The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Gerald M Reaven - One of the best experts on this subject based on the ideXlab platform.
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:Abstract This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P < .01 to .0001). Plasma insulin concentRations in response to oral glucose (2 g/kg) were increased 2-fold by fat feeding (P < .01), and adipocyte glucose clearance under maximal insulin stimulation was significantly reduced (P < .001), suggesting that fat feeding induced insulin resistance. STZ injection increased glucose (P < .05), insulin (P < .05), FFA (P < .05), and TG (P < .0001) concentRations in fat-fed Rats (Fat-fed/STZ Rats) compared with chow-fed, STZ-injected Rats (Chow-fed/STZ Rats). Fat-fed/STZ Rats were not insulin deficient compared with normal chow-fed Rats, but had hyperglycemia and a somewhat higher insulin response to an oral glucose challenge (both P < .05). In addition, insulin-stimulated adipocyte glucose clearance was reduced in Fat-fed/STZ Rats compared with both chow-fed and Chow-fed/STZ Rats (P < .001). Finally, Fat-fed/STZ Rats were sensitive to the glucose lowering effects of metformin and troglitazone. In conclusion, Fat-fed/STZ Rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.
M J Reed - One of the best experts on this subject based on the ideXlab platform.
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:Abstract This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P < .01 to .0001). Plasma insulin concentRations in response to oral glucose (2 g/kg) were increased 2-fold by fat feeding (P < .01), and adipocyte glucose clearance under maximal insulin stimulation was significantly reduced (P < .001), suggesting that fat feeding induced insulin resistance. STZ injection increased glucose (P < .05), insulin (P < .05), FFA (P < .05), and TG (P < .0001) concentRations in fat-fed Rats (Fat-fed/STZ Rats) compared with chow-fed, STZ-injected Rats (Chow-fed/STZ Rats). Fat-fed/STZ Rats were not insulin deficient compared with normal chow-fed Rats, but had hyperglycemia and a somewhat higher insulin response to an oral glucose challenge (both P < .05). In addition, insulin-stimulated adipocyte glucose clearance was reduced in Fat-fed/STZ Rats compared with both chow-fed and Chow-fed/STZ Rats (P < .001). Finally, Fat-fed/STZ Rats were sensitive to the glucose lowering effects of metformin and troglitazone. In conclusion, Fat-fed/STZ Rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.
L J Entes - One of the best experts on this subject based on the ideXlab platform.
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:Abstract This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P < .01 to .0001). Plasma insulin concentRations in response to oral glucose (2 g/kg) were increased 2-fold by fat feeding (P < .01), and adipocyte glucose clearance under maximal insulin stimulation was significantly reduced (P < .001), suggesting that fat feeding induced insulin resistance. STZ injection increased glucose (P < .05), insulin (P < .05), FFA (P < .05), and TG (P < .0001) concentRations in fat-fed Rats (Fat-fed/STZ Rats) compared with chow-fed, STZ-injected Rats (Chow-fed/STZ Rats). Fat-fed/STZ Rats were not insulin deficient compared with normal chow-fed Rats, but had hyperglycemia and a somewhat higher insulin response to an oral glucose challenge (both P < .05). In addition, insulin-stimulated adipocyte glucose clearance was reduced in Fat-fed/STZ Rats compared with both chow-fed and Chow-fed/STZ Rats (P < .001). Finally, Fat-fed/STZ Rats were sensitive to the glucose lowering effects of metformin and troglitazone. In conclusion, Fat-fed/STZ Rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.
T M Gadbois - One of the best experts on this subject based on the ideXlab platform.
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:Abstract This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P < .01 to .0001). Plasma insulin concentRations in response to oral glucose (2 g/kg) were increased 2-fold by fat feeding (P < .01), and adipocyte glucose clearance under maximal insulin stimulation was significantly reduced (P < .001), suggesting that fat feeding induced insulin resistance. STZ injection increased glucose (P < .05), insulin (P < .05), FFA (P < .05), and TG (P < .0001) concentRations in fat-fed Rats (Fat-fed/STZ Rats) compared with chow-fed, STZ-injected Rats (Chow-fed/STZ Rats). Fat-fed/STZ Rats were not insulin deficient compared with normal chow-fed Rats, but had hyperglycemia and a somewhat higher insulin response to an oral glucose challenge (both P < .05). In addition, insulin-stimulated adipocyte glucose clearance was reduced in Fat-fed/STZ Rats compared with both chow-fed and Chow-fed/STZ Rats (P < .001). Finally, Fat-fed/STZ Rats were sensitive to the glucose lowering effects of metformin and troglitazone. In conclusion, Fat-fed/STZ Rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.
J G Pinkett - One of the best experts on this subject based on the ideXlab platform.
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:Abstract This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P
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a new Rat model of type 2 diabetes the fat fed streptozotocin treated Rat
Metabolism-clinical and Experimental, 2000Co-Authors: M J Reed, K Meszaros, L J Entes, M D Claypool, J G Pinkett, T M Gadbois, Gerald M ReavenAbstract:This study was initiated to develop an animal model of type 2 diabetes in a non-obese, Outbred Rat Strain that replicates the natural history and metabolic characteristics of the human syndrome and is suitable for pharmaceutical research. Male Sprague-Dawley Rats (n = 31), 7 weeks old, were fed normal chow (12% of calories as fat), or high-fat diet (40% of calories as fat) for 2 weeks and then injected with streptozotocin (STZ, 50 mg/kg intravenously). Before STZ injection, fat-fed Rats had similar glucose concentRations to chow-fed Rats, but significantly higher insulin, free fatty acid (FFA), and triglyceride (TG) concentRations (P < .01 to .0001). Plasma insulin concentRations in response to oral glucose (2 g/kg) were increased 2-fold by fat feeding (P < .01), and adipocyte glucose clearance under maximal insulin stimulation was significantly reduced (P < .001), suggesting that fat feeding induced insulin resistance. STZ injection increased glucose (P < .05), insulin (P < .05), FFA (P < .05), and TG (P < .0001) concentRations in fat-fed Rats (Fat-fed/STZ Rats) compared with chow-fed, STZ-injected Rats (Chow-fed/STZ Rats). Fat-fed/STZ Rats were not insulin deficient compared with normal chow-fed Rats, but had hyperglycemia and a somewhat higher insulin response to an oral glucose challenge (both P < .05). In addition, insulin-stimulated adipocyte glucose clearance was reduced in Fat-fed/STZ Rats compared with both chow-fed and Chow-fed/STZ Rats (P < .001). Finally, Fat-fed/STZ Rats were sensitive to the glucose lowering effects of metformin and troglitazone. In conclusion, Fat-fed/STZ Rats provide a novel animal model for type 2 diabetes, simulates the human syndrome, and is suitable for the testing of antidiabetic compounds.
