The Experts below are selected from a list of 18 Experts worldwide ranked by ideXlab platform
Jean Christophe - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and Oxyphencyclimine, and of related antagonists, with four muscarinic receptors.
European journal of pharmacology, 1992Co-Authors: Magali Waelbroeck, Lise Schjelderup, Arne J. Aasen, Jean Claude Camus, Michèle Tastenoy, Ernst Mutschler, Carsten Strohmann, Reinhold Tacke, Günter Lambrecht, Jean ChristopheAbstract:We investigated the binding properties of the (R)- and (S)-enantiomers of the muscarinic antagonists trihexyphenidyl, procyclidine, hexahydro-difenidol, p-fluoro-hexahydro-difenidol, hexbutinol, p-fluoro-hexbutinol, and their corresponding methiodides at muscarinic M1, M2, M3 and M4 receptor subtypes. In addition, binding properties of the (R)- and (S)-enantiomers of Oxyphencyclimine were studied. The (R)- enantiomers (eutomers) of all the compounds had a greater affinity than the (S)-isomers for the four muscarinic receptor subtypes. The binding patterns of the (R)- and (S)-enantiomers were generally different. We did not observe any general correlation between the potency of the high-affinity enantiomer and the affinity ratio (eudismic ratio) of the two enantiomers. The results are discussed in terms of a 'four subsites' binding model.
Magali Waelbroeck - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and Oxyphencyclimine, and of related antagonists, with four muscarinic receptors.
European journal of pharmacology, 1992Co-Authors: Magali Waelbroeck, Lise Schjelderup, Arne J. Aasen, Jean Claude Camus, Michèle Tastenoy, Ernst Mutschler, Carsten Strohmann, Reinhold Tacke, Günter Lambrecht, Jean ChristopheAbstract:We investigated the binding properties of the (R)- and (S)-enantiomers of the muscarinic antagonists trihexyphenidyl, procyclidine, hexahydro-difenidol, p-fluoro-hexahydro-difenidol, hexbutinol, p-fluoro-hexbutinol, and their corresponding methiodides at muscarinic M1, M2, M3 and M4 receptor subtypes. In addition, binding properties of the (R)- and (S)-enantiomers of Oxyphencyclimine were studied. The (R)- enantiomers (eutomers) of all the compounds had a greater affinity than the (S)-isomers for the four muscarinic receptor subtypes. The binding patterns of the (R)- and (S)-enantiomers were generally different. We did not observe any general correlation between the potency of the high-affinity enantiomer and the affinity ratio (eudismic ratio) of the two enantiomers. The results are discussed in terms of a 'four subsites' binding model.
Michèle Tastenoy - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and Oxyphencyclimine, and of related antagonists, with four muscarinic receptors.
European journal of pharmacology, 1992Co-Authors: Magali Waelbroeck, Lise Schjelderup, Arne J. Aasen, Jean Claude Camus, Michèle Tastenoy, Ernst Mutschler, Carsten Strohmann, Reinhold Tacke, Günter Lambrecht, Jean ChristopheAbstract:We investigated the binding properties of the (R)- and (S)-enantiomers of the muscarinic antagonists trihexyphenidyl, procyclidine, hexahydro-difenidol, p-fluoro-hexahydro-difenidol, hexbutinol, p-fluoro-hexbutinol, and their corresponding methiodides at muscarinic M1, M2, M3 and M4 receptor subtypes. In addition, binding properties of the (R)- and (S)-enantiomers of Oxyphencyclimine were studied. The (R)- enantiomers (eutomers) of all the compounds had a greater affinity than the (S)-isomers for the four muscarinic receptor subtypes. The binding patterns of the (R)- and (S)-enantiomers were generally different. We did not observe any general correlation between the potency of the high-affinity enantiomer and the affinity ratio (eudismic ratio) of the two enantiomers. The results are discussed in terms of a 'four subsites' binding model.
Lise Schjelderup - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and Oxyphencyclimine, and of related antagonists, with four muscarinic receptors.
European journal of pharmacology, 1992Co-Authors: Magali Waelbroeck, Lise Schjelderup, Arne J. Aasen, Jean Claude Camus, Michèle Tastenoy, Ernst Mutschler, Carsten Strohmann, Reinhold Tacke, Günter Lambrecht, Jean ChristopheAbstract:We investigated the binding properties of the (R)- and (S)-enantiomers of the muscarinic antagonists trihexyphenidyl, procyclidine, hexahydro-difenidol, p-fluoro-hexahydro-difenidol, hexbutinol, p-fluoro-hexbutinol, and their corresponding methiodides at muscarinic M1, M2, M3 and M4 receptor subtypes. In addition, binding properties of the (R)- and (S)-enantiomers of Oxyphencyclimine were studied. The (R)- enantiomers (eutomers) of all the compounds had a greater affinity than the (S)-isomers for the four muscarinic receptor subtypes. The binding patterns of the (R)- and (S)-enantiomers were generally different. We did not observe any general correlation between the potency of the high-affinity enantiomer and the affinity ratio (eudismic ratio) of the two enantiomers. The results are discussed in terms of a 'four subsites' binding model.
Günter Lambrecht - One of the best experts on this subject based on the ideXlab platform.
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Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and Oxyphencyclimine, and of related antagonists, with four muscarinic receptors.
European journal of pharmacology, 1992Co-Authors: Magali Waelbroeck, Lise Schjelderup, Arne J. Aasen, Jean Claude Camus, Michèle Tastenoy, Ernst Mutschler, Carsten Strohmann, Reinhold Tacke, Günter Lambrecht, Jean ChristopheAbstract:We investigated the binding properties of the (R)- and (S)-enantiomers of the muscarinic antagonists trihexyphenidyl, procyclidine, hexahydro-difenidol, p-fluoro-hexahydro-difenidol, hexbutinol, p-fluoro-hexbutinol, and their corresponding methiodides at muscarinic M1, M2, M3 and M4 receptor subtypes. In addition, binding properties of the (R)- and (S)-enantiomers of Oxyphencyclimine were studied. The (R)- enantiomers (eutomers) of all the compounds had a greater affinity than the (S)-isomers for the four muscarinic receptor subtypes. The binding patterns of the (R)- and (S)-enantiomers were generally different. We did not observe any general correlation between the potency of the high-affinity enantiomer and the affinity ratio (eudismic ratio) of the two enantiomers. The results are discussed in terms of a 'four subsites' binding model.
