The Experts below are selected from a list of 255 Experts worldwide ranked by ideXlab platform
Sverre Grimnes - One of the best experts on this subject based on the ideXlab platform.
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a simplified concept for controlling Oxygen mixtures in the anaesthetic machine better cheaper and more user friendly
Acta Anaesthesiologica Scandinavica, 1995Co-Authors: J A Berge, L. Gramstad, Sverre GrimnesAbstract:: Modern anaesthetic machines are equipped with several safety components to prevent delivery of hypoxic mixtures. However, such a technical development has increased the complexity of the equipment. We report a reconstructed anaesthetic machine in which a paramagnetic Oxygen Analyzer has provided the means to simplify the apparatus. The new machine is devoid of several components conventionally included to prevent hypoxic mixtures: Oxygen failure protection device, reservoir O2 alarm, N2O/air selector, and proportioning system for Oxygen/nitrous oxide delivery. These devices have been replaced by a simple safety system using a paramagnetic Oxygen Analyzer at the common gas outlet, which in a feed-back system cuts off the supply of nitrous oxide whenever the Oxygen concentration falls below 25%. The simplified construction of the anaesthetic machine has important consequences for safety, cost and user-friendliness. Reducing the complexity of the construction also simplifies the pre-use checkout procedure, and an efficient 5-point check list is presented for the new machine.
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A simplified concept for controlling Oxygen mixtures in the anaesthetic machine — better, cheaper and more user-friendly?
Acta Anaesthesiologica Scandinavica, 1995Co-Authors: J A Berge, L. Gramstad, Sverre GrimnesAbstract:: Modern anaesthetic machines are equipped with several safety components to prevent delivery of hypoxic mixtures. However, such a technical development has increased the complexity of the equipment. We report a reconstructed anaesthetic machine in which a paramagnetic Oxygen Analyzer has provided the means to simplify the apparatus. The new machine is devoid of several components conventionally included to prevent hypoxic mixtures: Oxygen failure protection device, reservoir O2 alarm, N2O/air selector, and proportioning system for Oxygen/nitrous oxide delivery. These devices have been replaced by a simple safety system using a paramagnetic Oxygen Analyzer at the common gas outlet, which in a feed-back system cuts off the supply of nitrous oxide whenever the Oxygen concentration falls below 25%. The simplified construction of the anaesthetic machine has important consequences for safety, cost and user-friendliness. Reducing the complexity of the construction also simplifies the pre-use checkout procedure, and an efficient 5-point check list is presented for the new machine.
J A Berge - One of the best experts on this subject based on the ideXlab platform.
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a simplified concept for controlling Oxygen mixtures in the anaesthetic machine better cheaper and more user friendly
Acta Anaesthesiologica Scandinavica, 1995Co-Authors: J A Berge, L. Gramstad, Sverre GrimnesAbstract:: Modern anaesthetic machines are equipped with several safety components to prevent delivery of hypoxic mixtures. However, such a technical development has increased the complexity of the equipment. We report a reconstructed anaesthetic machine in which a paramagnetic Oxygen Analyzer has provided the means to simplify the apparatus. The new machine is devoid of several components conventionally included to prevent hypoxic mixtures: Oxygen failure protection device, reservoir O2 alarm, N2O/air selector, and proportioning system for Oxygen/nitrous oxide delivery. These devices have been replaced by a simple safety system using a paramagnetic Oxygen Analyzer at the common gas outlet, which in a feed-back system cuts off the supply of nitrous oxide whenever the Oxygen concentration falls below 25%. The simplified construction of the anaesthetic machine has important consequences for safety, cost and user-friendliness. Reducing the complexity of the construction also simplifies the pre-use checkout procedure, and an efficient 5-point check list is presented for the new machine.
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A simplified concept for controlling Oxygen mixtures in the anaesthetic machine — better, cheaper and more user-friendly?
Acta Anaesthesiologica Scandinavica, 1995Co-Authors: J A Berge, L. Gramstad, Sverre GrimnesAbstract:: Modern anaesthetic machines are equipped with several safety components to prevent delivery of hypoxic mixtures. However, such a technical development has increased the complexity of the equipment. We report a reconstructed anaesthetic machine in which a paramagnetic Oxygen Analyzer has provided the means to simplify the apparatus. The new machine is devoid of several components conventionally included to prevent hypoxic mixtures: Oxygen failure protection device, reservoir O2 alarm, N2O/air selector, and proportioning system for Oxygen/nitrous oxide delivery. These devices have been replaced by a simple safety system using a paramagnetic Oxygen Analyzer at the common gas outlet, which in a feed-back system cuts off the supply of nitrous oxide whenever the Oxygen concentration falls below 25%. The simplified construction of the anaesthetic machine has important consequences for safety, cost and user-friendliness. Reducing the complexity of the construction also simplifies the pre-use checkout procedure, and an efficient 5-point check list is presented for the new machine.
L. Gramstad - One of the best experts on this subject based on the ideXlab platform.
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a simplified concept for controlling Oxygen mixtures in the anaesthetic machine better cheaper and more user friendly
Acta Anaesthesiologica Scandinavica, 1995Co-Authors: J A Berge, L. Gramstad, Sverre GrimnesAbstract:: Modern anaesthetic machines are equipped with several safety components to prevent delivery of hypoxic mixtures. However, such a technical development has increased the complexity of the equipment. We report a reconstructed anaesthetic machine in which a paramagnetic Oxygen Analyzer has provided the means to simplify the apparatus. The new machine is devoid of several components conventionally included to prevent hypoxic mixtures: Oxygen failure protection device, reservoir O2 alarm, N2O/air selector, and proportioning system for Oxygen/nitrous oxide delivery. These devices have been replaced by a simple safety system using a paramagnetic Oxygen Analyzer at the common gas outlet, which in a feed-back system cuts off the supply of nitrous oxide whenever the Oxygen concentration falls below 25%. The simplified construction of the anaesthetic machine has important consequences for safety, cost and user-friendliness. Reducing the complexity of the construction also simplifies the pre-use checkout procedure, and an efficient 5-point check list is presented for the new machine.
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A simplified concept for controlling Oxygen mixtures in the anaesthetic machine — better, cheaper and more user-friendly?
Acta Anaesthesiologica Scandinavica, 1995Co-Authors: J A Berge, L. Gramstad, Sverre GrimnesAbstract:: Modern anaesthetic machines are equipped with several safety components to prevent delivery of hypoxic mixtures. However, such a technical development has increased the complexity of the equipment. We report a reconstructed anaesthetic machine in which a paramagnetic Oxygen Analyzer has provided the means to simplify the apparatus. The new machine is devoid of several components conventionally included to prevent hypoxic mixtures: Oxygen failure protection device, reservoir O2 alarm, N2O/air selector, and proportioning system for Oxygen/nitrous oxide delivery. These devices have been replaced by a simple safety system using a paramagnetic Oxygen Analyzer at the common gas outlet, which in a feed-back system cuts off the supply of nitrous oxide whenever the Oxygen concentration falls below 25%. The simplified construction of the anaesthetic machine has important consequences for safety, cost and user-friendliness. Reducing the complexity of the construction also simplifies the pre-use checkout procedure, and an efficient 5-point check list is presented for the new machine.
Sha Yuan - One of the best experts on this subject based on the ideXlab platform.
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The working principle and troubleshooting of the MKIV/S trace Oxygen Analyzer
Industrial Instrumentation & Automation, 2001Co-Authors: Sha YuanAbstract:This paper presents the working principle of the model MKIV/S trace Oxygen Analyzer and troubleshooting in practical applications.
Abdul-kader Souid - One of the best experts on this subject based on the ideXlab platform.
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Phosphorescence Oxygen Analyzer as a Measuring Tool for Cellular Bioenergetics
Bioenergetics, 2012Co-Authors: Fatma Al-jasmi, Ahmed R. Al Suwaidi, Mariam Al-shamsi, Farida Marzouqi, Aysha Al Mansouri, Sami Shaban, Harvey S. Penefsky, Abdul-kader SouidAbstract:The “phosphorescence Oxygen Analyzer” and its use to monitor O2 consumption by cells and tissues are discussed in this chapter (Lo et al., 1996; Souid et al., 2003). This analytical tool assesses bioenergetics in cells undergoing apoptosis (e.g., the mitochondrial cell death pathway), in cells exposed to toxins (e.g., loss of viability) and in cells with a genetically altered energy metabolism (e.g., mitochondrial disorders) (Tacka et al., 2004a-b; Tao et al., 2007; Tao et al., 2008a). This method is applicable to suspended (e.g., Jurkat and HL-60 cells) and adherent (TU183 human oral cancer cells) cells and to fresh tissues from humans (e.g., lymphocytes, spermatozoa and tumors) and animals (e.g., liver, spleen, heart, pancreas and kidney) (Badawy et al., 2009a-b; Whyte et al., 2010; Al Shamsi et al., 2010; Al-Salam et al., 2011; Al Samri et al., 2011). The Analyzer allows investigating anticancer compounds (single agents or combinations) for dosing, order of administration and exposure (Jones et al., 2009; Tao et al., 2008b; Souid et al., 2006; Goodisman et al., 2006; Tao et al., 2006a-b; Tack et al. 2004b). It can also be used to monitor reactions consuming or producing O2 (Tao et al., 2008b; Tao et al., 2009).
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The phosphorescence Oxygen Analyzer as a screening tool for disorders with impaired lymphocyte bioenergetics.
Molecular Genetics and Metabolism, 2011Co-Authors: Fatma Al-jasmi, Harvey S. Penefsky, Abdul-kader SouidAbstract:Abstract This study aimed to show the feasibility of using the phosphorescence Oxygen Analyzer to screen for clinical disorders with impaired cellular bioenergetics. [O 2 ] was determined as function of time from the phosphorescence decay of Pd (II) meso -tetra-(4-sulfonatophenyl)-tetrabenzoporphyrin. In sealed vials, O 2 consumption by peripheral blood mononuclear cells was linear with time, confirming its zero-order kinetics. Cyanide inhibited O 2 consumption, confirming the oxidation occurred in the mitochondrial respiratory chain. The rate of respiration (mean ± SD, in μM O 2 per min per 10 7 cells, set as the negative of the slope of [O 2 ] vs. t ) for adults was 2.1 ± 0.8 (n = 18), for children 2.0 ± 0.9 (n = 20), and for newborns (umbilical cord samples) 0.8 ± 0.4 (n = 18), p 2 per min per 10 7 cells. For a 3-month-old patient with hepatocerebral mitochondrial DNA depletion syndrome (MDS) with confirmed mutations in the MPV17 gene, the rate was 0.6 μM O 2 per min per 10 7 cells. For an18 month-old patient with MDS and confirmed mutations in the POLG gene, the rate was 0.5 μM O 2 per min per 10 7 cells. For a 6-year-old patient with MDS and confirmed mutations in the POLG gene, the rate was 0.6 μM O 2 per min per 10 7 cells. For 1-week-old patient with congenital lactic acidemia and hypotonia (confirmed mutations in DLD gene), the rate was 1.5 μM O 2 per min per 10 7 cells. For three siblings (9-year-old male, 8-year-old male and 2-month-old female) with congenital progressive myopathy, the rates were 0.9, 0.6 and 1.2 μM O 2 per min per 10 7 cells, respectively. Four patients with congenital lactic acidemia (with inadequate work-up) were also studied; their rates were 0.2, 1.5, 0.3 and 1.7 μM O 2 per min per 10 7 cells. This novel approach permits non-invasive, preliminary assessment of cellular bioenergetics. Potential applications and limitations of this technique are discussed.
