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Martin Bares - One of the best experts on this subject based on the ideXlab platform.
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17 functional anatomy of Outcome Evaluation during iowa gambling task performance in patients with parkinson s disease an fmri study
Clinical Neurophysiology, 2014Co-Authors: Tomas Gescheidt, Radek Marecek, Michal Mikl, Kristina Czekoova, Tomas Urbanek, Jiři Vanicek, Daniel Joel Shaw, Martin BaresAbstract:Introduction The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson’s disease (PD). Method We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on Outcome Evaluation following card selection, because we expected this aspect of decision making to be impaired in PD patients. Results The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Conclusions Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g. the limbic fronto-striatal circuit of the basal ganglia) during decision making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement following a loss in PD patients in the ON state in comparison to a healthy population. This work was supported by the project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund. The participation of T.U. was supported by a research project of the Czech Science Foundation, No. P407/12/2432. The participation of J.V. was supported by the European Regional Development Fund Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).
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functional anatomy of Outcome Evaluation during iowa gambling task performance in patients with parkinson s disease an fmri study
Neurological Sciences, 2013Co-Authors: Tomas Gescheidt, Radek Marecek, Michal Mikl, Kristina Czekoova, Tomas Urbanek, Jiři Vanicek, Daniel Joel Shaw, Martin BaresAbstract:The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson's disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on Outcome Evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.
Patricia L Judson - One of the best experts on this subject based on the ideXlab platform.
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vulvar cancer in young women demographic features and Outcome Evaluation
Obstetrical & Gynecological Survey, 2009Co-Authors: Grainger S Lanneau, Peter A Argenta, Marion S Lanneau, Robert H Riffenburgh, Michael A Gold, Scott D Mcmeekin, Nancy Webster, Patricia L JudsonAbstract:In the past 28 years, there has been a marked increase in the prevalence of in situ and invasive vulvar carcinoma with the increase of in situ disease occurring primarily in the under 65 age group and peaking at 40 to 49 years. The striking increase in the rates of premalignant lesions in women younger than 50 and other accumulating evidence suggests that the pathogenesis of vulvar cancer may be different in younger and older women. To investigate whether the pathogenesis may be different in these 2 age groups, this retrospective review evaluated prognostic and environmental risk factors associated with squamous cell vulvar cancer in a population of women at age 45 years or younger. The study population was comprised of 56 patients who were diagnosed with the cancer between 1994 and 2006. Their median age was 38 (range: 19-45). Demographic data that were collected and analyzed included a history of smoking, human papillomavirus infection and immunosuppression, and vulvar intraepithelial neoplasia. The median follow-up period was 25.3 months. Stage I disease was identified in 50% (28/56) of the patients. A history of smoking was found in 77% of the cases. In addition to being smokers, women with advanced disease (stage III and IV) had human papillomavirus infection (40%), vulvar intraepithelial neoplasia (46.7%), and were immunocompromised (6.7%). Symptoms longer than 12 months were present in 47% of patients with advanced stage disease. No significant relationship was found between the duration of symptoms and stage (P = 0.42) or positive lymph node metastases (P = 0.28). The disease recurred in 6 patients (10.7%) and three (5.4%) died of their disease. These findings of this small study are consistent with other reports suggesting that risk factors for vulvar cancer are different among younger women compared to the general, older vulvar cancer population. The majority of the risk factors associated with vulvar cancer in younger women appear to be modifiable.
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vulvar cancer in young women demographic features and Outcome Evaluation
American Journal of Obstetrics and Gynecology, 2009Co-Authors: Grainger S Lanneau, Peter A Argenta, Marion S Lanneau, Robert H Riffenburgh, Michael A Gold, Scott D Mcmeekin, Nancy Webster, Patricia L JudsonAbstract:Objective The objective of the study was to identify prognostic and environmental factors associated with vulvar carcinoma in young women. Study Design This study was a review of patients younger than 45 years who were diagnosed with vulvar squamous cell carcinoma between 1994 and 2006. Results Fifty-six patients were identified. Median age was 38 years and median follow-up was 25.3 months. Fifty-eight percent of patients presented with stage I disease; 77% smoked tobacco. Of patients with advanced disease, 53.3% were smokers, 40% had human papillomavirus (HPV) exposure, 46.7% had a history of vulvar intraepithelial neoplasia (VIN), and 6.7% were immunocompromised. Symptoms were present for more than 12 months in 47%, but symptom duration did not correlate with stage ( P = .42) or positive lymph nodes ( P = .28). Disease recurred in 10.7% and 5.4% died of disease. Conclusion Young women with vulvar cancer tend to have early-stage disease, smoke, have a history of HPV, and have VIN. Many of the factors that place these patients at continuous risk are modifiable.
Tomas Gescheidt - One of the best experts on this subject based on the ideXlab platform.
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17 functional anatomy of Outcome Evaluation during iowa gambling task performance in patients with parkinson s disease an fmri study
Clinical Neurophysiology, 2014Co-Authors: Tomas Gescheidt, Radek Marecek, Michal Mikl, Kristina Czekoova, Tomas Urbanek, Jiři Vanicek, Daniel Joel Shaw, Martin BaresAbstract:Introduction The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson’s disease (PD). Method We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on Outcome Evaluation following card selection, because we expected this aspect of decision making to be impaired in PD patients. Results The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Conclusions Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g. the limbic fronto-striatal circuit of the basal ganglia) during decision making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement following a loss in PD patients in the ON state in comparison to a healthy population. This work was supported by the project “CEITEC - Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from the European Regional Development Fund. The participation of T.U. was supported by a research project of the Czech Science Foundation, No. P407/12/2432. The participation of J.V. was supported by the European Regional Development Fund Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).
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functional anatomy of Outcome Evaluation during iowa gambling task performance in patients with parkinson s disease an fmri study
Neurological Sciences, 2013Co-Authors: Tomas Gescheidt, Radek Marecek, Michal Mikl, Kristina Czekoova, Tomas Urbanek, Jiři Vanicek, Daniel Joel Shaw, Martin BaresAbstract:The aim of this study was to investigate the functional anatomy of decision-making during the Iowa Gambling Task in patients with Parkinson's disease. We used event-related functional magnetic resonance imaging (fMRI) during a computerized version of IGT to compare 18 PD patients on dopaminergic medication in the ON state and 18 healthy control subjects. Our analyses focused on Outcome Evaluation following card selection, because we expected this aspect of decision-making to be impaired in PD patients. The PD patients exhibited lower activation of the left putamen than the control group as a reaction to penalty. Using psychophysiological interaction analysis, we identified decreased functional connectivity between the right globus pallidus internus and the left anterior cingulate gyrus in the PD group. In contrast, increased connectivity between these structures was observed after penalty in the control group. Our results suggest altered functioning of the basal ganglia and their connections with the cortical structures involved in the limbic loop (e.g., the limbic fronto-striatal circuit of the basal ganglia) during decision-making in PD patients. Differences in the response to loss could be associated with insufficient negative reinforcement after a loss in PD patients in the ON state in comparison to a healthy population.
Grainger S Lanneau - One of the best experts on this subject based on the ideXlab platform.
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vulvar cancer in young women demographic features and Outcome Evaluation
Obstetrical & Gynecological Survey, 2009Co-Authors: Grainger S Lanneau, Peter A Argenta, Marion S Lanneau, Robert H Riffenburgh, Michael A Gold, Scott D Mcmeekin, Nancy Webster, Patricia L JudsonAbstract:In the past 28 years, there has been a marked increase in the prevalence of in situ and invasive vulvar carcinoma with the increase of in situ disease occurring primarily in the under 65 age group and peaking at 40 to 49 years. The striking increase in the rates of premalignant lesions in women younger than 50 and other accumulating evidence suggests that the pathogenesis of vulvar cancer may be different in younger and older women. To investigate whether the pathogenesis may be different in these 2 age groups, this retrospective review evaluated prognostic and environmental risk factors associated with squamous cell vulvar cancer in a population of women at age 45 years or younger. The study population was comprised of 56 patients who were diagnosed with the cancer between 1994 and 2006. Their median age was 38 (range: 19-45). Demographic data that were collected and analyzed included a history of smoking, human papillomavirus infection and immunosuppression, and vulvar intraepithelial neoplasia. The median follow-up period was 25.3 months. Stage I disease was identified in 50% (28/56) of the patients. A history of smoking was found in 77% of the cases. In addition to being smokers, women with advanced disease (stage III and IV) had human papillomavirus infection (40%), vulvar intraepithelial neoplasia (46.7%), and were immunocompromised (6.7%). Symptoms longer than 12 months were present in 47% of patients with advanced stage disease. No significant relationship was found between the duration of symptoms and stage (P = 0.42) or positive lymph node metastases (P = 0.28). The disease recurred in 6 patients (10.7%) and three (5.4%) died of their disease. These findings of this small study are consistent with other reports suggesting that risk factors for vulvar cancer are different among younger women compared to the general, older vulvar cancer population. The majority of the risk factors associated with vulvar cancer in younger women appear to be modifiable.
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vulvar cancer in young women demographic features and Outcome Evaluation
American Journal of Obstetrics and Gynecology, 2009Co-Authors: Grainger S Lanneau, Peter A Argenta, Marion S Lanneau, Robert H Riffenburgh, Michael A Gold, Scott D Mcmeekin, Nancy Webster, Patricia L JudsonAbstract:Objective The objective of the study was to identify prognostic and environmental factors associated with vulvar carcinoma in young women. Study Design This study was a review of patients younger than 45 years who were diagnosed with vulvar squamous cell carcinoma between 1994 and 2006. Results Fifty-six patients were identified. Median age was 38 years and median follow-up was 25.3 months. Fifty-eight percent of patients presented with stage I disease; 77% smoked tobacco. Of patients with advanced disease, 53.3% were smokers, 40% had human papillomavirus (HPV) exposure, 46.7% had a history of vulvar intraepithelial neoplasia (VIN), and 6.7% were immunocompromised. Symptoms were present for more than 12 months in 47%, but symptom duration did not correlate with stage ( P = .42) or positive lymph nodes ( P = .28). Disease recurred in 10.7% and 5.4% died of disease. Conclusion Young women with vulvar cancer tend to have early-stage disease, smoke, have a history of HPV, and have VIN. Many of the factors that place these patients at continuous risk are modifiable.
Dongqing Terry Wang - One of the best experts on this subject based on the ideXlab platform.
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Gimme 5 Fruit, Juice, and Vegetables for Fun and Health: Outcome Evaluation
2016Co-Authors: Tom Baranowski, Marsha Davis, Ken Resnicow, Lillian S. Lin, Dongqing Terry WangAbstract:A theory-based multicomponent intervention (Gimme 5) was designed and implemented to impact fourth-and fifth-grade children’s fruit, juice, and vegetable (FJV) consumption and related psychosocial variables. Gimme 5 was a randomized controlled intervention trial with school (n = 16 elementary) as unit of random assignment and analysis. Participants included the cohort of students who were in the third grade in the winter of 1994 and students who joined them in the fourth and fifth grades. The intervention included a curriculum, news-letters, videotapes, and point-of-purchase education. Evaluation included 7-day food records and psychosocial measures from students, telephone interviews with parents, and observational assessments. Favorable results were observed for consumption of FJV combined, FJV consumed at weekday lunch, eating FJV self-efficacy, social norms, asking behaviors, and knowledge. A theory-based school nutrition education program can help change children’s FJV consumption and impact factors at home that predispose to FJV consumption, but changes were small, and their persistence is unknown. Programs to change children’s food preferences and practices hold the promise of decreasing chronic disease and promoting protective lifestyle behaviors that continue into adulthood.1 Both the Food Guide Pyramid2 and Healthy People 20003 recommen
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gimme 5 fruit juice and vegetables for fun and health Outcome Evaluation
Health Education & Behavior, 2000Co-Authors: Tom Baranowski, Marsha Davis, Ken Resnicow, Lillian S. Lin, Janice Baranowski, Colleen Doyle, Matthew Ryan Smith, Dongqing Terry WangAbstract:A theory-based multicomponent intervention (Gimme 5) was designed and implemented to impact fourth- and fifth-grade children’s fruit, juice, and vegetable (FJV) consumption and related psychosocial variables. Gimme 5 was a randomized controlled intervention trial with school (n = 16 elementary) as unit of random assignment and analysis. Participants included the cohort of students who were in the third grade in the winter of 1994 and students who joined them in the fourth and fifth grades. The intervention included a curriculum, newsletters, videotapes, and point-of-purchase education. Evaluation included 7-day food records and psychosocial measures from students, telephone interviews with parents, and observational assessments. Favorable results were observed for consumption of FJV combined, FJV consumed at weekday lunch, eating FJV self-efficacy, social norms, asking behaviors, and knowledge. A theory-based school nutrition education program can help change children’s FJV consumption and impact factors ...
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gimme 5 fruit juice and vegetables for fun and health Outcome Evaluation
Health Education & Behavior, 2000Co-Authors: Tom Baranowski, Marsha Davis, Ken Resnicow, Lillian S. Lin, Janice Baranowski, Colleen Doyle, Matthew Smith, Dongqing Terry WangAbstract:A theory-based multicomponent intervention (Gimme 5) was designed and implemented to impact fourth- and fifth-grade children's fruit, juice, and vegetable (FJV) consumption and related psychosocial variables. Gimme 5 was a randomized controlled intervention trial with school (n = 16 elementary) as unit of random assignment and analysis. Participants included the cohort of students who were in the third grade in the winter of 1994 and students who joined them in the fourth and fifth grades. The intervention included a curriculum, newsletters, videotapes, and point-of-purchase education. Evaluation included 7-day food records and psychosocial measures from students, telephone interviews with parents, and observational assessments. Favorable results were observed for consumption of FJV combined, FJV consumed at weekday lunch, eating FJV self-efficacy, social norms, asking behaviors, and knowledge. A theory-based school nutrition education program can help change children's FJV consumption and impact factors at home that predispose to FJV consumption, but changes were small, and their persistence is unknown.
