The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform
Richard L. Goode - One of the best experts on this subject based on the ideXlab platform.
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:Basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:It is generally accepted that bone conduction (BC) stimuli yield a traveling wave on the basilar membrane (BM) and hence stimulate the cochlea by the same mechanisms as normal air conduction (AC). The basis for this is the ability to cancel or mask a BC tone with an AC tone and the ability to generate two tone distortion products with a BC tone and an AC tone. The hypothesis is proposed that BC stimulates the BM not only through the hydrodynamics of the scala vestibuli and scala tympani, but also through Osseous Spiral Lamina (OSL) vibrations. To test this hypothesis the BM and OSL response with AC as well as BC stimulation was measured with a laser Doppler vibrometer. Human temporal bones mounted on a shaker were used to record the velocities of the bone per se, the BM and the OSL. The measurements were then converted to relative BM and OSL velocities. The results from the basal turn of the cochlea show similar behavior with AC and BC stimulation. The motion of the OSL at the edge where it connects to the BM is in phase and is typically 6 dB lower than the BM motion. With BC stimulation, there is less phase accumulation in the OSL after the cochlea is drained; the OSL moves due to inertial forces and resonates at approximately 7 kHz. Inertial vibration of the OSL may partially contribute to the total response of BC sound, especially at the high frequencies, although current models of the cochlea assume a rigid OSL. The measurements reported here can be used to include a flexible OSL in cochlear models.
Stefan Stenfelt - One of the best experts on this subject based on the ideXlab platform.
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:Basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:It is generally accepted that bone conduction (BC) stimuli yield a traveling wave on the basilar membrane (BM) and hence stimulate the cochlea by the same mechanisms as normal air conduction (AC). The basis for this is the ability to cancel or mask a BC tone with an AC tone and the ability to generate two tone distortion products with a BC tone and an AC tone. The hypothesis is proposed that BC stimulates the BM not only through the hydrodynamics of the scala vestibuli and scala tympani, but also through Osseous Spiral Lamina (OSL) vibrations. To test this hypothesis the BM and OSL response with AC as well as BC stimulation was measured with a laser Doppler vibrometer. Human temporal bones mounted on a shaker were used to record the velocities of the bone per se, the BM and the OSL. The measurements were then converted to relative BM and OSL velocities. The results from the basal turn of the cochlea show similar behavior with AC and BC stimulation. The motion of the OSL at the edge where it connects to the BM is in phase and is typically 6 dB lower than the BM motion. With BC stimulation, there is less phase accumulation in the OSL after the cochlea is drained; the OSL moves due to inertial forces and resonates at approximately 7 kHz. Inertial vibration of the OSL may partially contribute to the total response of BC sound, especially at the high frequencies, although current models of the cochlea assume a rigid OSL. The measurements reported here can be used to include a flexible OSL in cochlear models.
Naohito Hato - One of the best experts on this subject based on the ideXlab platform.
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:Basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:It is generally accepted that bone conduction (BC) stimuli yield a traveling wave on the basilar membrane (BM) and hence stimulate the cochlea by the same mechanisms as normal air conduction (AC). The basis for this is the ability to cancel or mask a BC tone with an AC tone and the ability to generate two tone distortion products with a BC tone and an AC tone. The hypothesis is proposed that BC stimulates the BM not only through the hydrodynamics of the scala vestibuli and scala tympani, but also through Osseous Spiral Lamina (OSL) vibrations. To test this hypothesis the BM and OSL response with AC as well as BC stimulation was measured with a laser Doppler vibrometer. Human temporal bones mounted on a shaker were used to record the velocities of the bone per se, the BM and the OSL. The measurements were then converted to relative BM and OSL velocities. The results from the basal turn of the cochlea show similar behavior with AC and BC stimulation. The motion of the OSL at the edge where it connects to the BM is in phase and is typically 6 dB lower than the BM motion. With BC stimulation, there is less phase accumulation in the OSL after the cochlea is drained; the OSL moves due to inertial forces and resonates at approximately 7 kHz. Inertial vibration of the OSL may partially contribute to the total response of BC sound, especially at the high frequencies, although current models of the cochlea assume a rigid OSL. The measurements reported here can be used to include a flexible OSL in cochlear models.
Sunil Puria - One of the best experts on this subject based on the ideXlab platform.
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:Basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
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basilar membrane and Osseous Spiral Lamina motion in human cadavers with air and bone conduction stimuli
Hearing Research, 2003Co-Authors: Stefan Stenfelt, Sunil Puria, Naohito Hato, Richard L. GoodeAbstract:It is generally accepted that bone conduction (BC) stimuli yield a traveling wave on the basilar membrane (BM) and hence stimulate the cochlea by the same mechanisms as normal air conduction (AC). The basis for this is the ability to cancel or mask a BC tone with an AC tone and the ability to generate two tone distortion products with a BC tone and an AC tone. The hypothesis is proposed that BC stimulates the BM not only through the hydrodynamics of the scala vestibuli and scala tympani, but also through Osseous Spiral Lamina (OSL) vibrations. To test this hypothesis the BM and OSL response with AC as well as BC stimulation was measured with a laser Doppler vibrometer. Human temporal bones mounted on a shaker were used to record the velocities of the bone per se, the BM and the OSL. The measurements were then converted to relative BM and OSL velocities. The results from the basal turn of the cochlea show similar behavior with AC and BC stimulation. The motion of the OSL at the edge where it connects to the BM is in phase and is typically 6 dB lower than the BM motion. With BC stimulation, there is less phase accumulation in the OSL after the cochlea is drained; the OSL moves due to inertial forces and resonates at approximately 7 kHz. Inertial vibration of the OSL may partially contribute to the total response of BC sound, especially at the high frequencies, although current models of the cochlea assume a rigid OSL. The measurements reported here can be used to include a flexible OSL in cochlear models.
Qian Li - One of the best experts on this subject based on the ideXlab platform.
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exome sequencing and linkage analysis identified tenascin c tnc as a novel causative gene in nonsyndromic hearing loss
PLOS ONE, 2013Co-Authors: Yali Zhao, Feifan Zhao, Liping Guan, Wei Chai, Liang Zong, Jianguo Zhang, Dayong Wang, Jing Wang, Peng Zhang, Qian LiAbstract:In this study, a five-generation Chinese family (family F013) with progressive autosomal dominant hearing loss was mapped to a critical region spanning 28.54 Mb on chromosome 9q31.3-q34.3 by linkage analysis, which was a novel DFNA locus, assigned as DFNA56. In this interval, there were 398 annotated genes. Then, whole exome sequencing was applied in three patients and one normal individual from this family. Six single nucleotide variants and two indels were found co-segregated with the phenotypes. Then using mass spectrum (Sequenom, Inc.) to rank the eight sites, we found only the TNC gene be co-segregated with hearing loss in 53 subjects of F013. And this missense mutation (c.5317G>A, p.V1773M) of TNC located exactly in the critical linked interval. Further screening to the coding region of this gene in 587 subjects with nonsyndromic hearing loss (NSHL) found a second missense mutation, c.5368A>T (p. T1796S), co-segregating with phenotype in the other family. These two mutations located in the conserved region of TNC and were absent in the 387 normal hearing individuals of matched geographical ancestry. Functional effects of the two mutations were predicted using SIFT and both mutations were deleterious. All these results supported that TNC may be the causal gene for the hearing loss inherited in these families. TNC encodes tenascin-C, a member of the extracellular matrix (ECM), is present in the basilar membrane (BM), and the Osseous Spiral Lamina of the cochlea. It plays an important role in cochlear development. The up-regulated expression of TNC gene in tissue repair and neural regeneration was seen in human and zebrafish, and in sensory receptor recovery in the vestibular organ after ototoxic injury in birds. Then the absence of normal tenascin-C was supposed to cause irreversible injuries in cochlea and caused hearing loss.
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exome sequencing and linkage analysis identified tenascin c tnc as a novel causative gene in nonsyndromic hearing loss
PLOS ONE, 2013Co-Authors: Yali Zhao, Feifan Zhao, Liping Guan, Wei Chai, Liang Zong, Jianguo Zhang, Dayong Wang, Jing Wang, Peng Zhang, Qian LiAbstract:In this study, a five-generation Chinese family (family F013) with progressive autosomal dominant hearing loss was mapped to a critical region spanning 28.54 Mb on chromosome 9q31.3-q34.3 by linkage analysis, which was a novel DFNA locus, assigned as DFNA56. In this interval, there were 398 annotated genes. Then, whole exome sequencing was applied in three patients and one normal individual from this family. Six single nucleotide variants and two indels were found co-segregated with the phenotypes. Then using mass spectrum (Sequenom, Inc.) to rank the eight sites, we found only the TNC gene be co-segregated with hearing loss in 53 subjects of F013. And this missense mutation (c.5317G>A, p.V1773M) of TNC located exactly in the critical linked interval. Further screening to the coding region of this gene in 587 subjects with nonsyndromic hearing loss (NSHL) found a second missense mutation, c.5368A>T (p. T1796S), co-segregating with phenotype in the other family. These two mutations located in the conserved region of TNC and were absent in the 387 normal hearing individuals of matched geographical ancestry. Functional effects of the two mutations were predicted using SIFT and both mutations were deleterious. All these results supported that TNC may be the causal gene for the hearing loss inherited in these families. TNC encodes tenascin-C, a member of the extracellular matrix (ECM), is present in the basilar membrane (BM), and the Osseous Spiral Lamina of the cochlea. It plays an important role in cochlear development. The up-regulated expression of TNC gene in tissue repair and neural regeneration was seen in human and zebrafish, and in sensory receptor recovery in the vestibular organ after ototoxic injury in birds. Then the absence of normal tenascin-C was supposed to cause irreversible injuries in cochlea and caused hearing loss.
