The Experts below are selected from a list of 12681 Experts worldwide ranked by ideXlab platform
Zhuangping Zhan - One of the best experts on this subject based on the ideXlab platform.
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Bronsted Acid-Catalyzed Propargylation/Cycloisomerization Tandem Reaction: One-Pot Synthesis of Substituted Oxazoles from Propargylic Alcohols and Amides
The Journal of organic chemistry, 2009Co-Authors: Ying-ming Pan, Fei‐jian Zheng, Haixin Lin, Zhuangping ZhanAbstract:An efficient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted Oxazole derivatives from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst. This method provides a rapid and efficient access to substituted Oxazoles.
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bronsted acid catalyzed propargylation cycloisomerization tandem reaction one pot synthesis of substituted Oxazoles from propargylic alcohols and amides
Journal of Organic Chemistry, 2009Co-Authors: Feijian Zheng, Zhuangping ZhanAbstract:An efficient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted Oxazole derivatives from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst. This method provides a rapid and efficient access to substituted Oxazoles.
Christophe Hoarau - One of the best experts on this subject based on the ideXlab platform.
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Synthesis and orthogonal functionalization of oxazolo[5′,4′:4,5]pyrano[2,3-b]pyridine by intra- and intermolecular Pd-catalyzed direct C–H bond heteroarylation
Organic and Biomolecular Chemistry, 2016Co-Authors: Laure Théveau, Cédric Schneider, Olivier Querolle, Lieven Meerpoel, Vincent Levacher, Christophe HoarauAbstract:The construction and subsequent orthogonal functionalization of a hitherto unknown oxazolo[5′,4′:4,5]pyrano[2,3-b]pyridine are reported. A palladium-catalyzed direct C–H bond functionalization methodology was used to build the tricyclic scaffold as well as to achieve the subsequent C–H bond functionalization at the C-2 position of the Oxazole unit with various (hetero)aryl iodides. Remarkably, selective C–H construction and functionalization procedures preserve the chorine atom on the pyridine moiety offering a late-stage substitution site to progress drug design.
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palladium catalyzed direct hetero arylation of ethyl Oxazole 4 carboxylate an efficient access to hetero arylOxazoles
Journal of Organic Chemistry, 2008Co-Authors: Cecile Verrier, Christophe Hoarau, Thibaut Martin, Francis MarsaisAbstract:A straightforward route toward 2-(hetero)arylated and 2,5-di(hetero)arylated Oxazoles through regiocontrolled palladium-catalyzed direct (hetero)arylation of ethyl Oxazole-4-carboxylate with iodo-, bromo-, and chloro(hetero)aromatics followed by a two-step hydrolysis/decarboxylation sequence was described. The method was applied here to a neat synthesis of two 2,5-di(hetero)arylOxazole natural products, balsoxin and texaline.
Aiwen Lei - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of Oxazoles by silver catalysed oxidative decarboxylation–cyclization of α-oxocarboxylates and isocyanides
Chemical communications (Cambridge England), 2015Co-Authors: Zhiyuan Yan, Changliang Bian, Xiao-wen Zhang, Mengfan Wang, Xinlong Gao, Heng Zhang, Aiwen LeiAbstract:A silver catalysed synthesis of Oxazoles by the oxidative decarboxylation–cyclization of α-oxocarboxylates and isocyanides was developed. This method provided a novel strategy to construct Oxazole rings compared to traditional methods. Mechanistic investigations such as operando IR, EPR and radical inhibition experiments were carefully done and confirmed the acyl cation and Ag(II) as the intermediates in this transformation, and the involvement of a radical decarboxylative process.
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synthesis of Oxazoles by silver catalysed oxidative decarboxylation cyclization of α oxocarboxylates and isocyanides
Chemical Communications, 2015Co-Authors: Zhiyuan Yan, Changliang Bian, Xiao-wen Zhang, Mengfan Wang, Xinlong Gao, Heng Zhang, Aiwen LeiAbstract:A silver catalysed synthesis of Oxazoles by the oxidative decarboxylation–cyclization of α-oxocarboxylates and isocyanides was developed. This method provided a novel strategy to construct Oxazole rings compared to traditional methods. Mechanistic investigations such as operando IR, EPR and radical inhibition experiments were carefully done and confirmed the acyl cation and Ag(II) as the intermediates in this transformation, and the involvement of a radical decarboxylative process.
Feijian Zheng - One of the best experts on this subject based on the ideXlab platform.
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bronsted acid catalyzed propargylation cycloisomerization tandem reaction one pot synthesis of substituted Oxazoles from propargylic alcohols and amides
Journal of Organic Chemistry, 2009Co-Authors: Feijian Zheng, Zhuangping ZhanAbstract:An efficient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted Oxazole derivatives from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst. This method provides a rapid and efficient access to substituted Oxazoles.
Ying-ming Pan - One of the best experts on this subject based on the ideXlab platform.
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Bronsted Acid-Catalyzed Propargylation/Cycloisomerization Tandem Reaction: One-Pot Synthesis of Substituted Oxazoles from Propargylic Alcohols and Amides
The Journal of organic chemistry, 2009Co-Authors: Ying-ming Pan, Fei‐jian Zheng, Haixin Lin, Zhuangping ZhanAbstract:An efficient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted Oxazole derivatives from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst. This method provides a rapid and efficient access to substituted Oxazoles.
