The Experts below are selected from a list of 240 Experts worldwide ranked by ideXlab platform
Ricardo Salazar - One of the best experts on this subject based on the ideXlab platform.
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degradation of Oxamic Acid using dimensionally stable anodes dsa based on a mixture of ruo2 and iro2 nanoparticles
Chemosphere, 2020Co-Authors: Carolina L Espinoza, Pamela Sepulveda, Alejandra Garcia, Denis Martins De Godoi, Ricardo SalazarAbstract:Abstract Dimensionally stable anodes (DSA) have been widely used to degrade organic compounds because these surfaces promote the electrogeneration of active chlorine species in the bulk of the solution, as well as in the vicinity of the anode when NaCl is used as supporting electrolyte. In this work, the nanoparticles synthesis of IrO2 and RuO2 was performed to obtain two types of DSA electrodes named Class I and II to degrade Oxamic Acid. For Class I and II DSA, the nanoparticles used were synthesized separately and in the same reaction medium, respectively. Electrolysis were carried out in an open cylindrical cell without division at 25 °C, DSAs were used as anodes and a stainless-steel electrode as cathode, both elements have a geometric area of 2.8 cm2 immersed in 0.05 mol L−1 of NaCl or Na2SO4 and a current density of 3 mA cm−2 was applied for 6 h. Active chlorine species generated in the absence of Oxamic Acid in NaCl were also detected and quantified through ion chromatography. In Na2SO4 there was no degradation of the compound, but in NaCl the Oxamic Acid concentration reaching 85% with Class I DSA. The same tendency is observed in mineralization, in which Class I DSA allowed reaching a CO2 transformation close to 73%. The difference in the results occurs because with Class I DSA, more hypochlorite is generated than with Class II and therefore there is a larger amount of oxidizing species in the solution that enables the degradation and mineralization of Oxamic Acid.
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Degradation of Oxamic Acid using dimensionally stable anodes (DSA) based on a mixture of RuO2 and IrO2 nanoparticles
Chemosphere, 2020Co-Authors: L. Carolina Espinoza, Pamela Sepulveda, Alejandra Garcia, Denis Martins De Godoi, Ricardo SalazarAbstract:Abstract Dimensionally stable anodes (DSA) have been widely used to degrade organic compounds because these surfaces promote the electrogeneration of active chlorine species in the bulk of the solution, as well as in the vicinity of the anode when NaCl is used as supporting electrolyte. In this work, the nanoparticles (NPs) synthesis of IrO2 and RuO2 was performed to obtain two types of DSA electrodes named Class I and II to degrade Oxamic Acid. For Class I and II DSA, the NPs used were synthesized separately and in the same reaction medium, respectively. Electrolysis were carried out in an open cylindrical cell without division at 25 °C, DSAs were used as anodes and a stainless-steel electrode as cathode, both elements have a geometric area of 2.8 cm2 immersed in 0.05 M of NaCl or Na2SO4 and a current density of 3 mA cm−2 was applied for 6 h. Active chlorine species generated in the absence of Oxamic Acid in NaCl were also detected and quantified through ion chromatography. In Na2SO4 there was no degradation of the compound, but in NaCl the Oxamic Acid concentration reaching 85% with Class I DSA. The same tendency is observed in mineralization, in which Class I DSA allowed reaching a CO2 transformation close to 73%. The difference in the results occurs because with Class I DSA, more hypochlorite is generated than with Class II and therefore there is a larger amount of oxidizing species in the solution that enables the degradation and mineralization of Oxamic Acid.
Eugene Morkin - One of the best experts on this subject based on the ideXlab platform.
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regulation of gene expression in cardiomyocytes by thyroid hormone and thyroid hormone analogs 3 5 diiodothyropropionic Acid and cgs 23425 n 3 5 dimethyl 4 4 hydroxy 3 isopropylphenoxy phenyl Oxamic Acid
Journal of Pharmacology and Experimental Therapeutics, 2004Co-Authors: Cynthia Adamson, Niranjan Maitra, Joseph J Bahl, Kevin A Greer, Scott E Klewer, James B Hoying, Eugene MorkinAbstract:The heart is an important target of thyroid hormone actions. Only a limited number of cardiac target genes have been identified, and little is known about their regulation by T3 (3,3′,5-triiodothyronine) and thyroid hormone analogs. We used an oligonucleotide microarray to identify novel cardiac genes regulated by T3 and two thyroid hormone analogs, 3,5-diidodothyropropionic Acid (DITPA) and CGS 23425 [ N -[3,5-dimethyl-4-(4′-hydroxy-3′-isopropylphenoxy)-phenyl]-Oxamic Acid]. DITPA binds with lower affinity than T3 to thyroid hormone receptor α1 and β1 isoforms, whereas CGS 23425 binds selectively to β1. Fluorescent-labeled cDNA was prepared from cultured heart cells maintained in medium stripped of thyroid hormone (“hypothyroid” control) or treated with T3, DITPA, and CGS 23425 at concentrations 5 times their respective K d values for 48 h. The arrays were scanned and analyzed using an analysis of variance program. Sixty-four genes were identified that were >1.5 times up- or down-regulated by one of the treatments with P < 0.05. The genes regulated by T3 and DITPA were nearly identical. Thirteen genes were differentially regulated by CGS 23425. Genes encoding contractile proteins, Ca2+-ATPase of sarcoplasmic reticulum and several proteins of mitochondrial oxidative phosphorylation, were up-regulated by T3 and DITPA but not by CGS 23425. These results indicate that some, but not all, of the actions of thyroid hormone analogs can be explained by differences in gene activation.
James A Sikorski - One of the best experts on this subject based on the ideXlab platform.
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epsp synthase inhibitor deisgn iii synthesis evaluation of a new 5 Oxamic Acid analog of epsp which incorporates a malonate ether as a 3 phosphate mimic
Bioorganic & Medicinal Chemistry Letters, 1993Co-Authors: Susan D Corey, Paul D Pansegrau, Mark C Walker, James A SikorskiAbstract:Abstract The unusual shikimate Oxamic Acid analog 3, containing a 3-malonate ether, was synthesized and found to be a potent product-analog inhibitor of EPSP synthase (Ki = 5.2 − 0.2 μM). The potency of 3 confirms that these 3-malonate ethers function as effective 3-phosphate replacements in this system and that the Oxamic Acid moiety represents an unusual mimetic of the EPSP carboxyvinyl ether group.
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EPSP synthase inhibitor deisgn III. Synthesis & evaluation of a new 5-Oxamic Acid analog of EPSP which incorporates a malonate ether as a 3-phosphate mimic
Bioorganic & Medicinal Chemistry Letters, 1993Co-Authors: Susan D Corey, Paul D Pansegrau, Mark C Walker, James A SikorskiAbstract:Abstract The unusual shikimate Oxamic Acid analog 3, containing a 3-malonate ether, was synthesized and found to be a potent product-analog inhibitor of EPSP synthase (Ki = 5.2 − 0.2 μM). The potency of 3 confirms that these 3-malonate ethers function as effective 3-phosphate replacements in this system and that the Oxamic Acid moiety represents an unusual mimetic of the EPSP carboxyvinyl ether group.
Massao Ionashiro - One of the best experts on this subject based on the ideXlab platform.
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thermal and spectroscopic data to investigate the Oxamic Acid sodium oxamate and its compounds with some bivalent transition metal ions
Journal of Thermal Analysis and Calorimetry, 2012Co-Authors: Flavio Junior Caires, L S Lima, Claudio Teodoro De Carvalho, A B Siqueira, O Treufilho, Massao IonashiroAbstract:Abstract Synthesis, characterization, and thermal behavior of transition metal oxamates, M(NH2C2O3)2·nH2O (M = Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II)), as well as the thermal behavior of Oxamic Acid and its sodium salt (NaNH2C2O3) were investigated employing simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC), experimental and theoretical infrared spectroscopy, TG-DSC coupled to FTIR, elemental analysis and complexometry. The results led to information about the composition, dehydration, thermal stability, thermal decomposition, as well as of the gaseous products evolved during the thermal decomposition of these compounds in dynamic air and N2 atmospheres.
Carolina L Espinoza - One of the best experts on this subject based on the ideXlab platform.
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degradation of Oxamic Acid using dimensionally stable anodes dsa based on a mixture of ruo2 and iro2 nanoparticles
Chemosphere, 2020Co-Authors: Carolina L Espinoza, Pamela Sepulveda, Alejandra Garcia, Denis Martins De Godoi, Ricardo SalazarAbstract:Abstract Dimensionally stable anodes (DSA) have been widely used to degrade organic compounds because these surfaces promote the electrogeneration of active chlorine species in the bulk of the solution, as well as in the vicinity of the anode when NaCl is used as supporting electrolyte. In this work, the nanoparticles synthesis of IrO2 and RuO2 was performed to obtain two types of DSA electrodes named Class I and II to degrade Oxamic Acid. For Class I and II DSA, the nanoparticles used were synthesized separately and in the same reaction medium, respectively. Electrolysis were carried out in an open cylindrical cell without division at 25 °C, DSAs were used as anodes and a stainless-steel electrode as cathode, both elements have a geometric area of 2.8 cm2 immersed in 0.05 mol L−1 of NaCl or Na2SO4 and a current density of 3 mA cm−2 was applied for 6 h. Active chlorine species generated in the absence of Oxamic Acid in NaCl were also detected and quantified through ion chromatography. In Na2SO4 there was no degradation of the compound, but in NaCl the Oxamic Acid concentration reaching 85% with Class I DSA. The same tendency is observed in mineralization, in which Class I DSA allowed reaching a CO2 transformation close to 73%. The difference in the results occurs because with Class I DSA, more hypochlorite is generated than with Class II and therefore there is a larger amount of oxidizing species in the solution that enables the degradation and mineralization of Oxamic Acid.
