The Experts below are selected from a list of 36 Experts worldwide ranked by ideXlab platform
Kak-shan Shia - One of the best experts on this subject based on the ideXlab platform.
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Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-Oxacephem: a novel agent against resistant pathogenic microorganisms
Organic and Biomolecular Chemistry, 2003Co-Authors: Gholam Hossein Hakimelahi, Pai-chi Li, Jamshid Chamani, Tai Wei Ly, Famil Valiyev, Max K. Leong, Shahram Hakimelahi, Ali Akbar Moosavi-movahedi, Ghadam Ali Khodarahmi, Kak-shan ShiaAbstract:Racemic 7-(phenylacetamido)-1-dethia-3-aza-1-carba-2-Oxacephem 3 was synthesized and found to possess antibacterial activity against Staphylococcus aureus FDA 209P, Escherichia coli ATCC 39188, Pseudomonas aeruginosa 1101–75 and Klebsiella pneumoniae NCTC 418 as well as the β-lactamase producing organisms E. coli A9675 and P. aeruginosa 18S-H and the methicillin-resistant organism S. aureus 95. Formation of the carbacephem 3 originated from the Barton photochemical reaction in the conversion of 8 to 10. Intramolecular cyclization of syn-oximino β-lactam 10 afforded 7-azido-2-oxa-3-azacephem 11, which was reduced and acylated to 12. Enzymatic removal of the methyl group from 12 gave the target molecule 3.
Gholam Hossein Hakimelahi - One of the best experts on this subject based on the ideXlab platform.
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Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-Oxacephem: a novel agent against resistant pathogenic microorganisms
Organic and Biomolecular Chemistry, 2003Co-Authors: Gholam Hossein Hakimelahi, Pai-chi Li, Jamshid Chamani, Tai Wei Ly, Famil Valiyev, Max K. Leong, Shahram Hakimelahi, Ali Akbar Moosavi-movahedi, Ghadam Ali Khodarahmi, Kak-shan ShiaAbstract:Racemic 7-(phenylacetamido)-1-dethia-3-aza-1-carba-2-Oxacephem 3 was synthesized and found to possess antibacterial activity against Staphylococcus aureus FDA 209P, Escherichia coli ATCC 39188, Pseudomonas aeruginosa 1101–75 and Klebsiella pneumoniae NCTC 418 as well as the β-lactamase producing organisms E. coli A9675 and P. aeruginosa 18S-H and the methicillin-resistant organism S. aureus 95. Formation of the carbacephem 3 originated from the Barton photochemical reaction in the conversion of 8 to 10. Intramolecular cyclization of syn-oximino β-lactam 10 afforded 7-azido-2-oxa-3-azacephem 11, which was reduced and acylated to 12. Enzymatic removal of the methyl group from 12 gave the target molecule 3.
Pai-chi Li - One of the best experts on this subject based on the ideXlab platform.
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Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-Oxacephem: a novel agent against resistant pathogenic microorganisms
Organic and Biomolecular Chemistry, 2003Co-Authors: Gholam Hossein Hakimelahi, Pai-chi Li, Jamshid Chamani, Tai Wei Ly, Famil Valiyev, Max K. Leong, Shahram Hakimelahi, Ali Akbar Moosavi-movahedi, Ghadam Ali Khodarahmi, Kak-shan ShiaAbstract:Racemic 7-(phenylacetamido)-1-dethia-3-aza-1-carba-2-Oxacephem 3 was synthesized and found to possess antibacterial activity against Staphylococcus aureus FDA 209P, Escherichia coli ATCC 39188, Pseudomonas aeruginosa 1101–75 and Klebsiella pneumoniae NCTC 418 as well as the β-lactamase producing organisms E. coli A9675 and P. aeruginosa 18S-H and the methicillin-resistant organism S. aureus 95. Formation of the carbacephem 3 originated from the Barton photochemical reaction in the conversion of 8 to 10. Intramolecular cyclization of syn-oximino β-lactam 10 afforded 7-azido-2-oxa-3-azacephem 11, which was reduced and acylated to 12. Enzymatic removal of the methyl group from 12 gave the target molecule 3.
Tai Wei Ly - One of the best experts on this subject based on the ideXlab platform.
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Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-Oxacephem: a novel agent against resistant pathogenic microorganisms
Organic and Biomolecular Chemistry, 2003Co-Authors: Gholam Hossein Hakimelahi, Pai-chi Li, Jamshid Chamani, Tai Wei Ly, Famil Valiyev, Max K. Leong, Shahram Hakimelahi, Ali Akbar Moosavi-movahedi, Ghadam Ali Khodarahmi, Kak-shan ShiaAbstract:Racemic 7-(phenylacetamido)-1-dethia-3-aza-1-carba-2-Oxacephem 3 was synthesized and found to possess antibacterial activity against Staphylococcus aureus FDA 209P, Escherichia coli ATCC 39188, Pseudomonas aeruginosa 1101–75 and Klebsiella pneumoniae NCTC 418 as well as the β-lactamase producing organisms E. coli A9675 and P. aeruginosa 18S-H and the methicillin-resistant organism S. aureus 95. Formation of the carbacephem 3 originated from the Barton photochemical reaction in the conversion of 8 to 10. Intramolecular cyclization of syn-oximino β-lactam 10 afforded 7-azido-2-oxa-3-azacephem 11, which was reduced and acylated to 12. Enzymatic removal of the methyl group from 12 gave the target molecule 3.
Famil Valiyev - One of the best experts on this subject based on the ideXlab platform.
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Application of the Barton photochemical reaction in the synthesis of 1-dethia-3-aza-1-carba-2-Oxacephem: a novel agent against resistant pathogenic microorganisms
Organic and Biomolecular Chemistry, 2003Co-Authors: Gholam Hossein Hakimelahi, Pai-chi Li, Jamshid Chamani, Tai Wei Ly, Famil Valiyev, Max K. Leong, Shahram Hakimelahi, Ali Akbar Moosavi-movahedi, Ghadam Ali Khodarahmi, Kak-shan ShiaAbstract:Racemic 7-(phenylacetamido)-1-dethia-3-aza-1-carba-2-Oxacephem 3 was synthesized and found to possess antibacterial activity against Staphylococcus aureus FDA 209P, Escherichia coli ATCC 39188, Pseudomonas aeruginosa 1101–75 and Klebsiella pneumoniae NCTC 418 as well as the β-lactamase producing organisms E. coli A9675 and P. aeruginosa 18S-H and the methicillin-resistant organism S. aureus 95. Formation of the carbacephem 3 originated from the Barton photochemical reaction in the conversion of 8 to 10. Intramolecular cyclization of syn-oximino β-lactam 10 afforded 7-azido-2-oxa-3-azacephem 11, which was reduced and acylated to 12. Enzymatic removal of the methyl group from 12 gave the target molecule 3.
