The Experts below are selected from a list of 144 Experts worldwide ranked by ideXlab platform
Tayyaba Hasan - One of the best experts on this subject based on the ideXlab platform.
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a singlet Oxygen Monitor as an in vivo photodynamic therapy dosimeter
12th World Congress of the International Photodynamic Association, 2009Co-Authors: Seonkyung Lee, Michael F. Hinds, Tayyaba Hasan, Alvin Liang, K Galballykinney, Julia A Ohara, Brian W Pogue, Steven J. DavisAbstract:In this paper we describe the development and testing of instruments to measure singlet molecular Oxygen produced by the photodynamic process. Singlet Oxygen is an active species in photodynamic therapy, and we are developing two instruments for PDT researchers with the goal of a real-time dosimeter for singlet Oxygen. We discuss both an ultrasensitive point sensor, and an imaging system that provides simultaneous 2D maps of the photosensitizer fluorescence and the singlet Oxygen emission. Results of in vitro tests to characterize the sensors and preliminary in vivo results are presented.
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pulsed diode laser based singlet Oxygen Monitor for photodynamic therapy in vivo studies of tumor laden rats
Journal of Biomedical Optics, 2008Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Alvin Liang, Tayyaba HasanAbstract:Photodynamic therapy (PDT) is a promising cancer treatment that involves optical excitation of photosensitizers that promote Oxygen molecules to the metastable O2(a1) state (singlet Oxygen). This species is believed to be responsible for the destruction of cancerous cells during PDT. We describe a fiber optic-coupled, pulsed diode laser-based diagnostic for singlet Oxygen. We use both temporal and spectral filtering to enhance the detection of the weak O2(aX) emission near 1.27 µm. We present data that demonstrate real-time singlet Oxygen production in tumor-laden rats with chlorin e6 and 5-aminolevulinic acid-induced protoporphyrin photosensitizers. We also observe a positive correlation between post-PDT treatment regression of the tumors and the relative amount of singlet Oxygen measured. These results are promising for the development of the sensor as a real-time dosimeter for PDT.
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A Diode Laser-Based Singlet Oxygen Monitor for Photodynamic Therapy; in- vitro and in- vivo Studies
Biomedical Optics, 2006Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Tayyaba Hasan, Alvin LiangAbstract:Singlet Oxygen is believed to be the active species in photodynamic therapy. We describe a real-time singlet Oxygen Monitor and its application to in-vivo studies on tumor-loaded rats and healthy human skin with ALA photosensitizer.
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diode laser Monitor for singlet molecular Oxygen
Biomedical optics, 2005Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Leyun Zhu, Ahmed M Minhaj, Anthony A Ferrante, David I Rosen, Tayyaba HasanAbstract:Monitoring singlet molecular Oxygen (1O2) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet Oxygen Monitor based on a pulsed diode laser technology. In this paper, we present results of singlet Oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet Oxygen Monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.
Seonkyung Lee - One of the best experts on this subject based on the ideXlab platform.
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a singlet Oxygen Monitor as an in vivo photodynamic therapy dosimeter
12th World Congress of the International Photodynamic Association, 2009Co-Authors: Seonkyung Lee, Michael F. Hinds, Tayyaba Hasan, Alvin Liang, K Galballykinney, Julia A Ohara, Brian W Pogue, Steven J. DavisAbstract:In this paper we describe the development and testing of instruments to measure singlet molecular Oxygen produced by the photodynamic process. Singlet Oxygen is an active species in photodynamic therapy, and we are developing two instruments for PDT researchers with the goal of a real-time dosimeter for singlet Oxygen. We discuss both an ultrasensitive point sensor, and an imaging system that provides simultaneous 2D maps of the photosensitizer fluorescence and the singlet Oxygen emission. Results of in vitro tests to characterize the sensors and preliminary in vivo results are presented.
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pulsed diode laser based singlet Oxygen Monitor for photodynamic therapy in vivo studies of tumor laden rats
Journal of Biomedical Optics, 2008Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Alvin Liang, Tayyaba HasanAbstract:Photodynamic therapy (PDT) is a promising cancer treatment that involves optical excitation of photosensitizers that promote Oxygen molecules to the metastable O2(a1) state (singlet Oxygen). This species is believed to be responsible for the destruction of cancerous cells during PDT. We describe a fiber optic-coupled, pulsed diode laser-based diagnostic for singlet Oxygen. We use both temporal and spectral filtering to enhance the detection of the weak O2(aX) emission near 1.27 µm. We present data that demonstrate real-time singlet Oxygen production in tumor-laden rats with chlorin e6 and 5-aminolevulinic acid-induced protoporphyrin photosensitizers. We also observe a positive correlation between post-PDT treatment regression of the tumors and the relative amount of singlet Oxygen measured. These results are promising for the development of the sensor as a real-time dosimeter for PDT.
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A Diode Laser-Based Singlet Oxygen Monitor for Photodynamic Therapy; in- vitro and in- vivo Studies
Biomedical Optics, 2006Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Tayyaba Hasan, Alvin LiangAbstract:Singlet Oxygen is believed to be the active species in photodynamic therapy. We describe a real-time singlet Oxygen Monitor and its application to in-vivo studies on tumor-loaded rats and healthy human skin with ALA photosensitizer.
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diode laser Monitor for singlet molecular Oxygen
Biomedical optics, 2005Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Leyun Zhu, Ahmed M Minhaj, Anthony A Ferrante, David I Rosen, Tayyaba HasanAbstract:Monitoring singlet molecular Oxygen (1O2) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet Oxygen Monitor based on a pulsed diode laser technology. In this paper, we present results of singlet Oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet Oxygen Monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.
Steven J. Davis - One of the best experts on this subject based on the ideXlab platform.
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a singlet Oxygen Monitor as an in vivo photodynamic therapy dosimeter
12th World Congress of the International Photodynamic Association, 2009Co-Authors: Seonkyung Lee, Michael F. Hinds, Tayyaba Hasan, Alvin Liang, K Galballykinney, Julia A Ohara, Brian W Pogue, Steven J. DavisAbstract:In this paper we describe the development and testing of instruments to measure singlet molecular Oxygen produced by the photodynamic process. Singlet Oxygen is an active species in photodynamic therapy, and we are developing two instruments for PDT researchers with the goal of a real-time dosimeter for singlet Oxygen. We discuss both an ultrasensitive point sensor, and an imaging system that provides simultaneous 2D maps of the photosensitizer fluorescence and the singlet Oxygen emission. Results of in vitro tests to characterize the sensors and preliminary in vivo results are presented.
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pulsed diode laser based singlet Oxygen Monitor for photodynamic therapy in vivo studies of tumor laden rats
Journal of Biomedical Optics, 2008Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Alvin Liang, Tayyaba HasanAbstract:Photodynamic therapy (PDT) is a promising cancer treatment that involves optical excitation of photosensitizers that promote Oxygen molecules to the metastable O2(a1) state (singlet Oxygen). This species is believed to be responsible for the destruction of cancerous cells during PDT. We describe a fiber optic-coupled, pulsed diode laser-based diagnostic for singlet Oxygen. We use both temporal and spectral filtering to enhance the detection of the weak O2(aX) emission near 1.27 µm. We present data that demonstrate real-time singlet Oxygen production in tumor-laden rats with chlorin e6 and 5-aminolevulinic acid-induced protoporphyrin photosensitizers. We also observe a positive correlation between post-PDT treatment regression of the tumors and the relative amount of singlet Oxygen measured. These results are promising for the development of the sensor as a real-time dosimeter for PDT.
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A Diode Laser-Based Singlet Oxygen Monitor for Photodynamic Therapy; in- vitro and in- vivo Studies
Biomedical Optics, 2006Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Tayyaba Hasan, Alvin LiangAbstract:Singlet Oxygen is believed to be the active species in photodynamic therapy. We describe a real-time singlet Oxygen Monitor and its application to in-vivo studies on tumor-loaded rats and healthy human skin with ALA photosensitizer.
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diode laser Monitor for singlet molecular Oxygen
Biomedical optics, 2005Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Leyun Zhu, Ahmed M Minhaj, Anthony A Ferrante, David I Rosen, Tayyaba HasanAbstract:Monitoring singlet molecular Oxygen (1O2) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet Oxygen Monitor based on a pulsed diode laser technology. In this paper, we present results of singlet Oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet Oxygen Monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.
Michael F. Hinds - One of the best experts on this subject based on the ideXlab platform.
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a singlet Oxygen Monitor as an in vivo photodynamic therapy dosimeter
12th World Congress of the International Photodynamic Association, 2009Co-Authors: Seonkyung Lee, Michael F. Hinds, Tayyaba Hasan, Alvin Liang, K Galballykinney, Julia A Ohara, Brian W Pogue, Steven J. DavisAbstract:In this paper we describe the development and testing of instruments to measure singlet molecular Oxygen produced by the photodynamic process. Singlet Oxygen is an active species in photodynamic therapy, and we are developing two instruments for PDT researchers with the goal of a real-time dosimeter for singlet Oxygen. We discuss both an ultrasensitive point sensor, and an imaging system that provides simultaneous 2D maps of the photosensitizer fluorescence and the singlet Oxygen emission. Results of in vitro tests to characterize the sensors and preliminary in vivo results are presented.
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pulsed diode laser based singlet Oxygen Monitor for photodynamic therapy in vivo studies of tumor laden rats
Journal of Biomedical Optics, 2008Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Alvin Liang, Tayyaba HasanAbstract:Photodynamic therapy (PDT) is a promising cancer treatment that involves optical excitation of photosensitizers that promote Oxygen molecules to the metastable O2(a1) state (singlet Oxygen). This species is believed to be responsible for the destruction of cancerous cells during PDT. We describe a fiber optic-coupled, pulsed diode laser-based diagnostic for singlet Oxygen. We use both temporal and spectral filtering to enhance the detection of the weak O2(aX) emission near 1.27 µm. We present data that demonstrate real-time singlet Oxygen production in tumor-laden rats with chlorin e6 and 5-aminolevulinic acid-induced protoporphyrin photosensitizers. We also observe a positive correlation between post-PDT treatment regression of the tumors and the relative amount of singlet Oxygen measured. These results are promising for the development of the sensor as a real-time dosimeter for PDT.
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A Diode Laser-Based Singlet Oxygen Monitor for Photodynamic Therapy; in- vitro and in- vivo Studies
Biomedical Optics, 2006Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Tayyaba Hasan, Alvin LiangAbstract:Singlet Oxygen is believed to be the active species in photodynamic therapy. We describe a real-time singlet Oxygen Monitor and its application to in-vivo studies on tumor-loaded rats and healthy human skin with ALA photosensitizer.
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diode laser Monitor for singlet molecular Oxygen
Biomedical optics, 2005Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Leyun Zhu, Ahmed M Minhaj, Anthony A Ferrante, David I Rosen, Tayyaba HasanAbstract:Monitoring singlet molecular Oxygen (1O2) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet Oxygen Monitor based on a pulsed diode laser technology. In this paper, we present results of singlet Oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet Oxygen Monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.
Alvin Liang - One of the best experts on this subject based on the ideXlab platform.
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a singlet Oxygen Monitor as an in vivo photodynamic therapy dosimeter
12th World Congress of the International Photodynamic Association, 2009Co-Authors: Seonkyung Lee, Michael F. Hinds, Tayyaba Hasan, Alvin Liang, K Galballykinney, Julia A Ohara, Brian W Pogue, Steven J. DavisAbstract:In this paper we describe the development and testing of instruments to measure singlet molecular Oxygen produced by the photodynamic process. Singlet Oxygen is an active species in photodynamic therapy, and we are developing two instruments for PDT researchers with the goal of a real-time dosimeter for singlet Oxygen. We discuss both an ultrasensitive point sensor, and an imaging system that provides simultaneous 2D maps of the photosensitizer fluorescence and the singlet Oxygen emission. Results of in vitro tests to characterize the sensors and preliminary in vivo results are presented.
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pulsed diode laser based singlet Oxygen Monitor for photodynamic therapy in vivo studies of tumor laden rats
Journal of Biomedical Optics, 2008Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Alvin Liang, Tayyaba HasanAbstract:Photodynamic therapy (PDT) is a promising cancer treatment that involves optical excitation of photosensitizers that promote Oxygen molecules to the metastable O2(a1) state (singlet Oxygen). This species is believed to be responsible for the destruction of cancerous cells during PDT. We describe a fiber optic-coupled, pulsed diode laser-based diagnostic for singlet Oxygen. We use both temporal and spectral filtering to enhance the detection of the weak O2(aX) emission near 1.27 µm. We present data that demonstrate real-time singlet Oxygen production in tumor-laden rats with chlorin e6 and 5-aminolevulinic acid-induced protoporphyrin photosensitizers. We also observe a positive correlation between post-PDT treatment regression of the tumors and the relative amount of singlet Oxygen measured. These results are promising for the development of the sensor as a real-time dosimeter for PDT.
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A Diode Laser-Based Singlet Oxygen Monitor for Photodynamic Therapy; in- vitro and in- vivo Studies
Biomedical Optics, 2006Co-Authors: Seonkyung Lee, Michael F. Hinds, Steven J. Davis, Tayyaba Hasan, Alvin LiangAbstract:Singlet Oxygen is believed to be the active species in photodynamic therapy. We describe a real-time singlet Oxygen Monitor and its application to in-vivo studies on tumor-loaded rats and healthy human skin with ALA photosensitizer.
