials Research Part A, 2005Co-Authors: Venu Perla, Thomas J. WebsterAbstract:Apart from problems such as poor osseointegration, stress shielding, and wear debris-associated bone cell death, a major concern of metallic Orthopedic implants is that they slowly corrode under in vivo environments. It is possible that continuous tissue exposure to metallic corrosion products limits Orthopedic implant efficacy; this is especially true for patients receiving implants due to bone cancer. To date, there is no metallic Orthopedic implant available in the market that specifically deals with the prevention and/or recurring cancer that may happen in these patients. The objective of this study was to deal with these problems in an integrated way by introducing a new bioMaterial to the Orthopedic community with anticancer chemistry: selenium (Se). In this study, six types of Se compacts were tested for bone cell (osteoblast) adhesion under in vitro conditions. Two types of cylindrical compacts were made with conventional Se metal particles in the micron (6.539 +/- 1.364-microm diameter) and submicron (0.963 +/- 0.139-microm diameter) range. These two types of compacts were chemically etched with different concentrations of NaOH to create two additional types of Se particles in each category: conventional size particles with nanosurface roughness and nanometer particles (0.204- to 0.264-microm diameter). Results showed for the first time, enhanced osteoblast adhesion on particulate surfaces of the compacts made from conventional Se compared with reference nonparticulate wrought titanium sheets. More importantly, this study provided the first evidence that osteoblast density was further increased on the surfaces of the Se compacts with nanometer particles. These initial findings indicate that there may be a promising future for nanoparticulate Se as an anticancer biocompatible Orthopedic Material.
Sungho Jin - One of the best experts on this subject based on the ideXlab platform.
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tio2 nanotubes for bone regeneration
Trends in Biotechnology, 2012Co-Authors: Karla S Brammer, Christine J Frandsen, Sungho JinAbstract:Nanostructured Materials are believed to play a fundamental role in Orthopedic research because bone itself has a structural hierarchy at the first level in the nanometer regime. Here, we report on titanium oxide (TiO 2 ) surface nanostructures utilized for Orthopedic implant considerations. Specifically, the effects of TiO 2 nanotube surfaces for bone regeneration will be discussed. This unique 3D tube shaped nanostructure created by electrochemical anodization has profound effects on osteogenic cells and is stimulating new avenues for Orthopedic Material surface designs. There is a growing body of data elucidating the benefits of using TiO 2 nanotubes for enhanced Orthopedic implant surfaces. The current trends discussed within foreshadow the great potential of TiO 2 nanotubes for clinical use.
Shicheng Wei - One of the best experts on this subject based on the ideXlab platform.
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preparation characterization cellular response and in vivo osseointegration of polyetheretherketone nano hydroxyapatite carbon fiber ternary biocomposite
Colloids and Surfaces B: Biointerfaces, 2015Co-Authors: Yi Deng, Xiaochen Liu, Ping Zhou, Lixin Wang, Xiaoling Xiong, Zhihui Tang, Jie Wei, Shicheng WeiAbstract:As FDA-approved implantable Material, polyetheretherketone (PEEK) is becoming a prime candidate to replace traditional surgical metallic implants made of titanium (Ti) and its alloys, since it has a lower elastic modulus than Ti. The bioinertness and defective osteointegration of PEEK, however, limit its clinical adoption as load-bearing dental/Orthopedic Material. The present work aimed at developing a PEEK bioactive ternary composite, polyetheretherketone/nano-hydroxyapatite/carbon fiber (PEEK/n-HA/CF), and evaluating it as a potential bone-repairing Material by assessment of growth and differentiation of osteoblast-like MG63 cells and by estimation of osteointegration in vivo. Our results indicated that the adhesion, proliferation and osteogenic differentiation of cells, as well as the mechanical properties were greatly promoted for the PEEK/n-HA/CF biocomposite compared with pure PEEK matrix. More importantly, the ternary composite implant boosted in vivo bioactivity and osseointegration in canine tooth defect model. Thus, the PEEK/n-HA/CF ternary biocomposite with enhanced mechanics and biological performances hold great potential as bioactive implant Material in dental and Orthopedic applications.
Phong A Tran - One of the best experts on this subject based on the ideXlab platform.
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titanium surfaces with adherent selenium nanoclusters as a novel anticancer Orthopedic Material
Journal of Biomedical Materials Research Part A, 2009Co-Authors: Phong A Tran, Love Sarin, Robert H Hurt, Thomas J. WebsterAbstract:Current Orthopedic implants have several problems that include poor osseointegration for extended periods of time, stress shielding and wear debris-associated bone cell death. In addition, numerous patients receive Orthopedic implants as a result of bone cancer resection, yet current Orthopedic Materials were not designed to prevent either the occurrence or reoccurrence of cancer. The objective of this in vitro study was to create a new bioMaterial which can both restore bone and prevent cancer growth at the implant-tissue interface. Elemental selenium was chosen as the biologically active agent in this study because of its known chemopreventive and chemotherapeutic properties. It was found that when selenite salts were reduced by glutathione in the presence of an immersed titanium substrate, elemental selenium nucleated and grew into adherent, hemispherical nanoclusters that formed a nanostructured composite surface. Three types of surfaces with different selenium surface densities on titanium were fabricated and confirmed by SEM images, AFM, and XPS profiles. Compared to conventional untreated titanium, a high-density selenium-doped surface inhibited cancerous bone cell proliferation while promoting healthy bone cell functions (including adhesion, proliferation, alkaline phosphatase activity and calcium deposition). These findings showed for the first time the potential of selenium nanoclusters as a chemopreventive titanium Orthopedic Material coating that can also promote healthy bone cell functions.
