The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Cg Lloyd - One of the best experts on this subject based on the ideXlab platform.
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Suspected adverse reactions to oral administration of a praziquantel-pyrantel combination in captive cheetahs (Acinonyx jubatus)
'American Veterinary Medical Association (AVMA)', 2017Co-Authors: Km Whitehouse-tedd, Smith L, Ja Budd, Cg LloydAbstract:Objective: To characterize adverse reactions to oral administration of a combination of praziquantel and pyrantel Embonate or pyrantel pamoate, with or without Oxantel Embonate, in captive cheetahs (Acinonyx jubatus). Design: Retrospective case series and case-control study. Animals: 16 captive cheetahs with signs of adverse reaction to oral administration of praziquantel and pyrantel, with or without Oxantel Embonate (affected group), and 27 cheetahs without such reactions (unaffected group), all from 3 independent facilities. Procedures: Medical records and postmortem findings for affected cheetahs were reviewed and compared with those of unaffected animals. Anthelmintic doses administered, age, and sex of cheetahs were compared between groups. Results: 3 reactions in affected cheetahs were fatal, whereas the remainder ranged from mild to severe. Postmortem examination failed to reveal any disease processes or conditions to explain the deaths. No differences in anthelmintic dose were identified between affected and unaffected cheetahs for all facilities combined, and no correlation existed between dose and reaction severity. No association with sex was detected, but affected cheetahs were significantly younger than unaffected cheetahs. This difference was not significant after controlling for facility. Conclusions and clinical relevance: Cheetahs were concluded to have had an adverse reaction to the praziquantel-pyrantel combination because of temporal proximity of onset of clinical signs to dose administration, similarity of signs to those reported for toxicosis in other species for these drugs, and a lack of other disease process or environmental explanatory factors. A highly cautious approach to the use of this drug combination is recommended for cheetahs
Km Whitehouse-tedd - One of the best experts on this subject based on the ideXlab platform.
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Suspected adverse reactions to oral administration of a praziquantel-pyrantel combination in captive cheetahs (Acinonyx jubatus)
'American Veterinary Medical Association (AVMA)', 2017Co-Authors: Km Whitehouse-tedd, Smith L, Ja Budd, Cg LloydAbstract:Objective: To characterize adverse reactions to oral administration of a combination of praziquantel and pyrantel Embonate or pyrantel pamoate, with or without Oxantel Embonate, in captive cheetahs (Acinonyx jubatus). Design: Retrospective case series and case-control study. Animals: 16 captive cheetahs with signs of adverse reaction to oral administration of praziquantel and pyrantel, with or without Oxantel Embonate (affected group), and 27 cheetahs without such reactions (unaffected group), all from 3 independent facilities. Procedures: Medical records and postmortem findings for affected cheetahs were reviewed and compared with those of unaffected animals. Anthelmintic doses administered, age, and sex of cheetahs were compared between groups. Results: 3 reactions in affected cheetahs were fatal, whereas the remainder ranged from mild to severe. Postmortem examination failed to reveal any disease processes or conditions to explain the deaths. No differences in anthelmintic dose were identified between affected and unaffected cheetahs for all facilities combined, and no correlation existed between dose and reaction severity. No association with sex was detected, but affected cheetahs were significantly younger than unaffected cheetahs. This difference was not significant after controlling for facility. Conclusions and clinical relevance: Cheetahs were concluded to have had an adverse reaction to the praziquantel-pyrantel combination because of temporal proximity of onset of clinical signs to dose administration, similarity of signs to those reported for toxicosis in other species for these drugs, and a lack of other disease process or environmental explanatory factors. A highly cautious approach to the use of this drug combination is recommended for cheetahs
Smith L - One of the best experts on this subject based on the ideXlab platform.
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Suspected adverse reactions to oral administration of a praziquantel-pyrantel combination in captive cheetahs (Acinonyx jubatus)
'American Veterinary Medical Association (AVMA)', 2017Co-Authors: Km Whitehouse-tedd, Smith L, Ja Budd, Cg LloydAbstract:Objective: To characterize adverse reactions to oral administration of a combination of praziquantel and pyrantel Embonate or pyrantel pamoate, with or without Oxantel Embonate, in captive cheetahs (Acinonyx jubatus). Design: Retrospective case series and case-control study. Animals: 16 captive cheetahs with signs of adverse reaction to oral administration of praziquantel and pyrantel, with or without Oxantel Embonate (affected group), and 27 cheetahs without such reactions (unaffected group), all from 3 independent facilities. Procedures: Medical records and postmortem findings for affected cheetahs were reviewed and compared with those of unaffected animals. Anthelmintic doses administered, age, and sex of cheetahs were compared between groups. Results: 3 reactions in affected cheetahs were fatal, whereas the remainder ranged from mild to severe. Postmortem examination failed to reveal any disease processes or conditions to explain the deaths. No differences in anthelmintic dose were identified between affected and unaffected cheetahs for all facilities combined, and no correlation existed between dose and reaction severity. No association with sex was detected, but affected cheetahs were significantly younger than unaffected cheetahs. This difference was not significant after controlling for facility. Conclusions and clinical relevance: Cheetahs were concluded to have had an adverse reaction to the praziquantel-pyrantel combination because of temporal proximity of onset of clinical signs to dose administration, similarity of signs to those reported for toxicosis in other species for these drugs, and a lack of other disease process or environmental explanatory factors. A highly cautious approach to the use of this drug combination is recommended for cheetahs
Ja Budd - One of the best experts on this subject based on the ideXlab platform.
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Suspected adverse reactions to oral administration of a praziquantel-pyrantel combination in captive cheetahs (Acinonyx jubatus)
'American Veterinary Medical Association (AVMA)', 2017Co-Authors: Km Whitehouse-tedd, Smith L, Ja Budd, Cg LloydAbstract:Objective: To characterize adverse reactions to oral administration of a combination of praziquantel and pyrantel Embonate or pyrantel pamoate, with or without Oxantel Embonate, in captive cheetahs (Acinonyx jubatus). Design: Retrospective case series and case-control study. Animals: 16 captive cheetahs with signs of adverse reaction to oral administration of praziquantel and pyrantel, with or without Oxantel Embonate (affected group), and 27 cheetahs without such reactions (unaffected group), all from 3 independent facilities. Procedures: Medical records and postmortem findings for affected cheetahs were reviewed and compared with those of unaffected animals. Anthelmintic doses administered, age, and sex of cheetahs were compared between groups. Results: 3 reactions in affected cheetahs were fatal, whereas the remainder ranged from mild to severe. Postmortem examination failed to reveal any disease processes or conditions to explain the deaths. No differences in anthelmintic dose were identified between affected and unaffected cheetahs for all facilities combined, and no correlation existed between dose and reaction severity. No association with sex was detected, but affected cheetahs were significantly younger than unaffected cheetahs. This difference was not significant after controlling for facility. Conclusions and clinical relevance: Cheetahs were concluded to have had an adverse reaction to the praziquantel-pyrantel combination because of temporal proximity of onset of clinical signs to dose administration, similarity of signs to those reported for toxicosis in other species for these drugs, and a lack of other disease process or environmental explanatory factors. A highly cautious approach to the use of this drug combination is recommended for cheetahs
