The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform
Pierre Dorny - One of the best experts on this subject based on the ideXlab platform.
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evaluation of pepsinogen gastrin and antibody response in diagnosing Ostertagiasis
Veterinary Parasitology, 1993Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre DornyAbstract:Abstract Ostertagia ostertagi is widely distributed and is one of the most important parasites affecting young bovine livestock. There is, therefore, a substantial need for sensitive and specific parameters in support of diagnosis of Ostertagiasis, especially for subclinical disease related to production losses. In this review, the value and application of pepsinogen, gastrin and antibody response as diagnostic tools are discussed. These three parameters are useful and comparable for confirming clinical disease in calves during their first grazing season. However, their value for detecting subclinical parasitism is questionable. Differences in the course of gastrin and pepsinogen late in the grazing season can be correlated with larval inhibition and the possibility of Ostertagiasis Type II. Relatively few serological methods have been developed for the immunodiagnosis of Ostertagia and until now the indirect antibody-detecting enzyme-linked immunosorbent assay (ELISA) has been the method of choice. Antibody measuring methods have several disadvantages, most notably a lack of sensitivity and specificity, which limits their use in longitudinal epidemiological studies. Considering the necessity of cost effectiveness and ease of use, it is anticipated that additional work will result in the enhancement and quality of current immunodiagnostic methods.
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Observations on parasitic gastroenteritis and parasitic bronchitis in calves over two grazing seasons
Veterinary Record, 1990Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre Dorny, W HollandersAbstract:Two outbreaks of parasitic gastroenteritis were observed in a group of 10 first-season grazing calves, one in mid-July and one in mid-September. In both cases emergency anthelmintic treatment was needed to prevent further damage. Severe clinical signs were observed together with high faecal egg counts and high serum pepsinogen and gastrin concentrations. Low total protein and albumin concentrations were also observed, especially during the second outbreak. The ostertagia antibody levels followed a similar pattern to the serum pepsinogen and gastrin concentrations. At the end of the housing period a mild type II Ostertagiasis was observed. In the second grazing season the heifers did not show any signs of parasitic gastroenteritis, but there was a serious outbreak of husk which required treatment.
Paul Berghen - One of the best experts on this subject based on the ideXlab platform.
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evaluation of pepsinogen gastrin and antibody response in diagnosing Ostertagiasis
Veterinary Parasitology, 1993Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre DornyAbstract:Abstract Ostertagia ostertagi is widely distributed and is one of the most important parasites affecting young bovine livestock. There is, therefore, a substantial need for sensitive and specific parameters in support of diagnosis of Ostertagiasis, especially for subclinical disease related to production losses. In this review, the value and application of pepsinogen, gastrin and antibody response as diagnostic tools are discussed. These three parameters are useful and comparable for confirming clinical disease in calves during their first grazing season. However, their value for detecting subclinical parasitism is questionable. Differences in the course of gastrin and pepsinogen late in the grazing season can be correlated with larval inhibition and the possibility of Ostertagiasis Type II. Relatively few serological methods have been developed for the immunodiagnosis of Ostertagia and until now the indirect antibody-detecting enzyme-linked immunosorbent assay (ELISA) has been the method of choice. Antibody measuring methods have several disadvantages, most notably a lack of sensitivity and specificity, which limits their use in longitudinal epidemiological studies. Considering the necessity of cost effectiveness and ease of use, it is anticipated that additional work will result in the enhancement and quality of current immunodiagnostic methods.
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Observations on parasitic gastroenteritis and parasitic bronchitis in calves over two grazing seasons
Veterinary Record, 1990Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre Dorny, W HollandersAbstract:Two outbreaks of parasitic gastroenteritis were observed in a group of 10 first-season grazing calves, one in mid-July and one in mid-September. In both cases emergency anthelmintic treatment was needed to prevent further damage. Severe clinical signs were observed together with high faecal egg counts and high serum pepsinogen and gastrin concentrations. Low total protein and albumin concentrations were also observed, especially during the second outbreak. The ostertagia antibody levels followed a similar pattern to the serum pepsinogen and gastrin concentrations. At the end of the housing period a mild type II Ostertagiasis was observed. In the second grazing season the heifers did not show any signs of parasitic gastroenteritis, but there was a serious outbreak of husk which required treatment.
Jozef Vercruysse - One of the best experts on this subject based on the ideXlab platform.
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The serological diagnosis of gastrointestinal nematode infections in cattle
Verhandelingen - Koninklijke Academie voor Geneeskunde van België, 1993Co-Authors: Jozef Vercruysse, Hilderson HAbstract:: Ostertagia ostertagi and Cooperia oncophora are widely distributed and are the most important parasites affecting young bovine livestock. Therefore, there is a substantial need for sensitive and specific parameters in support of their diagnosis, especially for sub-clinical disease correlated to production loss. In this review, the value and the application as a diagnostic tool of pepsinogen, gastrin and antibody response are discussed. An increase in pepsinogen or gastrin reflects mucosal damage caused by an Ostertagia infection. Some controversy exists about the level of pepsinogen and gastrin, which may be considered indicative for the diagnosis of clinical and sub-clinical Ostertagiasis. Pepsinogen levels between 3,000 tot 4,000 mU tyrosine are regarded indicative for subclinical disease, values in excess of 5,000 mU tyrosine are considered significant for diagnosing clinical disease. For gastrin, it is suggested that based on group means, values of 400 pg/ml are indicative for subclinical parasitic disease in calves with reduced daily weight gain, while threshold levels of > or = 1000 pg/ml gastrin are representative for clinical Ostertagiasis. Antibody responses to Ostertagia and Cooperia can be assessed using the enzyme immunoassay (EIA). Until now, mainly crude worm extracts have been used as antigen source in the EIA. They are not species-specific as discussed experiments provide evidence of a close relationship between the onset of parasitic disease and the evolution of the group mean parameters. However, data demonstrate serious variations between animals, which impede a reliable individual diagnosis. For longitudinal epidemiological studies especially pepsinogen and gastrin have proven their value, exhibiting fast fluctuations induced by infection or as a result of treatment. Conversely antibody levels were found to be more stable and therefore are useful in large cross-sectional studies, enabling a rough assessment of the degree of infection.
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evaluation of pepsinogen gastrin and antibody response in diagnosing Ostertagiasis
Veterinary Parasitology, 1993Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre DornyAbstract:Abstract Ostertagia ostertagi is widely distributed and is one of the most important parasites affecting young bovine livestock. There is, therefore, a substantial need for sensitive and specific parameters in support of diagnosis of Ostertagiasis, especially for subclinical disease related to production losses. In this review, the value and application of pepsinogen, gastrin and antibody response as diagnostic tools are discussed. These three parameters are useful and comparable for confirming clinical disease in calves during their first grazing season. However, their value for detecting subclinical parasitism is questionable. Differences in the course of gastrin and pepsinogen late in the grazing season can be correlated with larval inhibition and the possibility of Ostertagiasis Type II. Relatively few serological methods have been developed for the immunodiagnosis of Ostertagia and until now the indirect antibody-detecting enzyme-linked immunosorbent assay (ELISA) has been the method of choice. Antibody measuring methods have several disadvantages, most notably a lack of sensitivity and specificity, which limits their use in longitudinal epidemiological studies. Considering the necessity of cost effectiveness and ease of use, it is anticipated that additional work will result in the enhancement and quality of current immunodiagnostic methods.
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Observations on parasitic gastroenteritis and parasitic bronchitis in calves over two grazing seasons
Veterinary Record, 1990Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre Dorny, W HollandersAbstract:Two outbreaks of parasitic gastroenteritis were observed in a group of 10 first-season grazing calves, one in mid-July and one in mid-September. In both cases emergency anthelmintic treatment was needed to prevent further damage. Severe clinical signs were observed together with high faecal egg counts and high serum pepsinogen and gastrin concentrations. Low total protein and albumin concentrations were also observed, especially during the second outbreak. The ostertagia antibody levels followed a similar pattern to the serum pepsinogen and gastrin concentrations. At the end of the housing period a mild type II Ostertagiasis was observed. In the second grazing season the heifers did not show any signs of parasitic gastroenteritis, but there was a serious outbreak of husk which required treatment.
Harold C Gibbs - One of the best experts on this subject based on the ideXlab platform.
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Ostertagiasis in the cow and weaned calf in the northeastern usa
Veterinary Parasitology, 1993Co-Authors: Harold C GibbsAbstract:Abstract Most gastrointestinal nematode infections of cattle in the northeast USA are combinations of Ostertagia ostertagi and Cooperia oncophora. These infections are usually of little consequence in adult cattle because of immunity and consequent low levels of infection. Some work has been done on the effects of infection on milk production but the results are equivocal. Clinical Ostertagiasis in calves can lead to mortality. Such outbreaks are often associated with situations where calves are pastured at an early age onto special calf pastures that are used consistently for this purpose. Subclinical Ostertagiasis is more usual in this region where light infections become established in calves with no obvious clinical signs. Such infections exact a toll on productivity in the form of decreased weight gains, decreased carcass quality, reduced nitrogen balance and negative effects on post-absorptive protein metabolism. Subclinical infections can also cause transient suppression of cell-mediated immune responses in calves. Increases in fecal worm egg counts of cows have been shown to occur during the spring months and these may contribute to increased contamination of pastures. Ostertagia infective larvae overwinter successfully on pasture and can persist until midsummer. Typical egg production patterns in calves involve a prepatent period, after introduction to pasture in mid to late May, of approximately 3 weeks. Peak egg production occurs at about 6–8 weeks and is followed by a gradual decline in egg counts into the fall. Hypobiosis is very apparent in this region and is most pronounced in late fall (October–November). Most of the winter population of Ostertagia in cattle are hypobiotic fourth stage larvae and there appears to be a gradual resumption of development in the spring. Type II Ostertagiasis is rare. Infective larvae build up on pasture over the summer and there can be significant numbers available to calves in the fall. These larvae can cause pathologic damage in the abomasum as reflected by marked increases in plasma pepsinogen levels in these calves.
Hans Hilderson - One of the best experts on this subject based on the ideXlab platform.
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evaluation of pepsinogen gastrin and antibody response in diagnosing Ostertagiasis
Veterinary Parasitology, 1993Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre DornyAbstract:Abstract Ostertagia ostertagi is widely distributed and is one of the most important parasites affecting young bovine livestock. There is, therefore, a substantial need for sensitive and specific parameters in support of diagnosis of Ostertagiasis, especially for subclinical disease related to production losses. In this review, the value and application of pepsinogen, gastrin and antibody response as diagnostic tools are discussed. These three parameters are useful and comparable for confirming clinical disease in calves during their first grazing season. However, their value for detecting subclinical parasitism is questionable. Differences in the course of gastrin and pepsinogen late in the grazing season can be correlated with larval inhibition and the possibility of Ostertagiasis Type II. Relatively few serological methods have been developed for the immunodiagnosis of Ostertagia and until now the indirect antibody-detecting enzyme-linked immunosorbent assay (ELISA) has been the method of choice. Antibody measuring methods have several disadvantages, most notably a lack of sensitivity and specificity, which limits their use in longitudinal epidemiological studies. Considering the necessity of cost effectiveness and ease of use, it is anticipated that additional work will result in the enhancement and quality of current immunodiagnostic methods.
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Observations on parasitic gastroenteritis and parasitic bronchitis in calves over two grazing seasons
Veterinary Record, 1990Co-Authors: Paul Berghen, Hans Hilderson, Jozef Vercruysse, Pierre Dorny, W HollandersAbstract:Two outbreaks of parasitic gastroenteritis were observed in a group of 10 first-season grazing calves, one in mid-July and one in mid-September. In both cases emergency anthelmintic treatment was needed to prevent further damage. Severe clinical signs were observed together with high faecal egg counts and high serum pepsinogen and gastrin concentrations. Low total protein and albumin concentrations were also observed, especially during the second outbreak. The ostertagia antibody levels followed a similar pattern to the serum pepsinogen and gastrin concentrations. At the end of the housing period a mild type II Ostertagiasis was observed. In the second grazing season the heifers did not show any signs of parasitic gastroenteritis, but there was a serious outbreak of husk which required treatment.
