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James A De Lemos - One of the best experts on this subject based on the ideXlab platform.
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plasma Osteoprotegerin levels in the general population relation to indices of left ventricular structure and function
Hypertension, 2007Co-Authors: Torbjorn Omland, Mark H Drazner, Thor Ueland, Moeen Abedin, Sabina A Murphy, Pal Aukrust, James A De LemosAbstract:Osteoprotegerin, a member of the tumor necrosis factor receptor superfamily, has pleiotropic effects on bone metabolism, endocrine function, and the immune system. Myocardial expression and circulating levels of Osteoprotegerin are increased in heart failure. The relationship between Osteoprotegerin levels in the general population and indices of left ventricular structure and function is unknown. Plasma Osteoprotegerin levels and cardiac MRI indices of left ventricular structure and function were available in 2715 subjects (median age: 44 years; 45% male) enrolled in the Dallas Heart Study. The associations between Osteoprotegerin concentration and indices of left ventricular structure and function were assessed by linear regression analysis, adjusting for possible confounders. By gender-specific linear regression analysis, higher Osteoprotegerin levels were significantly associated with higher left ventricular mass, left ventricular wall thickness, left ventricular concentricity index, and lower left ventricular ejection fraction ( P 10, and presence of aortic plaque, Osteoprotegerin remained significantly associated with each of these left ventricular indices among male subjects ( P P
Pal Aukrust - One of the best experts on this subject based on the ideXlab platform.
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plasma Osteoprotegerin levels in the general population relation to indices of left ventricular structure and function
Hypertension, 2007Co-Authors: Torbjorn Omland, Mark H Drazner, Thor Ueland, Moeen Abedin, Sabina A Murphy, Pal Aukrust, James A De LemosAbstract:Osteoprotegerin, a member of the tumor necrosis factor receptor superfamily, has pleiotropic effects on bone metabolism, endocrine function, and the immune system. Myocardial expression and circulating levels of Osteoprotegerin are increased in heart failure. The relationship between Osteoprotegerin levels in the general population and indices of left ventricular structure and function is unknown. Plasma Osteoprotegerin levels and cardiac MRI indices of left ventricular structure and function were available in 2715 subjects (median age: 44 years; 45% male) enrolled in the Dallas Heart Study. The associations between Osteoprotegerin concentration and indices of left ventricular structure and function were assessed by linear regression analysis, adjusting for possible confounders. By gender-specific linear regression analysis, higher Osteoprotegerin levels were significantly associated with higher left ventricular mass, left ventricular wall thickness, left ventricular concentricity index, and lower left ventricular ejection fraction ( P 10, and presence of aortic plaque, Osteoprotegerin remained significantly associated with each of these left ventricular indices among male subjects ( P P
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dysregulated Osteoprotegerin rank ligand rank axis in clinical and experimental heart failure
Circulation, 2005Co-Authors: Thor Ueland, Arne Yndestad, Geir Florholmen, Bente Halvorsen, Stig S Froland, Svein Simonsen, Geir Christensen, Lars Gullestad, Pal AukrustAbstract:Background— Persistent inflammation appears to play a role in the development of heart failure (HF). Osteoprotegerin (OPG), the receptor activator of nuclear factor-κB (RANK), and RANK ligand (RANK...
Thor Ueland - One of the best experts on this subject based on the ideXlab platform.
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plasma Osteoprotegerin levels in the general population relation to indices of left ventricular structure and function
Hypertension, 2007Co-Authors: Torbjorn Omland, Mark H Drazner, Thor Ueland, Moeen Abedin, Sabina A Murphy, Pal Aukrust, James A De LemosAbstract:Osteoprotegerin, a member of the tumor necrosis factor receptor superfamily, has pleiotropic effects on bone metabolism, endocrine function, and the immune system. Myocardial expression and circulating levels of Osteoprotegerin are increased in heart failure. The relationship between Osteoprotegerin levels in the general population and indices of left ventricular structure and function is unknown. Plasma Osteoprotegerin levels and cardiac MRI indices of left ventricular structure and function were available in 2715 subjects (median age: 44 years; 45% male) enrolled in the Dallas Heart Study. The associations between Osteoprotegerin concentration and indices of left ventricular structure and function were assessed by linear regression analysis, adjusting for possible confounders. By gender-specific linear regression analysis, higher Osteoprotegerin levels were significantly associated with higher left ventricular mass, left ventricular wall thickness, left ventricular concentricity index, and lower left ventricular ejection fraction ( P 10, and presence of aortic plaque, Osteoprotegerin remained significantly associated with each of these left ventricular indices among male subjects ( P P
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dysregulated Osteoprotegerin rank ligand rank axis in clinical and experimental heart failure
Circulation, 2005Co-Authors: Thor Ueland, Arne Yndestad, Geir Florholmen, Bente Halvorsen, Stig S Froland, Svein Simonsen, Geir Christensen, Lars Gullestad, Pal AukrustAbstract:Background— Persistent inflammation appears to play a role in the development of heart failure (HF). Osteoprotegerin (OPG), the receptor activator of nuclear factor-κB (RANK), and RANK ligand (RANK...
Shi Tang - One of the best experts on this subject based on the ideXlab platform.
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Relationship between Osteoprotegerin and type 2 diabetes mellitus
International Journal of Pediatrics, 2016Co-Authors: Shi TangAbstract:Type 2 diabetes mellitus, a endocrine disease, threatens human health.Recent researches have indicated that the Osteoprotegerin is associated with type 2 diabetes mellitus closely.The content of Osteoprotegerin, existing in circulating system, pancreas, liver and fat of diabetic patients, changed significantly.The Osteoprotegerin is also closely related to the vascular complication of diabetes mellitus, which has been discussed by many scholars.In this paper, the relation between Osteoprotegerin and type 2 diabetes mellitus is summarized by reviewing relevant literatures, Providing new ideas concerning treatment of diabetes mellitus. Key words: Osteoprotegerin; Type 2 diabetes mellitus; Mechanism
Sina Noshad - One of the best experts on this subject based on the ideXlab platform.
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Association of Osteoprotegerin with peripheral artery disease in patients with type 2 diabetes
Archives of Cardiovascular Diseases, 2020Co-Authors: Alireza Esteghamati, Maryam Aflatoonian, Tina Mazaheri, Mostafa Mousavizadeh, Manouchehr Nakhjavani, Sina NoshadAbstract:SummaryBackgroundOsteoprotegerin plays a critical role in the pathogenesis of atherosclerosis. Elevated Osteoprotegerin concentrations have been reported in microvascular complications of diabetes. Patients with diabetes are at increased risk of macrovascular complications, particularly peripheral artery disease (PAD).AimTo investigate the association between Osteoprotegerin concentration and PAD in diabetes.MethodsIn a cross-sectional setting, patients with type 2 diabetes for>5 years and no apparent diabetic foot ulcer were recruited. Patients underwent colour Doppler ultrasonography of lower limbs and were designated PAD+ if arterial narrowing was detected. Ankle-brachial index (ABI) was measured. Serum Osteoprotegerin concentrations were determined.ResultsNinety-eight patients (47 PAD+, 51 PAD–) were recruited. Osteoprotegerin concentrations (median [interquartile range]) were significantly higher in PAD+ versus PAD– patients (0.80 [0.50–1.95] ng/mL vs 0.30 [0.25–0.40] ng/mL; P
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Association of Osteoprotegerin with peripheral artery disease in patients with type 2 diabetes.
Archives of cardiovascular diseases, 2015Co-Authors: Alireza Esteghamati, Maryam Aflatoonian, Tina Mazaheri, Mostafa Mousavizadeh, Manouchehr Nakhjavani, Sina NoshadAbstract:Osteoprotegerin plays a critical role in the pathogenesis of atherosclerosis. Elevated Osteoprotegerin concentrations have been reported in microvascular complications of diabetes. Patients with diabetes are at increased risk of macrovascular complications, particularly peripheral artery disease (PAD). To investigate the association between Osteoprotegerin concentration and PAD in diabetes. In a cross-sectional setting, patients with type 2 diabetes for>5 years and no apparent diabetic foot ulcer were recruited. Patients underwent colour Doppler ultrasonography of lower limbs and were designated PAD+ if arterial narrowing was detected. Ankle-brachial index (ABI) was measured. Serum Osteoprotegerin concentrations were determined. Ninety-eight patients (47 PAD+, 51 PAD-) were recruited. Osteoprotegerin concentrations (median [interquartile range]) were significantly higher in PAD+ versus PAD- patients (0.80 [0.50-1.95] ng/mL vs 0.30 [0.25-0.40] ng/mL; P<0.001). In logistic regression, log-Osteoprotegerin was a predictor of PAD in univariate and multivariable analyses. In the final multivariable model, adjusting for age, sex, body mass index, smoking, hypertension, glycaemic control, lipid profile, renal function and C-reactive protein, one standard deviation increase in log-Osteoprotegerin was associated with a more than twofold increase in the risk of having PAD (odds ratio 2.26, 95% confidence interval 1.50-3.40). In PAD+ patients, Osteoprotegerin was a significant predictor of disease severity, determined by ABI and percentage of vessel occlusion in univariate and multivariable models. Osteoprotegerin concentrations are increased in patients with diabetes and PAD. Osteoprotegerin is an independent predictor of the presence and severity of PAD in diabetic patients. Copyright © 2015 Elsevier Masson SAS. All rights reserved.
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Comparison of Osteoprotegerin and vascular endothelial growth factor in normoalbuminuric Type 1 diabetic and control subjects.
Journal of Endocrinological Investigation, 2013Co-Authors: Abdoulreza Esteghamati, Sina Noshad, Alireza Arefzadeh, Ali Zandieh, M. Salehi Sadaghiani, M. NakhjavaniAbstract:Background: The aim of the current study was to evaluate the association of Osteoprotegerin and vascular endothelial growth factor (VEGF) with glycemic indices and diabetes status. Methods: A total of 44 normoalbuminuric Type 1 diabetic patients and 44 healthy control subjects, matched for age, body mass index, sex ratio, and lipid measures were enrolled. Univariate and multivariate logistic regression analyses were used to determine the association of Osteoprotegerin and VEGF with diabetes status. Further, linear regression analysis was performed to investigate the roles of Osteoprotegerin and VEGF as determinants of glycated hemoglobin (HbA1c). Results: Osteoprotegerin and VEGF were significantly elevated in diabetic subjects (2.76±0.85 vs 2.26±0.75 pmol/l and 187.1±92.7 vs 125.9±52.3 pg/ml, respectively, p
