The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform
Christopher M. Rausch - One of the best experts on this subject based on the ideXlab platform.
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a novel approach to critical congenital heart disease cchd screening at moderate altitude
International Journal of Neonatal Screening, 2016Co-Authors: Erin Lueth, Jason Wright, Marci K Sontag, Cindy Eller, Leilani Russell, Mark Duster, Mary Kohn, Joshua Miller, Christopher M. RauschAbstract:The American Academy of Pediatrics (AAP) has endorsed Critical Congenital Heart Disease (CCHD) screening using pulse oximetry nationwide, but, however, acknowledges that altitude may impact failure rates and alternative algorithms may be required at high altitudes. We therefore evaluated a modified screening protocol at an altitude of 6200 feet with the hypothesis that modifications could decrease failure rates. We evaluated 2001 well, newborn infants ≥35 weeks gestation using a modified protocol, which included a lower saturation cutoff for the first screen (85% instead of the AAP recommended 90%) and an Oxygen Hood intervention between the first two screens. Using our modified screening algorithm, we found a 0.3% failure rate, which was similar to the 0.2% sea-level rate and statistically different from the 1.1% rate identified in a recent study at similar altitude. Had the AAP protocol been used, the failure rate would have increased to 0.8%, which is similar to prior reports near this altitude. Echocardiograms were performed on failing newborns with no CCHD identified. A Birth Defects Registry Database review demonstrated one newborn with CCHD was missed after meeting AAP passing criteria. Overall, this study demonstrates that an alternative algorithm can be implemented at moderate altitude with decreased failure rate and comparable false negative rate.
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Abstract 11174: A Novel Approach to Critical Congenital Heart Disease (CCHD) Screening at Moderate Altitude
Circulation, 2014Co-Authors: Jason Wright, Duster Mark, Leilani B Russell, Marci K Sontag, Cindy Eller, Christopher M. RauschAbstract:Introduction: Prenatal studies and postnatal physical exam leave 13- 55% of neonates with CCHD undiagnosed leading to presentation in extremis or death. The AHA has endorsed newborn pulse oximetry screening to capture these infants prior to hospital discharge. Moderate altitude can impart higher screening failure rates. We therefore evaluated a modified CCHD screening protocol in an attempt to reduce false positive screenings at a moderate altitude of 6200 feet (1890 m). Methods: We prospectively enlisted well newborn infants greater than 35 weeks. Near 24 hours of life, trained nursing staff performed pulse oximetry on the right hand and either foot. Those with saturations ≤95% with 3% difference in saturations were placed in an Oxygen Hood with FiO2 designed to replicate sea level atmospheric Oxygen tension for 20 minutes to accelerate neonatal transition. These inf...
Jason Wright - One of the best experts on this subject based on the ideXlab platform.
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a novel approach to critical congenital heart disease cchd screening at moderate altitude
International Journal of Neonatal Screening, 2016Co-Authors: Erin Lueth, Jason Wright, Marci K Sontag, Cindy Eller, Leilani Russell, Mark Duster, Mary Kohn, Joshua Miller, Christopher M. RauschAbstract:The American Academy of Pediatrics (AAP) has endorsed Critical Congenital Heart Disease (CCHD) screening using pulse oximetry nationwide, but, however, acknowledges that altitude may impact failure rates and alternative algorithms may be required at high altitudes. We therefore evaluated a modified screening protocol at an altitude of 6200 feet with the hypothesis that modifications could decrease failure rates. We evaluated 2001 well, newborn infants ≥35 weeks gestation using a modified protocol, which included a lower saturation cutoff for the first screen (85% instead of the AAP recommended 90%) and an Oxygen Hood intervention between the first two screens. Using our modified screening algorithm, we found a 0.3% failure rate, which was similar to the 0.2% sea-level rate and statistically different from the 1.1% rate identified in a recent study at similar altitude. Had the AAP protocol been used, the failure rate would have increased to 0.8%, which is similar to prior reports near this altitude. Echocardiograms were performed on failing newborns with no CCHD identified. A Birth Defects Registry Database review demonstrated one newborn with CCHD was missed after meeting AAP passing criteria. Overall, this study demonstrates that an alternative algorithm can be implemented at moderate altitude with decreased failure rate and comparable false negative rate.
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Abstract 11174: A Novel Approach to Critical Congenital Heart Disease (CCHD) Screening at Moderate Altitude
Circulation, 2014Co-Authors: Jason Wright, Duster Mark, Leilani B Russell, Marci K Sontag, Cindy Eller, Christopher M. RauschAbstract:Introduction: Prenatal studies and postnatal physical exam leave 13- 55% of neonates with CCHD undiagnosed leading to presentation in extremis or death. The AHA has endorsed newborn pulse oximetry screening to capture these infants prior to hospital discharge. Moderate altitude can impart higher screening failure rates. We therefore evaluated a modified CCHD screening protocol in an attempt to reduce false positive screenings at a moderate altitude of 6200 feet (1890 m). Methods: We prospectively enlisted well newborn infants greater than 35 weeks. Near 24 hours of life, trained nursing staff performed pulse oximetry on the right hand and either foot. Those with saturations ≤95% with 3% difference in saturations were placed in an Oxygen Hood with FiO2 designed to replicate sea level atmospheric Oxygen tension for 20 minutes to accelerate neonatal transition. These inf...
Waldemar A Carlo - One of the best experts on this subject based on the ideXlab platform.
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nitric oxide administration using an Oxygen Hood a pilot trial
PLOS ONE, 2009Co-Authors: Namasivayam Ambalavanan, George T Elferzli, Claire Roane, Robert D Johnson, Waldemar A CarloAbstract:Background We have shown earlier that inhaled nitric oxide (iNO) administered by Oxygen Hood reduces pulmonary hypertension in an animal model (J Perinatol 2002; 22:50-6). Our objective in this study was to determine feasibility of iNO by Oxygen Hood in neonates with elevated alveolar-arterial Oxygen gradients (A-aDO2).
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Feasibility of Nitric Oxide Administration by Oxygen Hood in Neonatal Pulmonary Hypertension
Journal of Perinatology, 2002Co-Authors: Namasivayam Ambalavanan, Waldemar A Carlo, Elaine St. John, Arlene Bulger, Joseph B PhilipsAbstract:OBJECTIVE: To test the hemodynamic efficacy and feasibility of nitric oxide (NO) administration by Oxygen Hood in neonatal pulmonary hypertension. STUDY DESIGN: A double-Hood apparatus was used in which a combination of NO, O_2, and N_2 was introduced into the inner Hood and suctioned from the outer Hood. Chronically instrumented non-intubated piglets were exposed to 10% O_2 (hypoxia; n =8) or group B streptococci infusion (GBS; n =5) to produce pulmonary hypertension and were then exposed to 20 ppm NO. RESULTS: NO decreased (>50%) pulmonary artery pressure and vascular resistance in both hypoxia- and GBS-induced pulmonary hypertension, with minimal effects on systemic arterial pressure and cardiac output. NO administration could be performed without detectable environmental leakage. CONCLUSION: Hood NO administration is feasible and shows hemodynamic efficacy in neonatal piglets with pulmonary hypertension.
Cindy Eller - One of the best experts on this subject based on the ideXlab platform.
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a novel approach to critical congenital heart disease cchd screening at moderate altitude
International Journal of Neonatal Screening, 2016Co-Authors: Erin Lueth, Jason Wright, Marci K Sontag, Cindy Eller, Leilani Russell, Mark Duster, Mary Kohn, Joshua Miller, Christopher M. RauschAbstract:The American Academy of Pediatrics (AAP) has endorsed Critical Congenital Heart Disease (CCHD) screening using pulse oximetry nationwide, but, however, acknowledges that altitude may impact failure rates and alternative algorithms may be required at high altitudes. We therefore evaluated a modified screening protocol at an altitude of 6200 feet with the hypothesis that modifications could decrease failure rates. We evaluated 2001 well, newborn infants ≥35 weeks gestation using a modified protocol, which included a lower saturation cutoff for the first screen (85% instead of the AAP recommended 90%) and an Oxygen Hood intervention between the first two screens. Using our modified screening algorithm, we found a 0.3% failure rate, which was similar to the 0.2% sea-level rate and statistically different from the 1.1% rate identified in a recent study at similar altitude. Had the AAP protocol been used, the failure rate would have increased to 0.8%, which is similar to prior reports near this altitude. Echocardiograms were performed on failing newborns with no CCHD identified. A Birth Defects Registry Database review demonstrated one newborn with CCHD was missed after meeting AAP passing criteria. Overall, this study demonstrates that an alternative algorithm can be implemented at moderate altitude with decreased failure rate and comparable false negative rate.
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Abstract 11174: A Novel Approach to Critical Congenital Heart Disease (CCHD) Screening at Moderate Altitude
Circulation, 2014Co-Authors: Jason Wright, Duster Mark, Leilani B Russell, Marci K Sontag, Cindy Eller, Christopher M. RauschAbstract:Introduction: Prenatal studies and postnatal physical exam leave 13- 55% of neonates with CCHD undiagnosed leading to presentation in extremis or death. The AHA has endorsed newborn pulse oximetry screening to capture these infants prior to hospital discharge. Moderate altitude can impart higher screening failure rates. We therefore evaluated a modified CCHD screening protocol in an attempt to reduce false positive screenings at a moderate altitude of 6200 feet (1890 m). Methods: We prospectively enlisted well newborn infants greater than 35 weeks. Near 24 hours of life, trained nursing staff performed pulse oximetry on the right hand and either foot. Those with saturations ≤95% with 3% difference in saturations were placed in an Oxygen Hood with FiO2 designed to replicate sea level atmospheric Oxygen tension for 20 minutes to accelerate neonatal transition. These inf...
Marci K Sontag - One of the best experts on this subject based on the ideXlab platform.
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a novel approach to critical congenital heart disease cchd screening at moderate altitude
International Journal of Neonatal Screening, 2016Co-Authors: Erin Lueth, Jason Wright, Marci K Sontag, Cindy Eller, Leilani Russell, Mark Duster, Mary Kohn, Joshua Miller, Christopher M. RauschAbstract:The American Academy of Pediatrics (AAP) has endorsed Critical Congenital Heart Disease (CCHD) screening using pulse oximetry nationwide, but, however, acknowledges that altitude may impact failure rates and alternative algorithms may be required at high altitudes. We therefore evaluated a modified screening protocol at an altitude of 6200 feet with the hypothesis that modifications could decrease failure rates. We evaluated 2001 well, newborn infants ≥35 weeks gestation using a modified protocol, which included a lower saturation cutoff for the first screen (85% instead of the AAP recommended 90%) and an Oxygen Hood intervention between the first two screens. Using our modified screening algorithm, we found a 0.3% failure rate, which was similar to the 0.2% sea-level rate and statistically different from the 1.1% rate identified in a recent study at similar altitude. Had the AAP protocol been used, the failure rate would have increased to 0.8%, which is similar to prior reports near this altitude. Echocardiograms were performed on failing newborns with no CCHD identified. A Birth Defects Registry Database review demonstrated one newborn with CCHD was missed after meeting AAP passing criteria. Overall, this study demonstrates that an alternative algorithm can be implemented at moderate altitude with decreased failure rate and comparable false negative rate.
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Abstract 11174: A Novel Approach to Critical Congenital Heart Disease (CCHD) Screening at Moderate Altitude
Circulation, 2014Co-Authors: Jason Wright, Duster Mark, Leilani B Russell, Marci K Sontag, Cindy Eller, Christopher M. RauschAbstract:Introduction: Prenatal studies and postnatal physical exam leave 13- 55% of neonates with CCHD undiagnosed leading to presentation in extremis or death. The AHA has endorsed newborn pulse oximetry screening to capture these infants prior to hospital discharge. Moderate altitude can impart higher screening failure rates. We therefore evaluated a modified CCHD screening protocol in an attempt to reduce false positive screenings at a moderate altitude of 6200 feet (1890 m). Methods: We prospectively enlisted well newborn infants greater than 35 weeks. Near 24 hours of life, trained nursing staff performed pulse oximetry on the right hand and either foot. Those with saturations ≤95% with 3% difference in saturations were placed in an Oxygen Hood with FiO2 designed to replicate sea level atmospheric Oxygen tension for 20 minutes to accelerate neonatal transition. These inf...
