The Experts below are selected from a list of 6723 Experts worldwide ranked by ideXlab platform
Xinmiao Liang - One of the best experts on this subject based on the ideXlab platform.
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enantioselective organocatalytic synthesis of Oxazolidine derivatives through a one pot cascade reaction
Advanced Synthesis & Catalysis, 2011Co-Authors: Zhichao Jin, Huicai Huang, Xiaoyan Luo, Xinmiao LiangAbstract:An asymmetric organocatalytic cascade reaction which can afford a series of Oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an Oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.
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Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One‐Pot Cascade Reaction
Advanced Synthesis & Catalysis, 2011Co-Authors: Zhichao Jin, Huicai Huang, Xiaoyan Luo, Xinmiao LiangAbstract:An asymmetric organocatalytic cascade reaction which can afford a series of Oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an Oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.
Zhichao Jin - One of the best experts on this subject based on the ideXlab platform.
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enantioselective organocatalytic synthesis of Oxazolidine derivatives through a one pot cascade reaction
Advanced Synthesis & Catalysis, 2011Co-Authors: Zhichao Jin, Huicai Huang, Xiaoyan Luo, Xinmiao LiangAbstract:An asymmetric organocatalytic cascade reaction which can afford a series of Oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an Oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.
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Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One‐Pot Cascade Reaction
Advanced Synthesis & Catalysis, 2011Co-Authors: Zhichao Jin, Huicai Huang, Xiaoyan Luo, Xinmiao LiangAbstract:An asymmetric organocatalytic cascade reaction which can afford a series of Oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an Oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.
Tad H. Koch - One of the best experts on this subject based on the ideXlab platform.
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correlation of in situ Oxazolidine formation with highly synergistic cytotoxicity and dna cross linking in cancer cells from combinations of doxorubicin and formaldehyde
Journal of Medicinal Chemistry, 2016Co-Authors: Benjamin L Barthel, Erin L. Mooz, Laura Elizabeth Wiener, Gary G. Koch, Tad H. KochAbstract:Anthracyclines are a class of antitumor compounds that are successful and widely used but suffer from cardiotoxicity and acquired tumor resistance. Formaldehyde interacts with anthracyclines to enhance antitumor efficacy, bypass resistance mechanisms, improve the therapeutic profile, and change the mechanism of action from a topoisomerase II poison to a DNA cross-linker. Contrary to current dogma, we show that both efficient DNA cross-linking and potent synergy in combination with formaldehyde correlate with the anthracycline’s ability to form cyclic formaldehyde conjugates as Oxazolidine moieties and that the cyclic conjugates are better cross-linking agents and cytotoxins than acyclic conjugates. We also provide evidence that suggests that the Oxazolidine forms in situ, since cotreatment with doxorubicin and formaldehyde is highly cytotoxic to dox-resistant tumor cell lines, and that this benefit is absent in combinations of formaldehyde and epirubicin, which cannot form stable Oxazolidines. These resul...
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Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde
2016Co-Authors: Benjamin L. Barthel, Erin L. Mooz, Laura Elizabeth Wiener, Gary G. Koch, Tad H. KochAbstract:Anthracyclines are a class of antitumor compounds that are successful and widely used but suffer from cardiotoxicity and acquired tumor resistance. Formaldehyde interacts with anthracyclines to enhance antitumor efficacy, bypass resistance mechanisms, improve the therapeutic profile, and change the mechanism of action from a topoisomerase II poison to a DNA cross-linker. Contrary to current dogma, we show that both efficient DNA cross-linking and potent synergy in combination with formaldehyde correlate with the anthracycline’s ability to form cyclic formaldehyde conjugates as Oxazolidine moieties and that the cyclic conjugates are better cross-linking agents and cytotoxins than acyclic conjugates. We also provide evidence that suggests that the Oxazolidine forms in situ, since cotreatment with doxorubicin and formaldehyde is highly cytotoxic to dox-resistant tumor cell lines, and that this benefit is absent in combinations of formaldehyde and epirubicin, which cannot form stable Oxazolidines. These results have potential clinical implications in the active field of anthracycline prodrug design and development
Horacio F Olivo - One of the best experts on this subject based on the ideXlab platform.
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stereochemical control on the michael addition of chiral 1 3 Oxazolidine 2 thiones to n crotonyl 1 3 oxazolidin 2 ones
Tetrahedron Letters, 2013Co-Authors: Laura Munive, Sena A Dzakuma, Horacio F OlivoAbstract:Abstract Addition of both antipodes of 4-phenyl 1,3-Oxazolidine-2-thione to 4-substituted N -crotonyl 1,3-oxazolidin-2-ones furnished Michael addition products. A perfect match occurred when both Michael donor and acceptor possessed the same stereochemistry and a mismatch when they had opposite stereochemistries. The newly created stereochemical center was shown to be governed by the Michael donor and not by the acceptor.
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desulfurization oxygenation of chiral 1 3 thiazolidine 2 thiones and 1 3 Oxazolidine 2 thiones using propylene oxide and microwave irradiation
Synlett, 2012Co-Authors: Leticia Minorvillar, Rodolfo Telloaburto, Horacio F Olivo, Aydee Fuentes, Moises RomeroortegaAbstract:An efficient method for the desulfurization–oxygenation of 1,3-thiazolidine-2-thiones and 1,3-Oxazolidine-2-thiones using propylene oxide and employing microwave irradiation is described. This strategy of oxygenation of the thiocarbonyl group provides an attractive methodology to prepare chiral 1,3-thiazolidin-2-ones and 1,3-oxazolidin-2-ones from the corresponding precursors in good yields.
Xiaoyan Luo - One of the best experts on this subject based on the ideXlab platform.
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enantioselective organocatalytic synthesis of Oxazolidine derivatives through a one pot cascade reaction
Advanced Synthesis & Catalysis, 2011Co-Authors: Zhichao Jin, Huicai Huang, Xiaoyan Luo, Xinmiao LiangAbstract:An asymmetric organocatalytic cascade reaction which can afford a series of Oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an Oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.
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Enantioselective Organocatalytic Synthesis of Oxazolidine Derivatives through a One‐Pot Cascade Reaction
Advanced Synthesis & Catalysis, 2011Co-Authors: Zhichao Jin, Huicai Huang, Xiaoyan Luo, Xinmiao LiangAbstract:An asymmetric organocatalytic cascade reaction which can afford a series of Oxazolidine derivatives has been developed. The one-pot reaction reported here can produce an Oxazolidine derivative in a highly enantioselective manner and good yield with good to excellent diastereomeric ratio.
