The Experts below are selected from a list of 993 Experts worldwide ranked by ideXlab platform
Emma C Wall - One of the best experts on this subject based on the ideXlab platform.
-
mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria
Cochrane Database of Systematic Reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:BACKGROUND:The main treatment for cerebral malaria is parenteral antimalarials. Mannitol and urea are used as adjunct therapy for cerebral malaria, but the World Health Organization does not recommend them. OBJECTIVES:To compare mannitol or urea to placebo or no treatment for treating children and adults with cerebral malaria. SEARCH STRATEGY:We searched the Cochrane Infectious Diseases Group Specialized Register (June 2004), CENTRAL (The Cochrane Library Issue 2, 2004), MEDLINE (1966 to June 2004), EMBASE (1974 to June 2004), LILACS (1982 to June 2004), and reference lists of articles. We contacted relevant organizations and researchers. SELECTION CRITERIA:Randomized and quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. DATA COLLECTION AND ANALYSIS:No trials met the inclusion criteria. MAIN RESULTS:No trials met the inclusion criteria. REVIEWERS' CONCLUSIONS:We identified no randomized or quasi-randomized controlled trials to support or refute the use of mannitol or urea as adjuncts for treating cerebral malaria in clinical practice. This is likely to require a multicentre trial.
-
mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria
Cochrane Database of Systematic Reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:Background Cerebral oedema occurs with cerebral malaria, and some clinicians think Osmotic Diuretics, such as mannitol or urea, may improve outcomes. Objectives To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. Search strategy We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. Selection criteria Randomized or quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Primary outcomes were death, life-threatenining sequelae and major neurological sequelae at six months. Data collection and analysis Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. Main results One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected. Authors' conclusions There are insufficient data to know what the effects of Osmotic Diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.
-
The Cochrane Library - Mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria.
The Cochrane database of systematic reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:Background Cerebral oedema occurs with cerebral malaria, and some clinicians think Osmotic Diuretics, such as mannitol or urea, may improve outcomes. Objectives To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. Search strategy We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. Selection criteria Randomized or quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Primary outcomes were death, life-threatenining sequelae and major neurological sequelae at six months. Data collection and analysis Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. Main results One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected. Authors' conclusions There are insufficient data to know what the effects of Osmotic Diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.
Christy A N Okoromah - One of the best experts on this subject based on the ideXlab platform.
-
mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria
Cochrane Database of Systematic Reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:BACKGROUND:The main treatment for cerebral malaria is parenteral antimalarials. Mannitol and urea are used as adjunct therapy for cerebral malaria, but the World Health Organization does not recommend them. OBJECTIVES:To compare mannitol or urea to placebo or no treatment for treating children and adults with cerebral malaria. SEARCH STRATEGY:We searched the Cochrane Infectious Diseases Group Specialized Register (June 2004), CENTRAL (The Cochrane Library Issue 2, 2004), MEDLINE (1966 to June 2004), EMBASE (1974 to June 2004), LILACS (1982 to June 2004), and reference lists of articles. We contacted relevant organizations and researchers. SELECTION CRITERIA:Randomized and quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. DATA COLLECTION AND ANALYSIS:No trials met the inclusion criteria. MAIN RESULTS:No trials met the inclusion criteria. REVIEWERS' CONCLUSIONS:We identified no randomized or quasi-randomized controlled trials to support or refute the use of mannitol or urea as adjuncts for treating cerebral malaria in clinical practice. This is likely to require a multicentre trial.
-
mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria
Cochrane Database of Systematic Reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:Background Cerebral oedema occurs with cerebral malaria, and some clinicians think Osmotic Diuretics, such as mannitol or urea, may improve outcomes. Objectives To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. Search strategy We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. Selection criteria Randomized or quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Primary outcomes were death, life-threatenining sequelae and major neurological sequelae at six months. Data collection and analysis Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. Main results One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected. Authors' conclusions There are insufficient data to know what the effects of Osmotic Diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.
-
The Cochrane Library - Mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria.
The Cochrane database of systematic reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:Background Cerebral oedema occurs with cerebral malaria, and some clinicians think Osmotic Diuretics, such as mannitol or urea, may improve outcomes. Objectives To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. Search strategy We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. Selection criteria Randomized or quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Primary outcomes were death, life-threatenining sequelae and major neurological sequelae at six months. Data collection and analysis Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. Main results One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected. Authors' conclusions There are insufficient data to know what the effects of Osmotic Diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.
Francisco Carlos De Andrade - One of the best experts on this subject based on the ideXlab platform.
-
Uses and abuses of the hyperventilation in severe traumatic brain injury
Academia Brasileira de Neurologia - ABNEURO, 2000Co-Authors: Francisco Carlos De AndradeAbstract:É feita avaliação crítica sobre as diretrizes atuais e consequências da manobra de hiperventilação (MHV) na prevenção e tratamento da hipertensão intracraniana (HIC) que segue aos traumatismos crânio-encefálicos (TCE) graves. O uso profilático da MHV deve ser evitado na fase aguda de TCE grave, a menos que se registrem altos valores de O2 no sangue venoso medido no bulbo jugular, ou para ganhar tempo quando o paciente apresenta evidentes sinais posturais de deterioração neurológica. A falta de resposta cerebrovascular à MHV para baixar a HIC significa que a barreira hemato-encefálica (BHE) está difusamente lesada. Então, a MHV pode ser utilizada como um crivo nos TCE graves, uma vez que a lesão da BHE atesta que os demais tratamentos disponíveis para combater a HIC (sedação, paralisia e diuréticos osmóticos) não funcionarão. Uma nova hipótese patogênica do edema encefálico traumático e abordagem terapêutica é apresentada.A critical evaluatin was done about the guidelines and effects of the hyperventilation maneuver on prevention and treatment of increased intracranial pressure (ICP) that follows severe traumatic brain injury (TBI). The prophylatic use of hyperventilation should be avoided after severe TBI acute phase, unless high venous O2 values are recorded at jugular bulb blood (SjO2), or to allow time when there are evidences of neurologic deterioration with posturing. The lack of cerebrovascular response to hyperventilation to low the ICP means that the blood brain barrier (BBB) function is extensively impaired. Then, hyperventilacion may be used as a screening therapeutic test in acute severe TBI, since BBB impairment is the pointer that other available clinical procedures for high ICP control (sedation, paralysis and Osmotic Diuretics) are not workable. A new pathogenetic hypothesis about traumatic brain edema and its therapeutic approach is presented
-
Usos e abusos da hiperventilação nos traumatismo crânio-encefálicos graves
Arquivos de neuro-psiquiatria, 2000Co-Authors: Francisco Carlos De AndradeAbstract:A critical evaluatin was done about the guidelines and effects of the hyperventilation maneuver on prevention and treatment of increased intracranial pressure (ICP) that follows severe traumatic brain injury (TBI). The prophylatic use of hyperventilation should be avoided after severe TBI acute phase, unless high venous O2 values are recorded at jugular bulb blood (SjO2), or to allow time when there are evidences of neurologic deterioration with posturing. The lack of cerebrovascular response to hyperventilation to low the ICP means that the blood brain barrier (BBB) function is extensively impaired. Then, hyperventilacion may be used as a screening therapeutic test in acute severe TBI, since BBB impairment is the pointer that other available clinical procedures for high ICP control (sedation, paralysis and Osmotic Diuretics) are not workable. A new pathogenetic hypothesis about traumatic brain edema and its therapeutic approach is presented.
-
Usos e abusos da hiperventilação nos traumatismo crânio-encefálicos graves Uses and abuses of the hyperventilation in severe traumatic brain injury
Academia Brasileira de Neurologia (ABNEURO), 2000Co-Authors: Francisco Carlos De AndradeAbstract:É feita avaliação crítica sobre as diretrizes atuais e consequências da manobra de hiperventilação (MHV) na prevenção e tratamento da hipertensão intracraniana (HIC) que segue aos traumatismos crânio-encefálicos (TCE) graves. O uso profilático da MHV deve ser evitado na fase aguda de TCE grave, a menos que se registrem altos valores de O2 no sangue venoso medido no bulbo jugular, ou para ganhar tempo quando o paciente apresenta evidentes sinais posturais de deterioração neurológica. A falta de resposta cerebrovascular à MHV para baixar a HIC significa que a barreira hemato-encefálica (BHE) está difusamente lesada. Então, a MHV pode ser utilizada como um crivo nos TCE graves, uma vez que a lesão da BHE atesta que os demais tratamentos disponíveis para combater a HIC (sedação, paralisia e diuréticos osmóticos) não funcionarão. Uma nova hipótese patogênica do edema encefálico traumático e abordagem terapêutica é apresentada.A critical evaluatin was done about the guidelines and effects of the hyperventilation maneuver on prevention and treatment of increased intracranial pressure (ICP) that follows severe traumatic brain injury (TBI). The prophylatic use of hyperventilation should be avoided after severe TBI acute phase, unless high venous O2 values are recorded at jugular bulb blood (SjO2), or to allow time when there are evidences of neurologic deterioration with posturing. The lack of cerebrovascular response to hyperventilation to low the ICP means that the blood brain barrier (BBB) function is extensively impaired. Then, hyperventilacion may be used as a screening therapeutic test in acute severe TBI, since BBB impairment is the pointer that other available clinical procedures for high ICP control (sedation, paralysis and Osmotic Diuretics) are not workable. A new pathogenetic hypothesis about traumatic brain edema and its therapeutic approach is presented
Bosede B Afolabi - One of the best experts on this subject based on the ideXlab platform.
-
mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria
Cochrane Database of Systematic Reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:BACKGROUND:The main treatment for cerebral malaria is parenteral antimalarials. Mannitol and urea are used as adjunct therapy for cerebral malaria, but the World Health Organization does not recommend them. OBJECTIVES:To compare mannitol or urea to placebo or no treatment for treating children and adults with cerebral malaria. SEARCH STRATEGY:We searched the Cochrane Infectious Diseases Group Specialized Register (June 2004), CENTRAL (The Cochrane Library Issue 2, 2004), MEDLINE (1966 to June 2004), EMBASE (1974 to June 2004), LILACS (1982 to June 2004), and reference lists of articles. We contacted relevant organizations and researchers. SELECTION CRITERIA:Randomized and quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. DATA COLLECTION AND ANALYSIS:No trials met the inclusion criteria. MAIN RESULTS:No trials met the inclusion criteria. REVIEWERS' CONCLUSIONS:We identified no randomized or quasi-randomized controlled trials to support or refute the use of mannitol or urea as adjuncts for treating cerebral malaria in clinical practice. This is likely to require a multicentre trial.
-
mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria
Cochrane Database of Systematic Reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:Background Cerebral oedema occurs with cerebral malaria, and some clinicians think Osmotic Diuretics, such as mannitol or urea, may improve outcomes. Objectives To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. Search strategy We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. Selection criteria Randomized or quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Primary outcomes were death, life-threatenining sequelae and major neurological sequelae at six months. Data collection and analysis Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. Main results One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected. Authors' conclusions There are insufficient data to know what the effects of Osmotic Diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.
-
The Cochrane Library - Mannitol and other Osmotic Diuretics as adjuncts for treating cerebral malaria.
The Cochrane database of systematic reviews, 2011Co-Authors: Christy A N Okoromah, Bosede B Afolabi, Emma C WallAbstract:Background Cerebral oedema occurs with cerebral malaria, and some clinicians think Osmotic Diuretics, such as mannitol or urea, may improve outcomes. Objectives To compare mannitol or urea to placebo or no diuretic for treating children or adults with cerebral malaria. Search strategy We searched the Cochrane Infectious Diseases Group Specialized Register (Issue 4, 2010), CENTRAL (The Cochrane Library Issue 12, 2010), MEDLINE (1966 to November 2010), EMBASE (1974 to November 2010), LILACS (1982 to November 2010), and the reference lists of articles. We contacted relevant organizations and researchers. Selection criteria Randomized or quasi-randomized controlled trials comparing mannitol or urea to placebo or no treatment in children and adults with cerebral malaria. Primary outcomes were death, life-threatenining sequelae and major neurological sequelae at six months. Data collection and analysis Two authors applied the inclusion criteria, assessed risk of bias, and extracted data independently. Main results One trial met the inclusion criteria, comparing mannitol 20% to saline placebo in 156 Ugandan children. Allocation was concealed. No difference in mortality, time to regain consciousness, or neurological sequelae were detected. Authors' conclusions There are insufficient data to know what the effects of Osmotic Diuretics are in children with cerebral malaria. Larger, multicentre trials are needed.
Drusakorn Wilairat - One of the best experts on this subject based on the ideXlab platform.
-
Serum electrolyte imbalance and prognostic factors of postoperative death in adult traumatic brain injury patients: A prospective cohort study
Medicine, 2018Co-Authors: Pathomporn Pin-on, Ananchanok Saringkarinkul, Yodying Punjasawadwong, Srisuluck Kacha, Drusakorn WilairatAbstract:AbstractElectrolyte imbalances are common in traumatic brain injury. It shares the cause of perioperative morbidity and mortality. Types of intravenous fluid resuscitation, Osmotic Diuretics, massive blood loss, and intracranial pathology were considered as the potential factors to worsen electrolyt
