The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform
Gunnur Yigit - One of the best experts on this subject based on the ideXlab platform.
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Erythrocyte Osmotic Fragility and lipid peroxidation in experimental hyperthyroidism.
Endocrine, 2009Co-Authors: Rifat Yucel, Nuran Dariyerli, Selmin Toplan, Mehmet Can Akyolcu, Semra Ozdemir, Gunnur YigitAbstract:This study investigated the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant state in primary hyperthyroidism induced experimental rats. Twenty-four Spraque-Dawley-type female rats weighing between 160 and 200 g were divided into two, as control (n = 10) and experimental (n = 12), groups. The experimental group animals have received tap water and L-Tiroksin (0.4 mg/100 g fodder) added standard fodder for 30 days to induce hyperthyroidism. Control group animals were fed tap water and standard fodder for the same period. Blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T₃, T₄, and TSH levels, Osmotic Fragility, malondialdehyde (MDA), superoxide dismutase, and glutathione levels were measured in the blood. There was a statistically significant deviation found in maximum and minimum Osmotic hemolysis limit values of experimental group when compared to controls. The standard hemolytic increment curve of the hyperthyroid group shifted to the right when compared to control group's curve. There was a statistically significant increase found in MDA and superoxide dismutase, but statistically a significant decrease was detected in glutathione levels in hyperthyroid group when compared to controls. As a result of our study, it may be concluded that hyperthyroidism may led to an increase in Osmotic Fragility of erythrocytes and this situation may possibly originate from the increased lipid peroxidation in hyperthyroidism.
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Erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control ( n =12) and experimental ( n =12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T_3, T_4, and TSH levels were measured and the animals that had relatively lower T_3, T_4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values ( p
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erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control (n=12) and experimental (n=12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T3, T4, and TSH levels were measured and the animals that had relatively lower T3, T4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values (p<0.02). The standard hemolysis and hemolytic increment curve of the hypothyroid group drawn according to Osmotic Fragility test results was found to be shifted to the right when compared to control group’s curve. This situation and hemolytic increment value, which shows maximum hemolysis ratio, is the proof of increased Osmotic Fragility of the erythrocytes in hypothyroidism. There is no statistically significant difference found between hypothyroid and control groups in the lipid peroxidation indicator MDA and antioxidant indicators SOD and GSH levels. As a result of our study it may be concluded that hypothyroidism may lead to an increase in Osmotic Fragility of erythrocytes. But the increase in erythrocyte Osmotic Fragility does not originate from lipid peroxidation.
Nuran Dariyerli - One of the best experts on this subject based on the ideXlab platform.
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Lithium-Induced Hypothyroidism: Oxidative Stress and Osmotic Fragility Status in Rats
Biological Trace Element Research, 2013Co-Authors: Selmin Toplan, Nuran Dariyerli, Semra Ozdemir, Dervis Ozcelik, Emel U. Zengin, Mehmet Can AkyolcuAbstract:The present study was conducted to explore the possible effects of different doses of lithium carbonate on thyroid functions, erythrocyte oxidant–antioxidant status, and Osmotic Fragility. Twenty-four Wistar-type male rats were equally divided into three groups: groups I and II received 0.1 and0.2 % lithium carbonate in their drinking water, respectively, for 30 days. The rats in group III served as controls, drinking tap water without added lithium. At the end of the experimental period, the erythrocyte Osmotic Fragility and the levels of triiodothyronine (T_3), thyroxine (T_4), thyroid-stimulating hormone (TSH), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were measured in blood samples. Compared to controls, there was a statistically significant increase of TSH but decreases of the T_3 and T_4 levels in group II. Both experimental groups showed a statistically significant increase of the maximum Osmotic Fragility limit. The minimum Osmotic Fragility values of the animals in group II were statistically higher than those of controls. The standard hemolytic increment curve of both experimental groups was shifted to the right when compared to the curve obtained from the controls. Also, relative to controls, the activities of MDA and SOD were significantly higher and the GSH level lower in group II, but not so in group I. The results of the present study show that treatment with lithium carbonate may result in thyroid function abnormalities, increased oxidative damage, and possible compromise of the erythrocyte membrane integrity resulting from increased Osmotic Fragility.
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Erythrocyte Osmotic Fragility and lipid peroxidation in experimental hyperthyroidism.
Endocrine, 2009Co-Authors: Rifat Yucel, Nuran Dariyerli, Selmin Toplan, Mehmet Can Akyolcu, Semra Ozdemir, Gunnur YigitAbstract:This study investigated the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant state in primary hyperthyroidism induced experimental rats. Twenty-four Spraque-Dawley-type female rats weighing between 160 and 200 g were divided into two, as control (n = 10) and experimental (n = 12), groups. The experimental group animals have received tap water and L-Tiroksin (0.4 mg/100 g fodder) added standard fodder for 30 days to induce hyperthyroidism. Control group animals were fed tap water and standard fodder for the same period. Blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T₃, T₄, and TSH levels, Osmotic Fragility, malondialdehyde (MDA), superoxide dismutase, and glutathione levels were measured in the blood. There was a statistically significant deviation found in maximum and minimum Osmotic hemolysis limit values of experimental group when compared to controls. The standard hemolytic increment curve of the hyperthyroid group shifted to the right when compared to control group's curve. There was a statistically significant increase found in MDA and superoxide dismutase, but statistically a significant decrease was detected in glutathione levels in hyperthyroid group when compared to controls. As a result of our study, it may be concluded that hyperthyroidism may led to an increase in Osmotic Fragility of erythrocytes and this situation may possibly originate from the increased lipid peroxidation in hyperthyroidism.
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Erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control ( n =12) and experimental ( n =12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T_3, T_4, and TSH levels were measured and the animals that had relatively lower T_3, T_4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values ( p
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erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control (n=12) and experimental (n=12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T3, T4, and TSH levels were measured and the animals that had relatively lower T3, T4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values (p<0.02). The standard hemolysis and hemolytic increment curve of the hypothyroid group drawn according to Osmotic Fragility test results was found to be shifted to the right when compared to control group’s curve. This situation and hemolytic increment value, which shows maximum hemolysis ratio, is the proof of increased Osmotic Fragility of the erythrocytes in hypothyroidism. There is no statistically significant difference found between hypothyroid and control groups in the lipid peroxidation indicator MDA and antioxidant indicators SOD and GSH levels. As a result of our study it may be concluded that hypothyroidism may lead to an increase in Osmotic Fragility of erythrocytes. But the increase in erythrocyte Osmotic Fragility does not originate from lipid peroxidation.
Mehmet Can Akyolcu - One of the best experts on this subject based on the ideXlab platform.
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Lithium-Induced Hypothyroidism: Oxidative Stress and Osmotic Fragility Status in Rats
Biological Trace Element Research, 2013Co-Authors: Selmin Toplan, Nuran Dariyerli, Semra Ozdemir, Dervis Ozcelik, Emel U. Zengin, Mehmet Can AkyolcuAbstract:The present study was conducted to explore the possible effects of different doses of lithium carbonate on thyroid functions, erythrocyte oxidant–antioxidant status, and Osmotic Fragility. Twenty-four Wistar-type male rats were equally divided into three groups: groups I and II received 0.1 and0.2 % lithium carbonate in their drinking water, respectively, for 30 days. The rats in group III served as controls, drinking tap water without added lithium. At the end of the experimental period, the erythrocyte Osmotic Fragility and the levels of triiodothyronine (T_3), thyroxine (T_4), thyroid-stimulating hormone (TSH), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were measured in blood samples. Compared to controls, there was a statistically significant increase of TSH but decreases of the T_3 and T_4 levels in group II. Both experimental groups showed a statistically significant increase of the maximum Osmotic Fragility limit. The minimum Osmotic Fragility values of the animals in group II were statistically higher than those of controls. The standard hemolytic increment curve of both experimental groups was shifted to the right when compared to the curve obtained from the controls. Also, relative to controls, the activities of MDA and SOD were significantly higher and the GSH level lower in group II, but not so in group I. The results of the present study show that treatment with lithium carbonate may result in thyroid function abnormalities, increased oxidative damage, and possible compromise of the erythrocyte membrane integrity resulting from increased Osmotic Fragility.
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Erythrocyte Osmotic Fragility and lipid peroxidation in experimental hyperthyroidism.
Endocrine, 2009Co-Authors: Rifat Yucel, Nuran Dariyerli, Selmin Toplan, Mehmet Can Akyolcu, Semra Ozdemir, Gunnur YigitAbstract:This study investigated the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant state in primary hyperthyroidism induced experimental rats. Twenty-four Spraque-Dawley-type female rats weighing between 160 and 200 g were divided into two, as control (n = 10) and experimental (n = 12), groups. The experimental group animals have received tap water and L-Tiroksin (0.4 mg/100 g fodder) added standard fodder for 30 days to induce hyperthyroidism. Control group animals were fed tap water and standard fodder for the same period. Blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T₃, T₄, and TSH levels, Osmotic Fragility, malondialdehyde (MDA), superoxide dismutase, and glutathione levels were measured in the blood. There was a statistically significant deviation found in maximum and minimum Osmotic hemolysis limit values of experimental group when compared to controls. The standard hemolytic increment curve of the hyperthyroid group shifted to the right when compared to control group's curve. There was a statistically significant increase found in MDA and superoxide dismutase, but statistically a significant decrease was detected in glutathione levels in hyperthyroid group when compared to controls. As a result of our study, it may be concluded that hyperthyroidism may led to an increase in Osmotic Fragility of erythrocytes and this situation may possibly originate from the increased lipid peroxidation in hyperthyroidism.
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Erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control ( n =12) and experimental ( n =12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T_3, T_4, and TSH levels were measured and the animals that had relatively lower T_3, T_4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values ( p
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erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control (n=12) and experimental (n=12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T3, T4, and TSH levels were measured and the animals that had relatively lower T3, T4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values (p<0.02). The standard hemolysis and hemolytic increment curve of the hypothyroid group drawn according to Osmotic Fragility test results was found to be shifted to the right when compared to control group’s curve. This situation and hemolytic increment value, which shows maximum hemolysis ratio, is the proof of increased Osmotic Fragility of the erythrocytes in hypothyroidism. There is no statistically significant difference found between hypothyroid and control groups in the lipid peroxidation indicator MDA and antioxidant indicators SOD and GSH levels. As a result of our study it may be concluded that hypothyroidism may lead to an increase in Osmotic Fragility of erythrocytes. But the increase in erythrocyte Osmotic Fragility does not originate from lipid peroxidation.
Selmin Toplan - One of the best experts on this subject based on the ideXlab platform.
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Lithium-Induced Hypothyroidism: Oxidative Stress and Osmotic Fragility Status in Rats
Biological Trace Element Research, 2013Co-Authors: Selmin Toplan, Nuran Dariyerli, Semra Ozdemir, Dervis Ozcelik, Emel U. Zengin, Mehmet Can AkyolcuAbstract:The present study was conducted to explore the possible effects of different doses of lithium carbonate on thyroid functions, erythrocyte oxidant–antioxidant status, and Osmotic Fragility. Twenty-four Wistar-type male rats were equally divided into three groups: groups I and II received 0.1 and0.2 % lithium carbonate in their drinking water, respectively, for 30 days. The rats in group III served as controls, drinking tap water without added lithium. At the end of the experimental period, the erythrocyte Osmotic Fragility and the levels of triiodothyronine (T_3), thyroxine (T_4), thyroid-stimulating hormone (TSH), malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) were measured in blood samples. Compared to controls, there was a statistically significant increase of TSH but decreases of the T_3 and T_4 levels in group II. Both experimental groups showed a statistically significant increase of the maximum Osmotic Fragility limit. The minimum Osmotic Fragility values of the animals in group II were statistically higher than those of controls. The standard hemolytic increment curve of both experimental groups was shifted to the right when compared to the curve obtained from the controls. Also, relative to controls, the activities of MDA and SOD were significantly higher and the GSH level lower in group II, but not so in group I. The results of the present study show that treatment with lithium carbonate may result in thyroid function abnormalities, increased oxidative damage, and possible compromise of the erythrocyte membrane integrity resulting from increased Osmotic Fragility.
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Erythrocyte Osmotic Fragility and lipid peroxidation in experimental hyperthyroidism.
Endocrine, 2009Co-Authors: Rifat Yucel, Nuran Dariyerli, Selmin Toplan, Mehmet Can Akyolcu, Semra Ozdemir, Gunnur YigitAbstract:This study investigated the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant state in primary hyperthyroidism induced experimental rats. Twenty-four Spraque-Dawley-type female rats weighing between 160 and 200 g were divided into two, as control (n = 10) and experimental (n = 12), groups. The experimental group animals have received tap water and L-Tiroksin (0.4 mg/100 g fodder) added standard fodder for 30 days to induce hyperthyroidism. Control group animals were fed tap water and standard fodder for the same period. Blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T₃, T₄, and TSH levels, Osmotic Fragility, malondialdehyde (MDA), superoxide dismutase, and glutathione levels were measured in the blood. There was a statistically significant deviation found in maximum and minimum Osmotic hemolysis limit values of experimental group when compared to controls. The standard hemolytic increment curve of the hyperthyroid group shifted to the right when compared to control group's curve. There was a statistically significant increase found in MDA and superoxide dismutase, but statistically a significant decrease was detected in glutathione levels in hyperthyroid group when compared to controls. As a result of our study, it may be concluded that hyperthyroidism may led to an increase in Osmotic Fragility of erythrocytes and this situation may possibly originate from the increased lipid peroxidation in hyperthyroidism.
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Erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control ( n =12) and experimental ( n =12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T_3, T_4, and TSH levels were measured and the animals that had relatively lower T_3, T_4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values ( p
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erythrocyte Osmotic Fragility and oxidative stress in experimental hypothyroidism
Endocrine, 2004Co-Authors: Nuran Dariyerli, Husrev Hatemi, Selmin Toplan, Mehmet Can Akyolcu, Gunnur YigitAbstract:The present study was planned to explain the relation between erythrocyte Osmotic Fragility and oxidative stress and antioxidant statue in primary hypothyroid-induced experimental rats. Twenty-four Spraque Dawley type female rats were divided into two, as control (n=12) and experimental (n=12), groups weighing between 160 and 200 g. The experimental group animals have received tap water methimazole added standard fodder to block the iodine pumps for 30 d (75 mg/100 g). Control group animals were fed tap water and only standard fodder for the same period. At the end of 30 d blood samples were drawn from the abdominal aorta of the rats under ether anesthesia. T3, T4, and TSH levels were measured and the animals that had relatively lower T3, T4, and higher TSH levels were accepted as hypothyroid group. Hormone levels of the control group were at euthyroid conditions. Osmotic Fragility, as a lipid peroxidation indicator malondialdehyde (MDA), antioxidant defense system indicators superoxide dismutase (SOD) and glutathione (GSH) levels were measured in the blood samples. Osmotic Fragility test results: There was no statistically significant difference found between maximum Osmotic hemolysis limit values of both group. Minimum Osmotic hemolysis limit value of hypothyroid group was found to be higher than that of control group values (p<0.02). The standard hemolysis and hemolytic increment curve of the hypothyroid group drawn according to Osmotic Fragility test results was found to be shifted to the right when compared to control group’s curve. This situation and hemolytic increment value, which shows maximum hemolysis ratio, is the proof of increased Osmotic Fragility of the erythrocytes in hypothyroidism. There is no statistically significant difference found between hypothyroid and control groups in the lipid peroxidation indicator MDA and antioxidant indicators SOD and GSH levels. As a result of our study it may be concluded that hypothyroidism may lead to an increase in Osmotic Fragility of erythrocytes. But the increase in erythrocyte Osmotic Fragility does not originate from lipid peroxidation.
Marina Krotenkova - One of the best experts on this subject based on the ideXlab platform.
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Salt sensitivity and Osmotic Fragility are newly specified risk factors for age-related cerebral microangiopathy
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2021Co-Authors: L A Dobrynina, A. A. Shabalina, K. V. Shamtieva, Marina Krotenkova, L A KalashnikovaAbstract:AIM/ To assess individual values of salt sensitivity and Osmotic Fragility on the patient's erythrocytes and evaluate predictive ability of these parameters in the development of cerebral small vessel disease (CSVD). MATERIAL AND METHODS The study included 73 patients with CSVD (48 women, mean age 60.1±6.5 years) and 19 volunteers (14 women, mean age 56.9±5.4 years). Their erythrocytes were used for the measurement of salt-sensitivity by a modified salt blood test and of Osmotic Fragility by the classical Osmotic Fragility test. Binary logistic regression was used to assess the ability of salt-sensitivity and Osmotic Fragility to predict CSVD development. ROC analysis was used to find out the optimal threshold values of these predictors, their sensitivity and specificity. RESULTS An increase in salt sensitivity (cut-off: 8.5 mm/h; sensitivity 64%, specificity 74%) and Osmotic Fragility (cut-off: 0.62 u.a.; sensitivity 52%, specificity 90%) or their simultaneous use (p of the model
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The Predictive Value of Salt Sensitivity and Osmotic Fragility in the Development of Cerebral Small Vessel Disease.
International journal of molecular sciences, 2020Co-Authors: L A Dobrynina, A. A. Shabalina, K. V. Shamtieva, Elena V. Gnedovskaya, Alexander B Berdalin, Marina KrotenkovaAbstract:Increased salt intake in food probably affects the progression of cerebral small vessel disease (CSVD), which justifies the study of disturbances in sodium homeostasis associated with the development of CSVD. We aimed to clarify the role of salt sensitivity and Osmotic Fragility in the development of CSVD. Erythrocyte salt sensitivity was measured using the modified salt blood test, and Osmotic Fragility was measured using the classic Osmotic Fragility test in 73 patients with CSVD (48 women; 60.1 ± 6.5 years) and 19 healthy volunteers (14 women; 56.9 ± 6.4 years). Salt sensitivity and Osmotic Fragility exhibited a predictive value in relation to CSVD. These parameters were associated with an increase in white matter hyperintensities (p = 0.019 and 0.004, respectively). Their simultaneous use increased their predictive ability for CSVD (p < 0.000001; AUC (95% CI), 0.824 (0.724–0.923)). The possibility of predicting CSVD using erythrocyte salt sensitivity and Osmotic Fragility indicates the value of the individual glycocalyx buffer capacity in relation to sodium and the activity of sodium channels in the development of CSVD. Increased salt sensitivity and Osmotic Fragility seem to be risk factors for CSVD.
